Newly discovered knowledge pertaining to glucagon and its clinical applications
Recent progress in basic research has shown that glucagon is closely involved in glucose and amino acid metabolism. Its secretion is intricately, but precisely, regulated by various mechanisms involving molecules in addition to glucose, thus showing its critical role in systemic nutrient metabolism. An innovative dual-antibody-linked immunosorbent assay for glucagon that improves measurement accuracy has been developed, and substantial clinical findings have been obtained using this new system. AbstractGlucagon has been defined as an ‘insulin counteracting hormone’, which raises blood glucose levels. Recent progress in...
Source: Journal of Diabetes Investigation - April 13, 2023 Category: Endocrinology Authors: Dan Kawamori,
Shugo Sasaki Tags: REVIEW Source Type: research
Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study
ConclusionsIn patients with type 2 diabetes with preserved renal function and normoalbuminuria, lower hemoglobin levels were a risk factor for rapid decliners, where disturbed iron metabolism might precede the development of diabetic kidney disease. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 7, 2023 Category: Endocrinology Authors: Daishi Hirano,
Hiroyuki Unoki ‐Kubota,
Toshiyuki Imasawa,
Ritsuko Yamamoto‐Honda,
Hiroshi Kajio,
Shigeo Yamashita,
Yuka Fukazawa,
Naoto Seki,
Mitsuhiko Noda,
Yasushi Kaburagi Tags: Original Article Source Type: research
Behavioral change stage might moderate the impact of multifaceted interventions on non ‐attendance from medical care among patients with type 2 diabetes: The Japan Diabetes Outcome Intervention Trial‐2 Large‐Scale Trial 007 (J‐DOIT2‐LT007)
ConclusionsAmong diabetes patients, the impact of multifaceted intervention on non-attendance from medical care might differ by the behavioral change stage. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 6, 2023 Category: Endocrinology Authors: Ryotaro Bouchi,
Mitsuhiko Noda,
Yasuaki Hayashino,
Atsushi Goto,
Katsuya Yamazaki,
Hikari Suzuki,
Toshiaki A Furukawa,
Kazuo Izumi,
Masashi Kobayashi,
J ‐DOIT2 Study Group Tags: Original Article Source Type: research
The influence of triglycerides on small dense low ‐density lipoprotein cholesterol levels is attenuated in low low‐density lipoprotein‐cholesterol range: Implications for the negative results of the PROMINENT trial
This report examined this possibilit y in 1,508 patients with type 2 diabetes and 670 healthy controls. LDL-C ranges were classified as ≤69, 70–99, 100–139 and 140≤ mg/dL. The slope of the regression curve between sdLDL-C and TG was found to flatten as LDL-C decreased; 0.18, 0.13, 0.10 and 0.04 for controls, and 0.18, 0.13, 0 .09 and 0.07 for diabetes patients. Correspondingly, the lower the LDL-C range, the lower the sdLDL-C/TG ratio. These results suggest that when LDL-C is tightly controlled, TG-lowering has only a weak inhibitory effect on sdLDL-C. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 5, 2023 Category: Endocrinology Authors: Tsutomu Hirano,
Yasuki Ito Tags: SHORT REPORT Source Type: research
Association of stressful life events with cognitive impairment in patients with type 2 diabetes mellitus
ConclusionsThese data suggested that SLEs were associated with cognitive function in patients with type 2 diabetes mellitus. Adverse life events, such as the death of an offspring or parent, were risk factors for cognitive impairment, whereas high work pressure in middle-aged people was a protective factor against cognitive impairment. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 29, 2023 Category: Endocrinology Authors: Lina Wang,
Shanshan Dong,
Chenxu Zhao,
Zhaoyu Gao,
Lei Jiang,
Rui Zhang,
Tingting Shen,
Yingying Guo,
Huimin Zhou,
Shunjiang Xu Tags: Original Article Source Type: research
Stimulatory effect of imeglimin on incretin secretion
ConclusionsOur data suggest that the imeglimin-induced increase in plasma GLP-1 levels likely contributes at least in part to its stimulatory effect on insulin secretion. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 28, 2023 Category: Endocrinology Authors: Quan Yingyue,
Kenji Sugawara,
Harumi Takahashi,
Norihide Yokoi,
Kento Ohbayashi,
Yusaku Iwasaki,
Susumu Seino,
Wataru Ogawa Tags: Original Article Source Type: research
Effect of the Diabetic Nephropathy Aggravation Prevention Program on medical visit behavior in individuals under the municipal national health insurance
ConclusionsOur findings showed that insurer efforts had an additive effect on the increase in the number of medical visits, suggesting that this national program could reduce the number of end-stage renal failures or dialysis in Japan. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 25, 2023 Category: Endocrinology Authors: Asuka Ikeda,
Makoto Fujii,
Yuko Ohno,
Kayo Godai,
Yaya Li,
Yuko Nakamura,
Daisuke Yabe,
Kazuyo Tsushita,
Naoki Kashihara,
Kei Kamide,
Mai Kabayama Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 23, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
A 7 day inpatient diabetes education program improves quality of life and glycemic control 12 months after discharge
ConclusionsOur program effectively improves quality of life and post-discharge glycemic control in patients with type 2 diabetes mellitus. It is particularly effective in patients of the male gender, with a shorter duration of diabetes mellitus and higher HbA1c at admission. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 21, 2023 Category: Endocrinology Authors: Mika Kurita,
Hiroaki Satoh,
Hideyoshi Kaga,
Satoshi Kadowaki,
Yuki Someya,
Yuka Tosaka,
Yuya Nishida,
Fuki Ikeda,
Yoshifumi Tamura,
Hirotaka Watada Tags: Original Article Source Type: research
Associations of sleep quality with the skeletal muscle strength in patients with type 2 diabetes with poor glycemic control
ConclusionsOur study revealed a significant association between the sleep quality and muscle strength in patients with type 2 diabetes mellitus. These results suggest that poor sleep quality is an important risk factor for sarcopenia in patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 20, 2023 Category: Endocrinology Authors: Takanori Hayashi,
Nobuhiro Wada,
Tetsuya Kubota,
Chie Koizumi,
Yoshitaka Sakurai,
Masakazu Aihara,
Satoshi Usami,
Toshimasa Yamauchi,
Naoto Kubota Tags: Original Article Source Type: research
Association of glucagon ‐like peptide‐1 receptor agonist treatment with gastric residue in an esophagogastroduodenoscopy
ConclusionGLP-1RA treatment is associated with gastric residue in an esophagogastroduodenoscopy in patients with diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 16, 2023 Category: Endocrinology Authors: Toshiko Kobori,
Yukiko Onishi,
Yoko Yoshida,
Tazu Tahara,
Takako Kikuchi,
Tetsuya Kubota,
Masahiko Iwamoto,
Tomonobu Sawada,
Reo Kobayashi,
Hiroaki Fujiwara,
Masato Kasuga Tags: Original Article Source Type: research
Resistin G –A haplotype at SNP‐420/‐358 is associated with the latent sarcopenic obesity index in the toon genome study
ConclusionsThe G –A haplotype was associated with the latent sarcopenic obesity index defined by grip strength in the Japanese cohort, could be mediated by TNF-α. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 11, 2023 Category: Endocrinology Authors: Yosuke Ikeda,
Ryoichi Kawamura,
Yasunori Takata,
Yasuharu Tabara,
Koutatsu Maruyama,
Misaki Takakado,
Toshimi Hadate,
Jun Ohashi,
Isao Saito,
Yoshihiro Ogawa,
Haruhiko Osawa Tags: Original Article Source Type: research
Risk heterogeneity of bullous pemphigoid among dipeptidyl peptidase ‐4 inhibitors: A population‐based cohort study using Japanese Latter‐Stage Elderly Healthcare Database
ConclusionsNot all the DPP-4 inhibitors could induce bullous pemphigoid significantly. Therefore, the association warrants further investigations before generalization. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 10, 2023 Category: Endocrinology Authors: Yumi Harano,
Yasutaka Mitamura,
Peng Jiang,
Takako Fujita,
Akira Babazono Tags: Original Article Source Type: research
Signaling pathways that regulate adaptive β‐cell proliferation for the treatment of diabetes
There are distinct signaling pathways that evoke adaptive β-cell proliferation between acute and chronic insulin resistance models. Those signals are, at least in part, mediated through humoral factors from the liver under chronic insulin resistance or fat under acute insulin resistance. AbstractThe decline in β-cell mass due to the failure of β-cell compensation is one cause of the development of type 2 diabetes. Therefore, elucidation of the mechanism by which an adaptive increase in β-cell mass occursin vivo will lead to the development of a cure for diabetes. Insulin and insulin receptor (IR)-mediated signalin...
Source: Journal of Diabetes Investigation - March 6, 2023 Category: Endocrinology Authors: Jun Shirakawa Tags: Mini Review Source Type: research
Effects of switching from liraglutide to semaglutide or dulaglutide in patients with type 2 diabetes: A randomized controlled trial
ConclusionsSwitching from once-daily liraglutide to once-weekly semaglutide 0.5 mg significantly improved glycemic control and body weight compared with switching to once-weekly dulaglutide 0.75 mg. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 5, 2023 Category: Endocrinology Authors: Takahiro Iijima,
Shibuya Makoto,
Yuzuru Ito,
Yasuo Terauchi Tags: Clinical Trial Source Type: research
