Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes
Glucagon secretion is suppressed by carbohydrate intake, and increased by protein intake, whereas oral lipid intake had little effect to glucagon secretion in young healthy people. Whereas protein intake robustly stimulated both insulin and glucagon secretion, plasma glucose levels were maintained at a constant level. AbstractFew studies in Asian populations have analyzed how glucagon secretion is affected by ingested glucose, proteins or lipids, individually. To investigate the fluctuations of glucagon secretion after the intake of each of these nutrients, 10 healthy volunteers underwent oral loading tests using each of g...
Source: Journal of Diabetes Investigation - July 22, 2023 Category: Endocrinology Authors: Raishi Ichikawa,
Koji Takano,
Kazumi Fujimoto,
Masaki Kobayashi,
Tadahiro Kitamura,
Masayoshi Shichiri,
Takeshi Miyatsuka Tags: SHORT REPORT Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 21, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
Fibroblast growth factor 21 as a candidate of a novel serum biomarker for mitochondrial diabetes
Serum fibroblast growth factor 21 levels in patients with mitochondrial diabetes might be much higher than in those with other diabetes types. The results of this study could lead to the establishment of a simple method for screening mitochondrial diabetes using peripheral blood serum. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 21, 2023 Category: Endocrinology Authors: Yuji Komorita,
Akiyo Shiroozu,
Hidetoshi Nakamura Tags: Letter to the Editor Source Type: research
Association of the triglyceride ‐glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus patients: A retrospective cross‐sectional study
ConclusionsThe TyG index is independently associated with SLVD in type 2 diabetes mellitus patients and is a more reliable indicator of SLVD than HOMA2-IR. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 21, 2023 Category: Endocrinology Authors: Qi ‐chao Sun,
Jie Liu,
Ran Meng,
Ning Zhang,
Jing Yao,
Fan Yang,
Da‐long Zhu Tags: Original Article Source Type: research
Erratum
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 15, 2023 Category: Endocrinology Tags: Erratum Source Type: research
A subtype of laminopathies: Generalized lipodystrophy ‐associated progeroid syndrome caused by LMNA gene c.29C > T mutation
This paper reports the first case of generalized lipodystrophy-associated progeroid syndrome (GLPS) with LMNA c.29C>T mutation in China. AbstractThe term laminopathies refers to a group of congenital diseases characterized by accelerated degeneration of human tissues. Mutations in LMNA, LMNB, ZMPSTE24, and other genes lead to structural and functional abnormalities associated with lamins. One subtype of laminopathy is the generalized lipodystrophy-associated progeroid syndrome (GLPS), which occurs in patients with heterozygous mutations of the LMNA gene c.29C>T(p.T10I). This paper reports the first case of GLPS in Ch...
Source: Journal of Diabetes Investigation - July 14, 2023 Category: Endocrinology Authors: Shipeng Huang,
Yan Zhang,
Zuan Zhan,
Shuhao Gong Tags: Case Report Source Type: research
Role of glycosylphosphatidylinositol ‐anchored high‐density lipoprotein binding protein 1 in hypertriglyceridemia and diabetes
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1) is a crucial molecule for the translocation of lipoprotein lipase from parenchymal cells to luminal surface of capillary endothelial cells, and maintenance of lipolytic activity. The null mutation of GPIHBP1 and the production of GPIHBP1 autoantibody induce severe hypertriglyceridemia and recurrent episodes of acute pancreatitis. In patients with type 2 diabetes, the circulating GPIHBP1 levels might not correlate well with triglyceride-rich lipoproteins, and rather well-reflect the microvascular complications, such diabetic reti...
Source: Journal of Diabetes Investigation - July 14, 2023 Category: Endocrinology Authors: Naoko Kurooka,
Jun Eguchi,
Jun Wada Tags: Review Article Source Type: research
Changes in glycemic control and skeletal muscle mass indices after dapagliflozin treatment in individuals with type 1 diabetes mellitus
ConclusionDapagliflozin treatment of individuals with type 1 diabetes, particularly non-obese individuals and older men, might result in loss of skeletal muscle mass. However, good glycemic control during treatment might prevent the onset and progression of sarcopenia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 10, 2023 Category: Endocrinology Authors: Yuta Yoshimura,
Yoshitaka Hashimoto,
Hiroshi Okada,
Maya Takegami,
Hanako Nakajima,
Tomoki Miyoshi,
Takashi Yoshimura,
Masahiro Yamazaki,
Masahide Hamaguchi,
Michiaki Fukui Tags: Clinical Trial Source Type: research
Effects of nutrient metabolism on pancreatic β‐cell mass and function: Recent findings
This article summarizes recent findings on the effects of nutrients on pancreatic ß-cell mass and function. Further studies are expected to facilitate the prevention of the onset and treatment of diabetes by nutritional therapy. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 10, 2023 Category: Endocrinology Authors: Takuma Yasuda,
Norio Harada Tags: Update Source Type: research
LINC01705 derived from adipocyte exosomes regulates hepatocyte lipid accumulation via an miR ‐552‐3p/LXR axis
ConclusionsWhen taken together, our findings showed that high glucose increased the LINC01705 levels in adipocyte exosomes, and thereby improved HepG2 lipid accumulationvia an miR-552-3p/LXR axis. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 7, 2023 Category: Endocrinology Authors: Anhua Lin,
Wenjing He Tags: Original Article Source Type: research
Validity of the short ‐form five‐item Problem Area in Diabetes questionnaire as a depression screening tool in type 2 diabetes mellitus patients
ConclusionsDepressive symptoms are prevalent in people with type 2 diabetes, with the degree of distress significantly related to the severity of depressive symptoms. PAID-5 is a valid and reliable screening tool, and a score ≥9 could prompt further confirmation for depression. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 6, 2023 Category: Endocrinology Authors: Donovan Tay,
Marvin Chua,
Joan Khoo Tags: Original Article Source Type: research
Contribution of animal models to diabetes research: Its history, significance, and translation to humans
Animal models of diabetes and application to human studies ABSTRACTDiabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes. Despite recent significant improvements of life expectancy in patients with diabetes, there is still a need for efforts to elucidate the complexities and mechanisms of the disease processes to overcome this difficult disorder. To this end, the use of appropriate animal models in diabetes studies is invaluable for translation to humans and...
Source: Journal of Diabetes Investigation - July 4, 2023 Category: Endocrinology Authors: Soroku Yagihashi Tags: Review Source Type: research
Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes
In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large-scale, long-term study is needed to validate uEGF as a reliable CAN biomarker. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 3, 2023 Category: Endocrinology Authors: Yu Kuei Lin,
Emily Tanner,
Yuee Wang,
Wen Ye,
Lynn Ang,
Wenjun Ju,
Rodica Pop ‐Busui Tags: Short Report Source Type: research
miR ‐31 ameliorates type 2 diabetic vascular damage through up‐regulation of hypoxia‐inducible factor‐1α/vascular endothelial growth factor‐A
ConclusionOur experiments show that miR-31 can delay the progression of type 2 diabetes mellitus and ameliorate diabetic vascular injury. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 3, 2023 Category: Endocrinology Authors: Yuan Fu,
Ruochen Du,
Yufei Wang,
Yitong Yuan,
Yujuan Zhang,
Chunfang Wang,
Xuanping Zhang Tags: Original Article Source Type: research
Non ‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease
ConclusionsNon-classical monocytes frequency and vitamin D3 levels were significantly reduced in DFU patients with PAD. Non-classical monocytes frequency was associated with vitamin D3 in DFUs patients, and both parameters were linked to lipid profile. Vitamin D3 upregulation was a risk-reducing factor for PAD occurrence. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 3, 2023 Category: Endocrinology Authors: Reham Hammad,
Maisa A Abdel Wahab,
Nehal Farouk,
Mohamed Yahia Zakaria,
Mona A Eldosoky,
Asmaa A Elmadbouly,
Sara A Tahoun,
Eman Mahmoud,
Seham K Khirala,
Amena Rezk Mohammed,
Wafaa Abdelaziz Emam,
Asmaa A Abo Elqasem,
Fatma M Kotb,
Rasha Abd Tags: ORIGINAL ARTICLE Source Type: research
