Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes

Glucagon secretion is suppressed by carbohydrate intake, and increased by protein intake, whereas oral lipid intake had little effect to glucagon secretion in young healthy people. Whereas protein intake robustly stimulated both insulin and glucagon secretion, plasma glucose levels were maintained at a constant level. AbstractFew studies in Asian populations have analyzed how glucagon secretion is affected by ingested glucose, proteins or lipids, individually. To investigate the fluctuations of glucagon secretion after the intake of each of these nutrients, 10 healthy volunteers underwent oral loading tests using each of glucose, proteins and lipids, and blood levels of glucose, insulin and glucagon were measured every 30  min for 120 min. Whereas glucagon secretion was suppressed and minimally affected by oral glucose intake and lipid intake, respectively, oral protein intake robustly increased glucagon secretion, as well as insulin secretion. Further studies are needed to elucidate the mechanism by which protei n loading increases glucagon secretion.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: SHORT REPORT Source Type: research