Glycemic variability: Measurement, target, impact on complications of diabetes and does it really matter?
AbstractOver the past two decades, there has been continuous advancement in the accuracy and complexity of continuous glucose monitoring devices. Continuous glucose monitoring provides valuable insights into blood glucose dynamics, and can record glucose fluctuations accurately and completely. Glycemic variability (GV) is a straightforward measure of the extent to which a patient's blood glucose levels fluctuate between high peaks and low nadirs. Many studies have investigated the relationship between GV and complications, primarily in the context of type 2 diabetes. Nevertheless, the exact contribution of GV to the dev...
Source: Journal of Diabetes Investigation - November 22, 2023 Category: Endocrinology Authors: Yifei Mo,
Jingyi Lu,
Jian Zhou Tags: Review Source Type: research
Effectiveness and safety of sodium –glucose cotransporter 2 inhibitors in Asian populations
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 21, 2023 Category: Endocrinology Authors: Kyoung Hwa Ha,
Dae Jung Kim Tags: Update Source Type: research
Circ_0068087 knockdown attenuates high ‐glucose‐induced human tubular epithelial cell injury in a microribonucleic acid/progestin and adipoQ receptor 3‐dependent manner in diabetic nephropathy
ConclusionCirc_0068087 promoted HG-induced HK2 cell injuries by the regulation of the miR-580-3p/PAQR3 pathway. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 21, 2023 Category: Endocrinology Authors: Shu ‐yan Liu,
Hong Wang,
Bo Yang,
Baohua Hou,
Li‐sha Sun,
Hui Pang,
Hui‐hui Wang,
Yan‐ping Fan Tags: Original Article Source Type: research
The association between alcohol drinking and glycemic management among people with type 2 diabetes in China
ConclusionsHeavy alcohol drinking might have a negative effect on glycemic management among patients with type 2 diabetes irrespective of the use of anti-diabetes agents in regional China. This study has important public health implications regarding precision intervention on patients' glycemia control for type 2 diabetes management. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 21, 2023 Category: Endocrinology Authors: Qing Ye,
Xiaojun Ouyang,
Zhenzhen Qin,
Yijia Chen,
Xuening Zhang,
Ye Liu,
Qinglin Lou,
Fei Xu Tags: Original Article Source Type: research
MiR ‐488‐3p facilitates wound healing through CYP1B1‐mediated Wnt/β‐catenin signaling pathway by targeting MeCP2
ConclusionsMiR-488-3p is a potential therapeutic target for diabetic wound healing since it improved wound healing by activating the CYP1B1-mediated Wnt4/-catenin signaling cascadevia MeCP2. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 14, 2023 Category: Endocrinology Authors: Chenchen Zuo,
Pengju Fan,
Ying Yang,
Chengjun Hu Tags: Original Article Source Type: research
Effects of hybrid closed ‐loop system on glycemic control and psychological aspects in persons with type 1 diabetes treated with sensor‐augmented pump: A prospective single‐center observational study
ConclusionsThe hybrid closed-loop system decreased hyperglycemia and minimized hypoglycemia, but did not improve psychological aspects compared with the predictive low-glucose suspend system, probably because sensor calibration was increased. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 8, 2023 Category: Endocrinology Authors: Tomoaki Akiyama,
Tadashi Yamakawa,
Kazuki Orime,
Masahiro Ichikawa,
Marina Harada,
Takumi Netsu,
Ryoichi Akamatsu,
Keita Nakamura,
Satoru Shinoda,
Yasuo Terauchi Tags: Clinical Trial Source Type: research
Delayed dinnertime impairs glucose tolerance in healthy young adults
We investigated the relationship between mealtime delays of up to 3 hours and subsequent glucose fluctuations in healthy young adults. After assessing glucose responses using intermittently scanned continuous glucose monitoring devices (isCGM), the peak glucose elevation, and incremental area under the curve (iAUC) of postprandial glucose during certain intervals increased significantly when the time between lunch and dinner was delayed by 1 h or more. Our findings support the importance of improving irregular mealtime habits, such as late eating. AbstractTo explore the relationship between mealtime delays of up to 3 h ...
Source: Journal of Diabetes Investigation - November 3, 2023 Category: Endocrinology Authors: Fuzuki Nakamura,
Yuki Shimba,
Saki Toyonaga,
Chiemi Kuroda,
Asuka Yamato,
Yuhi Yamada,
Toshio Hosaka Tags: Short Report Source Type: research
Mandatory monthly outpatient visits could improve therapeutic inertia in patients with poorly controlled type 2 diabetes
ConclusionsMandatory monthly outpatient visits could improve therapeutic inertia in patients with poorly controlled type 2 diabetes, especially in those with worsened control. The trajectory of HbA1c could significantly influence the assessment of the prevalence of therapeutic inertia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 27, 2023 Category: Endocrinology Authors: Ying ‐Ying Tsai,
Ting‐Yu Kuo,
Meng‐Hung Lin,
Feng‐Chih Shen,
Yung‐Hsiang Lin Tags: Original Article Source Type: research
The association between metabolic syndrome and insulin resistance with risk of cardiovascular events in different states of cardiovascular health status
ConclusionsMetabolic syndrome and the dyslipidemia component had a negligible but significant improvement in the prediction of cardiovascular disease among individuals with non-optimal iCVH status. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 25, 2023 Category: Endocrinology Authors: Somayeh Hosseinpour ‐Niazi,
Siamak Afaghi,
Parto Hadaegh,
Maryam Mahdavi,
Hossein Farhadnejad,
Maryam Tohidi,
Parvin Mirmiran,
Fereidoun Azizi,
Farzad Hadaegh Tags: Original Article Source Type: research
Dipeptidyl peptidase ‐4 inhibition targeting vascular senescence as a novel treatment for atherosclerosis
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 21, 2023 Category: Endocrinology Authors: I ‐Weng Yen,
Hung‐Yuan Li Tags: Commentary Source Type: research
Comment on the article titled “Association of the triglyceride‐glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus patients: A retrospective cross‐sectional study”
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 21, 2023 Category: Endocrinology Authors: Mehmet Ilkin Naharci Tags: Letter to the Editor Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 18, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
Pituitary gland agouti ‐related peptide cells: Novel player controlling glucose metabolism
The liver synthesizes and releases bile acids into the gut. Bile acids, either directly or indirectly, inhibit agouti-related peptide (AGRP)-B cells in the pars tuberalis of the pituitary gland. AGRP-B cells are assumed to promote pancreatic insulin secretion and/or to improve insulin sensitivities in insulin sensitive organs, resulting in improved glucose tolerance. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 17, 2023 Category: Endocrinology Authors: Kei Takahashi,
Hideki Katagiri Tags: COMMENTARY Source Type: research
Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle ‐aged and older adults: The Hisayama Study
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 17, 2023 Category: Endocrinology Authors: Susumu Tsuda,
Takanori Honda,
Mayu Higashioka,
Jun Hata,
Toshiaki Nakano,
Takanari Kitazono,
Toshiharu Ninomiya Tags: Letter to the Editor Source Type: research
Exploration of the mechanism of reinfusion of fresh autologous blood in type 2 diabetes mice to induce macrophage polarization and inhibit erythrocyte damage
ConclusionThe reinfusion of fresh autologous blood into the body of patients with type 2 diabetes can induce macrophage polarization to M2, thereby inhibiting red blood cell damage. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 17, 2023 Category: Endocrinology Authors: She ‐jun Hu,
Jia‐ming Xu,
Man‐di Wu,
Ke Yue,
Ying‐hui Cui,
Yu Bai,
Lai‐wei You,
Jian‐Rong Guo Tags: ORIGINAL ARTICLE Source Type: research
