Association of self ‐stigma with glycated hemoglobin: A single‐center, cross‐sectional study of adults with type 1 diabetes in Japan
ConclusionsThis cross-sectional study showed a significant association between self-stigma and HbA1c in persons with type 1 diabetes. Addressing self-stigma might be as equally essential as measuring HbA1c in evaluating glycemic outcome among individuals with type 1 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2023 Category: Endocrinology Authors: Shoko Hamano,
Yukiko Onishi,
Yoko Yoshida,
Toshiko Takao,
Tazu Tahara,
Takako Kikuchi,
Toshiko Kobori,
Tetsuya Kubota,
Masahiko Iwamoto,
Masato Kasuga Tags: ORIGINAL ARTICLE Source Type: research
Trends in incidence rates of childhood type 1 diabetes mellitus: A retrospective study in Isfahan province, Iran
ConclusionOur findings showed that currently our region is considered a region with a high incidence rate of type 1 diabetes mellitus. Although we have had fluctuations in the incidence rate over the 12 years, the overall trend is increasing. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2023 Category: Endocrinology Authors: Mahin Hashemipour,
Mohammadreza Maracy,
Shaghayegh Haghjooy Javanmard,
Farzane Zamaneh,
Neda Mostofizadeh,
Silva Hovsepian Tags: Original Article Source Type: research
Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol ‐requiring enzyme 1 alpha–X‐box binding protein 1 pathway by downregulating prostaglandin‐endoperoxide synthase 2
ConclusionSIN decreases the expression ofPTGS2 to inactivate the inositol-requiring enzyme 1 alpha–X-box binding protein 1 signaling pathway, which inhibits microglial activation, as well as the release of inflammatory factors, thus alleviating DPNP. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 24, 2023 Category: Endocrinology Authors: Ji Chen,
Peng Guo,
Xinxin Liu,
Huizhi Liao,
Kemin Chen,
Yuxia Wang,
Jie Qin,
Fengrui Yang Tags: Original Article Source Type: research
Bivalent GAD autoantibody ELISA improves clinical utility and risk prediction for adult autoimmune diabetes
ConclusionsThese results suggest that bivalent ELISA for GADA is superior to the RIA method in diagnosing type 1 diabetes. Moreover, the diagnostic superiority of the ELISA-GADA made possible the concurrent identification of SPIDDM patients at high-risk of early progression, and allowed for more accurate clinical diagnosis and management. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 24, 2023 Category: Endocrinology Authors: Eiji Kawasaki,
Akira Shimada,
Akihisa Imagawa,
Norio Abiru,
Takuya Awata,
Yoichi Oikawa,
Haruhiko Osawa,
Yumiko Kawabata,
Junji Kozawa,
Tetsuro Kobayashi,
Kazuma Takahashi,
Daisuke Chujo,
Tomoyasu Fukui,
Junnosuke Miura,
Kazuki Yasuda,
Hisa Tags: Original Article Source Type: research
Update information on type 1 diabetes in children/adolescents and adults
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 20, 2023 Category: Endocrinology Authors: Junnosuke Miura,
Yasuko Uchigata Tags: UPDATE Source Type: research
Progress in genetics of type 2 diabetes and diabetic complications
Genome-wide association studies (GWAS) were conducted and new genetic loci were identified that modulate the risk of developing type 2 diabetes and diabetic complications. The polygenic risk score and multi-omics analysis have begun to decipher the molecular mechanisms of diabetes and its complications. AbstractType 2 diabetes results from a complex interaction between genetic and environmental factors. Precision medicine for type 2 diabetes using genetic data is expected to predict the risk of developing diabetes and complications and to predict the effects of medications and life-style intervention more accurately for in...
Source: Journal of Diabetes Investigation - January 15, 2023 Category: Endocrinology Authors: Nobuhiro Shojima,
Toshimasa Yamauchi Tags: Review Source Type: research
New ‐onset type 1 diabetes and Graves' disease after antiretroviral therapy in a patient with human immunodeficiency virus infection
Human immunodeficiency virus patients receiving antiretroviral therapy can develop immune-inflammatory reconstitution syndrome. Type 1 diabetes is an autoimmune disease, but type 1 diabetes is rarely reported as immune-inflammatory reconstitution syndrome. In this article, we report a case of combined Graves' disease and type 1 diabetes after antiretroviral therapy initiation with possible immune-inflammatory reconstitution syndrome with previous case series. AbstractPatients with human immunodeficiency virus (HIV) infection receiving antiretroviral therapy can develop autoimmune diseases, referred to as immune-inflam...
Source: Journal of Diabetes Investigation - January 11, 2023 Category: Endocrinology Authors: Maho Taguchi,
Noriko Ihana ‐Sugiyama,
Daisuke Shiojiri,
Kazuo Izumi,
Michi Kobayashi,
Noriko Kodani,
Ryotaro Bouchi,
Mitsuru Ohsugi,
Akiyo Tanabe,
Kohjiro Ueki,
Hiroshi Kajio Tags: Case Report Source Type: research
Mechanisms and the strategy for remission of type 2 diabetes mellitus
Type 2 diabetes is no longer seen as being an irreversible natural course, accompanied by progressive beta cell failure and various chronic diabetes related complications. In contrast, remission can be achieved through a personalized approach. It is a paradigm shift in our understanding of type 2 diabetes and it may be necessary to change the concept of type 2 diabetes as an urgent condition requiring rapid intervention rather than a chronic progressive disease. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 10, 2023 Category: Endocrinology Authors: Tien ‐Jyun Chang Tags: EDITORIAL Source Type: research
False hemoglobin A1c value as a result of compound heterozygotes of hemoglobin E and hemoglobin New York
In this study, we report a case of the double hemoglobin (Hb) variants heterozygotes in the β-globin gene, the first reported compound heterozygote for HbE and Hb New York. High-performance liquid chromatography only showed HbE whether by glycated Hb program or Hb program, but capillary electrophoresis detected HbE and Hb New York. The double heterozygote caused erroneous results for HbA1c on high-performance liquid chromatography and enzyme assay. AbstractThe presence of hemoglobin (Hb) variants might interfere with some glycated hemoglobin (HbA1c) measurements. There have been a few reports of compound Hb variants affec...
Source: Journal of Diabetes Investigation - January 10, 2023 Category: Endocrinology Authors: Youqiong Li,
Jianling Tang,
Lihong Zheng,
Kaijian Tang,
Lingli Li Tags: Case Report Source Type: research
Neuroprotective properties of DPP ‐4i: A therapeutic target for dementia prevention in elderly diabetic patients?
Possible mechanisms of Alzheimer's disease-related cognitive impairment in patients with diabetes mellitus are shown in this figure. DPP-4i may modulate A β accumulation in the process of AD-related cognitive impairment. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 9, 2023 Category: Endocrinology Authors: Toshitaka Umemura,
Takahiko Kawamura Tags: Commentary Source Type: research
Effect of intensive lifestyle intervention on the association between weight variability and major adverse cardiovascular events in overweight or obese adults with type 2 diabetes mellitus
ConclusionsAmong the overweight or obese individuals with type 2 diabetes mellitus, rising weight variability was independently associated with increased MACE risks in the DSE arm. Therefore, a guideline-recommended ILI strategy for weight loss should be adopted to improve cardiovascular outcomes without worrying about the effect of weight fluctuations. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 4, 2023 Category: Endocrinology Authors: Xiangbin Zhong,
Xingfeng Xu,
Menghui Liu,
Peng Wang,
Lixiang He,
Odong Christopher,
Shaozhao Zhang,
Yifen Lin,
Yiquan Huang,
Zhenyu Xiong,
Xiaodong Zhuang,
Xinxue Liao Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 2, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
MNX1 mutations causing neonatal diabetes: Review of the literature and report of a case with extra ‐pancreatic congenital defects presenting in severe diabetic ketoacidosis
We describe the genetic and clinical features of a preterm male infant with a homozygous [c.816C > A p.(Phe272Leu)]MNX1 mutation. Our proband is the first case to present in severe diabetic ketoacidosis (DKA), indicating severe insulin deficiency. Unlike the previously reported female case who had the same mutation and presented with isolated PNDM, our proband had hypospadias and congenital umbilical hernia and showed poor growth on follow up. Our case suggests thatMNX1 mutations causing NDM can result in a range of extra-pancreatic features and a variable phenotype, similar to other transcription factors causing ...
Source: Journal of Diabetes Investigation - January 1, 2023 Category: Endocrinology Authors: Hanan Hassan Aly,
Elisa De Franco,
Sarah E. Flanagan,
Yasmine I. Elhenawy Tags: Mini Review Source Type: research
LncRNA TCF7 contributes to high glucose ‐induced damage in human podocytes by up‐regulating SEMA3A via sponging miR‐16‐5p
ConclusionsThese findings suggested that TCF7 silencing attenuated high glucose-induced podocyte damage partially through the miR-16-5p/SEMA3A regulation cascade. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 30, 2022 Category: Endocrinology Authors: Zhenzhen Jiang,
Lijie Qian,
Ruifeng Yang,
Yan Wu,
Yongping Guo,
Tingfang Chen Tags: Original Article Source Type: research
Promoting pancreatic β cell proliferation: A powerful key for realizing regenerative therapy for diabetes
This commentary is on a recent report on the regulation mechanism of beta cell proliferation. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 27, 2022 Category: Endocrinology Authors: Yukihiro Shimaya,
Nobuaki Shiraki,
Shoen Kume Tags: Commentary Source Type: research
