Targeted gene panel analysis of Japanese patients with maturity ‐onset diabetes of the young‐like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes
ConclusionsCausative genomic variants could be identified in at least 46.2% of clinically suspected MODY patients.ABCC8-MODY with inactivating variants could represent a distinct category of MODY. Genes of insulin resistance should be included in the sequencing panel for MODY. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 12, 2022 Category: Endocrinology Authors: Tohru Yorifuji,
Yoh Watanabe,
Kana Kitayama,
Yuki Yamada,
Shinji Higuchi,
Jun Mori,
Masaru Kato,
Toru Takahashi,
Tokuko Okuda,
Takane Aoyama Tags: Original Article Source Type: research
Association of cardiovascular health metrics with annual incidence of prediabetes or diabetes: Analysis of a nationwide real ‐world database
ConclusionsCVH metrics could stratify the risk of the annual development of prediabetes or diabetes. The risk of developing prediabetes or diabetes might be reduced by improving CVH metrics. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 10, 2022 Category: Endocrinology Authors: Akira Okada,
Hidehiro Kaneko,
Satoshi Matsuoka,
Hidetaka Itoh,
Yuta Suzuki,
Katsuhito Fujiu,
Nobuaki Michihata,
Taisuke Jo,
Norifumi Takeda,
Hiroyuki Morita,
Satoko Yamaguchi,
Koichi Node,
Toshimasa Yamauchi,
Hideo Yasunaga,
Issei Komuro Tags: Original Article Source Type: research
Circulating selenoprotein P levels predict glucose‐lowering and insulinotropic effects of metformin, but not alogliptin: A post‐hoc analysis
ConclusionsHigher baseline levels of SeP significantly predicted metformin-mediated, but not alogliptin-mediated, glucose-lowering and insulinotropic effects. Serum SeP levels might be a novel biomarker for predicting the outcomes of metformin therapy, which might be helpful in tailoring diabetes medication. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 8, 2022 Category: Endocrinology Authors: Yumie Takeshita,
Takeo Tanaka,
Hiroaki Takayama,
Yuki Kita,
Hisanori Goto,
Yujiro Nakano,
Yoshiro Saito,
Toshinari Takamura Tags: CLINICAL TRIAL Source Type: research
2022 Reviewer Acknowledgement
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 5, 2022 Category: Endocrinology Tags: Acknowledgment of Reviewers Source Type: research
Subject Index
Volume 13
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 5, 2022 Category: Endocrinology Tags: Subject Index Source Type: research
Pontine lesion in hyperglycemic crises: Relevance to osmotic demyelination syndrome and posterior reversible encephalopathy syndrome
Fluid-attenuated inversion recovery imaging (FLAIR) showed swelling of the pons with hyperintense signals extending to the cerebellar peduncle at second crises. Hyperintense signals were still observed 4 weeks after the second crisis. AbstractWe herein describe a case of type 1 diabetes that presented with a pontine lesion during two hyperglycemic crises accompanied by marked fluctuations in serum osmotic pressure and blood pressure. Magnetic resonance imaging showed swollen pons with osmotic demyelination syndrome characteristics accompanying cytotoxic edema at the f irst crisis. The involvement of vasogenic edema w...
Source: Journal of Diabetes Investigation - December 3, 2022 Category: Endocrinology Authors: Satoshi Murao,
Takaaki Kiuchi,
Momoka Hasegawa,
Ritsuko Yoshikawa Tags: CASE REPORT Source Type: research
Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma
ConclusionsThe different phases of diabetes have a major impact on PDAC by altering PMS2 expression and the tumor immune microenvironment, which can be targeted by an immune checkpoint inhibitor. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 1, 2022 Category: Endocrinology Authors: Xuekai Pan,
Hiroki Mizukami,
Yutaro Hara,
Takahiro Yamada,
Keisuke Yamazaki,
Kazuhiro Kudoh,
Yuki Takeuchi,
Takanori Sasaki,
Hanae Kushibiki,
Akiko Igawa,
Kenichi Hakamada Tags: Original Article Source Type: research
Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
Recent preclinical studies have provided insight on imeglimin's action on pancreatic β-cells and the mechanisms underlying its clinical benefits. Imeglimin may enhance glucose-induced insulin secretion (GIIS) and inhibit apoptosis of pancreatic ß-cells leading to preserved β-cell mass by maintaining or restoring the functional and structural integrity of the mitochondria and the endoplasmic reticulum homeostasis in pancreatic β-cells. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 1, 2022 Category: Endocrinology Authors: Muhammad Fauzi,
Takaaki Murakami,
Daisuke Yabe,
Nobuya Inagaki Tags: Commentary Source Type: research
Glucagon ‐like peptide‐1 therapy for youth with type 2 diabetes
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 30, 2022 Category: Endocrinology Authors: Young Min Cho Tags: Commentary Source Type: research
Immediate effect of textured insoles on the balance in patients with diabetic neuropathy
ConclusionsWearing textured insoles can increase the balance in patients with diabetic neuropathy. This can be due to its effect on the sensory feedback of the soles, improving the proprioception and tactile sensors that are the main sources of balance. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 29, 2022 Category: Endocrinology Authors: Seyed Javad Alaee,
Kourosh Barati,
Behnam Hajiaghaei,
Banafshe Ghomian,
Sedigheh Moradi,
Marziyeh Poorpirali Tags: ORIGINAL ARTICLE Source Type: research
Interaction among dietary n ‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients
ConclusionsOur results show the role of n-3/n-6 dietary polyunsaturated fatty acids in modifying the effects of genetic susceptibility on lipoprotein concentrations in patients with type 2 diabetes. Our findings highlight the potential of interventions with dietary polyunsaturated fatty acids regarding developing individualized prevention strategies for type 2 diabetes presenting with co-occurring dyslipidemia and cardiovascular diseases. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 23, 2022 Category: Endocrinology Authors: Pei ‐Chi Huang,
Hsuan Cheng,
Yu‐Ting Su,
Meng‐Chuan Huang,
Chih‐Cheng Hsu,
Shang‐Jyh Hwang,
Shyi‐Jang Shin,
Wen‐Tsan Chang Tags: Original Article Source Type: research
Association between serum gamma glutamyl transferase and fasting blood glucose in Chinese people: A 6 ‐year follow‐up study
ConclusionsThe annual mean increase in FBG levels showed a positive relationship with baseline GGT levels. Higher baseline GGT levels resulted in a faster annual mean increase in FBG. Thus, GGT can be used for the early detection of FBG-related disorders of glucose metabolism for clinical application. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 22, 2022 Category: Endocrinology Authors: Fei Teng,
Yan Ye,
Liying Wang,
Ruihao Qin,
Xuekui Liu,
Houfa Geng,
Wei Xu,
Peng Lai,
Jun Liang Tags: Original Article Source Type: research
Updates of incretin ‐related drugs for the treatment of type 2 diabetes
Mechanisms of dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists and glucagon-like peptide-1 receptor/glucose-dependent insulinotropic polypeptide receptor dual-agonist in glycemic control and/or weight loss. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 15, 2022 Category: Endocrinology Authors: Hirotaka Araki,
Takeshi Matsumura,
Noboru Furukawa,
Eiichi Araki Tags: Update Source Type: research
Safety and effectiveness of dulaglutide 0.75 mg in Japanese patients with type 2 diabetes in real‐world clinical pratice: 36 month post‐marketing observational study
ConclusionsThe current real-world data are in accordance with clinical trial findings and further confirm the safety and effectiveness of dulaglutide for elderly patients, whose numbers were limited in the clinical trials. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 12, 2022 Category: Endocrinology Authors: Rina Chin,
Soshi Nagaoka,
Haru Nakasawa,
Yoko Tanaka,
Nobuya Inagaki Tags: Original Article Source Type: research
Carotid atherosclerosis: An independent risk factor for small fiber nerve dysfunction in patients with type 2 diabetes mellitus
ConclusionsCarotid atherosclerosis was significantly associated with quantitative sensory testing and found to be an independent risk factor for small fiber nerve dysfunction in type 2 diabetes patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - November 10, 2022 Category: Endocrinology Authors: Simin Guo,
Yali Jing,
Chenxi Li,
Dalong Zhu,
Weimin Wang Tags: Original Article Source Type: research
