BASP1 promotes high glucose ‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 9, 2023 Category: Endocrinology Authors: Fengnan Sun,
Junwei Liu,
Yanzheng Wang,
Hongmei Yang,
Danfeng Song,
Haiyan Fu,
Xingxing Feng Tags: Original Article Source Type: research
Electrocardiogram abnormalities and renal impairment in patients with type 2 diabetes mellitus: A healthcare facilities‐based cross‐sectional study in Dang district of Nepal
ConclusionA significant proportion of patients with type 2 diabetes mellitus had ECG abnormalities and renal impairment, which were significantly associated with hypertension. Therefore, hypertension management and early screening are essential to prevent future cardiorenal complications among patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 7, 2023 Category: Endocrinology Authors: Mahesh Kumar Khanal,
Pratiksha Bhandari,
Raja Ram Dhungana,
Yadav Gurung,
Lal B. Rawal,
Gyanendra Pandey,
Madan Bhandari,
Rijwan Bhuiyan,
Surya Devkota,
Maximilian Courten,
Barbora Courten Tags: Original Article Source Type: research
Sleep duration and food intake in people with type 2 diabetes mellitus and factors affecting confectionery intake
ConclusionsShort sleep duration is associated with high confectionery intake in people with type 2 diabetes mellitus; this might disturb their glycemic control. Therefore, short sleepers with type 2 diabetes mellitus could improve their glycemic control by avoiding confectionery intake and maintaining adequate sleep duration. Confectionery intake was higher in short sleepers with type 2 diabetes mellitus than normal sleepers. Sleep duration of<6 h was associated with increased confectionery intake. Avoiding confectionery and maintaining adequate sleep duration are crucial. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 7, 2023 Category: Endocrinology Authors: Tomoaki Akiyama,
Tadashi Yamakawa,
Kazuki Orime,
Jun Suzuki,
Rika Sakamoto,
Minori Matsuura ‐Shinoda,
Erina Shigematsu,
Kenichiro Takahashi,
Mizuki Kaneshiro,
Taro Asakura,
Shunichi Tanaka,
Takehiro Kawata,
Yoshihiko Yamada,
Tetsuo Isozaki, Tags: Original Article Source Type: research
Risk of fetal undergrowth in the management of gestational diabetes mellitus in Japan
ConclusionsWe established a prospective GDM registry system in Japan. In the management of GDM in Japan, suppression of maternal weight gain may be associated with reduced fetal growth, especially in non-overweight/obese women with GDM; however, further investigation is required. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 4, 2023 Category: Endocrinology Authors: Maki Kawasaki,
Naoko Arata,
Takashi Sugiyama,
Tatsumi Moriya,
Atsuo Itakuda,
Ichiro Yasuhi,
Yasuko Uchigata,
Eiji Kawasaki,
Hirohito Sone,
Yuji Hiramatsu,
DREAMBee study gestational diabetes mellitus group Tags: Original Article Source Type: research
A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon ‐derived peptide levels
ConclusionsThe new ELISA enables more accurate measurement of plasma glucagon than the currently used ELISA, even in subjects with elevated proglucagon-derived peptide levels. It should be clinically useful in elucidating the pathophysiology of individual diabetic patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 3, 2023 Category: Endocrinology Authors: Masaki Kobayashi,
Nobuhiro Maruyama,
Yukako Yamamoto,
Takeshi Togawa,
Takanori Ida,
Morikatsu Yoshida,
Mikiya Miyazato,
Masahisa Kitada,
Yoshitaka Hayashi,
Atsunori Kashiwagi,
Tadahiro Kitamura Tags: Original Article Source Type: research
Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet ‐induced obese mice
ConclusionsIt was shown that caloric restriction is important for the effect of luseogliflozin on metabolic parameters and endothelial dysfunction. Furthermore, SGLT2 inhibition by luseogliflozin possibly ameliorates FFA-induced endothelial dysfunction by increasing SOD2 expression and decreasing reactive oxygen species production in the thoracic aorta. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 2, 2023 Category: Endocrinology Authors: Shigeru Kawade,
Kazuma Ogiso,
Sigfrid Casmir Shayo,
Takahiko Obo,
Aiko Arimura,
Hiroshi Hashiguchi,
Takahisa Deguchi,
Yoshihiko Nishio Tags: Original Article Source Type: research
Type 2 diabetes influences intraepithelial corneal nerve parameters and corneal stromal ‐epithelial nerve penetration sites
ConclusionsOur data suggest that diabetic peripheral neuropathy may be preceded by a phase of neuron growth rather than regression, and that the peripheral cornea is more sensitive than the center for detecting changes in innervation. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 2, 2023 Category: Endocrinology Authors: Joshua Machet,
Mijeong Park,
Alexander Richardson,
Michael Carnell,
Margaret A Mouat,
Nicola J Smith,
Nigel Turner,
Blake J Cochran,
Kerry ‐Anne Rye,
Nick Di Girolamo Tags: Original Article Source Type: research
Which comes first in type 1 diabetes: Autoimmunity or dysglycemia?
A recent study by Warnckeet al. suggested that islet autoimmunity is associated with or preceded by insults or changes to the pancreatic islets that impair glucose homeostasis, raising the possibility that β-cell insult occurs first, followed by autoimmunity to islets. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 2, 2023 Category: Endocrinology Authors: Hiroshi Ikegami Tags: Commentary Source Type: research
Can lipophilic pollutants in adipose tissue explain weight change ‐related risk in type 2 diabetes mellitus?
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 1, 2023 Category: Endocrinology Authors: Duk ‐Hee Lee,
In‐Kyu Lee Tags: Commentary Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 1, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
Empagliflozin is associated with lower risk of cardiovascular events and all ‐cause mortality in routine care in East Asia: Results from the EMPRISE study
ConclusionsThe results suggest that both empagliflozin and SGLT2i compared with DPP-4i are associated with a lower risk of cardiovascular events and all-cause mortality in routine clinical care in East Asia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 31, 2023 Category: Endocrinology Authors: Dae Jung Kim,
Wayne H ‐H Sheu,
Wook‐Jin Chung,
Daisuke Yabe,
Kyoung Hwa Ha,
Masaomi Nangaku,
Elise Chia‐Hui Tan,
Koichi Node,
Atsutaka Yasui,
Weiyu Lei,
Sunwoo Lee,
Laura Saarelainen,
Anouk Deruaz‐Luyet,
Moe H Kyaw,
Yutaka Seino,
EM Tags: ORIGINAL ARTICLE Source Type: research
No change in small low ‐density lipoprotein cholesterol levels with pemafibrate might explain the negative results of the PROMINENT trial
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 28, 2023 Category: Endocrinology Authors: Tsutomu Hirano Tags: Letter to the Editor Source Type: research
Association of acute ‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study
ConclusionsAmong patients with undiagnosed diabetes mellitus with COVID-19, the magnitude of elevation of blood glucose from chronic to acute levels is associated with worse outcomes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 28, 2023 Category: Endocrinology Authors: Masaki Uchihara,
Takehiro Sugiyama,
Ryotaro Bouchi,
Nobuaki Matsunaga,
Yusuke Asai,
Hiroyuki Gatanaga,
Mitsuru Ohsugi,
Norio Ohmagari,
Hiroshi Kajio,
Kohjiro Ueki Tags: Original Article Source Type: research
Association of self ‐stigma with glycated hemoglobin: A single‐center, cross‐sectional study of adults with type 1 diabetes in Japan
ConclusionsThis cross-sectional study showed a significant association between self-stigma and HbA1c in persons with type 1 diabetes. Addressing self-stigma might be as equally essential as measuring HbA1c in evaluating glycemic outcome among individuals with type 1 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2023 Category: Endocrinology Authors: Shoko Hamano,
Yukiko Onishi,
Yoko Yoshida,
Toshiko Takao,
Tazu Tahara,
Takako Kikuchi,
Toshiko Kobori,
Tetsuya Kubota,
Masahiko Iwamoto,
Masato Kasuga Tags: ORIGINAL ARTICLE Source Type: research
Trends in incidence rates of childhood type 1 diabetes mellitus: A retrospective study in Isfahan province, Iran
ConclusionOur findings showed that currently our region is considered a region with a high incidence rate of type 1 diabetes mellitus. Although we have had fluctuations in the incidence rate over the 12 years, the overall trend is increasing. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2023 Category: Endocrinology Authors: Mahin Hashemipour,
Mohammadreza Maracy,
Shaghayegh Haghjooy Javanmard,
Farzane Zamaneh,
Neda Mostofizadeh,
Silva Hovsepian Tags: Original Article Source Type: research
