Effect of patient characteristics on the efficacy and safety of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus: A post ‐hoc analysis of two randomized, placebo‐controlled trials
ConclusionsThe efficacy and safety of imeglimin was demonstrated across patient subgroups, irrespective of baseline demographic and clinical characteristics. Our findings confirm the efficacy and safety of imeglimin across a broad spectrum of patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 2, 2023 Category: Endocrinology Authors: Katsuhiko Hagi,
Kenji Kochi,
Hirotaka Watada,
Kohei Kaku,
Kohjiro Ueki Tags: Original Article Source Type: research
Fibroblast growth factor 21 as a candidate of a novel serum biomarker for mitochondrial diabetes
Serum fibroblast growth factor 21 levels in patients with mitochondrial diabetes might be much higher than in those with other diabetes types. The results of this study could lead to the establishment of a simple method for screening mitochondrial diabetes using peripheral blood serum. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 29, 2023 Category: Endocrinology Authors: Yuji Komorita,
Akiyo Shiroozu,
Hidetoshi Nakamura Tags: Letter to the Editor Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 23, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
Delivering value ‐based healthcare for people with diabetes in a national publicly funded health service: Lessons from Ireland and Wales
This article explores value-based healthcare (VBHC) in the context of the National Health Service in Wales and the Irish Health Service Executive. Some of the principles of VBHC are discussed and case studies from Ireland and Wales are used to illustrate these principles. AbstractThe term value-based healthcare (VBHC) describes an approach to the organization and delivery of care that emphasizes reducing the cost of care while improving outcomes. This involves increased investment earlier in the care pathway e.g., in the prevention, timely diagnosis, and screening for complications in order to maximize the overall impact o...
Source: Journal of Diabetes Investigation - May 19, 2023 Category: Endocrinology Authors: M áire T O’Donnell,
Sally Lewis,
Sarah Davies,
Sean F Dinneen Tags: Mini Review Source Type: research
Diabetes technology including automated insulin delivery systems to manage hyperglycemia in a failing pancreatic graft: Case series of people with type 1 diabetes and a pancreas kidney or pancreas ‐only transplant
AbstractWe share our experience of using continuous subcutaneous insulin infusion (CSII) therapy and diabetes technology in six people (5 men) with type 1 diabetes (mean duration 36 years), who developed hyperglycemia post-simultaneous kidney/pancreas (n = 5) or pancreas only (n = 1) transplant. All were on immunosuppression and multiple daily injections of insulin prior to CSII. Four people were started on automated insulin delivery, and two people on CSII and intermittently scanned continuous glucose monitoring. With diabetes technology, the median time in range gluc ose improved from 37% (24–49%) to 56.6%...
Source: Journal of Diabetes Investigation - May 17, 2023 Category: Endocrinology Authors: Dimitra Stathi,
Thomas Johnston,
Rebecca Hyslop,
Anna Brackenridge,
Janaka Karalliedde Tags: CASE REPORT Source Type: research
Impact of COVID ‐19 pandemic on behavioral changes and glycemic control and a survey of telemedicine in patients with diabetes: A multicenter retrospective observational study
ConclusionsOur data suggest that glycemic control did not deteriorate during the COVID-19 pandemic with appropriate intensification of diabetes treatment in patients with diabetes who continued to attend specialized diabetes care facilities, and that patients and physicians shared the same expectations and concerns about telemedicine. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 15, 2023 Category: Endocrinology Authors: Ryotaro Bouchi,
Takehiro Sugiyama,
Atsushi Goto,
Mitsuru Ohsugi,
Narihito Yoshioka,
Hideki Katagiri,
Tomoya Mita,
Yushi Hirota,
Hiroshi Ikegami,
Munehide Matsuhisa,
Eiichi Araki,
Hiroki Yokoyama,
Masae Minami,
Katsuya Yamazaki,
Hideaki Jinno Tags: ORIGINAL ARTICLE Source Type: research
Association of the triglyceride ‐glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus patients: A retrospective cross‐sectional study
ConclusionsThe TyG index is independently associated with SLVD in type 2 diabetes mellitus patients and is a more reliable indicator of SLVD than HOMA2-IR. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 8, 2023 Category: Endocrinology Authors: Qi ‐chao Sun,
Jie Liu,
Ran Meng,
Ning Zhang,
Jing Yao,
Fan Yang,
Da‐long Zhu Tags: Original Article Source Type: research
Cognitive protection of incretin ‐based therapies in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis based on clinical studies
ConclusionsCurrent evidence shows that incretin-based therapies might be more effective, when compared with the other hypoglycemic drugs, for cognitive improvement in patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 6, 2023 Category: Endocrinology Authors: Sanbao Chai,
Fengqi Liu,
Shuqing Yu,
Zhirong Yang,
Feng Sun Tags: Original Article Source Type: research
The era of continuous glucose monitoring and its expanded role in type 2 diabetes
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 5, 2023 Category: Endocrinology Authors: Jin Yu,
Jae ‐Hyoung Cho,
Seung‐Hwan Lee Tags: UPDATE Source Type: research
Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose –response meta‐analysis of cohort studies including 105,380 participants
ConclusionsThis study showed a positive association between uric acid levels and the risk of GDM. Also, our results indicate that measuring uric acid levels before 20 weeks of gestation can potentially predict GDM, especially in younger women. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 4, 2023 Category: Endocrinology Authors: Ali Nikparast,
Jamal Rahmani,
Reza Bagheri,
Saba Mohammadpour,
Mehdi Shadnoosh,
Alexei Wong,
Matin Ghanavati Tags: Original Article Source Type: research
Patient referral flow between physician and ophthalmologist visits for diabetic retinopathy screening among Japanese patients with diabetes: A retrospective cross ‐sectional cohort study using the National Database
ConclusionsLess than half of the patients who were prescribed antidiabetic medication by their physicians visited an ophthalmologist. However, most of the patients who visited an ophthalmologist had a fundus examination carried out. A similar tendency was noted for each prefecture. It is essential to reaffirm the necessity of recommending ophthalmologic examinations to physicians and healthcare professionals who care for patients with diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 3, 2023 Category: Endocrinology Authors: Noriko Ihana ‐Sugiyama,
Takehiro Sugiyama,
Takao Hirano,
Kenjiro Imai,
Mitsuru Ohsugi,
Ryo Kawasaki,
Toshinori Murata,
Youichiro Ogura,
Kohjirou Ueki,
Toshimasa Yamauchi,
Takashi Kadowaki Tags: Original Article Source Type: research
Gut as a source of new β‐cells and Segi's cap
A deficit of β-cells is a salient feature in both type 1 and type 2 diabetes mellitus. Due to the absolute lack of supplying β-cells for organ or cell transplantation, there is an urgent need to explore the efficient method to generate insulin-producing cells. Cell conversion of intestinal cryptic epitheli al cells to insulin-producing β-like cells is a novel and promising therapeutic target. Activation of β-cell differentiation factors or modulation of terminally differentiated factors with forkhead homeobox O1 effectively induced such conversion, and suppressed hyperglycemia in streptozotocin-indu ced and non-obe...
Source: Journal of Diabetes Investigation - May 3, 2023 Category: Endocrinology Authors: Soroku Yagihashi Tags: Commentary Source Type: research
Predictive values of metabolic score for insulin resistance on risk of major adverse cardiovascular events and comparison with other insulin resistance indices among Chinese with and without diabetes mellitus: Results from the 4C cohort study
ConclusionsThe METS-IR can be an effective clinical indicator for identifying MACEs, as it had superior predictive power when compared with other IR indices in individuals with diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 3, 2023 Category: Endocrinology Authors: Limeng Pan,
Huajie Zou,
Xiaoyu Meng,
Danpei Li,
Wenjun Li,
Xi Chen,
Yan Yang,
Xuefeng Yu Tags: Original Article Source Type: research
Impact of the COVID ‐19 pandemic on the glycemic control in people with diabetes mellitus: A retrospective cohort study
ConclusionsIt appears from our study that COVID-19 and its preventive measures had a negative impact on the glycemic and lipid control in people with diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 29, 2023 Category: Endocrinology Authors: Kanako Ohkuma,
Mika Sawada,
Masakazu Aihara,
Shunsuke Doi,
Rie Sekine,
Satoshi Usami,
Kazuhiko Ohe,
Naoto Kubota,
Toshimasa Yamauchi Tags: Original Article Source Type: research
Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis
ConclusionsLinagliptin showed excellent heart protection in mice with streptozotocin-induced diabetes associated with alterations in human disease-relevant hub genes. Further investigation is required to determine why DPP-4 inhibitors do not show similar superior organ-protective effects in the clinical setting. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 25, 2023 Category: Endocrinology Authors: Juthi Adhikari,
Taro Hirai,
Emi Kawakita,
Kunimitsu Iwai,
Daisuke Koya,
Keizo Kanasaki Tags: Original Article Source Type: research
