Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis

ConclusionsLinagliptin showed excellent heart protection in mice with streptozotocin-induced diabetes associated with alterations in human disease-relevant hub genes. Further investigation is required to determine why DPP-4 inhibitors do not show similar superior organ-protective effects in the clinical setting.

Source: Journal of Diabetes Investigation - April 25, 2023 Category: Endocrinology Authors: Juthi Adhikari, Taro Hirai, Emi Kawakita, Kunimitsu Iwai, Daisuke Koya, Keizo Kanasaki Tags: Original Article Source Type: research