Pituitary gland agouti ‐related peptide cells: Novel player controlling glucose metabolism

The liver synthesizes and releases bile acids into the gut. Bile acids, either directly or indirectly, inhibit agouti-related peptide (AGRP)-B cells in the pars tuberalis of the pituitary gland. AGRP-B cells are assumed to promote pancreatic insulin secretion and/or to improve insulin sensitivities in insulin sensitive organs, resulting in improved glucose tolerance.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: COMMENTARY Source Type: research