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The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
Sci Signal. 2024 Mar 12;17(827):eade3643. doi: 10.1126/scisignal.ade3643. Epub 2024 Mar 12.ABSTRACTActivation of the endoplasmic reticulum (ER)-resident adaptor protein STING, a component of a cytosolic DNA-sensing pathway, induces the transcription of genes encoding type I interferons (IFNs) and other proinflammatory factors. Because STING is activated at the Golgi apparatus, control of the localization and activation of STING is important in stimulating antiviral and antitumor immune responses. Through a genome-wide CRISPR interference screen, we found that STING activation required the Golgi-resident protein ACBD3, whic...
Source: Science Signaling - March 12, 2024 Category: Biomedical Science Authors: Rutger D Luteijn Sypke R van Terwisga Jill E Ver Eecke Liberty Onia Shivam A Zaver Joshua J Woodward Richard W Wubbolts David H Raulet Frank J M van Kuppeveld Source Type: research

DNA methylation landscapes in DIPG reveal methylome variability that can be modified pharmacologically
CONCLUSIONS: This study provides a resource for understanding the epigenetic instability that underlies DIPG heterogeneity. It suggests the application of epigenetic therapies to constrain the range of epigenetic states available to DIPG cells, as well as the use of decitabine in priming for immune-based therapies.PMID:38468866 | PMC:PMC10926944 | DOI:10.1093/noajnl/vdae023 (Source: Adv Data)
Source: Adv Data - March 12, 2024 Category: Epidemiology Authors: Ashley R Tetens Allison M Martin Antje Arnold Orlandi V Novak Adrian Idrizi Rakel Tryggvadottir Jordyn Craig-Schwartz Athanasia Liapodimitri Kayleigh Lunsford Michael I Barbato Charles G Eberhart Adam C Resnick Eric H Raabe Michael A Koldobskiy Source Type: research

Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits
EMBO Mol Med. 2024 Mar 11. doi: 10.1038/s44321-024-00046-w. Online ahead of print.ABSTRACTCytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in structures, molecular mechanisms, and origins but share a common function to detect intracellular microbial DNA and trigger the innate immune response like type 1 interferon production and autophagy. Cytosolic DNA sensors have been proven as indispensable defenders against the invasion of many pathogens; however, growing evidence shows that self-DNA misplacement to cytoplasm also frequently occurs in non-infectious circumstances. Accumulation of cyt...
Source: Molecular Medicine - March 12, 2024 Category: Molecular Biology Authors: Jiatian Xie Jinping Cheng Ho Ko Yamei Tang Source Type: research

Tracing the STING exocytosis pathway during herpes viruses infection
mBio. 2024 Mar 12:e0037324. doi: 10.1128/mbio.00373-24. Online ahead of print.ABSTRACTThe STimulator of INterferon Genes (STING) constitutes a major DNA-sensing pathway that restricts HSV-1 infection in different models by activating type I interferon and pro-inflammatory responses. To counteract STING, HSV-1 has evolved numerous strategies including mechanisms to interfere with its oligomerization, post-translational modifications, and downstream signaling. Previously, we demonstrated that STING is packaged in extracellular vesicles (EVs) produced from HSV-1-infected cells. These EVs activated antiviral responses in uninf...
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Christos Dogrammatzis Rabina Saud Hope Waisner Sarah Lasnier Sreenath Muraleedharan Suma Brandon Grieshaber Maria Kalamvoki Source Type: research

Saikosaponin d protects pancreatic acinar cells against cerulein ‐induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS‐STING pathway
In conclusion, SSd protected PACs against cerulein-induced pyroptosis by alleviating mitochondrial damage and inhibiting the cGAS-STING pathway, and it could be a therapeutic candidate for acute pancreatitis. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 12, 2024 Category: Toxicology Authors: Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie Tags: RESEARCH ARTICLE Source Type: research

5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached phase III in lung cancer clinical trials. How DMXAA is effective against human lung cancer is completely unknown. Here, we show that DMXAA is a partial STING agonist interfering with agonistic STING activation, which may explain its partial anti-tumor effect observed in humans, as STING was reported to be pro-tumorigenic for lung cancer cells with low antigenicity. Furthermore, we developed a DMXAA deriva...
Source: Frontiers in Immunology - March 12, 2024 Category: Allergy & Immunology Source Type: research

Heat Stroke Induces Pyroptosis in Spermatogonia via the cGAS-STING Signaling Pathway
This study can further enrich and improve the molecular mechanism of cryptorchidism.PMID:38466010 (Source: Physiological Research)
Source: Physiological Research - March 11, 2024 Category: Physiology Authors: Q-F Deng Y Liu H Chu B Peng X Li Y-S Cao Source Type: research

Heat Stroke Induces Pyroptosis in Spermatogonia via the cGAS-STING Signaling Pathway
This study can further enrich and improve the molecular mechanism of cryptorchidism.PMID:38466010 (Source: Cell Research)
Source: Cell Research - March 11, 2024 Category: Cytology Authors: Q-F Deng Y Liu H Chu B Peng X Li Y-S Cao Source Type: research