Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling
In this study, we studied the potential lung toxicity and PS-MPs-developed pulmonary fibrosis by long-term intranasal inhalation of PS-MPs. The results showed that after exposing to the PS-MPs, the lungs of model mouse had different levels of damage and fibrosis. Meanwhile, exposing to the PS-MPs resulted in a markedly decrease in glutathione (GSH), an increase in malondialdehyde (MDA), and iron overload in the lung tissue of mice and alveolar epithelial cells (AECs). These findings suggested the occurrence of PS-MP-induced ferroptosis. Inhibitor of ferroptosis (Fer-1) had alleviated the PS-MPs-induced ferroptosis. Mechani...
Source: Ecotoxicology and Environmental Safety - April 27, 2024 Category: Environmental Health Authors: Jinming Zhang Jiangzhou Du Dongyu Liu Jinzhong Zhuo Lanhe Chu Yanqun Li Lin Gao Mingming Xu Weimou Chen Wufeng Huang Lingyan Xie Junwei Chen Xiaojing Meng Fei Zou Shaoxi Cai Hangming Dong Source Type: research
Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
Cell Rep Med. 2024 Apr 23:101528. doi: 10.1016/j.xcrm.2024.101528. Online ahead of print.ABSTRACTStimulator of interferon genes (STING)-dependent signaling is requisite for effective anti-microbial and anti-tumor activity. STING signaling is commonly defective in cancer cells, which enables tumor cells to evade the immunosurveillance system. We evaluate here whether intrinsic STING signaling in such tumor cells could be reconstituted by creating recombinant herpes simplex viruses (rHSVs) that express components of the STING signaling pathway. We observe that rHSVs expressing STING and/or cGAS replicate inefficiently yet re...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Tiphaine Delaunay Sehee Son Seongji Park Balveen Kaur Jeonghyun Ahn Glen N Barber Source Type: research
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling
In this study, we studied the potential lung toxicity and PS-MPs-developed pulmonary fibrosis by long-term intranasal inhalation of PS-MPs. The results showed that after exposing to the PS-MPs, the lungs of model mouse had different levels of damage and fibrosis. Meanwhile, exposing to the PS-MPs resulted in a markedly decrease in glutathione (GSH), an increase in malondialdehyde (MDA), and iron overload in the lung tissue of mice and alveolar epithelial cells (AECs). These findings suggested the occurrence of PS-MP-induced ferroptosis. Inhibitor of ferroptosis (Fer-1) had alleviated the PS-MPs-induced ferroptosis. Mechani...
Source: Ecotoxicology and Environmental Safety - April 27, 2024 Category: Environmental Health Authors: Jinming Zhang Jiangzhou Du Dongyu Liu Jinzhong Zhuo Lanhe Chu Yanqun Li Lin Gao Mingming Xu Weimou Chen Wufeng Huang Lingyan Xie Junwei Chen Xiaojing Meng Fei Zou Shaoxi Cai Hangming Dong Source Type: research
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis
CONCLUSIONS: Negative regulation of any molecule in the mtDNA-cGAS-STING-IRF7/IRF3 pathway can affect the activation of NLRP3 inflammasomes, thereby reducing macrophage pyroptosis and improving SAP-ALI in mouse model.PMID:38671352 | DOI:10.1186/s11658-024-00575-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Yiqiu Peng Yuxi Yang Yingying Li Tingjuan Shi Ning Xu Ruixia Liu Yingyi Luan Yongming Yao Chenghong Yin Source Type: research
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis
CONCLUSIONS: Negative regulation of any molecule in the mtDNA-cGAS-STING-IRF7/IRF3 pathway can affect the activation of NLRP3 inflammasomes, thereby reducing macrophage pyroptosis and improving SAP-ALI in mouse model.PMID:38671352 | DOI:10.1186/s11658-024-00575-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 26, 2024 Category: Biochemistry Authors: Yiqiu Peng Yuxi Yang Yingying Li Tingjuan Shi Ning Xu Ruixia Liu Yingyi Luan Yongming Yao Chenghong Yin Source Type: research
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis
CONCLUSIONS: Negative regulation of any molecule in the mtDNA-cGAS-STING-IRF7/IRF3 pathway can affect the activation of NLRP3 inflammasomes, thereby reducing macrophage pyroptosis and improving SAP-ALI in mouse model.PMID:38671352 | PMC:PMC11055249 | DOI:10.1186/s11658-024-00575-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 26, 2024 Category: Biochemistry Authors: Yiqiu Peng Yuxi Yang Yingying Li Tingjuan Shi Ning Xu Ruixia Liu Yingyi Luan Yongming Yao Chenghong Yin Source Type: research
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis
CONCLUSIONS: Negative regulation of any molecule in the mtDNA-cGAS-STING-IRF7/IRF3 pathway can affect the activation of NLRP3 inflammasomes, thereby reducing macrophage pyroptosis and improving SAP-ALI in mouse model.PMID:38671352 | PMC:PMC11055249 | DOI:10.1186/s11658-024-00575-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 26, 2024 Category: Biochemistry Authors: Yiqiu Peng Yuxi Yang Yingying Li Tingjuan Shi Ning Xu Ruixia Liu Yingyi Luan Yongming Yao Chenghong Yin Source Type: research
STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation
AbstractSleep deprivation (SD) has been associated with several adverse effects, including cognitive deficit. Emerging evidence suggests microglia-associated neuroinflammation is a potential trigger of cognitive deficit after SD. Stimulator of interferon genes (STING) constitutes an important factor in host immune response to pathogenic organisms and is found in multiple cells, including microglia. STING is involved in neuroinflammation during neuronal degeneration, although how STING signaling affects SD-induced neuroinflammation remains unexplored. In the present study, the chronic sleep restriction (CSR) model was appli...
Source: Inflammation - April 26, 2024 Category: Allergy & Immunology Source Type: research
STING-deficiency in lung resident mesenchymal stromal cells contributes to the alleviation of LPS-induced lung injury
This study highlights that LR-MSC have a therapeutic role in acute lung injury, and we demonstrate that STING deficiency can enhance the immunomodulatory function of LR-MSC in controlling lung inflammation. Thus, STING can be used as an intervention target to enhance the therapeutic effect of MSC.PMID:38657444 | DOI:10.1016/j.bbrc.2024.149973 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 24, 2024 Category: Biochemistry Authors: Erming Zhao Jiawen Chen Dongbo Qiu Rukang Liang Di Lu Weikeng Tan Yunfei Qin Qiuli Liu Source Type: research
GSE244205 TCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks
Contributors : Lingzhen Kong ; Shan Li ; Chen Cheng ; Abigael Cheruiyot ; Jiayi Yuan ; Yichan Yang ; Sydney Hwang ; Daniel Foust ; Ning Tsao ; Emily Wilkerson ; Nima Mosammaparast ; M B Major ; David W Piston ; Zhongsheng YouSeries Type : OtherOrganism : Homo sapiensThe protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is triggered after the generation of cytosolic DNA and the activation of cGAS/STING. The resulting CaMKK2/AMPK activati...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE249852 A Single-atom Manganese Nanozyme Mn-N/C Promotes Anti-tumor Immune Response via Eliciting Type I Interferon Signaling
Contributors : Wen Qiao ; Jingqi Chen ; Huayuan Zhou ; Cegui Hu ; Sumiya Dalangood ; Hanjun Li ; Dandan Yang ; Yu Yang ; Gui JunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor microenvironment (TME)-induced nanocatalytic therapy is a promising strategy for cancer treatment, but the low catalytic efficiency limits its therapeutic efficacy. Single-atom catalysts (SACs) are a new type of nanozyme with incredible catalytic efficiency. Here we construct a single-atom manganese (Mn)-N/C nanozyme. Mn-N/C catalyzes the conversion of cellular H2O2 to ∙OH through a Fenton-like ...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice
AbstractMyeloid neoplasms are a group of bone marrow diseases distinguished by disruptions in the molecular pathways that regulate the balance between hematopoietic stem cell (HSC) self-renewal and the generation of specialized cells. Cytokines and chemokines, two important components of the inflammatory process, also influence hematological differentiation. In this scenario, immunological dysregulation plays a pivotal role in the pathogenesis of bone marrow neoplasms. The STING pathway recognizes DNA fragments in the cell cytoplasm and triggers an immune response by type I interferons. The role of STING in cancer has not ...
Source: Medical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
by Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BackgroundWorksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. MethodsIn th...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Archana Shrestha Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
