MPI-based bioinformatic analysis and co-inhibitory therapy with mannose for oral squamous cell carcinoma
In conclusion, theMPI gene showed a significant correlation with immune infiltration and genetic and clinical characteristics of HNSC. The treatment of ATM inhibitor, immune regulating cells of CD8+ T cells and MDSCs, and oral microbiomes in combination with mannose could exhibit co-inhibitory therapeutic effect for OSCC. (Source: Medical Oncology)
Source: Medical Oncology - July 27, 2021 Category: Cancer & Oncology Source Type: research

Investigation of the Osteopontin isoforms expression in patients with acute myeloid leukemia
AbstractAcute myeloid leukemia (AML) is one of the major hematological malignancies. Advances in molecular research have greatly improved our understanding of the process of leukemia formation in AML. Osteopontin (OPN) is a novel molecule that mediates critical processes for cancer progression. The aim of this study was to investigate the relative expression of OPN gene isoforms in AML patients on days 0, 14, and 28 after chemotherapy. The bone marrow samples were collected from 40 newly diagnosed AML patients (24 male and 16 female with a  mean age of 30 years) at the initial time of diagnosis, 14 and 28&nb...
Source: Medical Oncology - July 27, 2021 Category: Cancer & Oncology Source Type: research

Metabolic shift of chronic myeloid leukemia patients under imatinib –pioglitazone regimen and discontinuation
AbstractThe Estudo de Descontinua ção de Imatinibe após Pioglitazona (EDI-PIO) is a single-center, longitudinal, prospective, phase 2, non-randomized, open, clinical trial (NCT02852486, August 2, 2016 retrospectively registered) for the discontinuation of imatinib after concomitant use of pioglitazone, being the first of its kind in a Brazilian population with chronic myeloid leukemia. Due to remaining of leukemic quiescent cells that are not affected by tyrosine kinase inhibitors, it has been suggested the use of pioglitazone, a PPARγ agonist, together with imatinib as a strategy for the mainten...
Source: Medical Oncology - July 24, 2021 Category: Cancer & Oncology Source Type: research

Phase II study of neoadjuvant chemotherapy with S-1 plus oxaliplatin for gastric cancer clinical T4 or N2-3
AbstractIn Japan, the standard treatment for stage II or III gastric cancer is D2 gastrectomy followed by administration of S-1 for one year. However, patients with stage III disease have unsatisfactory survival rates. The purpose of this study was to evaluate the efficacy and safety of neoadjuvant chemotherapy consisting of S-1 and oxaliplatin for advanced gastric cancer. Patients with cT4 or cN2 –3 gastric cancer were scheduled to receive two courses of chemotherapy (130 mg/m2 oxaliplatin on Day 1, 80  mg/m2 S-1 per day twice daily for 14  days) followed by surgery. The primary endpoint was the R0 re...
Source: Medical Oncology - July 24, 2021 Category: Cancer & Oncology Source Type: research

Cancer and COVID-19: Why are cancer patients more susceptible to COVID-19?
AbstractThe COVID-19 pandemic has engulfed the entire world and has claimed more than 3 million lives worldwide. This viral disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and mainly characterized by fever, dry cough, fatigue, anosmia, anorexia, and dyspnea. The severity of the disease increases with age and presence of comorbidities, including cancer. Multiple clinical studies have shown that the cancer patients are highly susceptible to the severe form of the viral disease. In this review article, we have summarized the available scientific literature regarding the molecular links betwee...
Source: Medical Oncology - July 24, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Lentivirus-mediated RNAi knockdown of prostate-specific membrane antigen suppresses growth, reduces migration ability and the invasiveness of prostate cancer cells
A correction to this paper has been published: https://doi.org/10.1007/s12032-021-01527-5 (Source: Medical Oncology)
Source: Medical Oncology - July 24, 2021 Category: Cancer & Oncology Source Type: research

ARA-linker-TGF αL3: a novel chimera protein to target breast cancer cells
AbstractTargeted cancer therapies based on overexpressed receptors and the fractions containing immunotoxins and bacterial metabolites are one of the well-known methods to overcome the chemotherapy resistance of cancer cells. In this paper, we designed ARA-linker-TGF αL3, using Arazyme, aSerratia proteamaculans metabolite, and a third loop segment of TGF α to target EGFR-expressing breast cancer cells. After cloning in pET28a (+), the expression of recombinant protein was optimized inEscherichia coli strain BL21 (DE3). MDA-MB-468 (EGFR positive) and MDA-MB-453 (EGFR negative) breast cancer cell lines were emplo...
Source: Medical Oncology - July 17, 2021 Category: Cancer & Oncology Source Type: research

Resveratrol effects in oral cancer cells: a comprehensive review
AbstractOral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and chemotherapy; however, high failure rates and toxicity are noticed. Thus, the search of new drugs aiming a more effective treatment is welcomed. Natural products present chemopreventive and anti-cancer effects. Resveratrol is a naturally occurring antioxidant that contains several health benefits, including anti-inflammatory and antiproliferative activities. This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using mode...
Source: Medical Oncology - July 17, 2021 Category: Cancer & Oncology Source Type: research

The genomic architecture of metastasis in breast cancer: focus on mechanistic aspects, signalling pathways and therapeutic strategies
AbstractBreast cancer is a multifactorial, heterogeneous disease and the second most frequent cancer amongst women worldwide. Metastasis is one of the most leading causes of death in these patients. Early-stage or locally advanced breast cancer is limited to the breast or nearby lymph nodes. When breast cancer spreads to farther tissues/organs from its original site, it is referred to as metastatic or stage IV breast cancer. Normal breast development is regulated by specific genes and signalling pathways controlling cell proliferation, cell death, cell differentiation and cell motility. Dysregulation of genes involved in v...
Source: Medical Oncology - July 16, 2021 Category: Cancer & Oncology Source Type: research

Computational study on novel natural inhibitors targeting BCL2
AbstractIdeal lead compounds and candidate drugs with inhibitory effect on BCL2 were screened from ZINC database, which laid a foundation for drug development and compound improvement of drug treatment for diffuse large B-cell lymphoma (DLCBL). Identification of potential BCL2 inhibitors by computer-aided virtual screening. Libdock was applied to 17,931 compounds and the top 20 were selected for further analysis. Selected compounds were performed absorption, distribution, metabolism, and excretion (ADME) and toxicity prediction. The binding affinity between the selected ligands and BCL2 was confirmed by Molecular docking. ...
Source: Medical Oncology - July 14, 2021 Category: Cancer & Oncology Source Type: research

Impact of a combined integrative oncology and palliative care program on quality of life of patients with advanced cancer
AbstractMany oncology centers provide integrative oncology (IO) care, many within palliative care settings. The primary study objective was to examine the impact of IO-palliative patient-tailored program on quality of life (QoL) among patients with advanced cancer. In this pragmatic prospective controlled study, patients with advanced cancer undergoing chemotherapy/palliative care were referred by their oncology healthcare providers to an integrative physician (IP) consultation and weekly IO treatments. Patients with high adherence to integrative care (AIC;  ≥ 4 IO sessions/6 weeks) were compared with...
Source: Medical Oncology - July 9, 2021 Category: Cancer & Oncology Source Type: research

Vaccination of cancer patients against COVID-19: towards the end of a dilemma
AbstractWith the emergence of second wave of COVID-19 infection globally, particularly in India in March –April 2021, protection by massive vaccination drive has become the need of the hour. Vaccines have been proved to reduce the risk of developing severe illness and are emerging as vital tools in the battle against COVID-19. As per the GLOBOCAN database, nearly 19.3 million new cancer cases have b een reported in 2020 globally, which posed a significant challenge to health care providers to protect such large number of ‘vulnerable’ patients from COVID-19. Nevertheless, a considerable degree of doub...
Source: Medical Oncology - July 8, 2021 Category: Cancer & Oncology Source Type: research

Analyzing the impact of ATF3 in tumorigenesis and immune cell infiltration of ovarian tumor: a bioinformatics study
AbstractATF3 is an essential transcription activator in regulating cancer-related genetic expression. To identify the role ofATF3 in ovarian tumor, we investigated the correlation betweenATF3 expression and the clinicopathological properties using multiple database. The cBioPortal and GEPIA database displayed the clinical information of ovarian patients harboring or without harboringATF3 mutation. Furthermore, we assessed the relationship between survival andATF3 expression level using Kaplan –Meier plotter, which reveals that the ovarian patients with higher expression ofATF3 suffered the worse overall survival and ...
Source: Medical Oncology - July 3, 2021 Category: Cancer & Oncology Source Type: research

Can the host immune response against SARS-CoV2 also cause an anticancer effect?
AbstractDuring the COVID-19 pandemic, it is important to assure the safety and management of cancer patients. Despite preliminary studies revealed that patients with cancer are more susceptible to infection and have poorer prognosis than other infected patients without cancer, mortality from COVID-19 in cancer patients appears to be principally driven by age, gender, and comorbidities. So, we have some comments about the pathogenesis attributed to the COVID-19 disease and cancer relationship and determination of subgroups in this and oncoming studies. Variable effects of anticancer treatments on the patient's immune system...
Source: Medical Oncology - June 30, 2021 Category: Cancer & Oncology Source Type: research

Upregulation of apoptotic protease activating factor-1 expression correlates with anti-tumor effect of taxane drug
AbstractDrug resistance is a multifactorial process involving a variety of mechanisms and genes. Taxane drug class like Docetaxel is not effective for all types ’ breast cancers and presents a huge clinical challenge. To improve cancer treatment outcome, it is important to distinguish which proteins can kill the cancer cells and whether the expression levels of these proteins affect treatment. Cancer cells are wildly known to be protected from apoptosis, due to low level of apoptotic protease activating factor-1 (Apaf-1) compared with normal cells. Apaf-1 is an essential protein that defines whether cytochrome c rele...
Source: Medical Oncology - June 28, 2021 Category: Cancer & Oncology Source Type: research

PSMA: a game changer in the diagnosis and treatment of advanced prostate cancer
AbstractAlthough management of advanced prostate cancer is evolving, a lot of work remains to be done for patients who have exhausted all options. Molecular targeting of prostate specific membrane antigen (PSMA) is valuable not only for diagnostic but also for therapeutic reasons. PSMA is thus considered to be useful in a theranostic approach. PSMA scans are upcoming diagnostic modalities which detect metastatic lesions that are missed by conventional imaging modalities. PSMA ligand therapy is also an upcoming treatment modality that has been proven to be beneficial with minimal toxicity in patients with advanced prostate ...
Source: Medical Oncology - June 28, 2021 Category: Cancer & Oncology Source Type: research

Levofloxacin might be safe to use for OSCC patients
AbstractOral squamous cell carcinoma patients are exhausted against the powerful chemotherapies, radiotherapies after the surgery, and their immune system is devastated during the process and antibiotic usage become inescapable. Although prescribing an antibiotic might be fraught for such as drug interaction and undesirable proliferation danger, studies still look for the new ideas such as antibiotic combinations that might be safe to use. The antiproliferative and apoptotic outcomes of levofloxacin with cisplatin combination as well as their single usage were examined with WST-1, Caspase-3/BCA and Annexin V methods on SCC...
Source: Medical Oncology - June 25, 2021 Category: Cancer & Oncology Source Type: research

Immunotherapy era in the treatment of small cell lung cancer
AbstractSmall cell lung cancer (SCLC) is differentiated from non-small cell lung cancers with its histological and morphological features, rapid response to chemotherapy, and recurrence in a short time after treatment is discontinued. Platinum plus etoposide chemotherapy combination has been used as a standard treatment, and no new drug has been found for more than 30  years in this disease. In research, the targeted pathways that may affect survival have not been identified yet. During the second half of the second decade of the 2000s, with immunotherapies that inhibit immune checkpoints, improvements in survival wer...
Source: Medical Oncology - June 22, 2021 Category: Cancer & Oncology Source Type: research

Biological activity and molecular docking studies of some new quinolines as potent anticancer agents
The objective of this study is to investigate the antiproliferative and cytotoxic properties and the  action mechanism of substituted quinoline and tetrahydroquinolines3,4,5,7, and8 against rat glioblastoma (C6), human cervical cancer (HeLa), human adenocarcinoma (HT29) cancer cell lines by BrdU Cell Proliferation ELISA, Lactate Dehydrogenase, DNA laddering and Topoisomerase I assays. The results of the study showed that 6,8-dibromotetrahydroquinoline3 possess in vitro antiproliferative activity against C6, HeLa, and HT29 cell lines while morpholine/piperazine substituted quinoline7 and8 showed selective antiprolifera...
Source: Medical Oncology - June 19, 2021 Category: Cancer & Oncology Source Type: research

ceRNA network development and tumor-infiltrating immune cell analysis in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is among the primary causes of cancer deaths globally. Despite efforts to understand liver cancer, its high morbidity and mortality remain high. Herein, we constructed two nomograms based on competing endogenous RNA (ceRNA) networks and invading immune cells to describe the molecular mechanisms along with the clinical prognosis of HCC patients. RNA maps of tumors and normal samples were downloaded from The Cancer Genome Atlas database. HTseq counts and fragments per megapons per thousand bases were read from 421 samples, including 371 tumor samples and 50 normal samples. We establishe...
Source: Medical Oncology - June 19, 2021 Category: Cancer & Oncology Source Type: research

Identification of key genes in the tumor microenvironment of lung adenocarcinoma
In this study, we aimed to identify key genes associated with the microenvironment of lung adenocarcinoma (LUAD). Raw data for stromal and immune cells in malignant tumors were downloaded from The Cancer Genome Atlas (TCGA). These expression data were used to identify the differentially expressed genes (DEGs) in tissue samples of LUAD with high and low immune scores. A protein –protein interaction (PPI) network based on genes with significant differential expression was constructed. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to functionally anno...
Source: Medical Oncology - June 12, 2021 Category: Cancer & Oncology Source Type: research

How should we manage non-small-cell lung cancer “not-otherwise-specified”?
(Source: Medical Oncology)
Source: Medical Oncology - June 12, 2021 Category: Cancer & Oncology Source Type: research

Upfront metastasis ‑directed therapy in oligorecurrent prostate cancer does not decrease the time from initiation of androgen deprivation therapy to castration resistance: in regard to Triggiani et al.
(Source: Medical Oncology)
Source: Medical Oncology - June 11, 2021 Category: Cancer & Oncology Source Type: research

Peripheral androgen blockade in men with castrate-sensitive biochemical recurrent prostate cancer
AbstractThe aim of the study was to evaluate the feasibility of utilizing peripheral androgen blockade in men with biochemical recurrent castrate-sensitive prostate cancer. A registration study to track outcomes of men with biochemical recurrent castrate-sensitive prostate cancer treated with peripheral androgen blockade utilizing concomitant administration of finasteride and bicalutamide. Men were on intermittent peripheral blockade for a median 20.2  months, continuous peripheral blockade for a median 6.8 months, intermittent triple dose peripheral androgen blockade for a median 10.7 months, and continuous...
Source: Medical Oncology - June 5, 2021 Category: Cancer & Oncology Source Type: research

Systematic identification of the cancer pathways and molecules related with breast cancer immunogenicity
AbstractTo identify molecular features related to immunogenic activity in breast cancer (BC) and provide new targets and directions for BC immunotherapy, we firstly used ESTIMATE to evaluate the degree of immune cell infiltration of the BC patients in TCGA and METABRIC, and explore the relationship between the degree of immune cell infiltration and prognosis of BC patients. Then, we identified the cancer pathways, proteins and miRNAs related to BC immunogenicity, predicted the target genes of these miRNAs, and identified the pathways related to these target genes with KEGG pathway enrichment analysis. We also explored the ...
Source: Medical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway
The original version of this article unfortunately contained a mistakes in Fig.  2B and Fig.  4A. (Source: Medical Oncology)
Source: Medical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Melittin inhibits the expression of key genes involved in tumor microenvironment formation by suppressing HIF-1 α signaling in breast cancer cells
AbstractHIF-1 α has critical roles in the formation of tumor microenvironment by regulating genes involved in angiogenesis and anaerobic respiration. TME fuels tumors' growth and metastasis and presents therapy with several challenges. Therefore, we aimed to investigate if Melittin disrupts HIF-1α signaling pat hway in breast adenocarcinoma cell line MDA-MB-231. Breast adenocarcinoma cell line MDA-MB-231 was cultured in the presence of different doses of Melittin, and MTT assay was carried out to measure Melittin’s cytotoxic effects. Cells were exposed to 5% O2 to mimic hypoxic conditions and Melittin. We...
Source: Medical Oncology - June 2, 2021 Category: Cancer & Oncology Source Type: research

Cancer stem cell characteristics and their potential as therapeutic targets
AbstractCancer stem cells (CSCs) are a tumour subpopulation whose capacity for self-renewal, differentiation and proliferation generates unfavourable patient outcomes, including therapeutic resistance and metastasis. Much research has focused on the generation, biomarkers and therapeutic resistance of CSCs, as well as the development of CSC-targeted therapies. Reviews to date have either addressed general CSC characteristics or focused on CSCs from a well-studied cancer. Increasingly, specific treatment plans based on identification of molecular features and biomarkers of a patient ’s cancer, rather than classificati...
Source: Medical Oncology - May 29, 2021 Category: Cancer & Oncology Source Type: research

Triple-arm androgen blockade for advanced prostate cancer: a review
AbstractProstate cancer is estimated to be the second most common malignancy in men in the USA in 2020 and represents the second highest mortality from cancer behind lung and bronchial neoplasms. Management of advanced prostate cancer is evolving. Medical androgen deprivation therapy is currently a cornerstone of therapy for prostate cancer; however molecular mechanisms of resistance have emerged leading to castration-resistant prostate cancer that is proliferation of prostate cancer in the setting of low testosterone (
Source: Medical Oncology - May 25, 2021 Category: Cancer & Oncology Source Type: research

Novel therapeutic strategies and perspectives for pancreatic cancer: Autophagy and apoptosis are key mechanisms to fight pancreatic cancer
AbstractPancreatic cancer (PC) is the most lethal malignancy of the gastrointestinal tract. The poor prognosis of patients with PC is primarily due to lack of effective treatments against its progressive and metastatic behavior. Hence, figuring out the mechanisms underlying PC development and putting up with effective targeted therapies are of great significance to improve the prognosis of patients with PC. Apoptosis and autophagy serve to maintain tissue homoeostasis. Escaping from apoptosis or autophagy is one of the features of malignancy. PC is seriously resistant to autophagy and apoptosis, which explains its invasive...
Source: Medical Oncology - May 21, 2021 Category: Cancer & Oncology Source Type: research

The function of Cav-1 in MDA-MB-231 breast cancer cell migration and invasion induced by ectopic ATP5B
AbstractEctopic ATP5B, which is located in a unique type of lipid raft caveolar structure, can be upregulated by cholesterol loading. As the structural component of caveolae, Cav-1 is a molecular hub that is involved in transmembrane signaling. In a previous study, the ATP5B-specific binding peptide B04 was shown to inhibit the migration and invasion of prostate cancer cells, and the expression of ATP5B on the plasma membrane of MDA-MB-231 cells was confirmed. The present study investigated the effect of ectopic ATP5B on the migration and invasion of MDA-MB-231 cells and examined the involvement of Cav-1. Cholesterol loadi...
Source: Medical Oncology - May 19, 2021 Category: Cancer & Oncology Source Type: research

The role of BAFF and G-CSF for rituximab-induced late-onset neutropenia (LON) in lymphomas
AbstractMechanisms for late-onset neutropenia (LON) after rituximab treatment are poorly defined both for non-Hodgkin lymphoma (NHL) and for autoimmune disorders. We performed a case –control analysis of a prospective cohort of 169 evaluable consecutive rituximab-treated NHL patients to assess cytokines involved in neutro- and lymphopoiesis (G-CSF, SDF1, BAFF, APRIL) and inflammation (CRP) as possible LON mechanisms. Fifteen patients (9%) developed LON (peripheral blood /PB/ a bsolute neutrophil counts /ANC/ 
Source: Medical Oncology - May 18, 2021 Category: Cancer & Oncology Source Type: research

Upfront metastasis-directed therapy in oligorecurrent prostate cancer does not decrease the time from initiation of androgen deprivation therapy to castration resistance
AbstractThe aim of the present study was to explore the potential impact of upfront metastases-directed therapy (MDT) in terms of prolongation of castration-sensitive phase in a series of oligorecurrent castration-sensitive prostate cancer (PC) patients. The present article is a multicenter retrospective study. The population of interest was castrate-sensitive oligorecurrent PC, defined as the presence of 1 –3 uptakes in non-visceral sites such as bones or nodes detected by means of 18F-Choline PET/CT or 68-Gallium PSMA PET/CT. Primary endpoint was the time to castration resistance. Secondary endpoints were ADT-free ...
Source: Medical Oncology - May 18, 2021 Category: Cancer & Oncology Source Type: research

Preliminary evaluation on the beneficial effects of pioglitazone in the treatment of endometrial cancer
AbstractEndometrial cancer (EMC) is one of the complicated gynecological cancers, affecting more than three million women worldwide. Anticancer strategies such as chemotherapy, radiation, and surgery are found to be ineffective and are associated with patient incompliances. The aim of the present study is to repurpose non-oncological drug, i.e., Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR- γ) agonist, in the treatment of endometrial cancer. The study groups consist of 50 female Swiss albino mice, out of which 40 had endometrial cancer induced with N-ethyl-N-nitrosourea (ENU) and estradiol h...
Source: Medical Oncology - May 18, 2021 Category: Cancer & Oncology Source Type: research

CDK2-instigates C/EBP α degradation through SKP2 in Acute myeloid leukemia
AbstractTranscription factor CCAAT/enhancer-binding protein-alpha (C/EBP α) regulates myelopoiesis by coupling growth arrest with differentiation of myeloid progenitors. Mutations in one or both alleles are observed in 10–14% AML cases that render C/EBPα functionally inactive. Besides, antagonistic protein–protein interactions also impair C/EBPα expression and fun ction. In recent independent studies, we showed that CDK2 and SKP2 downregulated C/EBPα expression in an ubiquitin-dependent proteasome degradation manner leading to differentiation block in AML. Here, we demonstrate that CDK2-...
Source: Medical Oncology - May 17, 2021 Category: Cancer & Oncology Source Type: research

Identification of the dominant angiogenic CXCL class chemokines associated with non-small cell lung cancer via bioinformatics tools
AbstractChemokines play a critical role in lung cancer progression and metastasis. In non-small cell lung cancer, the determination of dominant angiogenic CXCL-type chemokines may increase the efficacy of targeted therapy and modulate the prognosis of lung cancer. Also, chemokine and chemokine receptors shape the immune response in the cross-talk between both cancer cells and immune cells in the tumor microenvironment. In this computational evaluation study based on databases containing mostly RNA-seq analyses, it is aimed to determine the dominant angiogenic CXCL-type chemokines with the highest expression in lung adenoca...
Source: Medical Oncology - May 13, 2021 Category: Cancer & Oncology Source Type: research

Hypofractionated breast irradiation: a multidisciplinary review of the Senonetwork study group
AbstractThe multidisciplinary management represents a crucial part of the care for cancer patients, resulting in better clinical and process outcomes, with evidence of improved survival among different cancer primary sites, including breast. According with international recommendations established by the European Society of Breast Cancer Specialists (EUSOMA), all breast-cancer patients have to be evaluated by a multidisciplinary team including radiologist, pathologist, surgeon, medical oncologist and radiation oncologist. Thus, variations in clinical practice of each specialty should be discussed and shared with all team m...
Source: Medical Oncology - May 10, 2021 Category: Cancer & Oncology Source Type: research

Luteolin and cancer metastasis suppression: focus on the role of epithelial to mesenchymal transition
AbstractEpithelial to mesenchymal transition (EMT) is a physiological process that assumes a primary role in the induction of cancer metastasis. This results in increased cell renewal, and resistance to cell death and therapies. EMT, therefore, represents an effective strategy for regulating cancerous cell activity. A need for efficacy and low cytotoxicity epithelial to mesenchymal transition modifying drugs has led to the investigational testing of the efficacy of plethora of different groups of phytonutrients. Luteolin is a natural flavonoid inhibits the growth of cancer cells by various mechanisms, such as the stimulati...
Source: Medical Oncology - May 5, 2021 Category: Cancer & Oncology Source Type: research

Resistin increases cisplatin-induced cytotoxicity in lung adenocarcinoma A549 cells via a mitochondria-mediated pathway
AbstractLung cancer is the most commonly diagnosed cancer with a high mortality rate. Cisplatin is one of the most important chemotherapeutic agents for the treatment of lung cancer patients, especially in advanced stages. Recent studies show that cisplatin may interact with mitochondria to induce apoptosis,  which may partly account for its cytotoxicity. In the study, we explored the effect of resistin on cisplatin-induced cytotoxicity in A549 cells and assessed whether mitochondria-dependent apoptosis was involved. Our results found that 25 ng/ml resistin could significantly increase cisplatin-induc ed apoptosi...
Source: Medical Oncology - April 30, 2021 Category: Cancer & Oncology Source Type: research

Treating MCF7 breast cancer cell with proteasome inhibitor Bortezomib restores apoptotic factors and sensitizes cell to Docetaxel
This study examined the role of proteasome inhibitor Bortezomib in the cytotoxic effects of Docetaxel on MCF7 cells response and its correlation with Apaf-1 expression level. MTT assay, caspase 3/7 activity assay, propidium iodide staining, adenosine triphosphate and reactive oxygen species amount measurements were utilized to demonstrate the role of Bortezomib in Docetaxel efficacy with and without Apaf-1 overexpressing. Meanwhile, two-dimensional cell migration assay was performed by scratch wound assay. The combination of Docetaxel with Bortezomib was significantly more cytotoxic compared single drug, more effectively d...
Source: Medical Oncology - April 27, 2021 Category: Cancer & Oncology Source Type: research

Identification of hub genes associated with obesity-induced hepatocellular carcinoma risk based on integrated bioinformatics analysis
AbstractObesity, which has become one of the biggest public health problems of the twenty-first century, accompanies many chronic conditions, including cancer. On the other hand, liver cancer, which is known to be associated with obesity, is considered another serious threat to public health. However, the underlying drivers of the development of obesity-associated hepatocellular carcinoma (HCC) remain blurry. The current study attempted to identify the key genes and pathways in the obesity-induced development of HCC using integrated bioinformatics analyses. Obesity and HCC-associated gene expression datasets were downloade...
Source: Medical Oncology - April 26, 2021 Category: Cancer & Oncology Source Type: research

PARP inhibitors: shifting the paradigm in the  treatment of pancreatic cancer
AbstractPancreatic cancer, being one of the most fatal cancers, is the 7th leading cause of death globally. Cancer that is resistant to current treatment proves that there is a need for personalized and targeted therapy, based on the tumor and genomic markers. Pembrolizumab and Larotrectinib are examples of current medications used as targeted therapy in pancreatic cancer. Pancreatic cancer has many different molecular subgroups, providing the opportunity for the development of new drugs that can target these groups. Poly (ADP-Ribose) polymerase inhibitors (PARPi) are a group of drugs inhibiting PARP to decrease the stabil...
Source: Medical Oncology - April 23, 2021 Category: Cancer & Oncology Source Type: research

The effect of the COVID-19 pandemic on routine adult vaccination in cancer patients
(Source: Medical Oncology)
Source: Medical Oncology - April 23, 2021 Category: Cancer & Oncology Source Type: research

H2O2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
AbstractCancer is one of the diseases that threatens human health and is a leading cause of mortality worldwide. High levels of reactive oxygen species (ROS) have been observed in cancer tissues compared with normal tissues in vivo, and it is not yet known how this influences chemotherapeutic drug action. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer used in photodynamic therapy (PDT) and a telomerase inhibitor used in the treatment of telomerase-positive cancer. Here, we investigated the anticancer activity of TMPyP4 in A549 and PANC cells cultured in H2O2. The results sh...
Source: Medical Oncology - April 21, 2021 Category: Cancer & Oncology Source Type: research

The anti-angiogenic agent lenvatinib induces tumor vessel normalization and enhances radiosensitivity in hepatocellular tumors
In this study, we analyzed the effects of both drugs on vascular structure and function, including vascular normalization, and investigated whether the normalization had a positive effect on a combination therapy with the drugs and radiation using micro X-ray computed tomography with gold nanoparticles as a contrast agent, as well as immunohistochemical analysis and interstitial fluid pressure (IFP) measurement. In mice subcutaneously transplanted with mouse HCC cells, treatment with lenvatinib or sorafenib for 14  days inhibited tumor growth and reduced the tumor vessel volume density. However, analysis of integrated...
Source: Medical Oncology - April 21, 2021 Category: Cancer & Oncology Source Type: research

H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
AbstractCancer is one of the diseases that threatens human health and is a leading cause of mortality worldwide. High levels of reactive oxygen species (ROS) have been observed in cancer tissues compared with normal tissues in vivo, and it is not yet known how this influences chemotherapeutic drug action. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer used in photodynamic therapy (PDT) and a telomerase inhibitor used in the treatment of telomerase-positive cancer. Here, we investigated the anticancer activity of TMPyP4 in A549 and PANC cells cultured in H2O2. The results sh...
Source: Medical Oncology - April 21, 2021 Category: Cancer & Oncology Source Type: research

The CXCL12/CXCR7 signalling axis promotes proliferation and metastasis in cervical cancer
AbstractC-X-C chemokine receptor 7 (CXCR7), a novel receptor of C-X-C motif chemokine ligand 12 (CXCL12), is associated with the occurrence and metastasis of various malignant tumours. However, the role, function and underlying mechanisms of CXCR7 expression in cervical cancer remain undefined. The expression level of CXCR7 was evaluated in cervical cancer samples by immunohistochemistry and real-time PCR analyses. Western blot analysis was used to examine the expression level of CXCR7 in cervical cancer cell lines. HeLa cells were genetically silenced or pharmacologically inhibited for CXCR7 or CXCR4. Transwell and CCK-8 ...
Source: Medical Oncology - April 13, 2021 Category: Cancer & Oncology Source Type: research

SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer
In this study, we found that SNRPB negatively regulates cisplatin resistance in NSCLC cells. Knocking out of SNRPB could significantly decrease cisplatin-induced cell growth inhibition, cell cycle arrest and apoptosis in H1299 cells. However, enforced expression of SNRPB in H460 cells can markedly promote cisplatin-induced cell growth inhibition, cell cycle arrest and apoptosis. Our results also indicate that overexpression of SNRPB enhances the inhibitory effects of cisplatin on H460 cell-mediated xenograft tumors. Our results suggest that SNRPB may be a prediction marker for NSCLC patients in response to cisplatin-based ...
Source: Medical Oncology - April 9, 2021 Category: Cancer & Oncology Source Type: research

The role of interleukins and the widely studied TNF- α in non-Hodgkin’s lymphoma
AbstractNon-Hodgkin ’s lymphoma is a relatively common cancer with malignant tendencies. Although there is no current cure for the disease, research has been successful in figuring out the mechanisms of how the disease progresses, however, there is still a lot of unknowns, and more research must be done to find the u ltimate cause of the disease. Interleukins and various cytokines play unique roles in the development of cancer. This review article summarizes the pathophysiology between certain interleukins and non-Hodgkin’s lymphoma. Although TNF-α is not an interleukin, the article examines TNF-α d...
Source: Medical Oncology - April 9, 2021 Category: Cancer & Oncology Source Type: research

The role of various interleukins in acute myeloid leukemia
AbstractInterleukins are signaling molecules involved in the immune system, and they play a variety of roles in different diseases and cancers. Acute myeloid leukemia (AML) is the most common type of leukemia in adults, and survival rate after diagnosis is very low. Investigating the role interleukins play in AML can help understand the progression of the disease. There exists a need for more effective treatment of AML. Interleukins can be used to guide immunotherapy for AML. This review article will examine how specific interleukins play a role in AML disease progression and how they can be utilized as a future treatment ...
Source: Medical Oncology - April 9, 2021 Category: Cancer & Oncology Source Type: research