Cervical spine immobilisation following blunt trauma in pre-hospital and emergency care: A systematic review
ConclusionsDespite the limited evidence, weak designs and limited generalisability, the available data suggest that pre-hospital cervical spine immobilisation (full immobilisation or movement minimisation) was of uncertain value due to the lack of demonstrable benefit and may lead to potential complications and adverse outcomes. High-quality randomised comparative studies are required to address this important question. Trial registrationPROSPERO REGISTRATION Fiona Lecky, Abdullah Pandor, Munira Essat, Anthea Sutton, Carl Marincowitz, Gordon Fuller, Stuart Reid, Jason Smith. A systematic review of cervical spine immobilisa...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Abdullah Pandor Source Type: research
Comparison of physiological markers, behavior monitoring, and clinical illness scoring as indicators of an inflammatory response in beef cattle
by Aiden E. Juge, Reinaldo F. Cooke, Guadalupe Ceja, Morgan Matt, Courtney L. Daigle
Clinical illness (CI) scoring using visual observation is the most widely applied method of detecting respiratory disease in cattle but has limited effectiveness in practice. In contrast, body-mounted sensor technology effectively facilitates disease detection. To evaluate whether a combination of movement behavior and CI scoring is effective for disease detection, cattle were vaccinated to induce a temporary inflammatory immune response. Cattle were evaluated before and after vaccination to identify the CI variables that are most indicat...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Aiden E. Juge Source Type: research
Aminotransferases as causal factors for metabolic syndrome: A bidirectional Mendelian randomization study
ConclusionsOur bidirectional MR analyses suggest that ALT and AST are causally associated with several metabolic syndrome-related traits, especially hypertension and type 2 diabetes. These findings highlight the potential role of aminotransferases as biomarkers and therapeutic targets for metabolic syndrome. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Meng Lingyu Source Type: research
Prevalence of childhood stunting and determinants in low and lower-middle income African countries: Evidence from standard demographic and health survey
ConclusionStunting among children under five years of age in low- and lower-middle-income African countries was relatively high. Individual, community, and country-level factors were statistically associated with childhood stunting. Equally importantly, with child, maternal, and community factors of stunting, the income of countries needs to be considered in providing nutritional interventions to mitigate childhood stunting in Africa. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Tadesse Tarik Tamir Source Type: research
Genetic background of adaptation of Crimean-Congo haemorrhagic fever virus to the different tick hosts
by Seyma S. Celina, Ji ří Černý
Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV) is a negative-sense, single-stranded RNA virus with a segmented genome and the causative agent of a severe Crimean-Congo haemorrhagic fever (CCHF) disease. The virus is transmitted mainly by tick species inHyalomma genus but other ticks such as representatives of generaDermacentor andRhipicephalus may also be involved in virus life cycle. To improve our understanding of CCHFV adaptation to its tick species, we compared nucleotide composition and codon usage patterns among the all CCHFV strains i) which sequences and other metadata...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Seyma S. Celina Source Type: research
The efficacy and safety of electroacupuncture for diabetic peripheral neuropathy: A protocol for a systematic review and meta-analysis
DiscussionThis protocol describes the intended scope and approach for a forthcoming systematic review and meta-analysis that will inform therapeutic decision-making by offering current information on the efficacy and safety of EA in the treatment of DPN. The results of the study will help standardize strategies for EA in the treatment of DPN. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Jiawei Wang Source Type: research
One-instrument, objective microsatellite instability analysis using high-resolution melt
In this study, we present a no vel, one-instrument, fast, and objective method for the detection of MSI (MicroSight® MSI 1-step HRM Analysis), which does not depend on the use of matched non-tumor tissue. The assay analyzes five well-described mononucleotide microsatellite sequences by real-time PCR followed by high-resolution m elt and evaluates microsatellite length variations via PCR product melting profiles. The assay was evaluated using two different patient cohorts and evaluation included several DNA extraction methodologies, two different PCR platforms, and an inter-laboratory ring study. The MicroSight® MSI assay...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Kamilla Kolding Bendixen Source Type: research
Polypharmacy and associated factors in South Korean elderly patients with dementia: An analysis using National Health Insurance claims data
ConclusionThis study reports the latest evidence on the status and risk factors of polypharmacy in elderly patients with dementia. We proposed that careful monitoring and management are required for patients at high risk for polypharmacy. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Hea-Lim Kim Source Type: research
< i > Seriphidium herba-alba < /i > (Asso): A comprehensive study of essential oils, extracts, and their antimicrobial properties
This study not only underscores the therapeutic potential ofSeriphidium herba-alba (Asso) in pharmaceutical applications but also sets a foundation for future research focused on isolating specific bioactive compounds and in vivo testing. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Hazem Aqel Source Type: research
Differences in maternal and paternal pressure to eat and perception of household responsibilities
by Paula Patel, Anusha Samant, Kychelle Del Rosario, Mara Z. Vitolins, Joseph A. Skelton, Edward H. Ip, Caroline B. Lucas, Callie L. Brown
Controlling feeding practices, such as pressure to eat, are associated with a child’s disinhibited eating and extremes in bodyweight. We aimed to explore which factors are associated with parent dyads’ pressuring feeding practices, including how mothers and fathers perceive the sharing of hous ehold tasks such as mealtime and child feeding responsibilities. In this cross-sectional study, parent dyads (mother and father) of healthy preschool-aged children completed an identical ques...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Paula Patel Source Type: research
Effect of SARS-CoV-2 S protein on the proteolytic cleavage of the epithelial Na < sup > + < /sup > channel ENaC
by Germ án Ricardo Magaña-Ávila, Erika Moreno, Consuelo Plata, Héctor Carbajal-Contreras, Adrian Rafael Murillo-de-Ozores, Kevin García-Ávila, Norma Vázquez, Maria Syed, Jan Wysocki, Daniel Batlle, Gerardo Gamba, María Castañeda-Bueno
Severe cases of COVID-19 are characterized by development of acute respiratory distress syndrome (ARDS). Water accumulation in the lungs is thought to occur as consequence of an exaggerated inflammatory response. A possible mechanism could involve decreased activity of the epithelial Na+ channel, ENaC, expressed in type II pneumocytes. Reduced transepithelial Na+ reabsorption could ...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Germ án Ricardo Magaña-Ávila Source Type: research
Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study
ConclusionA T-dominant genotype of rs1205 in theCRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Lyle G. Best Source Type: research
Vitamin B12 deficiency in diabetic patients treated with metformin: A cross-sectional study
This study set out to evaluate the rate of vitamin B12 deficiency in Vietnamese patients with type 2 diabetes who were t reated with metformin and to investigate factors associated with vitamin B12 deficiency. This is a cross-sectional study that was conducted in Vinmec Central Park Hospital from February to June 2023. The clinical and paraclinical characteristics of the participants were recorded, and the levels of v itamin B12 and folate were measured. The rate of vitamin B12 deficiency in patients treated with metformin was found to be 18.6%. Further, the duration of diabetes, duration of metformin use, metformin dose, ...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Dat Tan Huynh Source Type: research
Men ’s education and intimate partner violence—Beyond the victim-oriented perspective: Evidence from demographic and health surveys in Central Africa
ConclusionThese findings have policy and programmatic implications because they might impede progress towards SDG goals on the elimination of all forms of violence against girls and women in Central Africa, which recorded the worst development indicators in sub-Saharan Africa. On a methodological note, studies are increasingly using pooled data to increase statistical power. Those studies can be very limited to devise effective IPV —interventions since they mask geographical variations within and across countries. More effective IPV—interventions should be culturally rooted and accounting for geographical variations be...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Zacharie Tsala Dimbuene Source Type: research
The relationship between participation in leisure activities and incidence of falls in residential aged care
ConclusionsLeisure participation is associated with a lower rate of falls, a key quality indicator by which RACFs are benchmarked and funded in Australia and many other countries. More recognition and attention are needed for the currently underfunded leisure activities in RACFs in future funding arrangement. (Source: PLoS One)
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Guogui Huang Source Type: research
