Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity
This study revealed a novel role of the microtubule destabilizer in antiviral immune responses and provides a previously unexploited strategy based on STING-induced innate antiviral immunity.PMID:38408104 | DOI:10.1371/journal.ppat.1012048 (Source: Cancer Control)
Source: Cancer Control - February 26, 2024 Category: Cancer & Oncology Authors: Jing Han Zhimeng Wang Fangping Han Bo Peng Juanjuan Du Conggang Zhang Source Type: research
S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens
Nat Commun. 2024 Feb 26;15(1):1750. doi: 10.1038/s41467-024-46212-z.ABSTRACTOxidative (or respiratory) burst confers host defense against pathogens by generating reactive species, including reactive nitrogen species (RNS). The microbial infection-induced excessive RNS damages many biological molecules via S-nitrosothiol (SNO) accumulation. However, the mechanism by which the host enables innate immunity activation during oxidative burst remains largely unknown. Here, we demonstrate that S-nitrosoglutathione (GSNO), the main endogenous SNO, attenuates innate immune responses against herpes simplex virus-1 (HSV-1) and Lister...
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: Mutian Jia Li Chai Jie Wang Mengge Wang Danhui Qin Hui Song Yue Fu Chunyuan Zhao Chengjiang Gao Jihui Jia Wei Zhao Source Type: research
Development of STING degrader with double covalent ligands
In this study, we used a minimal covalent handle recently developed as the ligand portion of an E3 ligase. The engineered STING degrader with a low molecular weight compound covalently binds to STING and E3 ligase. Degrader 2 showed sustained STING degradation activity at lower concentrations (3 µM, 48 h, about 75 % degradation) compared to a reported STING PROTAC, SP23. This discovery holds significance for its potential in treating autoinflammatory and autoimmune diseases, offering promising avenues for developing more efficacious STING-targeted therapies.PMID:38408510 | DOI:10.1016/j.bmcl.2024.129677 (Source: Bioorgani...
Source: Bioorganic and Medicinal Chemistry Letters - February 26, 2024 Category: Chemistry Authors: Miki Nakamura Nobumichi Ohoka Norihito Shibata Takao Inoue Genichiro Tsuji Yosuke Demizu Source Type: research
African swine fever virus early protein pI73R suppresses the type-I IFN promoter activities
Virus Res. 2024 Feb 24:199342. doi: 10.1016/j.virusres.2024.199342. Online ahead of print.ABSTRACTAfrican swine fever virus is known to suppress type-I interferon (IFN) responses. The main objective of this study was to screen early-expressed viral genes for their ability to suppress IFN production. Out of 16 early genes examined, I73R exhibited robust suppression of cGAS-STING-induced IFN-β promoter activities, impeding the function of both IRF3 and NF-κB transcription factors. As a result, I73R obstructed IRF3 nuclear translocation following the treatment of cells with poly(dA:dT), a strong inducer of the cGAS-STING si...
Source: Virus Research - February 26, 2024 Category: Virology Authors: Danh Cong Lai Jayeshbhai Chaudhari Hiep L X Vu Source Type: research
CGRP attenuates pulmonary vascular remodeling by inhibiting the cGAS-STING-NF κB pathway in pulmonary arterial hypertension
CONCLUSION: This study identifies that CGRP attenuates cGAS-STING-NFκB axis-mediated vascular remodeling in PAH through PKA.PMID:38408681 | DOI:10.1016/j.bcp.2024.116093 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - February 26, 2024 Category: Drugs & Pharmacology Authors: Xin Yan Jun Huang Youjie Zeng Xuefeng Zhong Yangxia Fu Haiyan Xiao Xia Wang Huilin Lian Hui Luo Dai Li Ren Guo Source Type: research
