Up-regulation of HSP90 α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway
This study aimed to elucidate the underlying mechanism of HSP90α in asthma by focusing on the cGAS-STING-Endoplasmic Reticulum stress pathway in inflammatory airway epithelial cell death (i.e., pyroptosis; inflammatory cell death). To accomplish that, we modeled allergen exposure in C57/6BL mice and bronchial epithelial cells with house dust mite. Protein technologies and immunofluorescence utilized to study the expression of HSP90α, activation of cGAS-STING pathway and pyroptosis. The effect of inhibitors on HDM-exposed mice detected by histological techniques and examination of bronchoalveolar lavage fluid. Results sho...
Source: International Immunopharmacology - March 25, 2024 Category: Allergy & Immunology Authors: Haohua Huang Yujie Qiao Lanhe Chu Cuiping Ye Lishan Lin Hua Liao Xiaojing Meng Fei Zou Haijin Zhao Mengchen Zou Shaoxi Cai Hangming Dong Source Type: research
Up-regulation of HSP90 α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway
This study aimed to elucidate the underlying mechanism of HSP90α in asthma by focusing on the cGAS-STING-Endoplasmic Reticulum stress pathway in inflammatory airway epithelial cell death (i.e., pyroptosis; inflammatory cell death). To accomplish that, we modeled allergen exposure in C57/6BL mice and bronchial epithelial cells with house dust mite. Protein technologies and immunofluorescence utilized to study the expression of HSP90α, activation of cGAS-STING pathway and pyroptosis. The effect of inhibitors on HDM-exposed mice detected by histological techniques and examination of bronchoalveolar lavage fluid. Results sho...
Source: International Immunopharmacology - March 25, 2024 Category: Allergy & Immunology Authors: Haohua Huang Yujie Qiao Lanhe Chu Cuiping Ye Lishan Lin Hua Liao Xiaojing Meng Fei Zou Haijin Zhao Mengchen Zou Shaoxi Cai Hangming Dong Source Type: research
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF- κB pathway
Bioorg Chem. 2024 Mar 21;146:107303. doi: 10.1016/j.bioorg.2024.107303. Online ahead of print.ABSTRACTArylpropionic ester scaffold was found as anti-inflammatory agents for the treatment and prevention of acute kidney injury (AKI). To further study the structure-activity relationship (SAR) of this scaffold, a series of acryl amides were designed, synthesized, and evaluated their anti-inflammation. Of these, compound 9d displayed the protective effect on renal tubular epithelial cells to significantly enhance the survival rate through inhibiting NF-κB phosphorylation and promoting cell proliferation in cisplatin-induced HK...
Source: Bioorganic Chemistry - March 23, 2024 Category: Chemistry Authors: Xiaoming Wu Long Zhou Ziyun Li Kuanrong Rong Shan Gao Yun Chen Jiawei Zuo Wenjian Tang Source Type: research
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF- κB pathway
Bioorg Chem. 2024 Mar 21;146:107303. doi: 10.1016/j.bioorg.2024.107303. Online ahead of print.ABSTRACTArylpropionic ester scaffold was found as anti-inflammatory agents for the treatment and prevention of acute kidney injury (AKI). To further study the structure-activity relationship (SAR) of this scaffold, a series of acryl amides were designed, synthesized, and evaluated their anti-inflammation. Of these, compound 9d displayed the protective effect on renal tubular epithelial cells to significantly enhance the survival rate through inhibiting NF-κB phosphorylation and promoting cell proliferation in cisplatin-induced HK...
Source: Bioorganic Chemistry - March 23, 2024 Category: Chemistry Authors: Xiaoming Wu Long Zhou Ziyun Li Kuanrong Rong Shan Gao Yun Chen Jiawei Zuo Wenjian Tang Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
