Serum cytokine levels of COVID-19 patients after 7  days of treatment with Favipiravir or Kaletra
CONCLUSION: Antiviral treatments did not suppress the inflammatory phase of COVID-19 after 7 days treatment although CT, CRP and LDH suggest a decline in lung inflammation. There was limited evidence for a viral-mediated cytokine storm in these COVID-19 subjects.PMID:33631512 | PMC:PMC7826095 | DOI:10.1016/j.intimp.2021.107407 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 25, 2021 Category: Allergy & Immunology Authors: Esmaeil Mortaz Ali Bassir Neda Dalil Roofchayee Neda K Dezfuli Hamidreza Jamaati Payam Tabarsi Afshin Moniri Mitra Rezaei Payam Mehrian Mohammad Varahram Majid Marjani Sharon Mumby Ian M Adcock Source Type: research

Partial recovery of senescence in circulating follicular helper T cells after Dasatinib treatment
Int Immunopharmacol. 2021 Feb 22;94:107465. doi: 10.1016/j.intimp.2021.107465. Online ahead of print.ABSTRACTCellular senescence is an irreversible arrest of cell proliferation triggered by different stimuli, including DNA damage, telomere shortening and oncogenic stress. Senescent cells, by releasing the senescence-associated-secretory-phenotype (SASP), contribute to various diseases pathogenesis. Human atherosclerotic plaque contains cells with multiple markers of senescence that associate with disease severity. We characterized the frequency of senescent cTfh cells and genes expressions before and after treatment with D...
Source: International Immunopharmacology - February 25, 2021 Category: Allergy & Immunology Authors: Atefe Ghamar Talepoor Shahdad Khosropanah Mehrnoosh Doroudchi Source Type: research

p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss
In this study, we investigated whether A-485, a highly selective catalytic p300/CBP inhibitor, could attenuate RANKL-induced osteoclast differentiation and explored the underlying molecular mechanisms. The protective role of A-485 in osteoporosis was verified using a mouse model of ovariectomy (OVX)-induced bone loss and micro-CT scanning. A-485 inhibited RANKL-induced osteoclast differentiation in vitro by reducing the number of tartrate-resistant acid phosphatase-positive osteoclasts without inducing significant cytotoxicity. In particular, A-485 dose-dependently disrupted F-actin ring formation and downregulated the exp...
Source: International Immunopharmacology - February 24, 2021 Category: Allergy & Immunology Authors: Shicheng Huo Xuesong Liu Shutao Zhang Zhuocheng Lyu Jue Zhang You Wang Bin'en Nie Bing Yue Source Type: research

p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss
In this study, we investigated whether A-485, a highly selective catalytic p300/CBP inhibitor, could attenuate RANKL-induced osteoclast differentiation and explored the underlying molecular mechanisms. The protective role of A-485 in osteoporosis was verified using a mouse model of ovariectomy (OVX)-induced bone loss and micro-CT scanning. A-485 inhibited RANKL-induced osteoclast differentiation in vitro by reducing the number of tartrate-resistant acid phosphatase-positive osteoclasts without inducing significant cytotoxicity. In particular, A-485 dose-dependently disrupted F-actin ring formation and downregulated the exp...
Source: International Immunopharmacology - February 24, 2021 Category: Allergy & Immunology Authors: Shicheng Huo Xuesong Liu Shutao Zhang Zhuocheng Lyu Jue Zhang You Wang Bin'en Nie Bing Yue Source Type: research

Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex
In conclusion, this study explored the regulatory mechanism of luteolin on autophagy in allergic asthma, providing biologic evidence for its clinical application.PMID:33621850 | DOI:10.1016/j.intimp.2021.107460 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 23, 2021 Category: Allergy & Immunology Authors: Shiyuan Wang Tulake Wuniqiemu Weifeng Tang Fangzhou Teng Qin Bian La Yi Jingjing Qin Xueyi Zhu Ying Wei Jingcheng Dong Source Type: research

Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF- α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways
This study, evaluated the anti-RA effect of 19 phenylpropanoids on tumor necrosis factor (TNF)-α induced inflammation in MH7A cells and clarified their underlying mechanisms. As a result, 16 compounds remarkably suppressed nitric oxide (NO) production at a concentration of 40 μM in TNF-α-induced MH7A cells. Among them, pinoresinol (12) and dendrocoumarin A (1) were the most effective substances, which showed significant inhibitory effect on NO production, with IC50 values of 6.25 ± 0.42 and 7.87 ± 0.67 μM, respectively. Furthermore, pinoresinol and dendrocoumarin A remarkably decreased the l...
Source: International Immunopharmacology - February 22, 2021 Category: Allergy & Immunology Authors: Li Yang Ronghua Liu Yiwei Fang Junwei He Source Type: research

Immune response of frontline medical workers providing medical support for Wuhan COVID-19 patients, China
Int Immunopharmacol. 2021 Feb 16;94:107479. doi: 10.1016/j.intimp.2021.107479. Online ahead of print.ABSTRACTThe outbreak of novel coronavirus disease 2019 (COVID-19) posed a great challenge and stress to frontline medical workers in China. Stress is closely related to immunity. However, the immune response of frontline medical workers providing medical support for COVID-19 patients is unclear. Here, we reported the immune response of 76 frontline medical workers and 152 controls from the Second Affiliated Hospital of Xi'an Jiaotong University. The frontline medical workers were involved in the care for Wuhan COVID-19 pati...
Source: International Immunopharmacology - February 22, 2021 Category: Allergy & Immunology Authors: Juanjuan Yang Qian Wang Shuqun Zhang Zongfang Li Wei Jiang Source Type: research

Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF- α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways
This study, evaluated the anti-RA effect of 19 phenylpropanoids on tumor necrosis factor (TNF)-α induced inflammation in MH7A cells and clarified their underlying mechanisms. As a result, 16 compounds remarkably suppressed nitric oxide (NO) production at a concentration of 40 μM in TNF-α-induced MH7A cells. Among them, pinoresinol (12) and dendrocoumarin A (1) were the most effective substances, which showed significant inhibitory effect on NO production, with IC50 values of 6.25 ± 0.42 and 7.87 ± 0.67 μM, respectively. Furthermore, pinoresinol and dendrocoumarin A remarkably decreased the l...
Source: International Immunopharmacology - February 22, 2021 Category: Allergy & Immunology Authors: Li Yang Ronghua Liu Yiwei Fang Junwei He Source Type: research

Immune response of frontline medical workers providing medical support for Wuhan COVID-19 patients, China
Int Immunopharmacol. 2021 Feb 16;94:107479. doi: 10.1016/j.intimp.2021.107479. Online ahead of print.ABSTRACTThe outbreak of novel coronavirus disease 2019 (COVID-19) posed a great challenge and stress to frontline medical workers in China. Stress is closely related to immunity. However, the immune response of frontline medical workers providing medical support for COVID-19 patients is unclear. Here, we reported the immune response of 76 frontline medical workers and 152 controls from the Second Affiliated Hospital of Xi'an Jiaotong University. The frontline medical workers were involved in the care for Wuhan COVID-19 pati...
Source: International Immunopharmacology - February 22, 2021 Category: Allergy & Immunology Authors: Juanjuan Yang Qian Wang Shuqun Zhang Zongfang Li Wei Jiang Source Type: research

Doxycycline aggravates granulomatous inflammation and lung microstructural remodeling induced by Schistosoma mansoni infection
Int Immunopharmacol. 2021 Feb 19;94:107462. doi: 10.1016/j.intimp.2021.107462. Online ahead of print.ABSTRACTAlthough doxycycline exhibits immunomodulatory properties, its effects on pulmonary infection by Schistosoma mansoni remain overlooked. Thus, we investigated the impact of this drug on lung granulomatous inflammation and microstructural remodeling in a murine model of schistosomiasis. Swiss mice were randomized in four groups: (i) uninfected, (ii) infected with S. mansoni and untreated, (iii) infected treated with praziquantel (Pzq; 200 mg/kg), and (iv) infected treated with Dox (50 mg/kg). Pz was administered in a ...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Margarida P Santos Elda Gon çalves-Santos Reggiani V Gon çalves Elizi ária C Santos Camila C Campos Daniel S S Bastos Marcos J Marques Raquel L M Souza R ômulo D Novaes Source Type: research

Anti-inflammatory effects of Platycodin D on dextran sulfate sodium (DSS) induced colitis and E. coli Lipopolysaccharide (LPS) induced inflammation
In this study, PLD showed the potential to reduce inflammation, ameliorate intestinal damage, and maintain intestinal integrity in DSS-induced colitis. However, the beneficial effect of PLD was reduced when macrophages were depleted, indicating the key role of macrophages in the beneficial effect of PLD in DSS-induced colitis. Meanwhile, we found that PLD inhibited the expression of M1 markers and promoted the expression of M2 markers in colon. Similarly, we found PLD significantly attenuated the levels of pro-inflammatory cytokines, increased the level of anti-inflammatory cytokine and altered macrophage proportions in LP...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Ruiqi Guo Qingyu Meng Baisen Wang Fan Li Source Type: research

Indirubin attenuates IL-17A-induced CCL20 expression and production in keratinocytes through repressing TAK1 signaling pathway
Int Immunopharmacol. 2021 Feb 19;94:107229. doi: 10.1016/j.intimp.2020.107229. Online ahead of print.ABSTRACTPsoriatic skin inflammation is mainly driven by complex interactions of infiltrating immune cells and activated keratinocytes. Keratinocytes play an active role in initiating and maintenance of psoriatic skin inflammation by secreting chemokines and cytokines. IL-17A produced by T cells potently upregulates the production of chemokine CCL20 in the keratinocytes, which further chemoattracts IL-17A-producing CCR6+ immune cells to the site of inflammation. Indirubin, an active constituent of indigo naturalis, has been ...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Jingxia Zhao Xiangjiang Xie Tingting Di Yu Liu Cong Qi Zhaoxia Chen Ping Li Yan Wang Source Type: research

Exploring a novel triptolide derivative possess anti-colitis effect via regulating T cell differentiation
In this study, we evaluated the effects of ZT01 on DSS-induced colitis and investigated the underlying mechanism of action involved. Mice with DSS-induced acute or chronic colitis were used to assess the efficacy of ZT01 treatment, and T cells were cultured to analyze the differentiation of Th1 and Th17 cell by flow cytometry. In addition, intestinal epithelial barrier function, macrophage polarization, activation of the JAK-STAT signaling pathway, and the expression of cytokines and transcription factors were measured to assess the possible mechanisms of ZT01. We found that ZT01 had an obviously beneficial effect on DSS-i...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Junmin Fu Yingda Zang Yu Zhou Chengjuan Chen Shuai Shao Gaona Shi Lei Wu Guoyuan Zhu Tao Sun Dongming Zhang Tiantai Zhang Source Type: research

Serum levels of soluble programmed death-ligand 1 (sPD-L1): A possible biomarker in predicting post-treatment outcomes in patients with early hepatocellular carcinoma
Int Immunopharmacol. 2021 Feb 18;94:107467. doi: 10.1016/j.intimp.2021.107467. Online ahead of print.ABSTRACTBACKGROUND: There have been great advances in hepatocellular carcinoma management over the last years. However, there are still no prognostic biomarkers that can identify patients who will benefit the most from curative treatments. We aimed to investigate whether sPD-L1 levels measured before curative treatment is a prognostic biomarker of survival in patients with HCC.METHODS: HCC patients from a prospectively collected database were selected and soluble programmed death-ligand1(sPD-L1) levels were determined. The ...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Tudor Mocan Maria Ilies Iuliana Nenu Rares Craciun Adelina Horhat Ruxandra Susa Iulia Minciuna Ioana Rusu Lavinia-Patricia Mocan Andrada Seicean Cristina Adela Iuga Nadim Al Hajjar Mihaela Sparchez Daniel-Corneliu Leucuta Zeno Sparchez Source Type: research

Luteolin as an adjuvant effectively enhances CTL anti-tumor response in B16F10 mouse model
In this study, we investigated the function of luteolin as an antitumor vaccine adjuvant (to treat malignant melanoma) in vitro and in vivo. We found that Luteolin may activated the PI3K-Akt pathways in APCs (Antigen Presenting Cells), induced the activation of APCs, enhanced CTL (Cytotoxic T Lymphocyte) responses, and inhibited tolerogenic T cells. To prove the role of CD8+T cells in immune process, we sorted the CD8+T cells from the immunized mice and transferred them to the B16F10 tumor-bearing mice, the result showed that the survival rate was improved. We also observed that in the mice immunized with Luteolin as an ad...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Le Tian Shuang Wang Shasha Jiang Zeyuan Liu Xueqi Wan Chaochao Yang Li Zhang Zheng Zheng Bin Wang Ling Li Source Type: research

Inhibitory effect of acetyl-11-keto- β-boswellic acid on titanium particle-induced bone loss by abrogating osteoclast formation and downregulating the ERK signaling pathway
In this study, we detected the inhibitory effect of AKBA on titanium-induced bone erosion in vivo and used RAW264.7 cells and bone marrow macrophages (BMMs) to investigate the effect and underlying mechanism of AKBA on the differentiation and resorptive function of osteoclasts. Our findings revealed that AKBA inhibited particle-induced bone loss and osteoclast formation in vivo. Furthermore, AKBA exerted inhibitory effects on RANKL-induced osteoclastogenesis, osteoclastic ring-dependent resorption and the expression of osteoclast marker genes via the ERK signaling pathway in vitro. Our data further established the protecti...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Jiawei Shi Ye Gu Yong Wang Jiaxiang Bai Longbin Xiong Yunxia Tao Yi Xue Yaozeng Xu Huilin Yang Hongwei Ye Dechun Geng Source Type: research

Identification of unanimous immune subtypes for different hormone receptor phenotypes of human breast cancer with potential prognostic significance
In this study, we aimed at characterizing the breast cancer immune subtypes linked to CD8 T cells and associating with the patient characteristics and clinical outcomes. We analyzed the immune gene signatures of human breast cancer using The Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) database profiling of 1092 breast tumor patients. We performed hierarchical clustering to the immune gene expression by applying hormone receptor status including triple negative breast cancer to categorize 66 immune-related genes in breast tumors. The separation was characterized by dividing the breast tumors into tw...
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: ChenWei Yu Linlin Zhou Qiuyu Zhang Source Type: research

Hyperoside attenuates non-alcoholic fatty liver disease through targeting Nr4A1 in macrophages
In conclusion, hyperoside may have therapeutic potential in preventing the pathological progression of NAFLD.PMID:33611063 | DOI:10.1016/j.intimp.2021.107438 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 21, 2021 Category: Allergy & Immunology Authors: Bing Sun Ranteng Zhang Zicong Liang Aoqiang Fan Dongmei Kang Source Type: research

Type 2 diabetes mellitus impaired nasal immunity and increased the risk of hyposmia in COVID-19 mild pneumonia patients
Int Immunopharmacol. 2021 Jan 22;93:107406. doi: 10.1016/j.intimp.2021.107406. Online ahead of print.ABSTRACTIn patients with COVID-19,type 2 diabetes mellitus (T2DM) can impair the function of nasal-associated lymphoid tissue (NALT) and result in olfactory dysfunction. Exploring the causative alterations of T2DM within the nasal mucosa and NALT could provide insight into the pathogenic mechanisms and bridge the gap between innate immunity and adaptive immunity for virus clearance. Here, we designed a case-control study to compare the olfactory function (OF) among the groups of normal control (NC), COVID-19 mild pneumonia ...
Source: International Immunopharmacology - February 18, 2021 Category: Allergy & Immunology Authors: Yi Zhao Yujie Liu Fangzheng Yi Jun Zhang Zhaohui Xu Yehai Liu Ye Tao Source Type: research

Dual bronchodilator versus inhaled corticosteroid/long-acting β < sub > 2 < /sub > -agonist in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials
Int Immunopharmacol. 2021 Feb 15;93:107447. doi: 10.1016/j.intimp.2021.107447. Online ahead of print.ABSTRACTBACKGROUND: Long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA, also known as dual bronchodilator) and inhaled corticosteroid/LABA (ICS/LABA) are the cornerstone of maintenance treatment for stable chronic obstructive pulmonary disease (COPD) patients. We aimed to comprehensively compare the efficacy and safety of the two maintenance treatment in COPD patients.METHODS: We searched the database Embase, Cochrane Library, PubMed, and Clinical Trials.gov systematically (from inception until Septemb...
Source: International Immunopharmacology - February 18, 2021 Category: Allergy & Immunology Authors: Hong Chen Ke Wang Tao Yuan Xiaoming Wang Lan Huanng Zhenhuan Jiang Keyang Chen Yuejun Du Source Type: research

Immune and metabolic checkpoints blockade: Dual wielding against tumors
Int Immunopharmacol. 2021 Feb 13;94:107461. doi: 10.1016/j.intimp.2021.107461. Online ahead of print.ABSTRACTRecent advances in cancer immunotherapy have raised hopes for treating cancers that are resistant to conventional therapies. Among the various immunotherapy methods, the immune checkpoint (IC) blockers were more promising and have paved their way to the clinic. Tumor cells induce the expression of ICs on the immune cells and derive them to a hyporesponsive exhausted phenotype. IC blockers could hinder immune exhaustion in the tumor microenvironment and reinvigorate immune cells for an efficient antitumor response. D...
Source: International Immunopharmacology - February 16, 2021 Category: Allergy & Immunology Authors: Mohammad Hossein Kazemi Alireza Najafi Jafar Karami Foad Ghazizadeh Hassan Yousefi Reza Falak Elahe Safari Source Type: research

HMGB1-TLR4-IL-23-IL-17A axis accelerates renal ischemia-reperfusion injury via the recruitment and migration of neutrophils
Int Immunopharmacol. 2021 Feb 13;94:107433. doi: 10.1016/j.intimp.2021.107433. Online ahead of print.ABSTRACTRenal ischemia-reperfusion injury (IRI) is an important cause of setting off acute kidney injury. Neutrophil-mediated immunomodulation has a pivotal role in the evolving of IRI. The HMGB1-TLR4-IL-23-IL-17A axis gives rise to neutrophil activation. Therefore, in the study, the role of the HMGB1-TLR4-IL-23-IL-17A axis in IRI was evaluated. Cell viability, inflammation, apoptosis, oxidative stress, survival, renal function and pathology, and the activation of macrophages and neutrophils were measured. Moreover, we eval...
Source: International Immunopharmacology - February 16, 2021 Category: Allergy & Immunology Authors: Jiong Zhang Qing Li Yu-Rong Zou Shu-Kun Wu Xiang-Heng Lu Gui-Sen Li Jia Wang Source Type: research

Immunoregulatory activities of the selenylated polysaccharides of Lilium davidii var. unicolor Salisb in vitro and in vivo
Int Immunopharmacol. 2021 Feb 13;94:107445. doi: 10.1016/j.intimp.2021.107445. Online ahead of print.ABSTRACTStudies have demonstrated that the modification of selenylation can improve the activity of polysaccharides. Lilium davidii var. unicolor Salisb (known as "lily bulb") is the dried succulent bulb of the genus Lilium in the family Liliaceae. We wished to investigate the immunoregulatory activities of the selenized polysaccharides of lily bulb (sLP). We undertook experiments in vitro and in vivo taking the unmodified polysaccharides of lily bulb (LP) as controls. The results of in vitro studies showed that s...
Source: International Immunopharmacology - February 16, 2021 Category: Allergy & Immunology Authors: Shuangxi Li Fuyin Bao Yang Cui Source Type: research

Meta-analysis of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Henoch-Schonlein purpura and its complications
Int Immunopharmacol. 2021 Feb 12;94:107454. doi: 10.1016/j.intimp.2021.107454. Online ahead of print.ABSTRACTOBJECTIVE: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the severity of Henoch-Schonlein purpura (HSP). Therefore, we conducted a meta-analysis to evaluate the clinical significance of NLR and PLR in HSP and its complications.METHODS: A comprehensive literature search was conducted by searching the PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and SinoMed databases from their inception to September 31, 2...
Source: International Immunopharmacology - February 15, 2021 Category: Allergy & Immunology Authors: Wei Fu Weixia Ye Xianqiang Liu Sirui Zhu Hu Fu Rui Zhu Hongmin Li Haoyun Zeng Qin Wang Source Type: research

5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice
CONCLUSION: These findings document glucocorticoid-, allergen- and 5-lipoxygenase-dependent eosinophilia, which makes EWIp carriers an abundant source of pure, nontransgenic eosinophils for immunopharmacological studies.PMID:33588174 | DOI:10.1016/j.intimp.2021.107440 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 15, 2021 Category: Allergy & Immunology Authors: Bruno Marques Vieira Carina Corr êa de Souza Daniela Masid de Brito Renato Nunes Ferreira Rebeca S Brum Maria Ignez C Gaspar Elsas Pedro Xavier Elsas Source Type: research

Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts
CONCLUSION: Hypoxia and P. gingivalis-LPS synergistically induced NLRP3 inflammasome activation in HGFs, and subsequently high levels of interleukin-1β and GSDMD-mediated pyroptosis can cause an HGF inflammatory response, which plays an important role in the pathogenesis of periodontitis.PMID:33588175 | DOI:10.1016/j.intimp.2021.107456 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 15, 2021 Category: Allergy & Immunology Authors: Kai Yang Shuo Xu Hongmei Zhao Lingshuang Liu Xiaofang Lv Fang Hu Lei Wang Qiuxia Ji Source Type: research

Dual bronchodilator versus inhaled corticosteroid/long-acting β2-agonist in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials.
Dual bronchodilator versus inhaled corticosteroid/long-acting β2-agonist in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials. Int Immunopharmacol. 2021 Feb 15;93:107447 Authors: Chen H, Wang K, Yuan T, Wang X, Huanng L, Jiang Z, Chen K, Du Y Abstract BACKGROUND: Long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA, also known as dual bronchodilator) and inhaled corticosteroid/LABA (ICS/LABA) are the cornerstone of maintenance treatment for stable chronic obstructive pulmonary disease (COPD) patients. We aimed to comprehensive...
Source: International Immunopharmacology - February 15, 2021 Category: Allergy & Immunology Authors: Chen H, Wang K, Yuan T, Wang X, Huanng L, Jiang Z, Chen K, Du Y Tags: Int Immunopharmacol Source Type: research

Immune and metabolic checkpoints blockade: Dual wielding against tumors.
Abstract Recent advances in cancer immunotherapy have raised hopes for treating cancers that are resistant to conventional therapies. Among the various immunotherapy methods, the immune checkpoint (IC) blockers were more promising and have paved their way to the clinic. Tumor cells induce the expression of ICs on the immune cells and derive them to a hyporesponsive exhausted phenotype. IC blockers could hinder immune exhaustion in the tumor microenvironment and reinvigorate immune cells for an efficient antitumor response. Despite the primary success of IC blockers in the clinic, the growing numbers of refractory ...
Source: International Immunopharmacology - February 13, 2021 Category: Allergy & Immunology Authors: Kazemi MH, Najafi A, Karami J, Ghazizadeh F, Yousefi H, Falak R, Safari E Tags: Int Immunopharmacol Source Type: research

HMGB1-TLR4-IL-23-IL-17A axis accelerates renal ischemia-reperfusion injury via the recruitment and migration of neutrophils.
Abstract Renal ischemia-reperfusion injury (IRI) is an important cause of setting off acute kidney injury. Neutrophil-mediated immunomodulation has a pivotal role in the evolving of IRI. The HMGB1-TLR4-IL-23-IL-17A axis gives rise to neutrophil activation. Therefore, in the study, the role of the HMGB1-TLR4-IL-23-IL-17A axis in IRI was evaluated. Cell viability, inflammation, apoptosis, oxidative stress, survival, renal function and pathology, and the activation of macrophages and neutrophils were measured. Moreover, we evaluated the acetylation, translocation, and secretion of HMGB1 as well as levels of TLR-4, IL...
Source: International Immunopharmacology - February 13, 2021 Category: Allergy & Immunology Authors: Zhang J, Li Q, Zou YR, Wu SK, Lu XH, Li GS, Wang J Tags: Int Immunopharmacol Source Type: research

Immunoregulatory activities of the selenylated polysaccharides of Lilium davidii var. unicolor Salisb in vitro and in vivo.
Abstract Studies have demonstrated that the modification of selenylation can improve the activity of polysaccharides. Lilium davidii var. unicolor Salisb (known as "lily bulb") is the dried succulent bulb of the genus Lilium in the family Liliaceae. We wished to investigate the immunoregulatory activities of the selenized polysaccharides of lily bulb (sLP). We undertook experiments in vitro and in vivo taking the unmodified polysaccharides of lily bulb (LP) as controls. The results of in vitro studies showed that sLP could promote the phagocytosis of RAW 264.7 cells significantly, increase the content of...
Source: International Immunopharmacology - February 13, 2021 Category: Allergy & Immunology Authors: Li S, Bao F, Cui Y Tags: Int Immunopharmacol Source Type: research

Meta-analysis of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Henoch-Schonlein purpura and its complications.
Abstract OBJECTIVE: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the severity of Henoch-Schonlein purpura (HSP). Therefore, we conducted a meta-analysis to evaluate the clinical significance of NLR and PLR in HSP and its complications. METHODS: A comprehensive literature search was conducted by searching the PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and SinoMed databases from their inception to September 31, 2020. We used the standard mean difference (SMD) with a 95% confidence interval (CI) t...
Source: International Immunopharmacology - February 12, 2021 Category: Allergy & Immunology Authors: Fu W, Ye W, Liu X, Zhu S, Fu H, Zhu R, Li H, Zeng H, Wang Q Tags: Int Immunopharmacol Source Type: research

5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice.
CONCLUSION: These findings document glucocorticoid-, allergen- and 5-lipoxygenase-dependent eosinophilia, which makes EWIp carriers an abundant source of pure, nontransgenic eosinophils for immunopharmacological studies. PMID: 33588174 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 12, 2021 Category: Allergy & Immunology Authors: Vieira BM, Corrêa de Souza C, Masid de Brito D, Ferreira RN, Brum RS, Gaspar Elsas MIC, Xavier Elsas P Tags: Int Immunopharmacol Source Type: research

Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts.
CONCLUSION: Hypoxia and P. gingivalis-LPS synergistically induced NLRP3 inflammasome activation in HGFs, and subsequently high levels of interleukin-1β and GSDMD-mediated pyroptosis can cause an HGF inflammatory response, which plays an important role in the pathogenesis of periodontitis. PMID: 33588175 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 12, 2021 Category: Allergy & Immunology Authors: Yang K, Xu S, Zhao H, Liu L, Lv X, Hu F, Wang L, Ji Q Tags: Int Immunopharmacol Source Type: research

BMSCs-derived exosomal microRNA-150-5p attenuates myocardial infarction in mice.
CONCLUSION: On all accounts, the present study provides evidence that BMSCs-derived exosomal miR-150-5p attenuates apoptosis of cardiomyocytes and improves cardiac function of MI mice via targeting Bax. PMID: 33582480 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Wu Z, Cheng S, Wang S, Li W, Liu J Tags: Int Immunopharmacol Source Type: research

Inhibitory effects of cyanidin-3-O-glucoside in black soybean hull extract on RBL-2H3 cells degranulation and passive cutaneous anaphylaxis reaction in mice.
Abstract Black soybean hull extract (BSHE) exhibits a variety of biological activities. However, little is known about the effects of BSHE on immunoglobulin E (IgE)-mediated type I allergic reactions. The anti-allergic effect of BSHE was assessed with the degranulation assay using rat basophilic leukemia RBL-2H3 cells and the passive cutaneous anaphylaxis (PCA) reaction in mice. An active compound in BSHE was identified by ultra-performance liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry analysis. BSHE inhibited the release of β-hexosaminidase and hi...
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Hiemori-Kondo M, Morikawa E, Fujikura M, Nagayasu A, Maekawa Y Tags: Int Immunopharmacol Source Type: research

Efficacy and cost of different treatment in patients with idiopathic membranous nephropathy: A network meta-analysis and cost-effectiveness analysis.
CONCLUSIONS: CTX + GC was the cheapest treatment with obvious curative effect in China, while LEF + GC was a cost-effective alternative to CTX + GC. The remission rate of TAC + GC was highest despite the high single-dose cost. PMID: 33582591 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Dai P, Xie W, Yu X, Sun J, Wang S, Kawuki J Tags: Int Immunopharmacol Source Type: research

Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment.
CONCLUSIONS: GMSC-Exos reduce the release level and expression of inflammatory factors, inhibit lipid accumulation, and promote the polarization of pro-inflammatory macrophages into anti-inflammatory phenotype in a high-lipid microenvironment. PMID: 33582592 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Zhang Y, Wang Z, Shi B, Li Y, Wang R, Sun J, Hu Y, Yuan C, Xu Q Tags: Int Immunopharmacol Source Type: research

CD3E as a new predictive biomarker of response to omalizumab treatment in asthma patients: Evidence from bioinformatic analysis.
CONCLUSION: CD3E maybe a new predictive biomarker of response to omalizumab treatment in asthma patients and be used to select more suitable asthma patients for omalizumab treatment. PMID: 33578181 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 9, 2021 Category: Allergy & Immunology Authors: Zhang Q, Li H, Gao S, Wang J, Li C, Shu J, Lin J Tags: Int Immunopharmacol Source Type: research

Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/I κBα/NF-κB pathway through NCALD to reduce inflammation.
In conclusion, the antidepressant action of helicid was mediated through NCALD in rats of CUMS by repressing hippocampal neuro-inflammation and abating the activation of the IKK/IκBα/NF-κB pathway. PMID: 33578182 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 9, 2021 Category: Allergy & Immunology Authors: Zhang YX, Zhang XT, Li HJ, Zhou TF, Zhou AC, Zhong ZL, Liu YH, Yuan LL, Zhu HY, Luan D, Tong JC Tags: Int Immunopharmacol Source Type: research

Protective immune response against P32 oncogenic peptide-pulsed PBMCs in mouse models of breast cancer.
Abstract High expression of p32 in certain tumors makes it a potential target for immunotherapy. In the present study, the first goal was to design multi-epitope peptides from the P32 protein and the second goal was to compare the prophylactic effects of DCs- and PBMCs- based vaccines by pulsing them with designed peptides. For these purposes, 160 BALB/c mice were vaccinated in 5 different subgroups of each 4 peptides using PBS (F1-4a), F peptides alone (F1-4b), F peptides with CpG-ODN (F1-4c), F peptides with CpGODN and DCs (F1-4d), and F peptides with CpG-ODN and PBMCs (F1-4e). We found a significantly higher in...
Source: International Immunopharmacology - February 9, 2021 Category: Allergy & Immunology Authors: Dehghan-Manshadi M, Nikpoor AR, Hadinedoushan H, Zare F, Sankian M, Fesahat F, Rafatpanah H Tags: Int Immunopharmacol Source Type: research

Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: Possible role of endocannabinoid system modulation.
In conclusion, our findings imply a multi-target neuroprotective effect of PCM in PD which could be attributed to its antioxidant, anti-inflammatory and anti-apoptotic activities, in addition to cannabinoid receptors' modulation. PMID: 33578261 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 9, 2021 Category: Allergy & Immunology Authors: Labib AY, Ammar RM, El-Naga RN, El-Bahy AAZ, Tadros MG, Michel HE Tags: Int Immunopharmacol Source Type: research

Corrigendum to "Paeonol derivative-6 attenuates inflammation by activating ZEB2 in acute liver injury" [Int. Immunopharmacol. 91 (2021) 107235].
Corrigendum to "Paeonol derivative-6 attenuates inflammation by activating ZEB2 in acute liver injury" [Int. Immunopharmacol. 91 (2021) 107235]. Int Immunopharmacol. 2021 Feb 09;94:107410 Authors: Yang J, Xu L, Wu M, Fang H, Lu Y, Shi C, Wang Y, Li Z, Zhang L, Zhang L PMID: 33578262 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 9, 2021 Category: Allergy & Immunology Authors: Yang J, Xu L, Wu M, Fang H, Lu Y, Shi C, Wang Y, Li Z, Zhang L, Zhang L Tags: Int Immunopharmacol Source Type: research

Anti-DLL4 ameliorates toluene diisocyanate-induced experimental asthma by inhibiting Th17 response.
Abstract Toluene diisocyanate (TDI) exhibits an ability to induce steroid insensitive asthma with the involvement of Th17 cells. And emerging evidence has indicated that DLL4 signaling promotes Th17 differentiation through directly upregulating Rorc and IL-17 transcription. Thus, we sought to evaluate the effects of DLL4 blocking antibody on TDI-induced asthma model. Female BALB/c mice were sensitized and challenged with TDI to generate an asthma model. TDI-exposed mice were intraperitoneally injected with anti-DLL4 antibody and then analyzed for various parameters of the airway inflammatory responses. Increased e...
Source: International Immunopharmacology - February 9, 2021 Category: Allergy & Immunology Authors: Deng Y, Chen S, Song S, Huang Y, Chen R, Tao A Tags: Int Immunopharmacol Source Type: research

Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways.
Abstract Chronic obstructive pulmonary disease (COPD) is characterized by irreversible and progressive airflow limitation and encompasses varying degrees of chronic obstructive bronchitis and emphysema. Our previous study showed that Forkhead box protein A2 (FOXA2) is involved in cigarette smoke (CS)-induced squamous metaplasia. However, the contribution of FOXA2 activity to CS-induced cellular senescence and lung inflammation remains largely unknown. Here, we report that FOXA2 was underexpressed in CS-exposed mouse lungs, and decreased expression of FOXA2 was related to cell senescence and inflammation. Subsequen...
Source: International Immunopharmacology - February 8, 2021 Category: Allergy & Immunology Authors: Tao Y, Sun Y, Wu B, Xu D, Yang J, Gu L, Du C Tags: Int Immunopharmacol Source Type: research

Mesenchymal stem cell carriers enhance antitumor efficacy induced by oncolytic reovirus in acute myeloid leukemia.
Abstract Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the therapeutic efficacy is modest, and most commonly manifests as relapse from remission. Thus, improving long-term AML survival is a crucial clinical challenge. In recent years, oncolytic virotherapy has provided an alternative approach for AML treatment. The use of oncolytic reoviruses has been explored in more than 30 clinical trials for safety and feasibility issues. However, like other oncolytic viruses, neutralizing antibodies (NAbs) reduce therapeutic efficacy. To tackle this problem, human umbilical cord mesenchymal stem cel...
Source: International Immunopharmacology - February 8, 2021 Category: Allergy & Immunology Authors: Wang X, Yang Y, Wang N, Wu X, Xu J, Zhou Y, Zhao X, He Z Tags: Int Immunopharmacol Source Type: research

Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review.
This study aims to review the pharmacological and safety profile of LF with a focus on the LF-induced hepatic injury from the perspective of pathophysiology and possible protective agents. PMID: 33571819 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 8, 2021 Category: Allergy & Immunology Authors: Alamri RD, Elmeligy MA, Albalawi GA, Alquayr SM, Alsubhi SS, El-Ghaiesh SH Tags: Int Immunopharmacol Source Type: research

Enumerating the role of properdin in the pathogenesis of IgA nephropathy and its possible therapies.
CONCLUSION: With no specific cure still available, the treatment strategies are of great concern to find a better target to restrict the disease progression. More research and clinical trials are required to find out a prominent target to combat IgAN. PMID: 33571820 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 8, 2021 Category: Allergy & Immunology Authors: Ghosh S, Das S, Mukherjee J, Abdullah S, Mondal R, Sultana S, Sehgal A, Behl T Tags: Int Immunopharmacol Source Type: research

Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages.
The objective of the study was to evaluate a plant extract astragaloside IV (AS-IV) in treating ON-FN. Bone-marrow-derived macrophages (BMDMs) were treated with lipopolysaccharides (LPS), IFN-γ or IL-4 to induce M1 and M2-like phenotypes. Quantitative real-time PCR and Western blot were used to examine M1 and M2 phenotypic markers. Flow cytometry was used to analyze MHC II, CD206, F4/80, and CD11b levels and cell apoptosis. Glucocorticoid was used to induce ON-FN in mice. TNF-α and IL-1β levels in femoral head were determined using enzyme-linked immunosorbent assay. AS-IV repolarized macrophages from M1 to...
Source: International Immunopharmacology - February 6, 2021 Category: Allergy & Immunology Authors: Jiang C, Zhou Z, Lin Y, Shan H, Xia W, Yin F, Wang N, Zhou L, Gao Y, Yu X Tags: Int Immunopharmacol Source Type: research

Natural killer cells contributed to recurrent miscarriage by SP1-CASP3-PARP1.
In this study, weighted gene correlation network analysis was used to study the expression profile data of the endometrial tissue of patients with recurrent miscarriage and selected brown module as key module positively related to the numbers of miscarriages. With metascape tool, natural killer cells mediated cytotoxicity related genes, such as CASP3, were selected. DisNor database showed that CASP3 down-regulates PARP1. According to TRRUST database, CASP3 was regulated by SP1. Through comprehensive analysis of uNK cell related genes, we proposed that natural killer cells contribute to recurrent miscarriage by SP1-CASP3-PA...
Source: International Immunopharmacology - February 5, 2021 Category: Allergy & Immunology Authors: Liu Y, Chen P, Fei H, Li M, Li X, Li T Tags: Int Immunopharmacol Source Type: research

Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice.
This study aimed to assess the probable underlying mechanisms that mediate changes in the behavior, hippocampus, heart and serum in the mouse model of maternal separation (MS) stress. We evaluated the possible protective effects of auraptene in these changes focusing on inflammatory response and oxidative state. Mice were treated with auraptene (5, 10, and 50 mg/kg). In addition, anxiety-like behaviors were evaluated using behavioral tests; including open field test (OFT) and elevated plus maze (EPM). Hippocampus and heart samples were assessed histopathologically. Levels of malondialdehyde (MDA) and antioxidant capac...
Source: International Immunopharmacology - February 5, 2021 Category: Allergy & Immunology Authors: Arabi M, Nasab SH, Lorigooini Z, Boroujeni SN, Mortazavi SM, Anjomshoa M, Amini-Khoei H Tags: Int Immunopharmacol Source Type: research