Pre-existing interstitial lung disease in patients with coronavirus disease 2019: A meta-analysis
Int Immunopharmacol. 2021 Sep 9;100:108145. doi: 10.1016/j.intimp.2021.108145. Online ahead of print.ABSTRACTBACKGROUND: The impact of pre-existing interstitial lung disease (ILD) on the severity and mortality of COVID-19 remains largely unknown. The purpose of this meta-analysis was to investigate the prevalence of ILD among patients with COVID-19 and figure out the relationship between ILD and the poor clinical outcomes of COVID-19.METHODS: A systematic literature search was conducted in the PubMed, EMBASE, Web of Science and MedRxiv Database from 1 January 2020 to 26 May 2021.RESULTS: 15 studies with 135,263 COVID-19 pa...
Source: International Immunopharmacology - September 21, 2021 Category: Allergy & Immunology Authors: Lichen Ouyang Jie Gong Muqing Yu Source Type: research

Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells
In conclusion, the current data demonstrated that TRPC6 plays a significant role in osteoblastic differentiation of PDLCs, suggesting that it may be a promising therapeutic target in osteogenesis.PMID:34547679 | DOI:10.1016/j.intimp.2021.108134 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 21, 2021 Category: Allergy & Immunology Authors: Li Wang Jing Mi Bingjing Sun Gang Yang Shangfen Liu Meihua Chen Liming Yu Jie Pan Yuehua Liu Source Type: research

Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF- κB and VEGFR2 signaling
In this study, we explored the potential effects and mechanisms of nintedanib on psoriasis in vivo and in vitro. In vivo experiments showed that nintedanib effectively alleviated imiquimod-induced psoriasis-like skin lesions and reduced psoriasis severity index scores. For the mechanism research, we mainly focused on the abnormal phenotype of keratinocyte in the pathogenesis of psoriasis. We used HaCaT cells in the in vitro experiments and the result revealed that nintedanib restored keratinocyte homeostasis by downregulated the expression of proinflammatory factors, inhibited hyperproliferation, promoted apoptosis, mainta...
Source: International Immunopharmacology - September 21, 2021 Category: Allergy & Immunology Authors: Xiaohe Li Buri Xi Yang Miao Xiaoyang Ma Jianwei Zhang Jingjing Gao Wenguo Wei Honggang Zhou Cheng Yang Source Type: research

Ginsenoside Rg1 relieves experimental colitis by regulating balanced differentiation of Tfh/Treg cells
Int Immunopharmacol. 2021 Sep 17;100:108133. doi: 10.1016/j.intimp.2021.108133. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is typically characterized by the dysregulation of Tfh cell differentiation. we sought to explore the potential mechanism of Ginsenoside Rg1 (G-Rg1) treated IBD by observing the level of the Tfh/Treg cells and the activation of PI3K/Akt signaling pathway in the colitis mice. In the present study, G-Rg1 significantly inhibited the inflammatory response to mice colitis induced by dextran sodium sulfate (DSS), as evidenced by increased body weight and colon length, decreased colon weig...
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Jing Jin Youbao Zhong Jian Long Tiantian Wu Qingqing Jiang Haiyan Wang Wei Ge Haimei Zhao Duanyong Liu Source Type: research

Glial cell line-derived neurotrophic factor ameliorates dextran sulfate sodium-induced colitis in mice via a macrophage-mediated pathway
Int Immunopharmacol. 2021 Sep 17;100:108143. doi: 10.1016/j.intimp.2021.108143. Online ahead of print.ABSTRACTGlial cell line-derived neurotrophic factor (GDNF) has been reported to protect mice from intestinal inflammation, but its anti-inflammatory mechanisms are poorly understood. Here we found that there was a downregulation in intestinal expression of GDNF accompanied by an increase of M1 macrophages in dextran sulfate sodium (DSS)-induced colitis in mice. GDNF treatment could facilitate the macrophages polarization towards the M2-like phenotype in DSS-treated mice and LPS-stimulated RAW264.7 cells, and reduce pro-inf...
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Jian Zeng Huan Yu Hua-Tian Gan Source Type: research

Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients
In conclusion, the coexistence of increased microbial translocation and hyperinflammation in patients with severe COVID-19 may lead to higher monocyte activation, which may be associated with worsening outcomes, such as death.PMID:34543980 | PMC:PMC8426217 | DOI:10.1016/j.intimp.2021.108125 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Paula C Teixeira Gilson P Dorneles Paulo C Santana Filho Igor M da Silva Lucas L Schipper Isabelle A L Postiga Carla Andretta Moreira Neves Luiz Carlos Rodrigues Junior Alessandra Peres Janeusa Trindade de Souto Simone Gon çalves Fonseca Sarah Eller Tiag Source Type: research

Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis
Int Immunopharmacol. 2021 Sep 17;100:108155. doi: 10.1016/j.intimp.2021.108155. Online ahead of print.ABSTRACTGalectin-9 is a member of the galectin family of proteins, which were first identified to specifically bind to carbohydrates containing β-galactosides. Galectin-9 is conserved through evolution and recent evidence demonstrated its involvement in innate immune reactions to bacterial infections as well as the suppression of cytotoxic immune responses of T and natural killer cells. However, the molecular mechanisms underlying such differential immunological functions of galectin-9 remain largely unknown. In this ...
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Stephanie Schlichtner N Helge Meyer Inna M Yasinska Nijas Aliu Steffen M Berger Bernhard F Gibbs Elizaveta Fasler-Kan Vadim V Sumbayev Source Type: research

Ginsenoside Rg1 relieves experimental colitis by regulating balanced differentiation of Tfh/Treg cells
Int Immunopharmacol. 2021 Sep 17;100:108133. doi: 10.1016/j.intimp.2021.108133. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is typically characterized by the dysregulation of Tfh cell differentiation. we sought to explore the potential mechanism of Ginsenoside Rg1 (G-Rg1) treated IBD by observing the level of the Tfh/Treg cells and the activation of PI3K/Akt signaling pathway in the colitis mice. In the present study, G-Rg1 significantly inhibited the inflammatory response to mice colitis induced by dextran sodium sulfate (DSS), as evidenced by increased body weight and colon length, decreased colon weig...
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Jing Jin Youbao Zhong Jian Long Tiantian Wu Qingqing Jiang Haiyan Wang Wei Ge Haimei Zhao Duanyong Liu Source Type: research

Glial cell line-derived neurotrophic factor ameliorates dextran sulfate sodium-induced colitis in mice via a macrophage-mediated pathway
Int Immunopharmacol. 2021 Sep 17;100:108143. doi: 10.1016/j.intimp.2021.108143. Online ahead of print.ABSTRACTGlial cell line-derived neurotrophic factor (GDNF) has been reported to protect mice from intestinal inflammation, but its anti-inflammatory mechanisms are poorly understood. Here we found that there was a downregulation in intestinal expression of GDNF accompanied by an increase of M1 macrophages in dextran sulfate sodium (DSS)-induced colitis in mice. GDNF treatment could facilitate the macrophages polarization towards the M2-like phenotype in DSS-treated mice and LPS-stimulated RAW264.7 cells, and reduce pro-inf...
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Jian Zeng Huan Yu Hua-Tian Gan Source Type: research

Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients
In conclusion, the coexistence of increased microbial translocation and hyperinflammation in patients with severe COVID-19 may lead to higher monocyte activation, which may be associated with worsening outcomes, such as death.PMID:34543980 | DOI:10.1016/j.intimp.2021.108125 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Paula C Teixeira Gilson P Dorneles Paulo C Santana Filho Igor M da Silva Lucas L Schipper Isabelle A L Postiga Carla Andretta Moreira Neves Luiz Carlos Rodrigues Junior Alessandra Peres Janeusa Trindade de Souto Simone Gon çalves Fonseca Sarah Eller Tiag Source Type: research

Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis
Int Immunopharmacol. 2021 Sep 17;100:108155. doi: 10.1016/j.intimp.2021.108155. Online ahead of print.ABSTRACTGalectin-9 is a member of the galectin family of proteins, which were first identified to specifically bind to carbohydrates containing β-galactosides. Galectin-9 is conserved through evolution and recent evidence demonstrated its involvement in innate immune reactions to bacterial infections as well as the suppression of cytotoxic immune responses of T and natural killer cells. However, the molecular mechanisms underlying such differential immunological functions of galectin-9 remain largely unknown. In this ...
Source: International Immunopharmacology - September 20, 2021 Category: Allergy & Immunology Authors: Stephanie Schlichtner N Helge Meyer Inna M Yasinska Nijas Aliu Steffen M Berger Bernhard F Gibbs Elizaveta Fasler-Kan Vadim V Sumbayev Source Type: research

Anisakis simplex: Immunomodulatory effects of larval antigens on the activation of Toll like Receptors
CONCLUSION: Our findings confirm not only that the host genetic basis plays a role in the development of a Th2/Th1/Treg response, but also it states A. simplex larval antigens present specific mechanisms to modify the innate response of the host. As allergies share common pathways with the immune response against this particular helminth, our results provide a better understanding into the specific mechanisms of A. simplex allergy related diseases.PMID:34537480 | DOI:10.1016/j.intimp.2021.108120 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 19, 2021 Category: Allergy & Immunology Authors: Vega Zamora Juan Carlos Andreu-Ballester Marta Rodero Carmen Cu éllar Source Type: research

6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy
CONCLUSION: In brief, 6-Gingerol exerts antiapoptotic and anti-inflammatory effects via TRPV1/FAF1 complex dissociation-mediated autophagy during cerebral I/R injury. Therefore, 6-Gingerol may be an effective drug for the treatment of I/R injury.PMID:34537481 | DOI:10.1016/j.intimp.2021.108146 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 19, 2021 Category: Allergy & Immunology Authors: Jing Luo Jialei Chen Changhong Yang Junyi Tan Jing Zhao Ning Jiang Yong Zhao Source Type: research

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue
Int Immunopharmacol. 2021 Sep 13;100:108150. doi: 10.1016/j.intimp.2021.108150. Online ahead of print.ABSTRACTThe etiological agent of coronavirus disease (COVID-19) is the new member of the Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), responsible for the pandemic that is plaguing the world. The single-stranded RNA virus is capable of infecting the respiratory tract, by binding the spike (S) protein on its viral surface to receptors for the angiotensin II-converting enzyme (ACE2), highly expressed in the pulmonary tissue, enabling the interaction of the virus with alveolar epi...
Source: International Immunopharmacology - September 19, 2021 Category: Allergy & Immunology Authors: J úlia Leão Batista Simões Helena Fornari Basso Greicy Cristine Kosvoski Jullye Gavioli Filomena Marafon Charles Elias Assmann Fabiano Barbosa Carvalho Margarete Dulce Bagatini Source Type: research

Viral infections and the efficacy of PD-(L)1 inhibitors in virus-related cancers: Head and neck squamous cell carcinoma and hepatocellular carcinoma
CONCLUSION: Patients with advanced HNSCC and HCC, regardless of viral infection status, could benefit from ICI treatment. Patients with hepatitis B virus-associated HCC were more likely to benefit from ICI treatment than patients without viral infections.REGISTRATION: Our systematic review protocol was registered with the International Prospective Register of Systematic Reviews on March 27, 2020 (registration number CRD42020155326).PMID:34537483 | DOI:10.1016/j.intimp.2021.108128 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 19, 2021 Category: Allergy & Immunology Authors: Ting Liu Qing Li Zhen Lin Peipei Wang Yueyun Chen Yang Fu Zhenyu Ding Source Type: research

Rimonabant ameliorates hepatic ischemia/reperfusion injury in rats: Involvement of autophagy via modulating ERK- and PI3K/AKT-mTOR pathways
Int Immunopharmacol. 2021 Sep 15;100:108140. doi: 10.1016/j.intimp.2021.108140. Online ahead of print.ABSTRACTHepatic ischemia/reperfusion (HIR), which can result in severe liver injury and dysfunction, is usually associated with autophagy and endocannabinoid system derangements. Whether or not the modulation of the autophagic response following HIR injury is involved in the hepatoprotective effect of the cannabinoid receptor 1(CB1R) antagonist rimonabant remains elusive and is the aim of the current study. Rats pre-treated with rimonabant (3 mg/kg) or vehicle underwent 30 min hepatic ischemia followed by 6 hrs. reperfusio...
Source: International Immunopharmacology - September 18, 2021 Category: Allergy & Immunology Authors: Samar Rezq Reham Hassan Mona F Mahmoud Source Type: research

Identification of a novel immune-related prognostic signature associated with tumor microenvironment for breast cancer
Int Immunopharmacol. 2021 Sep 15;100:108122. doi: 10.1016/j.intimp.2021.108122. Online ahead of print.ABSTRACTBACKGROUND: In the view that immune-related genes play a crucial role in breast cancer progression and long-term patient outcomes, we aimed to identify a novel gene signature based on immune-related genes to improve the prognostic prediction of breast cancer.METHODS: RNA sequencing data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analyses were conducted to establish the immune-related prognostic signature (IRPS). Then, the IRPS was validated...
Source: International Immunopharmacology - September 18, 2021 Category: Allergy & Immunology Authors: Shuning Ding Xi Sun Li Zhu Yafen Li Weiguo Chen Kunwei Shen Source Type: research

A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19)
This study aimed to analyze the dynamic changes in serum levels of NE associated with inflammation, disease activity, and mortality rate in patients with COVID-19. We measured the serum concentrations of NE, C-Reactive protein (CRP), interleukin (IL)- 4, IL-6, IL-8, IL-10, and vitamin D levels in 83 ICU and 69 non-ICU patients compared with 82 healthy subjects (HS) in three-time points (T1-T3). Serum levels of NE, IL-6, IL-8, and CRP in ICU and non-ICU patients were significantly higher than HS (P
Source: International Immunopharmacology - September 18, 2021 Category: Allergy & Immunology Authors: Sajad Karampoor Khashayar Hesamizadeh Faezeh Maleki Mohammad Farahmand Hamid Zahednasab Rasoul Mirzaei Helene Banoun Farhad Zamani Marzieh Hajibaba Alireza Tabibzadeh Behnaz Bouzari Mohammad-Navid Bastani Azadeh Laali Hossein Keyvani Source Type: research

Calorie restriction modulates Neuro-immune system differently in young and aged rats
This study concludes that (a) aging significantly (p
Source: International Immunopharmacology - September 18, 2021 Category: Allergy & Immunology Authors: Apala Chakraborty Soumyabrata Banerjee Biswajit Mukherjee Mrinal K Poddar Nahid Ali Source Type: research

Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19
CONCLUSIONS: The results showed that the antioxidant/oxidant levels of infected patients can be estimated accurately and reliably with LYM, ferritin, D-dimer, WBC, CRP biomarkers in the COVID-19 outbreak.PMID:34536746 | PMC:PMC8426260 | DOI:10.1016/j.intimp.2021.108127 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 18, 2021 Category: Allergy & Immunology Authors: Mehmet Tahir Huyut Z übeyir Huyut Source Type: research

Role of vitamin D/VDR nuclear translocation in down-regulation of NF- κB/NLRP3/caspase-1 axis in lupus nephritis
CONCLUSION: LN pathogenesis decreased after paricalcitol treatment. We observed a marked improvement in renal pathology and a time-dependent decrease urine protein and serum anti-dsDNA antibody levels. In 16-week-old MRL/lpr LN mice, the upregulated expression of NLRP3/caspase-1/IL-1β/IL-18 axis was significantly downregulated after paricalcitol treatment. Paricalcitol can reverse the apoptosis induced by anti-dsDNA antibody via the NF-κB/NLRP3/caspase-1/IL-1β/IL-18 axis in mRTECs. Furthermore, paricalcitol suppressed NF-κB nuclear translocation by competitively binding to importin-4. In summary, the ...
Source: International Immunopharmacology - September 18, 2021 Category: Allergy & Immunology Authors: Jing Huang Qi An Bo-Miao Ju Jing Zhang Ping Fan Lan He Lei Wang Source Type: research

Anethole inhibits RANKL-induced osteoclastogenesis by downregulating ERK/AKT signaling and prevents ovariectomy-induced bone loss in vivo
In conclusion, our results show significant indications that anethole exhibits an osteoprotective effect and may be potential for the treatment of osteoporosis.PMID:34530203 | DOI:10.1016/j.intimp.2021.108113 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 16, 2021 Category: Allergy & Immunology Authors: Hao Qu Yuankang Zhang Rongxin He Nong Lin Cong Wang Source Type: research

Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury
CONCLUSION: GGPPS1 knockdown suppressed NLRP3 inflammasome activity via promoting autophagy and then attenuated sepsis-induced acute lung injury, revealing a novel target for treating sepsis-induced lung injury.PMID:34530204 | DOI:10.1016/j.intimp.2021.108106 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 16, 2021 Category: Allergy & Immunology Authors: Dahuan Li Chunyan Li Tianzhong Wang Chong Zhang Zhao Zhu Guoxiu Zhang Bangjiang Fang Source Type: research

Potential predictors for survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors: A meta-analysis
In this study, the correlations between OS and other early endpoints were evaluated in HCC patients who received ICI.METHODS: Pubmed and Embase were searched to October 2020. Clinical studies evaluating efficacy and outcomes of HCC patients treated with ICI were included. ORR, DCR, PFS and OS were extracted from individual studies. The Spearman's rank correlation coefficient and linear regression model were used to assess the correlation.RESULTS: 74 studies involving 9001 HCC cases were included. For HCC patients treated with ICI, the pooled ORR and DCR were 16% (95% CI: 14-18%) and 52% (95% CI: 47-57%), and the median PFS...
Source: International Immunopharmacology - September 16, 2021 Category: Allergy & Immunology Authors: Huilin Xu Dedong Cao Yongfa Zheng Dingjie Zhou Xin Chen Jinju Lei Wei Ge Ximing Xu Source Type: research

Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies
In this study, we engineered a monoclonal Jurkat/NFAT/CD32a-FcεRIγ effector cell line that stably expresses CD32a-FcεRIγ chimeric receptor and NFAT-controlled luciferase. The corresponding mAb could bind with the membrane antigens on the target cells with its Fab fragment and CD32a-FcεRIγ on the effector cells with its Fc fragment, leading to the crosslinking of CD32a-FcεRIγ and the resultant expression of subsequent NFAT-controlled luciferase, which represents the bioactivity of ADCP based on the MoA of the mAb. With rituximab as the model mAb, Raji cells as the targ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Chunyu Liu Chuanfei Yu Yalan Yang Jing Huang Xiaojuan Yu Maoqin Duan Lang Wang Junzhi Wang Source Type: research

Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway
Int Immunopharmacol. 2021 Sep 11;100:108097. doi: 10.1016/j.intimp.2021.108097. Online ahead of print.ABSTRACTZearalenone (ZEA) is a secondary metabolite produced by fungi such as Fusarium and Fusarium flavum, which is classified as a mycotoxin. Crops and feed in a humid surrounding are widely polluted by ZEA, which further endangering the healthful aquaculture of poultry and even human health. Up to now, prevention and cure of mycotoxicosis is still a crucial subject of poultry husbandry. Baicalin (BAI) is a flavonoid refined from dried roots of Scutellaria baicalensis possessing the function of hepatoprotective, anti-inf...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Jingnan Xu Shurou Li Liqiang Jiang Xinxin Gao Wei Liu Xingyi Zhu Wenlong Huang Haiguang Zhao Zhengkai Wei Kai Wang Zhengtao Yang Source Type: research

Immune response variables and viral mutations impact on COVID-19 reinfection and relapse
Int Immunopharmacol. 2021 Sep 8;100:108108. doi: 10.1016/j.intimp.2021.108108. Online ahead of print.ABSTRACTThe possibility of human reinfection with SARS-CoV-2, the coronavirus responsible for COVID-19, has not previously been thoroughly investigated. Although it is generally believed that virus-specific antibodies protect against COVID-19 pathogenesis, their duration of function and temporal activity remain unknown. Contrary to media reports that people retain protective antibody responses for a few months, science does not exclude reinfection and disease relapse shortly after initiating all immune responses during the ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Sarvin Sanaie Elham Golipour Ali Shamekh Mohammad Reza Sadaie Ata Mahmoodpoor Mehdi Yousefi Source Type: research

Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies
In this study, we engineered a monoclonal Jurkat/NFAT/CD32a-FcεRIγ effector cell line that stably expresses CD32a-FcεRIγ chimeric receptor and NFAT-controlled luciferase. The corresponding mAb could bind with the membrane antigens on the target cells with its Fab fragment and CD32a-FcεRIγ on the effector cells with its Fc fragment, leading to the crosslinking of CD32a-FcεRIγ and the resultant expression of subsequent NFAT-controlled luciferase, which represents the bioactivity of ADCP based on the MoA of the mAb. With rituximab as the model mAb, Raji cells as the targ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Chunyu Liu Chuanfei Yu Yalan Yang Jing Huang Xiaojuan Yu Maoqin Duan Lang Wang Junzhi Wang Source Type: research

Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway
Int Immunopharmacol. 2021 Sep 11;100:108097. doi: 10.1016/j.intimp.2021.108097. Online ahead of print.ABSTRACTZearalenone (ZEA) is a secondary metabolite produced by fungi such as Fusarium and Fusarium flavum, which is classified as a mycotoxin. Crops and feed in a humid surrounding are widely polluted by ZEA, which further endangering the healthful aquaculture of poultry and even human health. Up to now, prevention and cure of mycotoxicosis is still a crucial subject of poultry husbandry. Baicalin (BAI) is a flavonoid refined from dried roots of Scutellaria baicalensis possessing the function of hepatoprotective, anti-inf...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Jingnan Xu Shurou Li Liqiang Jiang Xinxin Gao Wei Liu Xingyi Zhu Wenlong Huang Haiguang Zhao Zhengkai Wei Kai Wang Zhengtao Yang Source Type: research

Immune response variables and viral mutations impact on COVID-19 reinfection and relapse
Int Immunopharmacol. 2021 Sep 8;100:108108. doi: 10.1016/j.intimp.2021.108108. Online ahead of print.ABSTRACTThe possibility of human reinfection with SARS-CoV-2, the coronavirus responsible for COVID-19, has not previously been thoroughly investigated. Although it is generally believed that virus-specific antibodies protect against COVID-19 pathogenesis, their duration of function and temporal activity remain unknown. Contrary to media reports that people retain protective antibody responses for a few months, science does not exclude reinfection and disease relapse shortly after initiating all immune responses during the ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Sarvin Sanaie Elham Golipour Ali Shamekh Mohammad Reza Sadaie Ata Mahmoodpoor Mehdi Yousefi Source Type: research

Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies
In this study, we engineered a monoclonal Jurkat/NFAT/CD32a-FcεRIγ effector cell line that stably expresses CD32a-FcεRIγ chimeric receptor and NFAT-controlled luciferase. The corresponding mAb could bind with the membrane antigens on the target cells with its Fab fragment and CD32a-FcεRIγ on the effector cells with its Fc fragment, leading to the crosslinking of CD32a-FcεRIγ and the resultant expression of subsequent NFAT-controlled luciferase, which represents the bioactivity of ADCP based on the MoA of the mAb. With rituximab as the model mAb, Raji cells as the targ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Chunyu Liu Chuanfei Yu Yalan Yang Jing Huang Xiaojuan Yu Maoqin Duan Lang Wang Junzhi Wang Source Type: research

Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway
Int Immunopharmacol. 2021 Sep 11;100:108097. doi: 10.1016/j.intimp.2021.108097. Online ahead of print.ABSTRACTZearalenone (ZEA) is a secondary metabolite produced by fungi such as Fusarium and Fusarium flavum, which is classified as a mycotoxin. Crops and feed in a humid surrounding are widely polluted by ZEA, which further endangering the healthful aquaculture of poultry and even human health. Up to now, prevention and cure of mycotoxicosis is still a crucial subject of poultry husbandry. Baicalin (BAI) is a flavonoid refined from dried roots of Scutellaria baicalensis possessing the function of hepatoprotective, anti-inf...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Jingnan Xu Shurou Li Liqiang Jiang Xinxin Gao Wei Liu Xingyi Zhu Wenlong Huang Haiguang Zhao Zhengkai Wei Kai Wang Zhengtao Yang Source Type: research

Immune response variables and viral mutations impact on COVID-19 reinfection and relapse
Int Immunopharmacol. 2021 Sep 8;100:108108. doi: 10.1016/j.intimp.2021.108108. Online ahead of print.ABSTRACTThe possibility of human reinfection with SARS-CoV-2, the coronavirus responsible for COVID-19, has not previously been thoroughly investigated. Although it is generally believed that virus-specific antibodies protect against COVID-19 pathogenesis, their duration of function and temporal activity remain unknown. Contrary to media reports that people retain protective antibody responses for a few months, science does not exclude reinfection and disease relapse shortly after initiating all immune responses during the ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Sarvin Sanaie Elham Golipour Ali Shamekh Mohammad Reza Sadaie Ata Mahmoodpoor Mehdi Yousefi Source Type: research

Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies
In this study, we engineered a monoclonal Jurkat/NFAT/CD32a-FcεRIγ effector cell line that stably expresses CD32a-FcεRIγ chimeric receptor and NFAT-controlled luciferase. The corresponding mAb could bind with the membrane antigens on the target cells with its Fab fragment and CD32a-FcεRIγ on the effector cells with its Fc fragment, leading to the crosslinking of CD32a-FcεRIγ and the resultant expression of subsequent NFAT-controlled luciferase, which represents the bioactivity of ADCP based on the MoA of the mAb. With rituximab as the model mAb, Raji cells as the targ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Chunyu Liu Chuanfei Yu Yalan Yang Jing Huang Xiaojuan Yu Maoqin Duan Lang Wang Junzhi Wang Source Type: research

Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway
Int Immunopharmacol. 2021 Sep 11;100:108097. doi: 10.1016/j.intimp.2021.108097. Online ahead of print.ABSTRACTZearalenone (ZEA) is a secondary metabolite produced by fungi such as Fusarium and Fusarium flavum, which is classified as a mycotoxin. Crops and feed in a humid surrounding are widely polluted by ZEA, which further endangering the healthful aquaculture of poultry and even human health. Up to now, prevention and cure of mycotoxicosis is still a crucial subject of poultry husbandry. Baicalin (BAI) is a flavonoid refined from dried roots of Scutellaria baicalensis possessing the function of hepatoprotective, anti-inf...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Jingnan Xu Shurou Li Liqiang Jiang Xinxin Gao Wei Liu Xingyi Zhu Wenlong Huang Haiguang Zhao Zhengkai Wei Kai Wang Zhengtao Yang Source Type: research

Immune response variables and viral mutations impact on COVID-19 reinfection and relapse
Int Immunopharmacol. 2021 Sep 8;100:108108. doi: 10.1016/j.intimp.2021.108108. Online ahead of print.ABSTRACTThe possibility of human reinfection with SARS-CoV-2, the coronavirus responsible for COVID-19, has not previously been thoroughly investigated. Although it is generally believed that virus-specific antibodies protect against COVID-19 pathogenesis, their duration of function and temporal activity remain unknown. Contrary to media reports that people retain protective antibody responses for a few months, science does not exclude reinfection and disease relapse shortly after initiating all immune responses during the ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Sarvin Sanaie Elham Golipour Ali Shamekh Mohammad Reza Sadaie Ata Mahmoodpoor Mehdi Yousefi Source Type: research

Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies
In this study, we engineered a monoclonal Jurkat/NFAT/CD32a-FcεRIγ effector cell line that stably expresses CD32a-FcεRIγ chimeric receptor and NFAT-controlled luciferase. The corresponding mAb could bind with the membrane antigens on the target cells with its Fab fragment and CD32a-FcεRIγ on the effector cells with its Fc fragment, leading to the crosslinking of CD32a-FcεRIγ and the resultant expression of subsequent NFAT-controlled luciferase, which represents the bioactivity of ADCP based on the MoA of the mAb. With rituximab as the model mAb, Raji cells as the targ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Chunyu Liu Chuanfei Yu Yalan Yang Jing Huang Xiaojuan Yu Maoqin Duan Lang Wang Junzhi Wang Source Type: research

Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway
Int Immunopharmacol. 2021 Sep 11;100:108097. doi: 10.1016/j.intimp.2021.108097. Online ahead of print.ABSTRACTZearalenone (ZEA) is a secondary metabolite produced by fungi such as Fusarium and Fusarium flavum, which is classified as a mycotoxin. Crops and feed in a humid surrounding are widely polluted by ZEA, which further endangering the healthful aquaculture of poultry and even human health. Up to now, prevention and cure of mycotoxicosis is still a crucial subject of poultry husbandry. Baicalin (BAI) is a flavonoid refined from dried roots of Scutellaria baicalensis possessing the function of hepatoprotective, anti-inf...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Jingnan Xu Shurou Li Liqiang Jiang Xinxin Gao Wei Liu Xingyi Zhu Wenlong Huang Haiguang Zhao Zhengkai Wei Kai Wang Zhengtao Yang Source Type: research

Immune response variables and viral mutations impact on COVID-19 reinfection and relapse
Int Immunopharmacol. 2021 Sep 8;100:108108. doi: 10.1016/j.intimp.2021.108108. Online ahead of print.ABSTRACTThe possibility of human reinfection with SARS-CoV-2, the coronavirus responsible for COVID-19, has not previously been thoroughly investigated. Although it is generally believed that virus-specific antibodies protect against COVID-19 pathogenesis, their duration of function and temporal activity remain unknown. Contrary to media reports that people retain protective antibody responses for a few months, science does not exclude reinfection and disease relapse shortly after initiating all immune responses during the ...
Source: International Immunopharmacology - September 14, 2021 Category: Allergy & Immunology Authors: Sarvin Sanaie Elham Golipour Ali Shamekh Mohammad Reza Sadaie Ata Mahmoodpoor Mehdi Yousefi Source Type: research

Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF- κB pathway
Int Immunopharmacol. 2021 Sep 10;100:108139. doi: 10.1016/j.intimp.2021.108139. Online ahead of print.ABSTRACTMicroglia are the primary immune cells involved in the immune response, inflammation, and injury repair in the central nervous system. Under different stimuli, the dual polarization of classically-activated M1 microglia and anti-inflammatory selectively-activated M2 microglia is observed. Oxymatrine (OMT) exerts various anti-inflammatory and neuroprotective effects, but the mechanism underlying its action remains unclear. In the present study, we investigated the effects of OMT on the polarization of M1/M2 microgli...
Source: International Immunopharmacology - September 13, 2021 Category: Allergy & Immunology Authors: Xiao-Long Wang Fei Chen Hui Shi Man Zhang Lin Yan Xiu-Ying Pei Xiao-Dong Peng Source Type: research

Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF- κB pathway
Int Immunopharmacol. 2021 Sep 10;100:108139. doi: 10.1016/j.intimp.2021.108139. Online ahead of print.ABSTRACTMicroglia are the primary immune cells involved in the immune response, inflammation, and injury repair in the central nervous system. Under different stimuli, the dual polarization of classically-activated M1 microglia and anti-inflammatory selectively-activated M2 microglia is observed. Oxymatrine (OMT) exerts various anti-inflammatory and neuroprotective effects, but the mechanism underlying its action remains unclear. In the present study, we investigated the effects of OMT on the polarization of M1/M2 microgli...
Source: International Immunopharmacology - September 13, 2021 Category: Allergy & Immunology Authors: Xiao-Long Wang Fei Chen Hui Shi Man Zhang Lin Yan Xiu-Ying Pei Xiao-Dong Peng Source Type: research

FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
Int Immunopharmacol. 2021 Sep 9;100:108117. doi: 10.1016/j.intimp.2021.108117. Online ahead of print.ABSTRACTFPS-ZM1 is an inhibitor of the receptor for advanced glycation end products (RAGE). Nevertheless, there are few reports about its direct effects on microglial inflammation, and the underlying molecular mechanisms remain to be clarified. The present study investigated the potential effects of FPS-ZM1 on lipopolysaccharide (LPS)-mediated microglial inflammation both in vivo and in vitro, and further elucidated the possible molecular mechanisms of action. FPS-ZM1 decreased LPS-induced overproduction of interleukin-1 be...
Source: International Immunopharmacology - September 12, 2021 Category: Allergy & Immunology Authors: Lan Wang Danfeng Zhao Huan Wang Lele Wang Xiaohui Liu Haiyan Zhang Source Type: research

LncRNA THUMPD3-AS1 enhances the proliferation and inflammatory response of chondrocytes in osteoarthritis
CONCLUSION: Our findings highlight the different effects of lncRNA THUMPD3-AS1 on cell apoptosis and inflammatory response, which extend the multiple functions of lncRNA epigenetics in OA biology.PMID:34509934 | DOI:10.1016/j.intimp.2021.108138 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 12, 2021 Category: Allergy & Immunology Authors: Yingjie Wang Tian Li Qi Yang Bin Feng Yongbo Xiang Zehui Lv Xisheng Weng Source Type: research

FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
Int Immunopharmacol. 2021 Sep 9;100:108117. doi: 10.1016/j.intimp.2021.108117. Online ahead of print.ABSTRACTFPS-ZM1 is an inhibitor of the receptor for advanced glycation end products (RAGE). Nevertheless, there are few reports about its direct effects on microglial inflammation, and the underlying molecular mechanisms remain to be clarified. The present study investigated the potential effects of FPS-ZM1 on lipopolysaccharide (LPS)-mediated microglial inflammation both in vivo and in vitro, and further elucidated the possible molecular mechanisms of action. FPS-ZM1 decreased LPS-induced overproduction of interleukin-1 be...
Source: International Immunopharmacology - September 12, 2021 Category: Allergy & Immunology Authors: Lan Wang Danfeng Zhao Huan Wang Lele Wang Xiaohui Liu Haiyan Zhang Source Type: research

LncRNA THUMPD3-AS1 enhances the proliferation and inflammatory response of chondrocytes in osteoarthritis
CONCLUSION: Our findings highlight the different effects of lncRNA THUMPD3-AS1 on cell apoptosis and inflammatory response, which extend the multiple functions of lncRNA epigenetics in OA biology.PMID:34509934 | DOI:10.1016/j.intimp.2021.108138 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 12, 2021 Category: Allergy & Immunology Authors: Yingjie Wang Tian Li Qi Yang Bin Feng Yongbo Xiang Zehui Lv Xisheng Weng Source Type: research

Immunomodulatory and anti-infective effects of Cratylia mollis lectin (Cramoll) in a model of wound infection induced by Staphylococcus aureus
Int Immunopharmacol. 2021 Sep 8;100:108094. doi: 10.1016/j.intimp.2021.108094. Online ahead of print.ABSTRACTThis work evaluated the immunomodulatory and anti-infective effects of Cratylia mollis lectin (Cramoll) in a model of wound infection induced by S. aureus. Swiss mice were divided into 3 groups (n = 12/group): non-inoculated (Control group); inoculated with S. aureus (Sa group); inoculated with S. aureus and treated with Cramoll (Sa + Cramoll group). In each animal, one lesion (64 mm2) was induced on the back and contaminated with S. aureus (~4.0 × 106 CFU/wound). The treatment with Cramoll (5 μg/animal/day...
Source: International Immunopharmacology - September 11, 2021 Category: Allergy & Immunology Authors: Mariela Andrea Medeiros Suarez Carneiro Lucas Dos Santos Silva Roseana Muniz Diniz Warlison Felipe da Silva Saminez Patr ícia Vieira de Oliveira Juliana Silva Pereira Mendon ça Arthur Henrique Mendes Colasso Izadora Souza Soeiro Silva Jannyson Jos é Br Source Type: research

An approach to chimeric subunit immunogen provides efficient protection against toxicity, type III and type v secretion systems of Shigella
CONCLUSION: This study revealed that the chimeric protein produced inE. colicould be a promising chimeric immunogen candidate against Shigella.PMID:34508943 | DOI:10.1016/j.intimp.2021.108132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 11, 2021 Category: Allergy & Immunology Authors: Alireza Felegary Shahram Nazarian Emad Kordbacheh Javad Fathi Mohamad Ebrahim Minae Source Type: research

Anti-inflammatory activity of caffeine (1,3,7-trimethylxanthine) after experimental challenge with virulent Listeria monocytogenes in Swiss mice
CONCLUSION: Caffeine has an anti-infectious potential and ameliorated infection-derived inflammation following experimental infection with L. monocytogenes.PMID:34507108 | DOI:10.1016/j.intimp.2021.108090 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 10, 2021 Category: Allergy & Immunology Authors: Ingrydt de Alc ântara Almeida Betty Mancebo Dorvigny Lethicia Souza Tavares Lucas Nunes Santana Jose Vitor Lima-Filho Source Type: research

Liposome-based nanocarriers loaded with anthrax lethal factor and armed with anti-CD19 VHH for effectively inhibiting MAPK pathway in B cells
CONCLUSIONS: In conclusion, anti-CD19 VHH immunoliposome was loaded with LF, a potent MAPK inhibitor targeting B cells, which curbs proliferation and ushers B cells toward apoptosis. Thus, immunoliposome presents as a versatile nanoparticle for delivery of LF to block aberrant MAPK activation. To use LF as a therapy, it would be necessary to materialize LF without PA. In the current study, PA was substituted with anti-CD19 immunoliposome to make it targeted to CD19+ while keeping the normal cells intact.PMID:34500284 | DOI:10.1016/j.intimp.2021.107927 (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 9, 2021 Category: Allergy & Immunology Authors: S Reza Banihashemi Fatemeh Rahbarizadeh Ahmad Zavaran Hosseini Davoud Ahmadvand Shahryar Khoshtinat Nikkhoi Source Type: research

The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy
Int Immunopharmacol. 2021 Sep 6;100:108116. doi: 10.1016/j.intimp.2021.108116. Online ahead of print.ABSTRACTThe treatment options for sepsis-associated encephalopathy caused by systemic inflammation are still not sufficient. Protein kinase C interaction protein 1 (PICK1) has attracted much attention because of its important physiological functions in many tissues. However, its role in sepsis-associated encephalopathy remains elusive. Our study results revealed that the expression levels of PICK1 protein in mice with lipopolysaccharide-induced sepsis-associated encephalopathy were not significantly changed, but PICK1 defic...
Source: International Immunopharmacology - September 9, 2021 Category: Allergy & Immunology Authors: Lu Wang Feihong Lin Miao Ren Xia Liu Wenjing Xie Anqi Zhang Meizi Qian Yunchang Mo Junlu Wang Ya Lv Source Type: research