The effect of IL-1R1 and IL-1RN polymorphisms on osteoporosis predisposition in a Chinese Han population.
CONCLUSION: This study is the first to find that rs10490571, rs956730 and rs3917225 in IL-1R1 and rs17042888 in IL-1RN may be genetic contributors to OP susceptibility among the Chinese Han population. Our findings increase the understanding of the role of IL-1R1 and IL-1RN in the genetic etiology of osteoporosis. Nevertheless, these results should be confirmed in larger cohorts. PMID: 32739831 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 30, 2020 Category: Allergy & Immunology Authors: Zhang L, Zhou Q, Wu Z, Zhu X, Geng T Tags: Int Immunopharmacol Source Type: research

Comprehensive analysis of significant genes and immune cell infiltration in HPV-related head and neck squamous cell carcinoma.
Abstract Head and neck squamous cell carcinoma (HNSCC) is malignancy which impairs the life quality of patients and seriously threatens human life. HPV infection has increasingly been recognized as a significant etiology for HNSCC initiation and progression. Emerging evidences have suggested that HPV+and HPV- HNSCC patients showed different responses to cancer therapy, which may be attributed to varied immune cell infiltration in tumor microenvironment. In the present study, we made a comprehensive analysis of significant genes and immune cell infiltration in HNSCC with different HPV status. Firstly, transcriptome...
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Xu L, Jin Y, Qin X Tags: Int Immunopharmacol Source Type: research

Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1 β and TNF-α.
Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1β and TNF-α. Int Immunopharmacol. 2020 Jul 29;87:106803 Authors: Cheeran V, Munuswamy-Ramanujam G Abstract Zaluzanin D (ZD) is a sesquiterpene lactone isolated from the leaves of Vernonia arborea. Earlier studies have highlighted the Sesquiterpene lactones (SLs) as molecules of medicinal value. The current study investigates the anti-inflammatory potential of ZD and its biotransformed derivatives in PMA differentiated human monocytic THP-1...
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Cheeran V, Munuswamy-Ramanujam G Tags: Int Immunopharmacol Source Type: research

Tumor mutational burden related classifier is predictive of response to PD-L1 blockade in locally advanced and metastatic urothelial carcinoma.
CONCLUSIONS: After in-depth analysis, we provide a new idea for stratified treatment of such patients, that is, patients with high TLS should use ICB and also may benefit from hormone therapy, while patients with low TLS respond poorly to ICB and maybe benefit from targeting TGFβ. PMID: 32738594 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Wang Y, Chen L, Ju L, Xiao Y, Wang X Tags: Int Immunopharmacol Source Type: research

The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF- κB pathway.
The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway. Int Immunopharmacol. 2020 Jul 29;87:106822 Authors: Vdovenko D, Bachmann M, Wijnen WJ, Hottiger MO, Eriksson U, Valaperti A Abstract C-Cbl-associated protein (CAP), also known as Sorbin and SH3 domain-containing protein 1 (Sorbs1) or ponsin, an adaptor protein of the insulin-signalling pathway, mediates anti-viral and anti-cytotoxic protection in acute viral heart disease. In the present study we describe a novel protective immuno-modulatory function of CAP in inflammat...
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Vdovenko D, Bachmann M, Wijnen WJ, Hottiger MO, Eriksson U, Valaperti A Tags: Int Immunopharmacol Source Type: research

Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1 α pathway.
Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway. Int Immunopharmacol. 2020 Jul 29;87:106830 Authors: Yu Y, Cai W, Zhou J, Lu H, Wang Y, Song Y, He R, Pei F, Wang X, Zhang R, Liu H, Wei F Abstract Berberine (BBR) is the effective constituent of Cortex phellodendri and was characterized as an excellent anti-microbial agent with significant anti-inflammatory effects. Previously, we had demonstrated that BBR alleviated the inflammatory response in adjuvant-induced arthritis (AA) rats by regulating polarization of macrophages...
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Yu Y, Cai W, Zhou J, Lu H, Wang Y, Song Y, He R, Pei F, Wang X, Zhang R, Liu H, Wei F Tags: Int Immunopharmacol Source Type: research

Integrative bioinformatics analysis of a prognostic index and immunotherapeutic targets in renal cell carcinoma.
Abstract Renal cell carcinoma (RCC) is one of the most common malignancies. The immunogenomic landscape signature significantly correlates with the progression and prognosis of RCC. Novel therapeutic targets and prognostic indices in RCC are highly desirable. The TCGA database enables comprehensive immunogenomic landscape analysis. Differentially expressed immune-related genes (IRGs) were obtained from TCGA and GO analyses, and KEGG pathway analyses were performed to explore their functions and molecular mechanisms. Multivariable Cox analysis was utilized to calculate the risk score of each patient and locate surv...
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Tao H, Li Z, Mei Y, Li X, Lou H, Dong L, Zhou L Tags: Int Immunopharmacol Source Type: research

MicroRNA and long noncoding RNA involvement in gout and prospects for treatment.
Abstract MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are both types of noncoding RNA. They have been demonstrated to be involved in the regulation of various human inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis, and even be developed into new drugs. Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue. Recent studies have shown that miRNAs and lncRNAs mediate the progress of gout. Based on the pathogenesis of gout, including hyperuricemia, MSU depositio...
Source: International Immunopharmacology - July 29, 2020 Category: Allergy & Immunology Authors: Xu YT, Leng YR, Liu MM, Dong RF, Bian J, Yuan LL, Zhang JG, Xia YZ, Kong LY Tags: Int Immunopharmacol Source Type: research

Corrigendum to "Melatonin prevents endothelial dysfunction in SLE by activating the nuclear receptor retinoic acid-related orphan receptor- α" [Int. Immunopharmacol. 83 (2020) 106365].
Corrigendum to "Melatonin prevents endothelial dysfunction in SLE by activating the nuclear receptor retinoic acid-related orphan receptor-α" [Int. Immunopharmacol. 83 (2020) 106365]. Int Immunopharmacol. 2020 Jul 28;:106817 Authors: Huang H, Liu X, Chen D, Lu Y, Li J, Du F, Zhang C, Lu L PMID: 32736997 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Huang H, Liu X, Chen D, Lu Y, Li J, Du F, Zhang C, Lu L Tags: Int Immunopharmacol Source Type: research

Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats.
This study provides evidence that the peripheral administration of TPPU reduces hypernociception and inflammation in TMJ experimental arthritis. PMID: 32736189 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Teixeira JM, Abdalla HB, Basting RT, Hammock BD, Napimoga MH, Clemente-Napimoga JT Tags: Int Immunopharmacol Source Type: research

A promising therapeutic target for psoriasis: Neuropeptides in human skin.
Abstract Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides, a class of peptides secreted by the nervous system, may play important roles in promoting excessive proliferation of keratinocyte, enhancing angiogenesis, vasodilation, plasma extravasation and chemotaxis of inflammatory cells during the development of psoriasis. To understand the pathogenes...
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Zhang Y, Zhang H, Jiang B, Yan S, Lu J Tags: Int Immunopharmacol Source Type: research

Effects of AS2819899, a novel selective PI3K δ inhibitor, in a NZB/W F1 mouse lupus-like nephritis model.
Effects of AS2819899, a novel selective PI3Kδ inhibitor, in a NZB/W F1 mouse lupus-like nephritis model. Int Immunopharmacol. 2020 Jul 28;87:106764 Authors: Kaneko Y, Fukahori H, Yamagami K, Kawashima T, Ito M, Akamatsu M, Marui T, Kato K, Takahashi F, Morokata T Abstract Phosphoinositide 3-kinases generate lipid-based second messengers that control an array of intracellular signaling pathways. In particular, phosphoinositide 3-kinases delta (PI3Kδ) is expressed primarily in hematopoietic cells and plays an important role in B-cell development and function. B cells play a critical role in ...
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Kaneko Y, Fukahori H, Yamagami K, Kawashima T, Ito M, Akamatsu M, Marui T, Kato K, Takahashi F, Morokata T Tags: Int Immunopharmacol Source Type: research

RNA sequencing analysis of cortex and hippocampus in a kainic acid rat model of temporal lobe epilepsy to identify mechanisms and therapeutic targets related to inflammation, immunity and cognition.
Abstract Temporal lobe epilepsy (TLE) is the most common type of refractory epilepsy, in which inflammation is suggested to cause abnormal neuronal connections and neural networks. However, the expression of inflammatory genes in epilepsy remains incomplete, particularly in the context of the cortex, which is a hub of epileptic transmission but also is essential for mediating sensory, motor and cognitive function. Here, a rat model of epilepsy was established by kainic acid (KA) administration Gene transcriptome was explored in 4 signature phases in the hippocampus and cortex: acute damage (3 h), onset of epi...
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Dong X, Hao X, Xu P, Fan M, Wang X, Huang X, Jiang P, Zeng L, Xie Y Tags: Int Immunopharmacol Source Type: research

BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates.
Abstract AIM: BicC family RNA-binding protein 1 (BICC1) codes an RNA-binding protein that regulates gene expression and modulates cell proliferation and apoptosis. We aim at investigating the role of BICC1 in gastric carcinogenesis. METHODS: BICC1 mRNA expression in gastric cancer (GC) was examined using the Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Correlations between BICC1 expression and clinicopathological parameters were analyzed. The Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan-Meier plotter databases were u...
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Zhao R, Peng C, Song C, Zhao Q, Rong J, Wang H, Ding W, Wang F, Xie Y Tags: Int Immunopharmacol Source Type: research

Acetylase inhibitor SI-2 is a potent anti-inflammatory agent by inhibiting NLRP3 inflammasome activation.
In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo. Intriguingly, SI-2 does not affect the acetylation of NLRP3. Instead, it disrupts the interaction between NLRP3 and adaptor apoptosis-associated speck-like protein containing CARD (ASC), then blocks the formation of ASC speck. Thus, our study identified a specific inhibitor for NLRP3 inflammasome and suggested SI-2 as a...
Source: International Immunopharmacology - July 28, 2020 Category: Allergy & Immunology Authors: Liu L, Xu X, Zhang N, Zhang Y, Zhao K Tags: Int Immunopharmacol Source Type: research

Vildagliptin, a CD26/DPP4 inhibitor, ameliorates bleomycin-induced pulmonary fibrosis via regulating the extracellular matrix.
CONCLUSION: As an inhibitor of CD26/DPP4, Vildagliptin could be a promising therapeutic candidate for idiopathic pulmonary fibrosis. PMID: 32731178 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 27, 2020 Category: Allergy & Immunology Authors: Liu Y, Qi Y Tags: Int Immunopharmacol Source Type: research

Ginsenoside Rg1 prevent and treat inflammatory diseases: A review.
Abstract Ginseng has been used as reinforcing drugs or for traditional Chinese medicine in aging, inflammation, stress, diabetes mellitus, hepatic diseases and cancer. The aim of this current review is to provide an integrative overview of the uses, relative human diseases and related mechanisms of ginseng. Nowadays, numerous animal experiments and clinical studies conducted to investigate the efficacy and safety of ginseng components. Inflammation is an immune response that protects human from pathogens, toxins and other dangers, which is initiated by recognizing pathogen- or danger- associated molecular patterns...
Source: International Immunopharmacology - July 27, 2020 Category: Allergy & Immunology Authors: Gao Y, Li J, Wang J, Li X, Li J, Chu S, Li L, Chen N, Zhang L Tags: Int Immunopharmacol Source Type: research

A novel immune checkpoint-related seven-gene signature for predicting prognosis and immunotherapy response in melanoma.
Abstract BACKGROUND: New emergence of immunotherapy has significantly improved clinical outcome of melanoma patients with advanced and metastatic diseases. We aimed to develop a gene signature based on the expression of PD-1/PD-L1 signaling pathway genes to predict prognosis and immunotherapy response in melanoma patients. METHODS: Melanoma samples from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) were used as the training set and external validation sets respectively. Prognostic genes for overall survival (OS) were identified by univariate Cox regression analysis. Then a multi-ge...
Source: International Immunopharmacology - July 27, 2020 Category: Allergy & Immunology Authors: Tian M, Yang J, Han J, He J, Liao W Tags: Int Immunopharmacol Source Type: research

Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy.
Abstract Neuroinflammation contributes to the generation of epileptic seizures and is associate with neuropathology and comorbidities. Transient receptor potential melastatin 2 (TRPM2) expresses in various cell types in the brain. It plays a pathological role in a wide range of neuroinflammatory diseases, but has yet been studied in epilepsy. Here, a temporal lobe epilepsy model was generated by pilocarpine administration in mice. At 24 h, knockout (KO) TRPM2 alleviated the level of neuroinflammation, showing a reduction of IL-1β, TNF-α, CXCL2 and IL-6 mRNA production, NLRP3, ASC, and Caspase-1 pro...
Source: International Immunopharmacology - July 27, 2020 Category: Allergy & Immunology Authors: Hu H, Zhu T, Gong L, Zhao Y, Shao Y, Li S, Sun Z, Ling Y, Tao Y, Ying Y, Lan C, Xie Y, Jiang P Tags: Int Immunopharmacol Source Type: research

High salt diet may promote progression of breast tumor through eliciting immune response.
Abstract OBJECTIVE: Dietary patterns are believed to regulate tumor progression by altering the tumor microenvironment. Of note, a high salt diet is a risk factor for various diseases. However, the role of high salt intake in the progression of cancers remains unknown. METHODS: We constructed an in vivo high salt diet model in MMTV-PyVT mice with spontaneous tumor-forming properties to explore the role of a high salt diet in the progression of breast cancer as well as the modulation of the tumor microenvironment. Also, in vitro experiments were performed to understand the mechanism. RESULTS: High salt di...
Source: International Immunopharmacology - July 25, 2020 Category: Allergy & Immunology Authors: Chen J, Liu X, Huang H, Zhang F, Lu Y, Hu H Tags: Int Immunopharmacol Source Type: research

Trophoblast-derived IL-6 serves as an important factor for normal pregnancy by activating Stat3-mediated M2 macrophages polarization.
Abstract Macrophages are major components of decidual microenvironment that play an important role in human implantation and placentation. Trophoblasts which migrate into the endometrium and interplay with decidual cells, have been reported to participate in the polarization of macrophages. However, the potential mechanisms of trophoblasts modulating M2 macrophages polarization still need further exploration. Herein, we used the co-cultured model to investigate the interaction between macrophages and trophoblasts. Our results illustrated that when co-cultured with trophoblasts, macrophages tended to polarize to M2...
Source: International Immunopharmacology - July 24, 2020 Category: Allergy & Immunology Authors: Ding J, Yang C, Cheng Y, Wang J, Zhang S, Yan S, He F, Yin T, Yang J Tags: Int Immunopharmacol Source Type: research

Clinical characteristics and prognostic risk factors of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).
CONCLUSION: This retrospective study demonstrates that AAV patients with low sC3 level at diagnosis tend to have lower baseline eGFR and poorer survival prognosis than those of the normal sC3 level. Furthermore, the high procalcitonin (PCT), low serum albumin and high lactate dehydrogenase in AVV patients may be predictors of poor prognosis. PMID: 32717565 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 24, 2020 Category: Allergy & Immunology Authors: Chen Z, Lin L, Yang W, Chen N, Lin Y Tags: Int Immunopharmacol Source Type: research

BNIP3 deletion ameliorated enterovirus 71 infection-induced hand, foot and mouth disease via inhibiting apoptosis, autophagy, and inflammation in mice.
Abstract Bcl2/adenovirus E1B protein-interacting protein 3 (BNIP3) plays a key role in cellular response to stress by regulating apoptosis and selective autophagy. The present study aimed to determine the effects of BNIP3 on enterovirus (EV) 71 infection-induced hand, foot and mouth disease (HFMD), and the apoptosis, autophagy and inflammatory in mice and SH-SY5Y human neuroblastoma cell line. Neonatal BALB/c mice were injected with EV 71 strain to induce the HFMD. Western blotting and ELISA were used to measure the protein expression and cytokine levels. The BNIP3 mRNA and protein levels in the brain were increas...
Source: International Immunopharmacology - July 24, 2020 Category: Allergy & Immunology Authors: Zhu L, Hao X, Cao J, Xie X, Wang H Tags: Int Immunopharmacol Source Type: research

SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha.
Abstract SerpinB1, previously known as MNEI (monocyte/neutrophil elastase inhibitor), has been well established to maintain the survival of neutrophils. Our recent studies showed that SerpinB1 is also the signature gene of IL-17-producing γδT cells and Th17 cells, and its expression is maintained by IL-23 signaling. Deficiency of SerpinB1 largely ameliorates the experimental autoimmune encephalomyelitis (EAE) with enhanced granule protease-mediated mitochondrial damage leading to suicidal cell death of pathogenic CD4 T cells. However, the mechanism that induces SerpinB1 expression in Th17 cells still r...
Source: International Immunopharmacology - July 24, 2020 Category: Allergy & Immunology Authors: Hou L, Yuki K Tags: Int Immunopharmacol Source Type: research

Activation of NLRP3 inflammasome assembly is associated with smoking status of patients with coronary artery disease.
CONCLUSION: Our data may imply NLRP3 inflammasome as a mediator of the pro-atherosclerotic property of cigarette smoking in atherosclerotic patients. PMID: 32711374 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 22, 2020 Category: Allergy & Immunology Authors: Mehta S, Vijayvergiya R, Dhawan V Tags: Int Immunopharmacol Source Type: research

Neutrophil-to-lymphocyte ratio as an independent inflammatory indicator of poor prognosis in IgA nephropathy.
CONCLUSIONS: We found patients with IgAN had elevated NLR levels than healthy controls, and the easily available NLR in clinical practice could serve as an independent risk factor for IgAN progression. PMID: 32711375 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 22, 2020 Category: Allergy & Immunology Authors: Li Q, Chen P, Shi S, Liu L, Lv J, Zhu L, Zhang H Tags: Int Immunopharmacol Source Type: research

Chemokines in bone-metastatic breast cancer: Therapeutic opportunities.
Abstract Due to non-response to chemotherapy, incomplete surgical resection, and resistance to checkpoint inhibitors, breast cancer with bone metastasis is notoriously difficult to cure. Therefore, the development of novel, efficient strategies to tackle bone metastasis of breast cancer is urgently needed. Chemokines, which induce directed migration of immune cells and act as guide molecules between diverse cells and tissues, are small proteins indispensable in immunity. These complex chemokine networks play pro-tumor roles or anti-tumor roles when produced by breast cancer cells in the tumor microenvironment. Add...
Source: International Immunopharmacology - July 22, 2020 Category: Allergy & Immunology Authors: Wang Y, Ren S, Wang Z, Wang Z, Zhu N, Cai D, Ye Z, Ruan J Tags: Int Immunopharmacol Source Type: research

A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment.
In conclusion, our study suggests that complement C3/C3a receptor signaling plays a key role in LPS-induced cognitive impairments, which may serve a therapeutic target for systemic inflammation related cognitive disorders. PMID: 32707491 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Li SM, Li B, Zhang L, Zhang GF, Sun J, Ji MH, Yang JJ Tags: Int Immunopharmacol Source Type: research

Halofuginone inhibits LPS-induced attachment of monocytes to HUVECs.
This study demonstrates that Halofuginone, an anti-malarial drug, possesses protective effects on human umbilical vein endothelial cells (HUVECs) against LPS-induced endothelial dysfunction. Through this study, we demonstrate that Halofuginone ameliorates LPS-induced attachment of THP-1 cells to HUVECs by inhibiting the expressions of adhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. Halofuginone also suppresses the production of pro-inflammatory cytokines, including tumor necrosis factor α. (TNF-α), interleukin-1β (IL-1β), and interleukin 6 (IL-6). Furthermore, ...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Zhong M, Zhang X, Shi X, Zheng C Tags: Int Immunopharmacol Source Type: research

In-vitro and in-vivo anti-breast cancer activity of synergistic effect of berberine and exercise through promoting the apoptosis and immunomodulatory effects.
Abstract PURPOSE: Breast cancer is the most common reason of cancer death in women. Berberine (BBR), a main alkaloid in Coptis chinensis, exerted anti-cancer activities. Exercise is a new immunotherapy treatment against cancer. However, it is unclear whether exercise has effects on breast cancer and whether exercise has synergistic anti-cancer effect when co-treated with BBR. Thus, it is assumed that exercise might exert an anti-cancer effect through the immune way. METHOD: The anti-tumor effect of exercise and BBR in vivo was studied in mice. The MTT method, hoechst staining and cell morphology were performe...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Ma W, Zhang Y, Yu M, Wang B, Xu S, Zhang J, Li X, Ye X Tags: Int Immunopharmacol Source Type: research

mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice.
In this study, after the Y-maze testing the spatial learning of the APP/PS1 mice and the TIPE2 overexpression APP/PS1 mice, high-throughput sequencing was performed on hippocampus tissues for analysis of mRNA profiles. A total of 183 differentially expressed genes (DEGs) were detected, of which 36 were down-regulated and 147 were up-regulated. Then, the mRNA profiles of the APP/PS1 mice and the wild-type mice were analyzed. A total of 196 DEGs were detected, of which 105 were down-regulated and 91 were up-regulated in the APP/PS1 mice. A comprehensive comparison of the mouse mRNAs showed that 20 genes were differentially e...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Xu Z, Lu W, Miao Y, Li H, Xie X, Zhang F Tags: Int Immunopharmacol Source Type: research

Identification of the prognostic value of immune gene signature and infiltrating immune cells for esophageal cancer patients.
CONCLUSION: Our study indicated that the immune-related prognostic signature could serve as a novel biomarker for predicting patients' prognosis and providing new immunotherapy targets in ESCA. PMID: 32707495 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Wang L, Wei Q, Zhang M, Chen L, Li Z, Zhou C, He M, Wei M, Zhao L Tags: Int Immunopharmacol Source Type: research

Piperine protects LPS-induced mastitis by inhibiting inflammatory response.
Abstract Mastitis, inflammation in the breast, affects breastfeedingwomenin the postpartumperiod. In the present study, we investigated the protective effects of piperine against mastitis using a mouse mastitis model. LPS-induced mastitis was established by injecting LPS into the canals of the mammary gland. Piperine was given intraperitoneally 1 h before and 12 h after LPS treatment. The results showed that the LPS-induced mammary histopathological changes and MPO activity were attenuated by piperine. LPS-induced inflammatory cytokines TNF-α andIL-1β were also inhibited by piperine. Furthermore, LP...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Yu S, Liu X, Yu D, E C, Yang J Tags: Int Immunopharmacol Source Type: research

An evaluation on potential anti-inflammatory effects of β-lapachone.
An evaluation on potential anti-inflammatory effects of β-lapachone. Int Immunopharmacol. 2020 Jul 21;87:106810 Authors: Mokarizadeh N, Karimi P, Kazemzadeh H, Fathi Maroufi N, Sadigh-Eteghad S, Nikanfar S, Rashtchizadeh N Abstract Inflammation plays a significant role in the pathogenesis of chronic diseases. Inflammatory diseases such as bacterial diseases, Alzheimer's disease, rheumatoid arthritis, multiple sclerosis, and so on, impose huge costs on the health systems. On the other hand, some side effects have been reported for the classic drugs used to treat these diseases. Plants phytochemica...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Mokarizadeh N, Karimi P, Kazemzadeh H, Fathi Maroufi N, Sadigh-Eteghad S, Nikanfar S, Rashtchizadeh N Tags: Int Immunopharmacol Source Type: research

Cigarette smoke extract combined with lipopolysaccharide reduces OCTN1/2 expression in human alveolar epithelial cells in vitro and rat lung in vivo under inflammatory conditions.
In this study, CSE combined with LPS was used to establish inflammation models in vitro and in vivo. Our study found that the expression of OCTN1/2 was downregulated in rat lung in vivo and in a human alveolar cell line in vitro after treatment with CSE and LPS compared with the control group, while the expression of inflammatory factors was upregulated. After treatment with ipratropium bromide (IB) or dexamethasone (DEX), the expression of OCTN1/2 was upregulated compared with that in the CSE-LPS model group, while the expression of inflammatory factors was significantly downregulated. After administration of the NF-&kapp...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Qi C, Zhou J, Wang Z, Fang X, Li D, Jin Y, Song J Tags: Int Immunopharmacol Source Type: research

Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NF κB balance and NLRP3 expression.
Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression. Int Immunopharmacol. 2020 Jul 21;87:106813 Authors: Alzahrani S, Zaitone SA, Said E, El-Sherbiny M, Ajwah S, Alsharif SY, Elsherbiny NM Abstract The prevalence of diabetes mellitus (DM) drastically increases worldwide. Persistent hyperglycemia affects body microvasculature causing injuries to kidney producing diabetic nephropathy (DNE). Manifestation of these microvascular complications is associated with disturbed redox homeostasis. The current study evaluated...
Source: International Immunopharmacology - July 21, 2020 Category: Allergy & Immunology Authors: Alzahrani S, Zaitone SA, Said E, El-Sherbiny M, Ajwah S, Alsharif SY, Elsherbiny NM Tags: Int Immunopharmacol Source Type: research

Differential risks of immune-related colitis among various immune checkpoint inhibitor regimens.
CONCLUSIONS: Our meta-analysis indicates that CTLA-4 inhibitor is associated with a higher risk of colitis compared with PD-1/PD-L1 inhibitor, whether used as a monotherapy or combination immunotherapy. Importantly, the combination of PD-1/PD-L1 inhibitor with chemotherapy or targeted therapy may not increase the risk of colitis significantly compared to PD-1/PD-L1 inhibitor alone. PMID: 32702598 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 20, 2020 Category: Allergy & Immunology Authors: Yao J, Li M, Zhang H, Ge Y, Weygant N, An G Tags: Int Immunopharmacol Source Type: research

Comprehensive analysis of the prognostic value and immune function of chemokine-CXC receptor family members in breast cancer.
In this study, we firstly found that in comparison to normal tissues, BC tissues, especially basal-like BC, showed increased mRNA levels of CXCR3/4/5/6/8, but decreased CXCR1/2/7 expression using UALCAN and TIMER database. Interestingly, it's was found that the mRNA levels of CXCR3/4/5/6 were decreased in lymphocyte depleted of the BC immune subtype. Subsequently, functional enrichment analysis of distinct CXCRs indicated that CXCR3/4/5/6 were strongly associated to immune-related biological functions. Therefore, further analysis using TIMER and TISIDB database suggested that CXCR3/4/5/6 expression were strongly correlated...
Source: International Immunopharmacology - July 20, 2020 Category: Allergy & Immunology Authors: Lyu L, Zheng Y, Hong Y, Wang M, Deng Y, Wu Y, Xu P, Yang S, Wang S, Yao J, Zhang D, Guo Y, Lyu J, Dai Z Tags: Int Immunopharmacol Source Type: research

COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice.
Abstract Epilepsy is one of the most common neurological diseases. It adversely affects cognitive function. Neuroinflammation has been widely recognized as an important factor involved in the pathophysiology of epilepsy. Cyclooxygenase (COX) is a type of oxidoreductase enzyme that acts in the metabolic pathway converting arachidonic acid to prostaglandins, which mediate inflammatory reactions. The activation of inducible cyclooxygenase-2 (COX-2) is considered to be a precipitating factor of neuroinflammation in the brain. Neuroinflammatory processes in the brain are known to contribute to the cascade of events lea...
Source: International Immunopharmacology - July 20, 2020 Category: Allergy & Immunology Authors: Zhu X, Yao Y, Yang J, Zhengxie J, Li X, Hu S, Zhang A, Dong J, Zhang C, Gan G Tags: Int Immunopharmacol Source Type: research

[6]-Gingerol exhibits potent anti-mycobacterial and immunomodulatory activity against tuberculosis.
Abstract The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against the pathogen and the host is required to counter tuberculosis (TB). Here we demonstrate that [6]-Gingerol, one of the most potent and pharmacologically active ingredients of ginger restricted mycobacterial growth inside the lungs, spleen and liver of mice infected with Mycobacterium tuberculosis (Mtb). The spleen of [6]-Gingerol treated mice dis...
Source: International Immunopharmacology - July 18, 2020 Category: Allergy & Immunology Authors: Bhaskar A, Kumari A, Singh M, Kumar S, Kumar S, Dabla A, Chaturvedi S, Yadav V, Chattopadhyay D, Prakash Dwivedi V Tags: Int Immunopharmacol Source Type: research

Identification of the collagen family as prognostic biomarkers and immune-associated targets in gastric cancer.
CONCLUSIONS: The collagen family, especially COL1A1, COL1A2, and COL12A1, may act as potential prognostic biomarkers and immune-associated therapeutic targets in gastric cancer. PMID: 32693357 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 18, 2020 Category: Allergy & Immunology Authors: Chen Y, Chen W, Dai X, Zhang C, Zhang Q, Lu J Tags: Int Immunopharmacol Source Type: research

IL-10-producing B cells play important role in the pathogenesis of recurrent pregnancy loss.
Abstract Interleukin (IL)-10-producing B cells are recently known for their regulatory function in several disorders. However, the possible role of these cells remains unclear in recurrent pregnancy loss (RPL) pathogenesis. Total B cells from 24 RPL patients with cellular immune abnormalities, as well as that of 25 normal pregnant women were cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod). Then, the frequency of IL-10+ CD19+ B cells was found out using flow cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of IL-10 in sup...
Source: International Immunopharmacology - July 18, 2020 Category: Allergy & Immunology Authors: Danaii S, Ghorbani F, Ahmadi M, Abbaszadeh H, Koushaeian L, Soltani-Zangbar MS, Mehdizadeh A, Hojjat-Farsangi M, Kafil HS, Aghebati-Maleki L, Yousefi M Tags: Int Immunopharmacol Source Type: research

The immunoregulatory and neuroprotective effects of human adipose derived stem cells overexpressing IL-11 and IL-13 in the experimental autoimmune encephalomyelitis mice.
This study aimed to evaluate the effects of human adipose derived stem cells (hADSCs) overexpressing interleukin 11 and interleukin 13 (IL-11, 13-hADSCs) on the experimental autoimmune encephalomyelitis (EAE), an animal model of MS.12 days after immunization of C57Bl/6 female mice with MOG35-55 and initial clinical symptoms appearance, the IL-11, 13-hADSCs were injected via the tail vein into the EAE mice. Then, the mice were sacrificed at 30 days post-immunization (DPI) and the spinal cords of experimental groups were extracted for histopathological and real-time RT-PCR studies.The results indicated that the cli...
Source: International Immunopharmacology - July 18, 2020 Category: Allergy & Immunology Authors: Azimzadeh M, Mahmoodi M, Kazemi M, Hakemi MG, Jafarinia M, Eslami A, Salehi H, Amirpour N Tags: Int Immunopharmacol Source Type: research

Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4/NF- κB/MAPK signaling pathway.
In this study, the C57BL/6 mice model of ulcerative colitis was established by DSS [3% (w/v)] and treated with intraperitoneal injection of B4 and oral administration of mesalazine, respectively. During the experiment, the clinical symptoms of the mice were scored by the disease activity index (DAI). Histopathological changes were observed by HE staining. In addition, the effect of LPS on Raw264.7 cells was also studied. In vivo studies showed that B4 could prevent DSS-induced colitis mice from losing weight, shortening colon length and improving pathological changes of colon tissues. B4 significantly reduced levels of inf...
Source: International Immunopharmacology - July 17, 2020 Category: Allergy & Immunology Authors: Ma H, Zhou M, Duan W, Chen L, Wang L, Liu P Tags: Int Immunopharmacol Source Type: research

RELL1, a novel oncogene, accelerates tumor progression and regulates immune infiltrates in glioma.
CONCLUSION: We conclude that RELL1 might serve as a potential therapeutic target or prognostic marker in glioblastoma and diffuse glioma cases. PMID: 32683297 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 16, 2020 Category: Allergy & Immunology Authors: Jin X, Xie H, Liu X, Shen Q, Wang Z, Hao H, Gu Y Tags: Int Immunopharmacol Source Type: research

Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1.
Abstract Type I interferons are broadly used for antiviral therapy in clinical. However, the IFNs-mediated antiviral efficacy is commonly restricted by negative regulators. Here, we show that the ubiquitin-specific protease 5 (USP5) inhibits the IFNs-induced p-STAT1 activation (phosphorylation at tyrosine site of STAT1) and its downstream antiviral genes expression. We clarify that USP5 physically interacts with SMURF1 (Smad ubiquitination regulating factor 1) and IFNs signaling regulates the interaction and turnover of both proteins. USP5 enhances the stability and turnover of SMURF1 via decreasing its polyubiqui...
Source: International Immunopharmacology - July 16, 2020 Category: Allergy & Immunology Authors: Qian G, Zhu L, Huang C, Liu Y, Ren Y, Ding Y, Qian W, Xu Q, Zheng H, Lv H Tags: Int Immunopharmacol Source Type: research

The interactions and communications in tumor resistance to radiotherapy: Therapy perspectives.
Abstract Tumor microenvironment (TME) includes a wide range of cell types including cancer cells, cells which are involved in stromal structure and immune cells (tumor suppressor and tumor promoting cells). These cells have several interactions with each other that are mainly regulated via the release of intercellular mediators. Radiotherapy can modulate these interactions via shifting secretions into inflammatory or anti-inflammatory responses. Radiotherapy also can trigger resistance of cancer (stem) cells via activation of stromal cells. The main mechanisms of tumor resistance to radiotherapy is the exhaustion ...
Source: International Immunopharmacology - July 16, 2020 Category: Allergy & Immunology Authors: Ashrafizadeh M, Farhood B, Eleojo Musa A, Taeb S, Najafi M Tags: Int Immunopharmacol Source Type: research

Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension.
Abstract Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and serum IL-22 level in hypertensive renal injury, and explore the effects and mechanisms of a widely used angiotensin II type 1 receptor blocker irbesartan on Th22 cells infiltration and related renal injury. Hypertension was induced by administering 1.5 mg/kg Ang II subcutaneously daily in C5...
Source: International Immunopharmacology - July 16, 2020 Category: Allergy & Immunology Authors: Zhong Y, Tang R, Lu Y, Wang W, Xiao C, Meng T, Ao X, Li X, Peng L, Kwadwo Nuro-Gyina P, Zhou Q Tags: Int Immunopharmacol Source Type: research

LAGE3 correlates with tumorigenic immune infiltrates in the clear cell renal cell carcinoma microenvironment.
CONCLUSION: The present findings disclose that LAGE3 could be an independent survival predictor, and might contribute to developing novel ccRCC immunological treatment strategies. PMID: 32683301 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 16, 2020 Category: Allergy & Immunology Authors: Dong X, Gu DN, Wang O, Ye Z Tags: Int Immunopharmacol Source Type: research

Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis.
In this study, we aimed to explore the effects of (S, R)-3-(4-hydroxyphenyl)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of MIF, on maternal thyroid injury associated with APIP and its potential mechanisms in a pregnant rat model. APIP model was induced by retrograde injection of sodium taurocholate. ISO-1 was injected intraperitoneally 30 min before model establishment. The severity of pancreatitis was assessed by levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL-6 of maternal serum as well as histopathological score. Thyroid injury was determined by free triiodothy...
Source: International Immunopharmacology - July 16, 2020 Category: Allergy & Immunology Authors: Chen Y, Wang CY, Zhao L, Hong YP, Zhang XY, Mei FC, Zhou Y, Guo WY, Shi Q, Zhao KL, Chen C, Yu J, Wang WX Tags: Int Immunopharmacol Source Type: research