p300 mediates the histone acetylation of ORMDL3 to affect airway inflammation and remodeling in asthma.
CONCLUSION: p300-mediated HAT modulates the expression of the asthma susceptibility gene ORMDL3, thereby improving the process of airway inflammation and remodeling in asthma. PMID: 31536903 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 16, 2019 Category: Allergy & Immunology Authors: Cheng Q, Shang Y, Huang W, Zhang Q, Li X, Zhou Q Tags: Int Immunopharmacol Source Type: research

MicroRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase.
This study aimed to evaluate the involvement of miR-23b in ICH models in vivo and in vitro, using basal ganglia injection of collagenase type VII in rats and hemin stimulation for cells, respectively. Exogenous overexpression of miR-23b by transfection with lentivirus-miR-23b (LV-miR-23b) or miR-23b mimics was evaluated by RT-qPCR. In this study, we found miR-23b was downregulated in the ICH models and its overexpression effectively alleviated neurological deficits, brain edema, hematoma area, and neuronal apoptosis in ICH rats. Western blotting for neuroinflammation markers and immunofluorescence staining for microglial a...
Source: International Immunopharmacology - September 16, 2019 Category: Allergy & Immunology Authors: Hu L, Zhang H, Wang B, Ao Q, Shi J, He Z Tags: Int Immunopharmacol Source Type: research

The effect of pulse methylprednisolone induction therapy in Chinese patients with dialysis-dependent MPO-ANCA associated vasculitis.
CONCLUSIONS: This retrospective study of MPO-AAV patients who required dialysis at presentation in a single Chinese center suggests that the addition of pulse MP to standard immunosuppressive induction therapy for remission appears to confer no benefit in terms of improving patient outcomes. Further research is required to determine the role of pulse MP in severe MPO-AAV. PMID: 31536905 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 16, 2019 Category: Allergy & Immunology Authors: Huang L, Zhong Y, Ooi JD, Zhou YO, Zuo X, Luo H, Chen JB, Wu T, Yang Y, Meng T, Xiao Z, Lin W, Ao X, Xiao X, Zhou Q, Xiao P Tags: Int Immunopharmacol Source Type: research

Notch signaling pathway regulates T cell dysfunction in septic patients.
Abstract Sepsis disrupts innate and adaptive immune response, and immune disorders may also impact clinical course of sepsis. Notch signaling pathway plays a vital role in T cell modulation and differentiation. The aim of current study was to investigate the immunoregulatory function of Notch signaling pathway to T cells in patients with sepsis and septic shock. Twenty-seven sepsis patients, twenty-five septic shock patients, and twenty-one normal controls (NCs) were enrolled. Notch receptors mRNA levels were semi-quantified by real-time PCR. The absolute numbers of CD3+, CD4+, and CD8+ T cells were measured by fl...
Source: International Immunopharmacology - September 13, 2019 Category: Allergy & Immunology Authors: Jin B, Liang Y, Liu Y, Zhang LX, Xi FY, Wu WJ, Li Y, Liu GH Tags: Int Immunopharmacol Source Type: research

A review on the role of M2 macrophages in bladder cancer; pathophysiology and targeting.
Abstract Tumor-associated macrophages (TAMs) which are often referred to as immunosuppressive cells (M2 macrophage), constitute a subset of tumor microenvironment cells and affect tumor progression in solid tumors. Recently, these cells have gained remarkable importance as therapeutic candidates for solid tumors. In bladder cancer, major studies have focused on evaluating TAMs in response to Bacillus Calmette-Guerin (BCG) therapy. M2 macrophages may directly impact the BCG-induced immune responses against tumor in bladder cancer. They are the main inhibitors of the tumor microenvironment that promotes growth and m...
Source: International Immunopharmacology - September 12, 2019 Category: Allergy & Immunology Authors: Sharifi L, Nowroozi MR, Amini E, Arami MK, Ayati M, Mohsenzadegan M Tags: Int Immunopharmacol Source Type: research

RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar macrophages.
Abstract Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are life-threatening critical syndromes characterized by the infiltration of a large number of inflammatory cells that lead to an excessive inflammatory response. Resolvin D1 (RvD1), an endogenous lipid mediator, is believed to have anti-inflammatory and proresolving effects. In the present study, we examined the impact of RvD1 on the pulmonary inflammatory response, neutrophil influx, and lung damage in a murine model of lipopolysaccharide (LPS)-induced ALI. Treatment with RvD1 protected mice against LPS-induced ALI, and compared t...
Source: International Immunopharmacology - September 12, 2019 Category: Allergy & Immunology Authors: Zhang HW, Wang Q, Mei HX, Zheng SX, Ali AM, Wu QX, Ye Y, Xu HR, Xiang SY, Jin SW Tags: Int Immunopharmacol Source Type: research

Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling.
In conclusion, our findings demonstrated that, TSN alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis. PMID: 31520988 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Fan H, Chen W, Zhu J, Zhang J, Peng S Tags: Int Immunopharmacol Source Type: research

Association of immunosuppressive agents and cytomegalovirus infection with de novo donor-specific antibody development within 1 year after renal transplantation.
Abstract The association between immunosuppressive therapy or cytomegalovirus (CMV) infection and detection of de novo donor-specific antibody (dnDSA) at 1 year after transplantation was evaluated. The impact of dnDSA positivity at 1 year after transplantation on long-term death-censored renal graft survival was also evaluated. One hundred and sixty adults receiving living renal allografts were studied. Inclusion criteria were renal graft survival for at least 1 year and a standard regimen of immunosuppressive therapy with tacrolimus, mycophenolate mofetil (MMF), steroids, and basiliximab. DSA were measured ...
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Fujiyama N, Satoh S, Saito M, Numakura K, Inoue T, Yamamoto R, Saito T, Nara T, Kanda S, Narita S, Kagaya H, Miura M, Habuchi T Tags: Int Immunopharmacol Source Type: research

Suppression of NLRP3 and NF- κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.
In conclusion, α-Cyperone showed the protective effect on LPS-induced ALI in mice by suppressing the NF-κB and NLRP3 signaling pathways, mainly via up-regulating SIRT1. This provides a potential drug for the treatment of LPS-induced ALI. PMID: 31520990 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Liu X, Jin X, Yu D, Liu G Tags: Int Immunopharmacol Source Type: research

Modulation of anti-malaria immunity by vitamin A in C57BL/6J mice infected with heterogenic plasmodium.
Abstract Vitamin A (VA) is an anti-inflammatory agent that is important in modulating and balancing the immune system. The present study aimed to investigate the immunoregulatory effects of vitamin A supplement (VAS) in C57BL/6J mice infected with Plasmodium yoelii 17XL (P.y17XL) or Plasmodium berghei ANKA (P.bANKA). Following VA treatment, parasitaemia decreased, but survival rate did not significantly change during P.y17XL infection. However, in P.bANKA infected C57BL/6J mice, VA pretreatment decreased parasitaemia, and a lag in cerebral malaria (CM) was observed during the early stages of infection. Furthermore...
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Chen G, Du YT, Liu JH, Li Y, Zheng L, Qin XS, Cao YM Tags: Int Immunopharmacol Source Type: research

Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF- κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms.
CONCLUSIONS: Our data highlight the pivotal function of α7nAChR and intact vagus nerves in protecting against LPS-induced ALI through inhibiting the TLR4/MyD88/NF-κB signaling pathway upon pretreatment with DEX. PMID: 31520992 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Zi SF, Li JH, Liu L, Deng C, Ao X, Chen DD, Wu SZ Tags: Int Immunopharmacol Source Type: research

PM2.5 inhibits SOD1 expression by up-regulating microRNA-206 and promotes ROS accumulation and disease progression in asthmatic mice.
This study found the possible molecular mechanism of PM2.5 aggravating asthma, and miR-206 may be a potential target for asthma treatment. PMID: 31520993 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Wang L, Xu J, Liu H, Li J, Hao H Tags: Int Immunopharmacol Source Type: research

Magnolin inhibits IgE/Ag-induced allergy in vivo and in vitro.
Abstract Mast cells (MCs) play critical roles in allergic reactions and modulating the activation of MCs could be an effective strategy to treat allergic diseases, which cause a rapidly increasing threat to the public health. Herein, we described that Magnolin, a major component from Flos magnoliae could inhibit IgE-dependent MCs activation. We found Magnolin inhibited IgE/Ag-induced calcium mobilization, degranulation, and cytokines release in LAD2 cells. Magnolin was also found to attenuate IgE/Ag-induced mice paw swelling in a dose-dependent manner. Further mechanistic studies suggested a possible anti-allergic...
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Ma P, Che D, Zhao T, Zhang Y, Li C, An H, Zhang T, He H Tags: Int Immunopharmacol Source Type: research

MicroRNA-27a alleviates IL-1 β-induced inflammatory response and articular cartilage degradation via TLR4/NF-κB signaling pathway in articular chondrocytes.
MicroRNA-27a alleviates IL-1β-induced inflammatory response and articular cartilage degradation via TLR4/NF-κB signaling pathway in articular chondrocytes. Int Immunopharmacol. 2019 Sep 11;76:105839 Authors: Qiu WJ, Xu MZ, Zhu XD, Ji YH Abstract Osteoarthritis (OA) is a common disease of the articular cartilage, and inflammatory response and articular cartilage degradation have been implicated in the pathogenesis of OA. In recent years, microRNAs (miRNAs) have been potentially involved in the pathogenesis of OA. However, little is known about the role of miRNAs in the inflammatory response ...
Source: International Immunopharmacology - September 11, 2019 Category: Allergy & Immunology Authors: Qiu WJ, Xu MZ, Zhu XD, Ji YH Tags: Int Immunopharmacol Source Type: research

Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis.
We reported here that the expression of EZH2 and H3K27me3 was significantly upregulated in the circulation of septic patients, whereas patients who survived presented downregulated the expression of EZH2 on CD14+ monocytes. We further identified increased expression of EZH2 in the circulation, peritoneal fluid, and septic lungs from CLP mice. 3-DZNeP treated CLP mice improved mortality and protected from organ injury. EZH2 inhibition not only suppressed the activation of inflammatory cells and release of cytokines in the circulation and infectious sites, but also promoted bacteria clearance and replenished the circulating ...
Source: International Immunopharmacology - September 10, 2019 Category: Allergy & Immunology Authors: Zhang Q, Sun H, Zhuang S, Liu N, Bao X, Liu X, Ren H, Lv D, Li Z, Bai J, Zhou X, Tang L Tags: Int Immunopharmacol Source Type: research

Long non-coding RNA Mirt2 prevents TNF- α-triggered inflammation via the repression of microRNA-101.
Long non-coding RNA Mirt2 prevents TNF-α-triggered inflammation via the repression of microRNA-101. Int Immunopharmacol. 2019 Sep 09;76:105878 Authors: Han Y, Kang C, Kang M, Quan W, Gao H, Zhong Z Abstract Parkinson's disease is normally accompanied by excessive inflammation. Myocardial infraction associated transcript 2 (Mirt2) has an activity to relieve inflammation in numerous cell types. Here, we aimed to investigate whether Mirt2 could elevate the resistance of SH-Sy5y cells to inflammation. Tumor necrosis factor alpha (TNF-α) was used to induce inflammation in SH-Sy5y cells. Mirt2 o...
Source: International Immunopharmacology - September 9, 2019 Category: Allergy & Immunology Authors: Han Y, Kang C, Kang M, Quan W, Gao H, Zhong Z Tags: Int Immunopharmacol Source Type: research

Febuxostat attenuates ulcerative colitis by the inhibition of NF- κB, proinflammatory cytokines, and oxidative stress in mice.
Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in mice. Int Immunopharmacol. 2019 Sep 06;76:105884 Authors: Amirshahrokhi K Abstract Ulcerative colitis is a chronic inflammatory disorder characterized by oxidative stress and upregulation of proinflammatory mediators in colonic tissue. Febuxostat, a xanthine oxidase inhibitor has been shown to exert anti-inflammatory and antioxidant effects. The aim of this study was to investigate the protective effect of febuxostat against ulcerative colitis, and to elucidate the potential me...
Source: International Immunopharmacology - September 6, 2019 Category: Allergy & Immunology Authors: Amirshahrokhi K Tags: Int Immunopharmacol Source Type: research

Production, purification, and in vivo evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccine.
Abstract Melanoma cells are significantly resistance to the current treatments. Therefore, the best option for high-risk populations is prevention. Recently, many preventive cancer vaccines have been developed. In our previous study, several bioinformatic tools were employed for selection of the most immunodominant epitopes of acrosin binding protein (ACRBP) and synaptonemal complex protein 1 (SYCP1) antigens to design multiepitope DNA and peptide cancer vaccines. In the current study, the final construct of the multiepitope DNA vaccine was placed into a pcDNA3.1 vector and then, subcloned into a pET-28a (+) expre...
Source: International Immunopharmacology - September 6, 2019 Category: Allergy & Immunology Authors: Safavi A, Kefayat A, Sotoodehnejadnematalahi F, Salehi M, Modarressi MH Tags: Int Immunopharmacol Source Type: research

IL1A & IL1B genetic polymorphisms are risk factors for thyroid cancer in a Chinese Han population.
CONCLUSIONS: Our study is the first to report that IL1A and IL1B polymorphisms are risk factors for thyroid carcinoma in a Chinese Han population. PMID: 31499272 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 6, 2019 Category: Allergy & Immunology Authors: Li H, Duan N, Zhang Q, Shao Y Tags: Int Immunopharmacol Source Type: research

miR-140-5p regulates T cell differentiation and attenuates experimental autoimmune encephalomyelitis by affecting CD4+T cell metabolism and DNA methylation.
In this study, we analyzed the levels of miR-140-5p in a mouse model of experimental autoimmune encephalomyelitis (EAE). We also analyzed the outcomes in response to either over- or under-expression of miR-140-5p. We found that the expression of miR-140-5p was inversely related to the progression of EAE. With the remission of the disease, the expression of miR-140-5p was restored to levels comparable to the control. The expression of miR-140-5p was downregulated in the encephalomyelitic CD4+T cells whereas enhanced expression of miR-140-5p inhibited the development of T helper type 1 (Th1) cell and significantly attenuated...
Source: International Immunopharmacology - September 5, 2019 Category: Allergy & Immunology Authors: Zhu S, Zhang X, Guan H, Huang F, Wu L, Hou D, Zheng Z, Yu M, Huang L, Ge L Tags: Int Immunopharmacol Source Type: research

Effects of adiponectin on random pattern skin flap survival in rats.
CONCLUSIONS: Adiponectin is useful for improving random skin flap survival. PMID: 31499269 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 5, 2019 Category: Allergy & Immunology Authors: Tu Q, Liu S, Chen T, Li Z, Lin D Tags: Int Immunopharmacol Source Type: research

The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE.
In conclusion, MIF may serve as a biomarker and a therapeutic target of SLE-associated PAH. Pharmacologic MIF antagonism may be an effective means to ameliorate SLE-PAH. PMID: 31499270 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 5, 2019 Category: Allergy & Immunology Authors: Huang H, Chen D, Pu J, Yuan A, Fu Q, Li J, Leng L, Bucala R, Ye S, Lu L Tags: Int Immunopharmacol Source Type: research

The immune-adjuvant activity and the mechanism of resveratrol on pseudorabies virus vaccine in a mouse model.
Abstract Resveratrol had shown various properties before, like immunomodulatory, anti-inflammatory and antiviral activities. Based on these properties, the present study was designed to evaluate the effects and mechanism of resveratrol as an immune-adjuvant for pseudorabies virus (PRV) vaccine. We found that oral administration of resveratrol to mice significantly increased the number of T lymphocytes in the spleen, and elevated the concentrations of antibodies and cytokines in the serum. Resveratrol (30 mg/kg) could enhance phagocytic capacity of peritoneal macrophage (PM) by boosting the percentage of phagocyt...
Source: International Immunopharmacology - September 5, 2019 Category: Allergy & Immunology Authors: Chen M, Chen X, Song X, Muhammad A, Jia R, Zou Y, Yin L, Li L, He C, Ye G, Lv C, Zhang W, Yin Z Tags: Int Immunopharmacol Source Type: research

Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF- κB in a murine asthma model.
This study aims to explore the therapeutic effect of NBP on airway inflammation, mucus hypersecretion and their possible mechanism in asthma mice. BALB/c mice were sensitized and challenged with ovalbumin (OVA) for establishment of asthma model and then treated with NBP during day 22-77. The pulmonary function of the mice was determined, and the pathology of lung tissue and goblet cell hyperplasia were observed through analyzing inflammation scores and goblet cell percentage, respectively. Cytokine IL-4, IL-8, IL-13 and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage fluid (BALF) and total immunogloblin...
Source: International Immunopharmacology - September 4, 2019 Category: Allergy & Immunology Authors: Wang Z, Yao N, Fu X, Wei L, Ding M, Pang Y, Liu D, Ren Y, Guo M Tags: Int Immunopharmacol Source Type: research

Peripheral blood mononuclear cellular viability and its correlation with long-term pulmonary complications after sulfur mustard exposure.
CONCLUSION: Exposure to SM even after a long time, can affect hematologic parameters and vital activity of PBMCs. PMID: 31493666 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 4, 2019 Category: Allergy & Immunology Authors: Mirsharif ES, Shams J, Falahi F, Moghadam MRS, Majd AMM, Dilmaghanian R, Ghazanfari T Tags: Int Immunopharmacol Source Type: research

Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice.
In this study, mice were pretreated with GA (100 mg/kg) three times a day by gavage prior to I/R injury, and then hepatic histopathological damages, biochemical parameters and inflammatory molecules were evaluated. We found that mice performed with liver I/R showed a significantly increase in plasma aminotransferase (ALT), aspartate aminotransferase (AST), liver cell apoptosis and infiltration of neutrophils compared with the control group. GA pretreatment notably improved liver function, histopathology of liver tissues, and lowered liver cell apoptosis and infiltration of neutrophils. Besides, further analysis indicated...
Source: International Immunopharmacology - September 3, 2019 Category: Allergy & Immunology Authors: Jiang X, Kuang G, Gong X, Jiang R, Xie T, Tie H, Wu S, Wang T, Wan J, Wang B Tags: Int Immunopharmacol Source Type: research

Myocarditis following the use of different immune checkpoint inhibitor regimens: A real-world analysis of post-marketing surveillance data.
Abstract BACKGROUNDS: Although myocarditis has been reported in patients treated with immune checkpoint inhibitors (ICIs), there are few real-world studies to compare the occurrences and characteristics of myocarditis after different ICI regimens. METHODS: Disproportionality analysis and Bayesian analysis were utilized for data mining of the suspected adverse events of myocarditis after ICIs use based on the Food and Drug Administration's Adverse Event Reporting System (FAERS) from January 2004 to June 2018. The times to onset and fatality rates of myocarditis following different ICI regimens were also compar...
Source: International Immunopharmacology - September 3, 2019 Category: Allergy & Immunology Authors: Fan Q, Hu Y, Yang C, Zhao B Tags: Int Immunopharmacol Source Type: research

Changing trends in IVIG use in pediatric patients: A retrospective review of practices in a network of major USA pediatric hospitals.
The objective of this study was to analyze trends in the IVIG use in pediatric patients hospitalized to 47 US-based children's hospitals from 2007 to 2014. IVIG was used for the treatment of>2300 primary diagnoses in 53,648 unique patients. The number of IVIG admissions increased by 30.2% during the study period, while the mean rate of IVIG admissions/100,000 admissions increased only 5.8%. Most patients receiving IVIG were children and adolescents. IVIG was frequently used off-label or for the treatment of FDA-approved indications in children under two years of age and BMT patients
Source: International Immunopharmacology - September 2, 2019 Category: Allergy & Immunology Authors: Balch A, Wilkes J, Thorell E, Pavia A, Sherwin CMT, Enioutina EY Tags: Int Immunopharmacol Source Type: research

Therapeutic effects of gentiopicroside on adjuvant-induced arthritis by inhibiting inflammation and oxidative stress in rats.
Abstract The purpose of this research was to evaluate the therapeutic effects of gentiopicroside (GPS) on adjuvant-induced arthritis (AA) rats. Rats were injected with complete Freund's adjuvant (CFA) for 0.1 mL in the right hind paw to induce AA. Thirty rats from three groups were treated with GPS (30, 60, 90 mg/kg) from day 15 to day 26. Arthritis was evaluated by arthritis index, paw volume, paw thickness, and X-ray. The effect of GPS on inflammation was assessed by measuring the levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6 and IL-17, as well as related mRNA. Glutathione per...
Source: International Immunopharmacology - September 2, 2019 Category: Allergy & Immunology Authors: Xie X, Li H, Wang Y, Wan Z, Luo S, Zhao Z, Liu J, Wu X, Li X, Li X Tags: Int Immunopharmacol Source Type: research

Alteration in serum levels of ICAM-1 and P-, E- and L-selectins in seriously eye-injured long-term following sulfur-mustard exposure.
CONCLUSION: The changes in the levels of selectins and ICAM-1 in the SM-exposed group with various ocular abnormalities is a defense mechanism against the toxicity of SM. Further analysis is required to understand the molecular mechanisms of the relationship between adhesion molecules with ocular complications in SM-exposed individuals. PMID: 31480003 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 31, 2019 Category: Allergy & Immunology Authors: Heidary F, Ardestani SK, Ghasemi H, Javadi MA, Mahmoudi M, Yaraee R, Shams J, Falahi F, Sedighi Moghadam MR, Shariatpanahi S, Shakeri R, Naghizadeh MM, Ghazanfari T Tags: Int Immunopharmacol Source Type: research

Combined MEK inhibition and tumor-associated macrophages depletion suppresses tumor growth in a triple-negative breast cancer mouse model.
Abstract Tumor-associated macrophages (TAMs) are closely related to poor prognosis in triple-negative breast cancer (TNBC). Thus, gaining insight into how TAMs support cancer progression could contribute to effective therapies. We utilized the 4 T1 murine TNBC cell line and murine bone marrow-derived macrophages to assess TAM-mediated pro-proliferative effects in vivo and in vitro. Further, Transcriptional analysis was performed to identify pathways activated in TAM-stimulated 4 T1 cells. We also explored the therapeutic efficacy of combining a mitogen-activated protein kinase kinase (MEK) inhibitor with TAM-t...
Source: International Immunopharmacology - August 31, 2019 Category: Allergy & Immunology Authors: Zhang Q, Le K, Xu M, Zhou J, Xiao Y, Yang W, Jiang Y, Xi Z, Huang T Tags: Int Immunopharmacol Source Type: research

Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent.
d P, Mendonça-Junior FJB Abstract The search for new drugs with anti-inflammatory properties remains a challenge for modern medicine. Among the various strategies for drug discovery, deriving new chemical entities from known bioactive natural and/or synthetic compounds remains a promising approach. Here, we designed and synthesized CVIB, a codrug developed by association of carvacrol (a phenolic monoterpene) with ibuprofen (a non-steroidal anti-inflammatory drug). In silico pharmacokinetic and physicochemical properties evaluation indicated low aqueous solubility (LogP ≥5.0). Nevertheless, the hybrid pre...
Source: International Immunopharmacology - August 31, 2019 Category: Allergy & Immunology Authors: de Oliveira Pedrosa Rolim M, de Almeida AR, da Rocha Pitta MG, de Melo Rêgo MJB, Quintans-Júnior LJ, de Souza Siqueira Quintans J, Heimfarth L, Scotti L, Scotti MT, da Cruz RMD, de Almeida RN, da Silva TG, de Oliveira JA, de Campos ML, Marchand P, Mendo Tags: Int Immunopharmacol Source Type: research

MicroRNA-124 alleviates the lung injury in mice with septic shock through inhibiting the activation of the MAPK signaling pathway by downregulating MAPK14.
CONCLUSION: These results indicated that miR-124 could alleviate the symptoms of ALI by inhibiting the activation of MAPK signaling pathway via subsequent targeting of MAPK14. Additionally, miR-124 may serve as a useful biomarker to alleviate the severity of septic shock-induced lung injury. PMID: 31476692 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 30, 2019 Category: Allergy & Immunology Authors: Pan W, Wei N, Xu W, Wang G, Gong F, Li N Tags: Int Immunopharmacol Source Type: research

Eupatilin attenuates the inflammatory response induced by intracerebral hemorrhage through the TLR4/MyD88 pathway.
CONCLUSION: Eupatilin has a therapeutic effect on inflammation caused by ICH. The underlying mechanism may be related to TLR4/MyD88, which brings new hope for clinical patients to improve symptoms and prognosis. PMID: 31476693 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 30, 2019 Category: Allergy & Immunology Authors: Fei X, Chen C, Kai S, Fu X, Man W, Ding B, Wang C, Xu R Tags: Int Immunopharmacol Source Type: research

Crocin inhibits titanium particle-induced inflammation and promotes osteogenesis by regulating macrophage polarization.
Abstract Wear particle-induced periprosthetic inflammatory osteolysis and resultant aseptic loosening are major causes of orthopedic implant failure, for which there are no effective treatments other than revision surgery. Crocin, a carotenoid compound derived from crocus flowers, has anti-inflammatory properties, but its immunomodulatory function and role in particle-induced osteolysis are not well characterized. Here we report the effect of crocin on titanium (Ti) particle-induced macrophage polarization and osteogenic differentiation. We found that crocin induced anti-inflammatory (M2) macrophage polarization a...
Source: International Immunopharmacology - August 30, 2019 Category: Allergy & Immunology Authors: Zhu K, Yang C, Dai H, Li J, Liu W, Luo Y, Zhang X, Wang Q Tags: Int Immunopharmacol Source Type: research

Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms.
Abstract Hepatic fibrosis, a common pathological feature and leading cause of various chronic liver diseases, still lacks effective therapy. Hesperetin derivative (HD) is a derivative of Traditional Chinese Medicine monomer isolated from the fruit peel of Citrusaurantium L. (Rutaceae). In the present study, we revealed the anti-fibrotic effects of HD in CCl4-induced mouse hepatic fibrosis model and in TGF-β1-activated LX-2 cells, in vivo and in vitro. Results showed that HD prevented CCl4-induced liver injury and histological damage. Consistently, HD inhibited the up-regulation of liver fibrogenesis markers &...
Source: International Immunopharmacology - August 29, 2019 Category: Allergy & Immunology Authors: Chen X, Li XF, Chen Y, Zhu S, Li HD, Chen SY, Wang JN, Pan XY, Bu FT, Huang C, Li J Tags: Int Immunopharmacol Source Type: research

Sodium butyrate alleviates high-glucose-induced renal glomerular endothelial cells damage via inhibiting pyroptosis.
In conclusion, NaB could ameliorate high-glucose induced GECs via caspase1-GSDMD canonical pyroptosis pathway; and NF-κB/IκB-α signaling pathway was involved in it. PMID: 31473434 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 29, 2019 Category: Allergy & Immunology Authors: Gu J, Huang W, Zhang W, Zhao T, Gao C, Gan W, Rao M, Chen Q, Guo M, Xu Y, Xu YH Tags: Int Immunopharmacol Source Type: research

Corrigendum to "Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction" [Int. Immunopharmacol. 10 (2010) 1135-1141].
Corrigendum to "Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction" [Int. Immunopharmacol. 10 (2010) 1135-1141]. Int Immunopharmacol. 2019 Aug 28;:105863 Authors: Qin HD, Shi YQ, Liu ZH, Li ZG, Wang HS, Wang H, Liu ZP PMID: 31473097 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 28, 2019 Category: Allergy & Immunology Authors: Qin HD, Shi YQ, Liu ZH, Li ZG, Wang HS, Wang H, Liu ZP Tags: Int Immunopharmacol Source Type: research

Accumulation of cytosolic dsDNA contributes to fibroblast-like synoviocytes-mediated rheumatoid arthritis synovial inflammation.
Abstract The accumulation of cytosolic dsDNA plays important roles in the regulation of cellular processes. However, whether cytosolic dsDNA is involved in the pathogenesis of rheumatoid arthritis (RA) is not clear. Therefore, the present study investigated the roles of cytosolic dsDNA in the modulation of inflammatory responses of fibroblast-like synoviocytes (FLS) in patients with RA. FLS were obtained from active RA patients. dsDNA accumulation in the cytosol was detected by immunofluorescence staining and the Qubit® dsDNA HS Assay. Immunohistochemistry was employed to detect the dsDNA and cGMP-AMP synthase...
Source: International Immunopharmacology - August 28, 2019 Category: Allergy & Immunology Authors: Wang J, Li R, Lin H, Qiu Q, Lao M, Zeng S, Wang C, Xu S, Zou Y, Shi M, Liang L, Xu H, Xiao Y Tags: Int Immunopharmacol Source Type: research

Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2.
Abstract Sorafenib has been systemically utilized to therapy the advanced hepatocellular carcinoma (HCC). Natural killer cells (NKs) are important cytotoxic innate lymphocytes, which can exert effector functions especially in liver and tumor. However, how Sorafenib affects the function of NKs remains to be elucidated. Here, we utilized the subcutaneous and in situ tumor bearing mice with mouse hepatoma cell line hepa 1-6. At the endpoint, the number and function of NKs in blood, liver, TDLN, and tumor were explored using FACS, ELISA, WB, etc. To confirm the direct effects of Sorafenib on NKs, the NKs were sorted u...
Source: International Immunopharmacology - August 28, 2019 Category: Allergy & Immunology Authors: Li C, Wei S, Xu X, Jiang Y, Xue L, Jiang P, Wang J Tags: Int Immunopharmacol Source Type: research

Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.
CONCLUSION: Col I - or gelatin-coated culture induced the formation of multicellular aggregates and increased production of NF-κB-associated pro-inflammatory molecules in MPMs through up-regulation of ROS levels. PMID: 31470266 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 27, 2019 Category: Allergy & Immunology Authors: Zhang X, Chen YR, Zhao YL, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ogura T, Onodera S, Ikejima T Tags: Int Immunopharmacol Source Type: research

Immunomodulatory effects of dietary IMUNO-2865 in mice, pre-and post-vaccine challenge with parainfluenza virus 5.
Abstract Herbal remedies and nutraceuticals continue to be used as treatments for a variety of maladies ranging from joint disease to obesity. IMUNO-2865 is a natural nutraceutical supplement that has been advertised to modulate inflammation, boost cytokine activity promoting a robust immunity, but has yet to be evaluated as an adjuvant. In the present study, 4-week-old C57BL/6 female mice (n = 45) were fed 0, 5 or 50 mg/5 g tablet IMUNO-2865 (I-2865) in a tablet formulated feed. One group of mice (n = 15, 5 mice/diet) were placed on a feed diet for 14 days, while the other group of 30 mice (10 mice/...
Source: International Immunopharmacology - August 27, 2019 Category: Allergy & Immunology Authors: Mayer J, Williams R, Kleine S, He B, Meichner T, Gogal RM Tags: Int Immunopharmacol Source Type: research

Critical role of OX40/OX40L in ILC2-mediated activation of CD4+T cells during respiratory syncytial virus infection in mice.
Abstract CD4+T cells are crucial cellular source of type 2 cytokines and responsible for RSV-induced asthma-like symptoms and asthma exacerbations. However, the mechanism for regulating the activation of CD4+T cells during RSV infection is not clear completely. We show in this study that infection with RSV may induce an expansion and activation of CD4+T cells in the lungs of BALB/c mice. RSV-induced CD4+T cell expansion and activation seems to depend upon the pulmonary group 2 innate lymphoid cells (ILC2s), since adoptive transfer of lung ILC2s can enhance not only the numbers of CD4+T cells but also the cytokine ...
Source: International Immunopharmacology - August 27, 2019 Category: Allergy & Immunology Authors: Wu J, Cui Y, Zhu W, Bai S, Zhao N, Liu B Tags: Int Immunopharmacol Source Type: research

Treatment of plaque psoriasis with IL-23p19 blockers: A systematic review and meta-analysis.
Abstract OBJECTIVES: Interleukin(IL)-23 is a key cytokine in the pathogenesis of psoriasis, this meta-analysis was to analyze the efficacy and safety of IL-23p19 blockers in patients with plaque psoriasis. METHODS: A systematic review of the literature was performed to collect double-blind randomized controlled trials(RCTs). The pooled relative risk(RR) with 95% confidence interval(CI) was calculated. All analyses were conducted with intention-to-treat basis. RESULTS: A total of 13 studies contained 5155 plaque psoriasis patients were included in our meta-analysis. The results indicated that IL-23p19 blo...
Source: International Immunopharmacology - August 26, 2019 Category: Allergy & Immunology Authors: Xu S, Zhang X, Pan M, Shuai Z, Xu S, Pan F Tags: Int Immunopharmacol Source Type: research

Metallothionein-1 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells.
CONCLUSION: The data had shown that the MT-1 was up-regulated in EIOA patients and positively correlated with the disease activity. The recombinant MT-1 could suppress the expression of pro-inflammatory cytokines in both PBMCs and synovial cells from EIOA patients. Therefore, the MT-1 might become a novel therapeutic target for OA treatment. PMID: 31465913 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 26, 2019 Category: Allergy & Immunology Authors: Wang C, Gong Z, Hu S, Zhang G Tags: Int Immunopharmacol Source Type: research

Transforming growth factor- β1 and hypoxia inducible factor-1α synergistically inhibit the osteogenesis of periodontal ligament stem cells.
In conclusion, our results showed that TGF-β1 can induce the stabilization of HIF-1α in PDLSCs under nonhypoxic conditions, that HIF-1α can negatively regulate the TGF-β1/Smad3 signal pathway in PDLSCs, and that TGF-β1 and HIF-1α can synergistically inhibit the osteogenesis of PDLSCs. PMID: 31465914 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 26, 2019 Category: Allergy & Immunology Authors: Liu Z, Guo L, Li R, Xu Q, Yang J, Chen J, Deng M Tags: Int Immunopharmacol Source Type: research

Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.
Abstract The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In the present study, we aimed to determine whether the PI3K/AKT pathway is involved in the protective effects of genipin against mitochondrial-dependent apoptosis, endoplasmic reticulum stress (ERS), and inflammation in ALI. We constructed in vivo and in vitro models of LPS-induced ALI. PI3K/A...
Source: International Immunopharmacology - August 26, 2019 Category: Allergy & Immunology Authors: Luo X, Lin B, Gao Y, Lei X, Wang X, Li Y, Li T Tags: Int Immunopharmacol Source Type: research

Targets for improving tumor response to radiotherapy.
Abstract Radiotherapy is one of the most common treatment modalities for controlling a wide range of tumors. However, it has been shown that radiotherapy alone is unable to completely eradicate some tumors and could be associated with a high possibility of tumor recurrence. To date, various experimental and clinical studies have been conducted to explore some efficient targets within tumor microenvironment (TME) to enhance tumor response to radiotherapy; thus help eliminate or eradicate tumors. Although targeting DNA damage responses (DDRs) is associated with severe toxicities, studies in recent decade suggest tha...
Source: International Immunopharmacology - August 26, 2019 Category: Allergy & Immunology Authors: Mortezaee K, Parwaie W, Motevaseli E, Mirtavoos-Mahyari H, Musa AE, Shabeeb D, Esmaely F, Najafi M, Farhood B Tags: Int Immunopharmacol Source Type: research

Gene polymorphisms and circulating levels of the TNF-alpha are associated with ischemic stroke: A meta-analysis based on 19,873 individuals.
CONCLUSIONS: Rs1800629 and rs1800610 polymorphisms were elucidated to be a protective factor for IS (especially in Asians) and a risk factor for Asians patients, respectively. The TNF-α level was elevated in IS, indicating that TNF-α plays an important role in the pathogenesis of IS and is a promising therapeutic target for IS. PMID: 31454695 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 24, 2019 Category: Allergy & Immunology Authors: Wu JC, Zhang X, Wang JH, Liu QW, Wang XQ, Wu ZQ, Wang J, Zhang C, Qun S Tags: Int Immunopharmacol Source Type: research

Hepatoprotection of yangonin against hepatic fibrosis in mice via farnesoid X receptor activation.
Abstract Hepatic fibrosis is a reversible would-healing response following chronic liver injury of different aetiologies and represents a major worldwide health problem. Up to date, there is no satisfactory drugs treated for liver fibrosis. The present study was to investigate hepatoprotection of yangonin against liver fibrosis induced by thioacetamide (TAA) in mice and further to clarify the involvement of farnesoid X receptor (FXR) in vivo and in vitro. Yangonin treatment remarkably ameliorated TAA-induced liver injury by reducing relative liver weight, as well as serum ALT and AST activities. Moreover, yangonin...
Source: International Immunopharmacology - August 23, 2019 Category: Allergy & Immunology Authors: Wang X, Fu T, Wang J, Wang C, Liu K, Wu J, Sun H, Ma X, Sun P, Meng Q Tags: Int Immunopharmacol Source Type: research