CD4 < sup > + < /sup > CD25 < sup > + < /sup > CD127 < sup > low < /sup > regulatory T cells associated with the effect of CD19 CAR-T therapy for relapsed/refractory B-cell acute lymphoblastic leukemia
Int Immunopharmacol. 2021 May 10;96:107742. doi: 10.1016/j.intimp.2021.107742. Online ahead of print.ABSTRACTBACKGROUND: CD19-specific chimeric antigen receptor T-cell (CAR-T) therapy has shown promising clinical outcomes in relapsed/refractory acute B-cell lymphoblastic leukemia (R/R B-ALL) patients. However, some patients did not respond to this therapy or relapsed after remission. Regulatory T cells (Tregs) have shown great importance in promoting tumor escape, but little is known about their role in R/R B-ALL patients with CAR-T therapy. Our previous study has proved that higher Tregs before infusion was an independent...
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Ying Pan Huiping Wang Furun An Fan Wu Qianshan Tao Yingwei Li Yanjie Ruan Zhimin Zhai Source Type: research

A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial
CONCLUSION: Resolved clinical symptoms, improved oxygenation, clearance of infiltrates on Chest X-ray and improvement in biomarkers in a short period with non-progression of the disease showed that IV ozonised saline therapy was safe and effective to prevent disease progression in COVID-19, making it an effective novel therapeutic tool.PMID:33984718 | PMC:PMC8084612 | DOI:10.1016/j.intimp.2021.107743 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Alok Sharma Mili Shah Satya Lakshmi Hemangi Sane Jignasha Captain Nandini Gokulchandran Pallavi Khubchandani M K Pradeep Prakash Gote Balaji Tuppekar Pooja Kulkarni Amruta Paranjape Radhika Pradhan Ritu Varghese Sushil Kasekar Vivek Nair Ummeammara Khanba Source Type: research

The potential protective effects of miR-497 on corneal neovascularization are mediated via macrophage through the IL-6/STAT3/VEGF signaling pathway
Int Immunopharmacol. 2021 May 10;96:107745. doi: 10.1016/j.intimp.2021.107745. Online ahead of print.ABSTRACTCorneal neovascularization (CoNV) can cause abnormal blood vessels to grow in the transparent cornea, leading to various sight-threatening eye diseases. MicroRNAs are known to play essential roles in the regulation of numerous biological functions. We try to clarify the role of a specific microRNA, miR‑497, which has been shown to regulate the growth of tumor cells and angiogenesis on the basis of available data. However, the association between miR-497 and vascularized cornea remains unclear. Therefore, it is urg...
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Yang Wang Yuelan Gao Yuqing Huang Yumiao Pan Yi Yu Yiwen Zhou Shan-Shan Wan Yan-Ning Yang Source Type: research

Berberine attenuates the inflammatory response by activating the Keap1/Nrf2 signaling pathway in bovine endometrial epithelial cells
In conclusion, our findings suggest that berberine exerts anti-inflammatory effects partially by activating the Keap1/Nrf2 signaling pathway.PMID:33984720 | DOI:10.1016/j.intimp.2021.107738 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Kaiqiang Fu Zezhi Wang Rongfeng Cao Source Type: research

MicroRNA-211 regulates the expression of TAB1 and inhibits the NF- κB signaling pathway in lipopolysaccharide-induced endometritis
This study aims to investigate the regulatory role of miR-211 in the innate immune response involved in endometritis, and to evaluate its potential therapeutic value. Here, we found that the expression of miR-211 in bovine endometrial epithelial cells (bEECs) stimulated by lipopolysaccharide (LPS) was significantly reduced. Importantly, overexpression of miR-211 can significantly reduce the production of pro-inflammatory cytokines (IL-1β , IL-6 and TNF-α). In addition, we proved that TAB1 is the target gene of miR-211. MiR-211 inhibits TAB1 protein expression by binding to the 3'-UTR of TAB1 mRNA. Subsequently, ...
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Cheng Yang Chao Yang Jinxin Zhang Yingfang Guo Nuoer Chen Baoyi Yin Qingqing Zhou Tao Zhang Shuai Guo Ganzhen Deng Source Type: research

Food antigens exacerbate intestinal damage and inflammation following the disruption of the mucosal barrier
Int Immunopharmacol. 2021 May 10;96:107670. doi: 10.1016/j.intimp.2021.107670. Online ahead of print.ABSTRACTFood antigens are closely related to progression of inflammatory bowel disease; however, details of how they induce intestinal immune responses and causes intestinal inflammation is not yet clear. The present study aimed to examine the effects of oral collagen on the intestinal mucosa, and elucidate the mechanism of food antigen-induced enteritis. Here, we provide evidence that Aspirin (a mucosal-damaging agent) and type II collagen (CII; a food antigen) acted synergistically to disrupt the intestinal mucosal barrie...
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Yanmei Ma Zhihua Yin Li Li Bingni Chen Hanying Dai Dandan Wu Junxiao Cong Liang Ye Chenghui Liao Lingyun Li Zhizhong Ye Zhong Huang Source Type: research

Absence of Toll-like receptor 7 protects mice against Pseudomonas aeruginosa pneumonia
Int Immunopharmacol. 2021 May 10;96:107739. doi: 10.1016/j.intimp.2021.107739. Online ahead of print.ABSTRACTToll-like receptor 7 (TLR7) is a sensor of microbial ssRNA that participates in the immune response process in many diseases. We herein sought to establish the role of TLR7 in Pseudomonas aeruginosa pneumonia. Pneumonia model was created by intratracheally injecting Pseudomonas aeruginosa and the effects of TLR7 on survival, bacterial burden, lung pathology, cytokine and chemokine production, and pulmonary leukocyte recruitment were measured after Pseudomonas aeruginosa challenge. TLR7 expression was significantly e...
Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Haofeng Xu Lili Huang Qin Luo Qianqian Tu Jiayu Liu Renlin Yu Jun Huang Te Chen Yibing Yin Ju Cao Source Type: research

JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation
Int Immunopharmacol. 2021 May 8;96:107726. doi: 10.1016/j.intimp.2021.107726. Online ahead of print.ABSTRACTNeuroinflammation plays an early and prominent role in the pathology of Alzheimer's disease (AD). Studies have shown that cholinergic lesion is a contributor for the pathophysiology of AD. The α7 nicotinic acetylcholine receptors (nAChRs), a subtype of nAChRs, are abundantly expressed in the brain regions related to cognition and memory, such as hippocampus and frontal cortex. The α7 nAChR is rapidly activated and desensitized by agonists. JWX-A0108 is a type I positive allosteric modulator (PAM) of &alph...
Source: International Immunopharmacology - May 11, 2021 Category: Allergy & Immunology Authors: Hui Li Jie Gao Yue Chang Kexin Li Lei Wang Chuanxia Ju Fang Zhang Source Type: research

JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation
Int Immunopharmacol. 2021 May 8;96:107726. doi: 10.1016/j.intimp.2021.107726. Online ahead of print.ABSTRACTNeuroinflammation plays an early and prominent role in the pathology of Alzheimer's disease (AD). Studies have shown that cholinergic lesion is a contributor for the pathophysiology of AD. The α7 nicotinic acetylcholine receptors (nAChRs), a subtype of nAChRs, are abundantly expressed in the brain regions related to cognition and memory, such as hippocampus and frontal cortex. The α7 nAChR is rapidly activated and desensitized by agonists. JWX-A0108 is a type I positive allosteric modulator (PAM) of &alph...
Source: International Immunopharmacology - May 11, 2021 Category: Allergy & Immunology Authors: Hui Li Jie Gao Yue Chang Kexin Li Lei Wang Chuanxia Ju Fang Zhang Source Type: research

CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5
CONCLUSION: Taken together, the results in this study suggested that circATRNL1 might ameliorate the development and progression of OA through regulating miR-153-3p/KLF5 axis. Our study increased the understanding of circRNAs as therapeutic targets in the treatment of OA.PMID:33971492 | DOI:10.1016/j.intimp.2021.107704 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Kai-Fu Wang Zuo-Wei Shi Da-Ming Dong Source Type: research

Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats
CONCLUSION: The combination protocol of antioxidants with Ph&M activities mitigated SI&PM-induced progressive risk of AD.PMID:33971493 | DOI:10.1016/j.intimp.2021.107729 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Azza A Ali Abeer I Abd El-Fattah Karema Abu-Elfotuh Hemat A Elariny Source Type: research

Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF- κB/NLRP3 and PGC1a/SIRT3 pathways
Int Immunopharmacol. 2021 May 7;96:107728. doi: 10.1016/j.intimp.2021.107728. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a chronic multifactorial complication of type-2 diabetes mellitus, leading to heart failure. A combination of multifaceted therapeutics for the management of DCM is needed. Here, we investigated the combined effect of syringin and tilianin on DCM by evaluating cardiac function, inflammation, oxidative stress, apoptosis and mitochondrial function, and explored the contribution of TLR4/NF-κB/NLRP3 and PGC1α/SIRT3 pathways in diabetic rats and hyperglycemic-H9c2 cells. Syring...
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Jianping Yao Ying Li Yueping Jin Yuan Chen Linlin Tian Wenxia He Source Type: research

Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF- κB signaling pathways mediated antiviral responses against Gammacoronavirus infection
In conclusion, these results showed that at high concentration CGA is a strong anti-IBV compound that can effectively regulate the innate immunity through MDA5, TLR7 and NF-κB signaling pathways and have the potential to induce the cell mediated and humoral immune response in IBV infected chickens.PMID:33971495 | DOI:10.1016/j.intimp.2021.107671 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Muhammad Abaidullah Shuwei Peng Xu Song Yuanfeng Zou Lixia Li Renyong Jia Zhongqiong Yin Source Type: research

CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5
CONCLUSION: Taken together, the results in this study suggested that circATRNL1 might ameliorate the development and progression of OA through regulating miR-153-3p/KLF5 axis. Our study increased the understanding of circRNAs as therapeutic targets in the treatment of OA.PMID:33971492 | DOI:10.1016/j.intimp.2021.107704 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Kai-Fu Wang Zuo-Wei Shi Da-Ming Dong Source Type: research

Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats
CONCLUSION: The combination protocol of antioxidants with Ph&M activities mitigated SI&PM-induced progressive risk of AD.PMID:33971493 | DOI:10.1016/j.intimp.2021.107729 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Azza A Ali Abeer I Abd El-Fattah Karema Abu-Elfotuh Hemat A Elariny Source Type: research

Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF- κB/NLRP3 and PGC1a/SIRT3 pathways
Int Immunopharmacol. 2021 May 7;96:107728. doi: 10.1016/j.intimp.2021.107728. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a chronic multifactorial complication of type-2 diabetes mellitus, leading to heart failure. A combination of multifaceted therapeutics for the management of DCM is needed. Here, we investigated the combined effect of syringin and tilianin on DCM by evaluating cardiac function, inflammation, oxidative stress, apoptosis and mitochondrial function, and explored the contribution of TLR4/NF-κB/NLRP3 and PGC1α/SIRT3 pathways in diabetic rats and hyperglycemic-H9c2 cells. Syring...
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Jianping Yao Ying Li Yueping Jin Yuan Chen Linlin Tian Wenxia He Source Type: research

Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF- κB signaling pathways mediated antiviral responses against Gammacoronavirus infection
In conclusion, these results showed that at high concentration CGA is a strong anti-IBV compound that can effectively regulate the innate immunity through MDA5, TLR7 and NF-κB signaling pathways and have the potential to induce the cell mediated and humoral immune response in IBV infected chickens.PMID:33971495 | DOI:10.1016/j.intimp.2021.107671 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Muhammad Abaidullah Shuwei Peng Xu Song Yuanfeng Zou Lixia Li Renyong Jia Zhongqiong Yin Source Type: research

Cell therapy in transplantation: A comprehensive review of the current applications of cell therapy in transplant patients with the focus on Tregs, CAR Tregs, and Mesenchymal stem cells
Int Immunopharmacol. 2021 May 6;97:107669. doi: 10.1016/j.intimp.2021.107669. Online ahead of print.ABSTRACTOrgan transplantation is a practical treatment for patients with end-stage organ failure. Despite the advances in short-term graft survival, long-term graft survival remains the main challenge considering the increased mortality and morbidity associated with chronic rejection and the toxicity of immunosuppressive drugs. Since a novel therapeutic strategy to induce allograft tolerance seems urgent, focusing on developing novel and safe approaches to prolong graft survival is one of the main goals of transplant investi...
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Amir Hossein Mansourabadi Leila Mohamed Khosroshahi Farshid Noorbakhsh Aliakbar Amirzargar Source Type: research

Infliximab modifies regulatory T cells and co-inhibitory receptor expression on circulating T cells in psoriasis
CONCLUSION: Anti-TNF-α therapy increased the frequency of Tregs and TIGIT, LAG-3, CTLA-4 expression but reduced PROCR expression on circulating CD4+ T cells in psoriasis patients. The baseline proportion of Tregs and the expression level of TIGIT on circulating CD4+ T cells might serve as predictive markers for the degree of disease remission benefited from infliximab treatment.PMID:33965878 | DOI:10.1016/j.intimp.2021.107722 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Yingyuan Yu Zeyu Chen Yu Wang Ying Li Jiajing Lu Lian Cui Zengyang Yu Yangfeng Ding Chunyuan Guo Xilin Zhang Yuling Shi Source Type: research

Paeoniflorin attenuates the allergic contact dermatitis response via inhibiting the IFN- γ production and the NF-κB/IκBα signaling pathway in T lymphocytes
Int Immunopharmacol. 2021 May 6;96:107687. doi: 10.1016/j.intimp.2021.107687. Online ahead of print.ABSTRACTPaeoniflorin (PF) has been demonstrated to have an anti-allergic and anti-inflammatory effect in the treatment of allergic contact dermatitis (ACD). However, its clinical application is hampered by the lacking of comprehensive mechanical explanation. This research aimed to study the effect of PF on the proliferation, apoptosis and cytokines secretion as well as the expression of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways of T lymphocytes activation in vitro and...
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Xiaoting Wu Xiaoyi Qi Jing Wang Yunying Zhang Yanwei Xiao Caixia Tu Aoxue Wang Source Type: research

Chimeric antigen receptor T cells targeting CD7 in a child with high-risk T-cell acute lymphoblastic leukemia
This study aimed to describe the safe and effective use of autologous CD7-CAR T cells (4SCAR7) for the treatment of T-ALL with induction failure in an 11-year-old patient. Based on The Chinese Children's Cancer Group-ALL (CCCG-ALL) study protocol, minimal residual disease (MRD) by flow cytometry (FC) analysis was detected on days 19 and 46 of remission induction. At the end of remission-induction chemotherapy, the patient achieved morphologic complete remission, though with MRD 16.13% and RT-PCR of KMT2A-MLLT1 fusion positive, which indicated induction failure. The cerebrospinal fluid (CSF) was negative for blasts at diagn...
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Lichun Xie Lian Ma Sixi Liu LungJi Chang Feiqiu Wen Source Type: research

Immunomodulatory effect of in vitro calcitriol in fit and frail elderly
CONCLUSION: In vitro administration of calcitriol showed anti-inflammatory potential by increasing IL-10 mainly in pre-frail subjects.PMID:33965881 | DOI:10.1016/j.intimp.2021.107737 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Aulia Rizka Siti Setiati M Sadikin Indra G Mansur Source Type: research

Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma
In conclusion, MENK provides an effective method with therapeutic potential to modulate the CSCC microenvironment by utilizing autophagy in the cancer cells.PMID:33965882 | DOI:10.1016/j.intimp.2021.107733 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Xueli Bai Xia Cao Na Qu Hai Huang Mike Handley Shuling Zhang Fengping Shan Source Type: research

Cell therapy in transplantation: A comprehensive review of the current applications of cell therapy in transplant patients with the focus on Tregs, CAR Tregs, and Mesenchymal stem cells
Int Immunopharmacol. 2021 May 6;97:107669. doi: 10.1016/j.intimp.2021.107669. Online ahead of print.ABSTRACTOrgan transplantation is a practical treatment for patients with end-stage organ failure. Despite the advances in short-term graft survival, long-term graft survival remains the main challenge considering the increased mortality and morbidity associated with chronic rejection and the toxicity of immunosuppressive drugs. Since a novel therapeutic strategy to induce allograft tolerance seems urgent, focusing on developing novel and safe approaches to prolong graft survival is one of the main goals of transplant investi...
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Amir Hossein Mansourabadi Leila Mohamed Khosroshahi Farshid Noorbakhsh Aliakbar Amirzargar Source Type: research

Infliximab modifies regulatory T cells and co-inhibitory receptor expression on circulating T cells in psoriasis
CONCLUSION: Anti-TNF-α therapy increased the frequency of Tregs and TIGIT, LAG-3, CTLA-4 expression but reduced PROCR expression on circulating CD4+ T cells in psoriasis patients. The baseline proportion of Tregs and the expression level of TIGIT on circulating CD4+ T cells might serve as predictive markers for the degree of disease remission benefited from infliximab treatment.PMID:33965878 | DOI:10.1016/j.intimp.2021.107722 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Yingyuan Yu Zeyu Chen Yu Wang Ying Li Jiajing Lu Lian Cui Zengyang Yu Yangfeng Ding Chunyuan Guo Xilin Zhang Yuling Shi Source Type: research

Paeoniflorin attenuates the allergic contact dermatitis response via inhibiting the IFN- γ production and the NF-κB/IκBα signaling pathway in T lymphocytes
Int Immunopharmacol. 2021 May 6;96:107687. doi: 10.1016/j.intimp.2021.107687. Online ahead of print.ABSTRACTPaeoniflorin (PF) has been demonstrated to have an anti-allergic and anti-inflammatory effect in the treatment of allergic contact dermatitis (ACD). However, its clinical application is hampered by the lacking of comprehensive mechanical explanation. This research aimed to study the effect of PF on the proliferation, apoptosis and cytokines secretion as well as the expression of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways of T lymphocytes activation in vitro and...
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Xiaoting Wu Xiaoyi Qi Jing Wang Yunying Zhang Yanwei Xiao Caixia Tu Aoxue Wang Source Type: research

Chimeric antigen receptor T cells targeting CD7 in a child with high-risk T-cell acute lymphoblastic leukemia
This study aimed to describe the safe and effective use of autologous CD7-CAR T cells (4SCAR7) for the treatment of T-ALL with induction failure in an 11-year-old patient. Based on The Chinese Children's Cancer Group-ALL (CCCG-ALL) study protocol, minimal residual disease (MRD) by flow cytometry (FC) analysis was detected on days 19 and 46 of remission induction. At the end of remission-induction chemotherapy, the patient achieved morphologic complete remission, though with MRD 16.13% and RT-PCR of KMT2A-MLLT1 fusion positive, which indicated induction failure. The cerebrospinal fluid (CSF) was negative for blasts at diagn...
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Lichun Xie Lian Ma Sixi Liu LungJi Chang Feiqiu Wen Source Type: research

Immunomodulatory effect of in vitro calcitriol in fit and frail elderly
CONCLUSION: In vitro administration of calcitriol showed anti-inflammatory potential by increasing IL-10 mainly in pre-frail subjects.PMID:33965881 | DOI:10.1016/j.intimp.2021.107737 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Aulia Rizka Siti Setiati M Sadikin Indra G Mansur Source Type: research

Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma
In conclusion, MENK provides an effective method with therapeutic potential to modulate the CSCC microenvironment by utilizing autophagy in the cancer cells.PMID:33965882 | DOI:10.1016/j.intimp.2021.107733 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Xueli Bai Xia Cao Na Qu Hai Huang Mike Handley Shuling Zhang Fengping Shan Source Type: research

APE1 facilitates PD-L1-mediated progression of laryngeal and hypopharyngeal squamous cell carcinoma
In conclusion, the combine detection of the expressions of PD-1, PD-L1 and APE1 will provide predictive value for the treatment of LSCC and HSCC via immune checkpoint inhibitors, which will help us to identify the patient population more likely to benefit from the immune checkpoint inhibitors based on the tumor immune microenvironment.PMID:33964809 | DOI:10.1016/j.intimp.2021.107675 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 8, 2021 Category: Allergy & Immunology Authors: Juan Wang Limin Lun Xin Jiang Yi Wang Xiaopeng Li Guoqiang Du Jin Wang Source Type: research

Evaluating the elimination status of medications used for COVID-19 during hemoperfusion and therapeutic plasma exchange: A review
Int Immunopharmacol. 2021 Apr 21;97:107707. doi: 10.1016/j.intimp.2021.107707. Online ahead of print.ABSTRACTSince late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, better known as COVID-19) has rapidly spread worldwide. The primary pathophysiology by which COVID-19 leads to severe lung damage is cytokine releasing syndrome (CRS), which can cause death. Therefore, removing cytokines via therapeutic plasma exchange or hemoperfusion could be a therapeutic approach to treat CRS. However, hemoperfusion or therapeutic plasma exchange could alter the effectiveness of concomitant medications. Thus, concomita...
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Shervin Shokouhi Saghar Barati Neda Kazeminia Faezeh Jamali Baran Roshan Zahra Sahraei Source Type: research

A systematic review of population pharmacokinetic analyses of polyclonal immunoglobulin G therapy
CONCLUSIONS: Seven popPK studies of IgG were found and discussed, with only weight being a significant covariate across all studies. Future studies linking pharmacokinetics with pharmacodynamics in PID and other patient populations are required.PMID:33962225 | DOI:10.1016/j.intimp.2021.107721 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Jian Lynn Lee Noraida Mohamed Shah Mohd Makmor-Bakry Farida Islahudin Hamidah Alias Shamin Mohd Saffian Source Type: research

MiR-133a delivery to osteoblasts ameliorates mechanical unloading-triggered osteopenia progression in vitro and in vivo
In conclusion, our results suggested that miR-133a may be a promising factor in mediating the occurrence and progression of osteopenia caused by mechanical unloading, and thus targeting miR-133a could be considered as an effective therapeutic strategy for the suppression of pathological osteopenia.PMID:33962226 | DOI:10.1016/j.intimp.2021.107613 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Youlong Zhou Xing Chen Zemin Zhu Daochi Bi Shuyun Ma Source Type: research

Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement
In this study, an attempt had been taken to utilize the functional relationship or cross-talking between TLR-2 and GR during the pathogenesis of brain abscesses. Here, the combination of an antibiotic (i.e. ciprofloxacin) and dexamethasone was used to regulate the brain inflammation either in TLR-2 or GR blocking condition. We were also interested to figure out the possible impact of alternative therapy on behavioral impairments. The results indicated that combination treatment during TLR-2 blockade significantly reduced the bacterial burden and abscess area score in the infected brain. However, marked improvements were ob...
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Rajen Dey Biswadev Bishayi Source Type: research

LncRNA NEAT1 inhibition upregulates miR-16-5p to restrain the progression of sepsis-induced lung injury via suppressing BRD4 in a mouse model
CONCLUSION: NEAT1 inhibition upregulates miR-16-5p to repress the progression of sepsis-induced lung injury via downregulating BRD4.PMID:33962228 | DOI:10.1016/j.intimp.2021.107691 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Jianhong Yin Bin Han Yuan Shen Source Type: research

Evaluating the elimination status of medications used for COVID-19 during hemoperfusion and therapeutic plasma exchange: A review
Int Immunopharmacol. 2021 Apr 21;97:107707. doi: 10.1016/j.intimp.2021.107707. Online ahead of print.ABSTRACTSince late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, better known as COVID-19) has rapidly spread worldwide. The primary pathophysiology by which COVID-19 leads to severe lung damage is cytokine releasing syndrome (CRS), which can cause death. Therefore, removing cytokines via therapeutic plasma exchange or hemoperfusion could be a therapeutic approach to treat CRS. However, hemoperfusion or therapeutic plasma exchange could alter the effectiveness of concomitant medications. Thus, concomita...
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Shervin Shokouhi Saghar Barati Neda Kazeminia Faezeh Jamali Baran Roshan Zahra Sahraei Source Type: research

A systematic review of population pharmacokinetic analyses of polyclonal immunoglobulin G therapy
CONCLUSIONS: Seven popPK studies of IgG were found and discussed, with only weight being a significant covariate across all studies. Future studies linking pharmacokinetics with pharmacodynamics in PID and other patient populations are required.PMID:33962225 | DOI:10.1016/j.intimp.2021.107721 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Jian Lynn Lee Noraida Mohamed Shah Mohd Makmor-Bakry Farida Islahudin Hamidah Alias Shamin Mohd Saffian Source Type: research

MiR-133a delivery to osteoblasts ameliorates mechanical unloading-triggered osteopenia progression in vitro and in vivo
In conclusion, our results suggested that miR-133a may be a promising factor in mediating the occurrence and progression of osteopenia caused by mechanical unloading, and thus targeting miR-133a could be considered as an effective therapeutic strategy for the suppression of pathological osteopenia.PMID:33962226 | DOI:10.1016/j.intimp.2021.107613 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Youlong Zhou Xing Chen Zemin Zhu Daochi Bi Shuyun Ma Source Type: research

Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement
In this study, an attempt had been taken to utilize the functional relationship or cross-talking between TLR-2 and GR during the pathogenesis of brain abscesses. Here, the combination of an antibiotic (i.e. ciprofloxacin) and dexamethasone was used to regulate the brain inflammation either in TLR-2 or GR blocking condition. We were also interested to figure out the possible impact of alternative therapy on behavioral impairments. The results indicated that combination treatment during TLR-2 blockade significantly reduced the bacterial burden and abscess area score in the infected brain. However, marked improvements were ob...
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Rajen Dey Biswadev Bishayi Source Type: research

LncRNA NEAT1 inhibition upregulates miR-16-5p to restrain the progression of sepsis-induced lung injury via suppressing BRD4 in a mouse model
CONCLUSION: NEAT1 inhibition upregulates miR-16-5p to repress the progression of sepsis-induced lung injury via downregulating BRD4.PMID:33962228 | DOI:10.1016/j.intimp.2021.107691 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 7, 2021 Category: Allergy & Immunology Authors: Jianhong Yin Bin Han Yuan Shen Source Type: research

COVID-19 vaccine hesitancy and related fears and anxiety
Int Immunopharmacol. 2021 Apr 27;97:107724. doi: 10.1016/j.intimp.2021.107724. Online ahead of print.ABSTRACTBACKGROUND: Vaccination is crucial to limit the pandemic spread of SARS-CoV-2/COVID-19. Therefore, besides the development and supply of vaccines, it is essential that sufficient individuals are willing to get vaccinated, but concerning proportions of populations worldwide show vaccine hesitancy. This makes it important to determine factors that are associated with vaccine acceptance.METHODS: 1779 adults of a non-probability convenience sample in Germany were assessed with an online survey in a cross-sectional surve...
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Antonia Bendau Jens Plag Moritz Bruno Petzold Andreas Str öhle Source Type: research

Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice
Int Immunopharmacol. 2021 May 2;97:107716. doi: 10.1016/j.intimp.2021.107716. Online ahead of print.ABSTRACTSeveral experiments confirmed that vitamin D3 protected against acetaminophen (APAP)-induced acute liver injury (ALI). This research aimed to evaluate the influence of vitamin D deficiency (VDD) on APAP-induced ALI. In VDD and VDD + APAP groups, mice were fed with VDD diet. In APAP and VDD + APAP groups, mice were intraperitoneally injected with a sublethal dose of APAP (150 mg/kg). A sublethal dose of APAP caused a slight elevation of ALT and AST. Interestingly, APAP-induced elevation of ALT and AST was aggravated i...
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Ya-Qi Wang Xiao-Pan Geng Ming-Wei Wang Hong-Qian Wang Cheng Zhang Xue He Shi-Min Liang De-Xiang Xu Xi Chen Source Type: research

Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients
CONCLUSION: Thus, elicitation of the hyperactive cytokine-mediated inflammatory response, dysregulation of CD8 T and NK cells, and deficiency of host myeloid and plasmacytoid DCs, may contribute to COVID-19 pathogenesis and provide insights into potential therapeutic targets and strategies.PMID:33951560 | PMC:PMC8052478 | DOI:10.1016/j.intimp.2021.107685 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Qigao Chen Baodan Yu Yihao Yang Jiewen Huang Ying Liang Jing Zhou Lianzhong Li Xuechun Peng Bolin Cheng Yongping Lin Source Type: research

COVID-19 vaccine hesitancy and related fears and anxiety
Int Immunopharmacol. 2021 Apr 27;97:107724. doi: 10.1016/j.intimp.2021.107724. Online ahead of print.ABSTRACTBACKGROUND: Vaccination is crucial to limit the pandemic spread of SARS-CoV-2/COVID-19. Therefore, besides the development and supply of vaccines, it is essential that sufficient individuals are willing to get vaccinated, but concerning proportions of populations worldwide show vaccine hesitancy. This makes it important to determine factors that are associated with vaccine acceptance.METHODS: 1779 adults of a non-probability convenience sample in Germany were assessed with an online survey in a cross-sectional surve...
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Antonia Bendau Jens Plag Moritz Bruno Petzold Andreas Str öhle Source Type: research

Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice
Int Immunopharmacol. 2021 May 2;97:107716. doi: 10.1016/j.intimp.2021.107716. Online ahead of print.ABSTRACTSeveral experiments confirmed that vitamin D3 protected against acetaminophen (APAP)-induced acute liver injury (ALI). This research aimed to evaluate the influence of vitamin D deficiency (VDD) on APAP-induced ALI. In VDD and VDD + APAP groups, mice were fed with VDD diet. In APAP and VDD + APAP groups, mice were intraperitoneally injected with a sublethal dose of APAP (150 mg/kg). A sublethal dose of APAP caused a slight elevation of ALT and AST. Interestingly, APAP-induced elevation of ALT and AST was aggravated i...
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Ya-Qi Wang Xiao-Pan Geng Ming-Wei Wang Hong-Qian Wang Cheng Zhang Xue He Shi-Min Liang De-Xiang Xu Xi Chen Source Type: research

Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients
CONCLUSION: Thus, elicitation of the hyperactive cytokine-mediated inflammatory response, dysregulation of CD8 T and NK cells, and deficiency of host myeloid and plasmacytoid DCs, may contribute to COVID-19 pathogenesis and provide insights into potential therapeutic targets and strategies.PMID:33951560 | PMC:PMC8052478 | DOI:10.1016/j.intimp.2021.107685 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Qigao Chen Baodan Yu Yihao Yang Jiewen Huang Ying Liang Jing Zhou Lianzhong Li Xuechun Peng Bolin Cheng Yongping Lin Source Type: research

COVID-19 vaccine hesitancy and related fears and anxiety
Int Immunopharmacol. 2021 Apr 27;97:107724. doi: 10.1016/j.intimp.2021.107724. Online ahead of print.ABSTRACTBACKGROUND: Vaccination is crucial to limit the pandemic spread of SARS-CoV-2/COVID-19. Therefore, besides the development and supply of vaccines, it is essential that sufficient individuals are willing to get vaccinated, but concerning proportions of populations worldwide show vaccine hesitancy. This makes it important to determine factors that are associated with vaccine acceptance.METHODS: 1779 adults of a non-probability convenience sample in Germany were assessed with an online survey in a cross-sectional surve...
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Antonia Bendau Jens Plag Moritz Bruno Petzold Andreas Str öhle Source Type: research

Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice
Int Immunopharmacol. 2021 May 2;97:107716. doi: 10.1016/j.intimp.2021.107716. Online ahead of print.ABSTRACTSeveral experiments confirmed that vitamin D3 protected against acetaminophen (APAP)-induced acute liver injury (ALI). This research aimed to evaluate the influence of vitamin D deficiency (VDD) on APAP-induced ALI. In VDD and VDD + APAP groups, mice were fed with VDD diet. In APAP and VDD + APAP groups, mice were intraperitoneally injected with a sublethal dose of APAP (150 mg/kg). A sublethal dose of APAP caused a slight elevation of ALT and AST. Interestingly, APAP-induced elevation of ALT and AST was aggravated i...
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Ya-Qi Wang Xiao-Pan Geng Ming-Wei Wang Hong-Qian Wang Cheng Zhang Xue He Shi-Min Liang De-Xiang Xu Xi Chen Source Type: research

Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients
CONCLUSION: Thus, elicitation of the hyperactive cytokine-mediated inflammatory response, dysregulation of CD8 T and NK cells, and deficiency of host myeloid and plasmacytoid DCs, may contribute to COVID-19 pathogenesis and provide insights into potential therapeutic targets and strategies.PMID:33951560 | DOI:10.1016/j.intimp.2021.107685 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 5, 2021 Category: Allergy & Immunology Authors: Qigao Chen Baodan Yu Yihao Yang Jiewen Huang Ying Liang Jing Zhou Lianzhong Li Xuechun Peng Bolin Cheng Yongping Lin Source Type: research

Aloperine improves osteoporosis in ovariectomized mice by inhibiting RANKL-induced NF- κB, ERK and JNK approaches
This study shows that aloperine can inhibit activity and formation of osteoclast mediated by RANKL in a dose-dependent manner without affecting the activity of bone marrow macrophages (BMM). In addition, it is found that aloperine can inhibit the expression of osteoclast specific marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), tartrate resistant acid phosphatase (TRAcP), matrix metallopeptidase 9 (MMP9), cathepsin K (Ctsk), V-ATPase d2 and calcitonin receptor. The in vitro experiment of aloperine proved that aloperine can inhibit the degradation of IκBα and the phosphorylatio...
Source: International Immunopharmacology - May 4, 2021 Category: Allergy & Immunology Authors: Rong Hu Libo Chen Xiaolong Chen Zhong Xie Chao Xia Yong Chen Source Type: research