Transcatheter arterial chemoembolisation combined with lenvatinib and cabozantinib in the treatment of advanced hepatocellular carcinoma
CONCLUSION: Transcatheter arterial chemoembolisation combined with lenvatinib and cabozantinib is safe and effective in the treatment of advanced uHCC, with controllable adverse reactions. High NLR and PLR and low BMI values before treatment were independent risk factors for the ORR. Body mass index, NLR and PLR predicted responses to triple switch therapy and survival outcomes in uHCC. Patients with pretreatment NLR ≥ 2.96 and PLR ≥ 184.41 had worse OS and PFS rates. Patients with pretreatment BMI ≥ 23 kg/m2 had improved OS and a reduced risk of death.PMID:38422766 | DOI:10.1016/j.intimp.2024.111510 (Source: Interna...
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Hong Liu Xue-Mei Gan Jian-Ming Sun Qin Yang Dai-Zhong Zhang Yong-Qing Zuo Feng-Ling Liu Bo Li Qi-Liang Tan Jun Zhang Source Type: research

miR-128-3p alleviates airway inflammation in asthma by targeting SIX1 to regulate mitochondrial fission and fusion
In this study, we aim to explore the mechanism of miR-128-3p in asthma-related airway inflammation by targeting sine oculis homeobox homolog 1 (SIX1) to regulate the mitochondrial function. In an ovalbumin (OVA) asthma mouse model, miR-128-3p levels were found to be significantly diminished. Administration of miR-128-3p agomir decreased peribronchial inflammatory cell infiltration and improved airway inflammation. Afterwards, we used the luciferase reporter assay to predict and confirmed that SIX1 is a target gene of miR-128-3p. Overexpression of miR-128-3p attenuated IL-13-induced cellular inflammation and ROS production ...
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Xiaohan Liu Hong Cui Qiaoyun Bai Hongmei Piao Yilan Song Guanghai Yan Source Type: research

The XPO1 inhibitor selinexor ameliorates bleomycin-induced pulmonary fibrosis in mice via GBP5/NLRP3 inflammasome signaling
Int Immunopharmacol. 2024 Feb 28;130:111734. doi: 10.1016/j.intimp.2024.111734. Online ahead of print.ABSTRACTPulmonary fibrosis is an irreversible and progressive lung disease with limited treatments available. Selinexor (Sel), an orally available, small-molecule, selective inhibitor of XPO1, exhibits notable antitumor, anti-inflammatory and antiviral activities. However, its potential role in treating pulmonary fibrosis is unknown. C57BL/6J mice were used to establish a pulmonary fibrosis model by intratracheal administration of bleomycin (BLM). Subsequently, Sel was administered intraperitoneally. Our data demonstrated ...
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Jia Zhang Yihua Zhang Qi Chen Yong Qi Xiaoju Zhang Source Type: research

Multi-centers experience using therapeutic plasma exchange for corticosteroid/tocilizumab-refractory cytokine release syndrome following CAR-T therapy
In conclusion, TPE may serve as a valuable and safe adjunct to corticosteroids and tocilizumab in the management of severe CRS resulting from CAR-T cell infusion. We eagerly await further prospective studies to validate this finding.PMID:38422769 | DOI:10.1016/j.intimp.2024.111761 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Yedi Pu Yifan Zhao Yuekun Qi Yang Liu Meng Zhang Xia Xiao Hairong Lyu Juanxia Meng Haibo Zhu Kailin Xu Weidong Han Mingfeng Zhao Source Type: research

Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms
In conclusion, Pleurocidin alleviates UC symptoms in mice, and its effects on the gut microbiome may be potential pathways. It is providing a promising therapeutic option for UC.PMID:38422770 | DOI:10.1016/j.intimp.2024.111757 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Keyi Nong Zhineng Liu Xinyun Qin Wanyan Chen Bin Zhang Yijia Wu Zihan Wang Xin Fang Youming Liu Xuemei Wang Huiyu Shi Haiwen Zhang Source Type: research

Asiatic acid prevents glucocorticoid-induced femoral head osteonecrosis via PI3K/AKT pathway
Int Immunopharmacol. 2024 Feb 28;130:111758. doi: 10.1016/j.intimp.2024.111758. Online ahead of print.ABSTRACTGlucocorticoid-induced osteonecrosis of the femoral head (GIONFH) represents a predominant etiology of non-traumatic osteonecrosis, imposing substantial pain, restricting hip mobility, and diminishing overall quality of life for affected individuals. Centella asiatica (L.) Urb. (CA), an herbal remedy deeply rooted in traditional oriental medicine, has exhibited noteworthy therapeutic efficacy in addressing inflammation and facilitating wound healing. Drawing from CA's historical applications, its anti-inflammatory,...
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Chihao Lin Hongyi Jiang Chao Lou Weidan Wang Tingwen Cai Zhongnan Lin Liting Jiang Shida Lin Xinghe Xue Xiaoyun Pan Source Type: research

Fragility index analysis for randomized controlled trials of approved biologicals and small molecule drugs in inflammatory bowel diseases
CONCLUSION: Results from trials assessing administration-approved biologics or small molecules for treating CD or UC were vulnerable to small changes by measuring FI or FQ. Pivotal studies contributing to regulatory approvals exhibited a relatively higher degree of resilience compared to non-pivotal trials.PMID:38422772 | DOI:10.1016/j.intimp.2024.111752 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 29, 2024 Category: Allergy & Immunology Authors: Xiaoyin Bai Ziqi Wan Yi Li Qingwei Jiang Xia Wu Bing Xu Xiang Li Runing Zhou Jiarui Mi Yinghao Sun Gechong Ruan Wei Han Guanqiao Li Hong Yang Source Type: research

Efficacy of anti-interleukin-17A biological agents for palmoplantar psoriasis and palmoplantar pustulosis: A network meta-analysis
CONCLUSION: IL-17A biological agents had better PP disease clearance compared with placebo and on-label secukinumab was identified as the most effective treatment option for PP patients. Secukinumab 300 mg showed benefit for PPP patients.PMID:38417367 | DOI:10.1016/j.intimp.2024.111716 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 28, 2024 Category: Allergy & Immunology Authors: RuiYuan Xia ZiYue Diao DanDan Chen YuFei Wang ChaoJing Zhou YaMei Gao ZhiQiang Yin Source Type: research

Diannexin alleviates myocardial ischemia-reperfusion injury by orchestrating cardiomyocyte oxidative damage, macrophage polarization and fibrotic process by TLR4-NF-kB-mediated inactivation of NLRP3 inflammasome
Int Immunopharmacol. 2024 Feb 27;130:111668. doi: 10.1016/j.intimp.2024.111668. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury is a pathogenic mechanism of myocardial infarction and heart failure, constituting a major health concern globally. Diannexin is a homodimer of recombinant human annexin V and elicits important roles in several I/R injuries. Nevertheless, its function in MI/R remains elusive. Here, Diannexin alleviated simulated I/R (SI/R)-induced cardiomyocyte death and oxidative injury by increasing cell viability and inhibiting cell apoptosis, ROS, lactate dehydrogenase, malondialdehy...
Source: International Immunopharmacology - February 28, 2024 Category: Allergy & Immunology Authors: Lin Zhang Songlin Zhao Yaqi Wang Source Type: research

Efficacy of anti-interleukin-17A biological agents for palmoplantar psoriasis and palmoplantar pustulosis: A network meta-analysis
CONCLUSION: IL-17A biological agents had better PP disease clearance compared with placebo and on-label secukinumab was identified as the most effective treatment option for PP patients. Secukinumab 300 mg showed benefit for PPP patients.PMID:38417367 | DOI:10.1016/j.intimp.2024.111716 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 28, 2024 Category: Allergy & Immunology Authors: RuiYuan Xia ZiYue Diao DanDan Chen YuFei Wang ChaoJing Zhou YaMei Gao ZhiQiang Yin Source Type: research

Diannexin alleviates myocardial ischemia-reperfusion injury by orchestrating cardiomyocyte oxidative damage, macrophage polarization and fibrotic process by TLR4-NF-kB-mediated inactivation of NLRP3 inflammasome
Int Immunopharmacol. 2024 Feb 27;130:111668. doi: 10.1016/j.intimp.2024.111668. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury is a pathogenic mechanism of myocardial infarction and heart failure, constituting a major health concern globally. Diannexin is a homodimer of recombinant human annexin V and elicits important roles in several I/R injuries. Nevertheless, its function in MI/R remains elusive. Here, Diannexin alleviated simulated I/R (SI/R)-induced cardiomyocyte death and oxidative injury by increasing cell viability and inhibiting cell apoptosis, ROS, lactate dehydrogenase, malondialdehy...
Source: International Immunopharmacology - February 28, 2024 Category: Allergy & Immunology Authors: Lin Zhang Songlin Zhao Yaqi Wang Source Type: research

Combined metabolomic and proteomic analysis of sepsis related acute liver injury and its pathogenesis research
CONCLUSIONS: Our study suggests that the differential protein Epb42 may be key proteins causing sepsis-associated acute liver injury, providing new and valuable information on the possible mechanism of sepsis-associated acute liver injury.PMID:38412671 | DOI:10.1016/j.intimp.2024.111666 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2024 Category: Allergy & Immunology Authors: Jin Zhang Xibo Wang Yahui Peng Jieling Wei Yinghao Luo Feiyu Luan Hongxu Li Yang Zhou Changsong Wang Kaijiang Yu Source Type: research

Prognostic implication of UBE2C  + CD8 + T cell in neoadjuvant immune checkpoint blockade plus chemotherapy for locally advanced esophageal cancer
CONCLUSIONS: Neoadjuvant ICBs plus chemotherapy shows promising efficacy in locally advanced EC, with MPR being a significant predictor of lower recurrence risk. Immunological analyses identified UBE2C + CD8 + T cells as adverse prognostic factors, suggesting their potential as biomarkers for patient stratification and treatment response.PMID:38412672 | DOI:10.1016/j.intimp.2024.111696 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2024 Category: Allergy & Immunology Authors: Qiuming Chen Shaocong Mo Linhai Zhu Muhu Tang Jun Cheng Peng Ye Wanwei Zheng Jian Hu Source Type: research

G-CSF improving combined whole brain radiotherapy and immunotherapy prognosis of non-small cell lung cancer brain metastases
CONCLUSION: Integrating G-CSF with WBRT and immunotherapy as a first-line treatment for NSCLC-BMs has exhibited significant efficacy and favorable tolerability.PMID:38412673 | DOI:10.1016/j.intimp.2024.111705 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2024 Category: Allergy & Immunology Authors: Shilan Luo Peng Li Anqi Zhang Lu Meng Litang Huang Xiaoting Wu Hongxia Cheng Hongbin Tu Xiaomei Gong Source Type: research

Performance of assessment tools in predicting neural autoantibody positivity in patients with seizures
CONCLUSIONS: The ONES checklist demonstrates superior sensitivity for neural antibody positivity than APE2 score. Specificity of the two assessment tools was similar. ONES checklist performed better NPV than the APE2 score. Both assessment tools performed less well in predicting the presence of LGI1- Abs when compared to NMDAR-Abs.PMID:38412674 | DOI:10.1016/j.intimp.2024.111763 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2024 Category: Allergy & Immunology Authors: Wei Peng Minjin Wang Wenyan Shi Jierui Wang Dong Zhou Jinmei Li Source Type: research