Leishmanial CpG DNA nanovesicles: A propitious prophylactic approach against visceral leishmaniasis.
Abstract Unmethylated CpG motifs with phosphothioate backbone trigger TLR9 to elicit innate immune response characterized by the production of Th1 cytokines. The use of CpG DNA as an adjuvant has established its role in potentiating the humoral and cell mediated vaccine specific immune response. However, none of the synthetic oligodeoxynucleotides (ODNs) know and used till date are associated with the parasite itself. Our group identified a novel CG rich sequence of 14 base pairs from Leishmania donovani genome (Ld CpG ODN) and established it as a TLR9 agonist. The present study was designed to ascertain the adjuv...
Source: International Immunopharmacology - November 25, 2020 Category: Allergy & Immunology Authors: Tiwari RK, Chandrakar P, Gupta CL, Sayyed U, Shekh R, Bajpai P Tags: Int Immunopharmacol Source Type: research

Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis.
Abstract Sophoricoside (SOP), an isoflavone glycoside isolated from seed of Sophora japonica L., has been reported to have various pharmacological activities, including anti-cancer, anti-allergy and anti-inflammation. However, the effect of SOP on lipopolysaccharides (LPS)-acute lung injury (ALI) is completely unclear. Here, we found that SOP pretreatment significantly ameliorated LPS-induced pathological damage, tissue permeability, neutrophil infiltration and the production of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in a murine model of ALI. Besides, SOP reduced the production of pro-inflam...
Source: International Immunopharmacology - November 25, 2020 Category: Allergy & Immunology Authors: Wu YX, Zeng S, Wan BB, Wang YY, Sun HX, Liu G, Gao ZQ, Chen D, Chen YQ, Lu MD, Pang QF Tags: Int Immunopharmacol Source Type: research

Autoantigen-specific immune tolerance in pathological and physiological cell death: Nanotechnology comes into view.
Abstract Apoptotic cells are tolerogenic and can present self-antigens in the absence of inflammation, to antigen-presenting cells by the process of efferocytosis, resulting in anergy and depletion of immune effector cells. This tolerance is essential to maintain immune homeostasis and prevent systemic autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Consequently, effective efferocytosis can result in the induction of immune tolerance mediated via triggering modulatory lymphocytes and anti-inflammatory responses. Furthermore, several distinct soluble factors, receptors and pathwa...
Source: International Immunopharmacology - November 25, 2020 Category: Allergy & Immunology Authors: Tajbakhsh A, Farahani N, Gheibihayat SM, Mirkhabbaz AM, Savardashtaki A, Hamblin MR, Mirzaei H Tags: Int Immunopharmacol Source Type: research

CAR T-cells profiling in carcinogenesis and tumorigenesis: An overview of CAR T-cells cancer therapy.
Abstract Immunotherapy of cancer by chimeric antigen receptors (CAR) modified T-cell has a remarkable clinical potential for malignancies. Meaningly, it is a suitable cancer therapy to treat different solid tumors. CAR is a special recombinant protein combination with an antibody targeting structure alongside with signaling domain capacity on order to activate T cells. It is confirmed that the CAR-modified T cells have this ability to terminate and remove B cell malignancies. So, methodologies for investigations the pro risks and also strategies for neutralizing possible off-tumor consequences of are great importa...
Source: International Immunopharmacology - November 25, 2020 Category: Allergy & Immunology Authors: Samadani AA, Keymoradzdeh A, Shams S, Soleymanpour A, Rashidy-Pour A, Hashemian H, Vahidi S, Norollahi SE Tags: Int Immunopharmacol Source Type: research

Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line.
Abstract Macrophages are the most abundant tumor-infiltrating immune cells. Macrophages are conventionally classified as M1 or M2 types. M2 type is the dominant phenotype of macrophages in the tumor microenvironment. M2 macrophages support different aspects of tumor development, including tumor formation, growth, and metastasis. MicroRNAs (miRNAs) have been demonstrated to regulate numerous cellular processes, including macrophage polarization. To determine whether miR-33 containing exosomes can alter macrophage polarization, we used the exosomes isolated from 4T1 breast cancer cells to deliver miR-33 mimic into I...
Source: International Immunopharmacology - November 25, 2020 Category: Allergy & Immunology Authors: Moradi-Chaleshtori M, Bandehpour M, Heidari N, Mohammadi-Yeganeh S, Mahmoud Hashemi S Tags: Int Immunopharmacol Source Type: research

Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears.
Abstract Hypertrophic scar (HS) is a dermal fibroproliferative disease that often occurs following abnormal wound healing. To date, there is no satisfied treatment strategies for improvement of scar formation with few side effects. The effects of gambogenic acid (GNA) on scar hypertrophy has not been studied previously. The present study was undertaken to find out the scar-reducing effects of GNA (0.48, 0.96 or 1.92 mg/ml) on skin wounds in rabbit ears. Scar evaluation index (SEI), collagen I (Col1) and collagen III (Col3), microvascular density (MVD), CD4+T cells and macrophages, vascular endothelial growth ...
Source: International Immunopharmacology - November 24, 2020 Category: Allergy & Immunology Authors: Jun-Zeng, Huang TY, Wang ZZ, Gong YF, Liu XC, Zhang XM, Huang XY Tags: Int Immunopharmacol Source Type: research

Physcion 8-O- β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression. Int Immunopharmacol. 2020 Nov 24;:107206 Authors: Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z Abstract Physcion 8-O-β-glucopyranoside (PSG), an anthraquinone extracted from Rumex japonicus Houtt, has various pharmacological effects, however, the effect of PSG on liver fibrosis and its related mechanism remain to be determined. We here showed that PSG ameliorated liver injury and liver fibrosis, decreased collagen deposition a...
Source: International Immunopharmacology - November 24, 2020 Category: Allergy & Immunology Authors: Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z Tags: Int Immunopharmacol Source Type: research

Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity.
Abstract Microvascular complications of diabetes mellitus are progressively significant reasons for mortality. Metformin (MET) is considered as the first-line therapy for type 2 diabetes patients, and may be especially beneficial in cases of diabetic retinopathy although the precise mechanisms of MET action are not fully elucidated. The current study was designed to inspect the antioxidant and modulatory actions of MET on DRET in streptozotocin-induced diabetic rats. The effect of MET on the toll-like receptor 4/nuclear factor kappa B (TLR4/NFkB), inflammatory burden and glutamate excitotoxicity was assessed. Twen...
Source: International Immunopharmacology - November 24, 2020 Category: Allergy & Immunology Authors: Alomar SY, M Barakat B, Eldosoky M, Atef H, Mohamed AS, Elhawary R, El-Shafey M, Youssef AM, Elkazaz AY, Gabr AM, Elaskary AA, Salih MAK, Alolayan SO, Zaitone SA Tags: Int Immunopharmacol Source Type: research

Do novel treatment strategies enhance T cell-mediated Immunity: Opportunities and challenges in pancreatic cancer immunotherapy.
Abstract Although immunotherapy is successful when included as component of treatment strategies for advanced cancers, data are insufficient for evaluating its efficacy for treating patients with pancreatic cancer (PC). PC is remarkably resistant to current immunotherapies because of its strongly immunosuppressive tumor microenvironment comprising immunosuppressive cells such as myeloid-derived suppressor cells and regulatory T cells, which limit the efficacy of T cell infiltration. Thus, the ability to achieve robust and durable intrinsic T cell efficacy may represent the key for improving patients' outcomes. Rec...
Source: International Immunopharmacology - November 24, 2020 Category: Allergy & Immunology Authors: Luo W, Zheng L, Zhang T Tags: Int Immunopharmacol Source Type: research

A novel target anti-interleukin-13 receptor subunit alpha-2 monoclonal antibody inhibits tumor growth and metastasis in lung cancer.
Abstract IL13Rα2 shows high expression in different types of tumors and can be a target for cancer therapy in humans due to its poor prognosis. The aim of our study is to characterize and investigate the effect of interleukin-13 receptor subunit alpha-2monoclonal antibody mAb15D8 on lung cancer cells in vitro and in vivo by blocking its specific epitope in IL13Rα2 antigen. The mAb15D8 blocking epitope was analyzed through the mutagenesis of IL13Rα2 and confirmed with western blot. We found that the IL13Rα2 epitope recognized by mAb15D8 antibody is a new binding site localized in the fibrone...
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Raza G, Yunus FU, Mangukiya HB, Merugu SB, Mashausi DS, Zeling W, Negi H, Zhou B, Roy D, Wu Z, Li D Tags: Int Immunopharmacol Source Type: research

The role of the cholinergic anti-inflammatory pathway in septic cardiomyopathy.
Abstract Septic cardiomyopathy (SCM)is common in septic patients and results in cardiovascular failure. The pathogenesis of SCM is complicated, and patients with SCM have high mortality because current treatment methods are limited. The cholinergic anti-inflammatory pathway (CAP) modulates inflammatory responses through vagus nerve stimulation that leads to the release of acetylcholine (ACh), which binds to the alpha7 nicotinic acetylcholine receptor (α7nAChR). Moreover, α7nAChR activation by its agonists at the tissue level inhibits inflammatory mediators and regulates the function of immune cells in ...
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Wang W, Xu H, Lin H, Molnar M, Ren H Tags: Int Immunopharmacol Source Type: research

A novel prognostic model based on immunogenomics for clear cell renal cell carcinoma.
CONCLUSIONS: These findings may contribute to the research of ccRCC in immunization part. PMID: 33243605 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Wu Z, Shen Y, Fan D, Liu J, Chen D, Wang K, Xu X Tags: Int Immunopharmacol Source Type: research

Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway.
Abstract Roflupram (ROF) is a novel phosphodiesterase 4 inhibitor. We previously found that ROF suppressed the production of pro-inflammatory factors in microglial cells; however, the underlying mechanisms are largely unknown. The present study aimed to elucidate the underlying molecular mechanisms of the anti-neuroinflammatory effects of ROF in lipopolysaccharide (LPS)-activated microglial cells and LPS-challenged mice. Treatment with ROF suppressed LPS-induced expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in BV-2 microglia cell line. Immunofluorescence and Western blotting analysis sho...
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Li D, Xu J, Qin Y, Cai N, Cheng Y, Wang H Tags: Int Immunopharmacol Source Type: research

Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
Abstract Psoriasis is not only a chronic inflammatory skin disease but also a psychosomatic disorder. Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients. Clinical experiments establish a correlation between psoriasis and depression; however, the mechanisms yet unclear because only a few related studies are available. Therefore, to investigate whether imiquimod-induced psoriasis-like mice showed depressive-like behavior, 5% imiquimod cream was smeared on the back of mice to induce psoriasis-like skin lesions for 8 days. Con...
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Guo J, Liu Y, Guo X, Meng Y, Qi C, Zhao J, Di T, Zhang L, Guo X, Wang Y, Wang Y, Li P Tags: Int Immunopharmacol Source Type: research

Ameliorative effects of alginate oligosaccharide on tumour necrosis factor- α-induced intestinal epithelial cell injury.
Ameliorative effects of alginate oligosaccharide on tumour necrosis factor-α-induced intestinal epithelial cell injury. Int Immunopharmacol. 2020 Nov 23;89(Pt B):107084 Authors: Wan J, Zhang J, Yin H, Chen D, Yu B, He J Abstract Alginate oligosaccharide (AOS), produced by the depolymerisation of alginate (a polysaccharide naturally present in certain species of brown algae), has been shown to have versatile biological functions. In the present study, the porcine small intestinal epithelial cell line IPEC-J2 was used to assess the ameliorative effects of AOS on tumour necrosis factor-α (TNF...
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Wan J, Zhang J, Yin H, Chen D, Yu B, He J Tags: Int Immunopharmacol Source Type: research

Anti-tumour effect of the fourth-generation chimeric antigen receptor T cells targeting CD133 against cholangiocarcinoma cells.
This study may guide future in vivo study and clinical trials. PMID: 33242709 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Sangsuwannukul T, Supimon K, Sujjitjoon J, Phanthaphol N, Chieochansin T, Poungvarin N, Wongkham S, Junking M, Yenchitsomanus PT Tags: Int Immunopharmacol Source Type: research

Value of C-reactive protein/albumin ratio in predicting intravenous immunoglobulin-resistant Kawasaki disease- a data from multi-institutional study in China.
Abstract BACKGROUND: C-reactive protein/albumin ratio (CAR) is associated with inflammation. However, it prognostic value for intravenous immunoglobulin (IVIG) resistant Kawasaki disease (KD) has scarcely investigated. METHODS: A total of 957 patients with KD including 159 IVIG-resistant patients and 798 with IVIG-responsive patients between Jun 2013 and August 2019 were reviewed and the laboratory records were compared between IVIG-resistant patients and IVIG-responsive patients. Univariate and multivariate logistic analysis were performed to determine the independent predictors of IVIG resistance. A receive...
Source: International Immunopharmacology - November 23, 2020 Category: Allergy & Immunology Authors: Li G, Wang T, Gou Y, Zeng R, Liu D, Duan Y, Liu B Tags: Int Immunopharmacol Source Type: research

NLR, d-NLR and PLR can be affected by many factors.
Abstract We have read the article by Yang et al, entitled "The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients" with great interest. The authors emphasized that the NLR (Neutrophil to lymphocyte ratio) is an independent prognostic biomarker for COVID-19 patients. First of all, we congratulate the authors for their valuable contribution to the literature in these difficult conditions. However, we would like to add on a few cases that need more attention. PMID: 33234416 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 21, 2020 Category: Allergy & Immunology Authors: Bedel C, Korkut M, Armağan HH Tags: Int Immunopharmacol Source Type: research

Anti-pulmonary metastases from cervical cancer responses induced by a human papillomavirus peptide vaccine adjuvanted with CpG-oligodeoxynucleotides in vivo.
In this study, we investigated the anti-metastases responses induced by this vaccine using a murine model of pulmonary metastases from cervical cancer. The results showed that subcutaneous administration of the vaccine inhibited the growth of pulmonary metastases, which may be attributed to the increased infiltration of CD4 + and CD8 + T cells, and decreased number of immunosuppressive cells (including myeloid-derived suppressive cells and tumor-associated macrophages) in the lungs. Meanwhile, the alteration in a panel of cytokines, chemokines, and matrix metalloproteinases induced by the vaccination ma...
Source: International Immunopharmacology - November 21, 2020 Category: Allergy & Immunology Authors: Suo J, Yang Y, Che Y, Chen C, Lv X, Wang X Tags: Int Immunopharmacol Source Type: research

Emerging role of Fli1 in autoimmune diseases.
Abstract The Ets transcription factor family exerts crucial role in cell proliferation, apoptosis, differentiation and migration. Friend leukemia integration 1 (Fli1), a member of the Ets family, is expressed in fibroblasts, endothelial cells and immune cells. Fli1 gene is participated in the development, proliferation, activation, migration and other processes of immune cells. Fli1 can also affect the function of immune cells by regulating cytokines and chemokines. Emerging evidence has shown that Fli1 is implicated in the etiology of several autoimmune diseases, including systemic sclerosis (SSc) and systemic lu...
Source: International Immunopharmacology - November 21, 2020 Category: Allergy & Immunology Authors: He YS, Yang XK, Hu YQ, Xiang K, Pan HF Tags: Int Immunopharmacol Source Type: research

Bacteroides thetaiotaomicron relieves colon inflammation by activating aryl hydrocarbon receptor and modulating CD4+T cell homeostasis.
Abstract Inflammatory bowel disease (IBD) is a form of nonspecific chronic intestinal inflammation associated with gut microbiome dysbiosis. Modulating the composition of the intestinal flora may be a viable means of alleviating such inflammatory pathology. Bacteroides thetaiotaomicron (B. thetaiotaomicron) is a symbiotic intestinal microbe that has been associated with IBD, although the mechanistic basis for this association remains to be clarified. In this present study, we determined that B. thetaiotaomicron can alleviate colonic inflammation through mechanisms associated with the modulation of tryptophan metab...
Source: International Immunopharmacology - November 20, 2020 Category: Allergy & Immunology Authors: Li K, Hao Z, Du J, Gao Y, Yang S, Zhou Y Tags: Int Immunopharmacol Source Type: research

LncRNA MIAT correlates with immune infiltrates and drug reactions in hepatocellular carcinoma.
This study made a meaningful attempt to reveal the immune escape mechanism and to find the effectiveness of targeted drugs in patients with HCC. PMID: 33221703 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 19, 2020 Category: Allergy & Immunology Authors: Peng L, Chen Y, Ou Q, Wang X, Tang N Tags: Int Immunopharmacol Source Type: research

Shionone alleviates NLRP3 inflammasome mediated pyroptosis in interstitial cystitis injury.
In this study, we established an interstitial cystitis (IC) rat model and SV-HUC-1 cell model with CYP or LPS + ATP treatment to mimic inflammation response and induce NLRP3 inflammasome activation. Shionone treatment significantly attenuated the bladder wet weight, score of edema and hemorrhage, enhanced the viability of SV-HUC-1 cell, decreased the rate of pyroptosis. Moreover, Shionone reduced the expression of NF-κB, NLRP3, ASC, Pro-caspase-1, Caspase-1, GSDMD, GSDMD-N at the mRNA and protein levels both in rat and SV-HUC-1 cell model, demonstrating NLRP3 inflammasome pathway was blocked and pyroptosis ...
Source: International Immunopharmacology - November 19, 2020 Category: Allergy & Immunology Authors: Wang X, Yin H, Fan L, Zhou Y, Tang X, Fei X, Tang H, Peng J, Zhang J, Xue Y, Luo J, Jin Q, Jin Q Tags: Int Immunopharmacol Source Type: research

PD-1 in Tregs predicts the survival in sepsis patients using sepsis-3 criteria: A prospective, two-stage study.
CONCLUSION: PD-1 overexpression in Tregs was associated with poor outcomes, and PD-1 in Tregs is considered to be a valuable tool for the prediction of prognosis in septic patients using sepsis-3.0 criteria. PMID: 33223466 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 19, 2020 Category: Allergy & Immunology Authors: Jiang W, Li X, Ding H, Wang K, Liu X, Wang Q, Li Y, Zhou M, Chen S, Zhong W, Li X, Zeng H Tags: Int Immunopharmacol Source Type: research

Tricarbonyldichlororuthenium(II) dimer, the lipid-soluble carbon monoxide-releasing molecule, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1 β in murine macrophages.
In conclusion, CORM-2 suppresses NO and IL-1β production caused by P. intermedia LPS. CORM-2 exerts its effect by a mechanism involving anti-inflammatory HO-1 induction and attenuation of NF-κB and STAT1/3 activation, independently of PPAR-γ as well as JNK and p38. CORM-2 may hold promise as host response modulation agent for periodontal disease, though further research is indicated to verify the therapeutic effect. PMID: 33223468 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 19, 2020 Category: Allergy & Immunology Authors: Choi EY, Keum BR, Choe SH, Hyeon JY, Choi IS, Kim SJ Tags: Int Immunopharmacol Source Type: research

Regulation and characterization of tumor-infiltrating immune cells in breast cancer.
Abstract The effect of immunosuppression blockade therapies depends on the infiltration of effector T cells and other immune cells in tumor. However, it is unclear how molecular pathways regulate the infiltration of immune cells, as well as how interactions between tumor-infiltrating immune cells and T cell activation affect breast cancer patient survival. CIBERSORT was used to estimate the relative abundance of 22 immune cell types. The association between mRNAs and immune cell abundance were assessed by Spearman correlation analysis. Enriched pathways were identified using MetaCore pathway analysis. The interact...
Source: International Immunopharmacology - November 19, 2020 Category: Allergy & Immunology Authors: Dai Q, Wu W, Amei A, Yan X, Lu L, Wang Z Tags: Int Immunopharmacol Source Type: research

Hepatocyte growth factor mediates a novel form of hepatic stem/progenitor cell-induced tolerance in a rat xenogeneic liver rejection model.
Abstract We have previously identified novel neural/glial antigen 2-expressing hepatic stem/progenitor cells (NG2+ HSPs) that are beneficial for tissue repair by inhibiting the immune cell response. In this in vivo study, we investigated the use of hepatocyte growth factor (HGF)-secreting NG2+ HSPs as a tolerogen in the well-established Syrian golden hamster (SGH) to Lewis (LEW) xenogeneic rat acute liver rejection (ARJ) model. Liver and blood cells were collected for histology and functional analyses using immunofluorescence staining, western blot, ELISA, and TUNEL assays. All recipient rats were randomly divided...
Source: International Immunopharmacology - November 18, 2020 Category: Allergy & Immunology Authors: Chen Q, You Y, Zhang Y, Zhang H, Bai L Tags: Int Immunopharmacol Source Type: research

Anti-allergic effects of vitamin E in allergic diseases: An updated review.
Abstract Allergic diseases are caused by the immune system's response to innocent antigens called allergens. Recent decades have seen a significant increase in the prevalence of allergic diseases worldwide, which has imposed various socio-economic effects in different countries. Various factors, including genetic factors, industrialization, improved hygiene, and climate change contribute to the development of allergic diseases in many parts of the world. Moreover, changes in lifestyle and diet habits play pivotal roles in the prevalence of allergic diseases. Dietary changes caused by decreased intake of antioxidan...
Source: International Immunopharmacology - November 18, 2020 Category: Allergy & Immunology Authors: Shams MH, Jafari R, Eskandari N, Masjedi M, Kheirandish F, Ganjalikhani Hakemi M, Ghasemi R, Varzi AM, Sohrabi SM, Baharvand PA, Safari M Tags: Int Immunopharmacol Source Type: research

In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate.
Abstract The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-o...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Wang Y, Zhang J, Gao X, Li Q, Sun D Tags: Int Immunopharmacol Source Type: research

AHNAK2 is a novel prognostic marker and correlates with immune infiltration in papillary thyroid cancer: Evidence from integrated analysis.
In this study, we identified AHNAK2 as a key gene in PTC by differential expression analysis among four GEO datasets and validated its overexpression profile by data from the Oncomine, TCGA, and HPA databases and IHC staining analysis. AHNAK2 upregulation significantly correlated with advanced grades, stages, and lymph node events. Survival analysis suggested that AHNAK2 overexpression was coupled with poor overall survival. The immune infiltration analysis by TIMER and CIBERSORT indicated that AHNAK2 expression tightly correlated with the infiltration of diverse immune cell types, especially T cell subtypes. In addition, ...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Zheng L, Li S, Zheng X, Guo R, Qu W Tags: Int Immunopharmacol Source Type: research

A nomogram to predict short-term outcome of radiotherapy or chemoradiotherapy based on pre/post-treatment inflammatory biomarkers and their dynamic changes in esophageal squamous cell carcinoma.
Abstract OBJECTIVE: We initially aimed to investigate pre/post-treatment inflammatory biomarkers (pre/post-IBs) and their dynamic changes (delta-IBs) on the short-term outcome (STO) of radiotherapy or chemoradiotherapy in esophageal squamous cell carcinoma (ESCC). Furthermore, a nomogram was built to provide an accurate prediction of STO. METHODS: The STO using the treatment response evaluation was assessed according to RECIST 1.1 at 1 month after radiotherapy or chemoradiotherapy. The IBs (absolute lymphocyte counts (ALC), neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), and lymphocyte/monocyte (...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Liang S, Li C, Gao Z, Li J, Zhao H, Yu J, Meng X Tags: Int Immunopharmacol Source Type: research

Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro.
In this study, the anti-inflammatory effect of IMP was explored in oxidized low-density lipoprotein (ox-LDL)-induced VSMCs and high fat diet (HFD)-induced ApoE-/- mice. The results showed that IMP attenuated the elevation of TNF-α, IL-6, MCP-1 and NO induced by ox-LDL in supernatant of VSMCs. IMP has normalized the levels of serum lipids (TC, TG, LDL-C and HDL-C) and attenuated inflammatory cytokines in serum. IMP also improved pathological changes and lipid accumulation in aorta. Matrix metalloproteinase-2 (MMP-2) expression in aorta was down-regulated by IMP. IMP could inhibit the phosphorylation of MAPKs pathway i...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Li W, Yu J, Xiao X, Zang L, Yang Y, Yu J, Huang Q, Niu X, Li W Tags: Int Immunopharmacol Source Type: research

Long non-coding RNA SNHG1 regulates rheumatoid synovial invasion and proliferation by interaction with PTBP1.
Abstract Fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) present proliferative and aggressive cell phenotype. RA-FLSs are the essential effector cells that lead to symptoms like synovial inflammation and joint destruction. Currently, the cause of RA-FLSs involving in the pathological process of RA remains unknown. Accumulate researches have demonstrated that lncRNAs may play a critical role in regulating the biological behaviors of RA-FLSs, but the mechanism is still unclear. Here, we found that lncRNA small nucleolar RNA host gene 1 (SNHG1) is up-regulated in RA-FLSs compared with FLSs from traum...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Liu F, Feng XX, Zhu SL, Lin L, Huang HY, Zhang BY, Huang JL Tags: Int Immunopharmacol Source Type: research

Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Abstract PURPOSE: To investigate the protective effect and mechanism of rebamipide on NSAIDs associated intestinal injury. METHODS: Intestinal injury was induced in Sprague Dawley rats by intragastric administration of diclofenac with rebamipide intervention, and LPS and TAK-242 were given intraperitoneally respectively. The expression of TLR4/NF-κB and the related proteins in the intestinal mucosa were detected. 55 patients taking NSAIDs and diagnosed as NSAIDs associated small intestinal injury were recruited as NSAIDs group. Another 55 patients without NSAIDs and no obvious abnormality in the small b...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Xu N, Zhang C, Jing L, Mou S, Cao X, Yu Z Tags: Int Immunopharmacol Source Type: research

Riparin II potentials the effect of ephedrine on inflammation and remodelling in the airway of rats suffering from asthma by regulating transforming growth factor- β/Smad3 signalling pathway.
In conclusion, riparin II treatment alone and in combination with ephedrine ameliorated the hyperresponsiveness of lung tissue due to reductions in airway remodelling and inflammation in asthmatic rats. PMID: 33218943 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Wang Q, Cui Y, Wu X, Wang J Tags: Int Immunopharmacol Source Type: research

Orientin relieves lipopolysaccharide-induced acute lung injury in mice: The involvement of its anti-inflammatory and anti-oxidant properties.
Abstract Oxidative stress and inflammatory responses are nearly involved in the pathogenesis of various diseases, including acute lung injury (ALI). Orientin (Ori), a flavonoid component extracted from natural plants, displayed anti-inflammatory and antioxidant properties in our previous studies. In the current study, we aimed to investigate the amelioration effect of Ori on lipopolysaccharide (LPS)-induced ALI, and we further explored the potential molecular mechanisms. The present results indicated that Ori effectively alleviated LPS-induced ALI by improving the histological changes of lung; decreasing the lung ...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Xiao Q, Cui Y, Zhao Y, Liu L, Wang H, Yang L Tags: Int Immunopharmacol Source Type: research

Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice.
This study aims to elucidate the effects of salidroside on diabetes-induced liver inflammation. The levels of glucose, inflammatory cytokines and hepatic functional parameters in serum and liver of type 2 diabetic db/db mice were examined. Immunohistochemistry, immunofluorescence and western blot tests were performed to determine the mechanisms underlying the action. Palmitic acid (PA) or HMGB1-stimulated was adopted as an in vitro cell model. Salidroside treatment improved glucose tolerance, lipid profiles while decreased the production of inflammatory cytokines. It also reduced the levels of serum biochemical markers. In...
Source: International Immunopharmacology - November 17, 2020 Category: Allergy & Immunology Authors: Yang L, Zhou L, Wang X, Wang W, Wang J Tags: Int Immunopharmacol Source Type: research

Gene and systemic inflammatory effects and neuroendocrine response in surgical patients anesthetized with desflurane-nitrous oxide or desflurane-nitrous oxide-free: A randomized trial.
In conclusion, N2O does not impair the inflammatory profile and neuroendocrine response compared to patients who receive only desflurane anesthesia. PMID: 33214094 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 16, 2020 Category: Allergy & Immunology Authors: Arruda NM, Braz LG, Nogueira FR, Souza KM, Aun AG, de Carvalho LR, Braz JRC, Braz MG Tags: Int Immunopharmacol Source Type: research

Exenatide inhibits necrosis by enhancing angiogenesis and ameliorating ischemia/reperfusion injury in a random skin flap rat model.
CONCLUSIONS: Exenatide potentially inhibits necrosis in our rat random skin flap model. PMID: 33214096 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 16, 2020 Category: Allergy & Immunology Authors: He JB, Ma XY, Li WJ, Liu YY, Lin DS Tags: Int Immunopharmacol Source Type: research

Sex specific effect of alcohol on hepatic plasmacytoid dendritic cells.
Abstract Alcoholic liver disease includes a spectrum of clinical and histological entities. They result from the combined direct effect of alcohol and its metabolites on immune cells and resident tissue cells. In humans and mice, females are more susceptible to alcoholic liver injury than males. Despite being involved in sex specific differences of immune mediated tissue injury, plasmacytoid dendritic cells (pDCs) have not been thoroughly assessed as a cellular target of alcohol in humans or mice. Therefore, Meadows-Cook diet was used to study alcohol effect on hepatic dendritic cells. Alcohol consumption for 12&n...
Source: International Immunopharmacology - November 14, 2020 Category: Allergy & Immunology Authors: Alharshawi K, Fey H, Vogle A, Klenk T, Kim M, Aloman C Tags: Int Immunopharmacol Source Type: research

Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
This study inspected the role of ROS in the cyclic stretch-induced inflammatory reaction in HPDLCs and studied the inhibitory effect of antioxidant apocynin on this inflammatory reaction. Results confirmed that cyclic stretch induced inflammatory reaction and production of ROS in HPDLCs. This inflammatory reaction was inhibited by apocynin through blocking the production of ROS. The cyclic stretch also induced the expression of caspase-1 and NLRP3 inflammasome, which could also be inhibited by apocynin. Moreover, the cyclic stretch-induced inflammatory reaction was inhibited by caspase-1 inhibitor. Collectively, it is the ...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Wang Y, Song Y, Zhong Q, Wu Y, Zhuang J, Qu F, Xu C Tags: Int Immunopharmacol Source Type: research

Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice.
In this study, we found that AGR inhibited RANKL-induced osteoclastogenesis, bone-resorption, F-actin ring formation, and the mRNA expression of osteoclast-associated genes such as CTSK, TRAP, MMP-9, and ATP6v0d2 in vitro. In addition, AGR suppressed RANKL-induced expression of c-Fos and NFATc1. However, AGR treatment did not affect NF-κB activation and MAPKs phosphorylation in RANKL-stimulated BMMs, which implicated that AGR might not influence the initial expression of NFATc1 mediated by NF-κB and MAPKs signaling. Our results further indicated that AGR did not alter phosphorylation levels of GSK3β and th...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Cao J, Wang S, Wei C, Lin H, Zhang C, Gao Y, Xu Z, Cheng Z, Sun WC, Wang HB Tags: Int Immunopharmacol Source Type: research

Urinary sediments could differentiate endocapillary proliferative lupus nephritis and endocapillary proliferative IgA nephropathy.
This study investigated the differences in urinary sediment findings between patients with endocapillary proliferative lupus nephritis (LN) and patients with endocapillary proliferative IgA nephropathy (IgAN) and further evaluated the associations of leukocyturia with disease activity, pathological features and prognosis. METHODS: The urinary sediments of 126 patients, including 92 with LN and 34 with IgAN, with renal-biopsy-proven endocapillary proliferative glomerulonephritis (EPGN) were examined by a standardized method. The urinary elements investigated included various cells, casts and crystals. The associations ...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Yuan M, Tan Y, Li J, Yu X, Zhang H, Zhao M Tags: Int Immunopharmacol Source Type: research

Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling.
CONCLUSION: Gaba confers cardioprotective effects against DOX-induced myocardial injury and cardiotoxicity by modulating the inflammatory/apoptotic signaling pathway. PMID: 33199237 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Samra YA, Amin MN, Said E Tags: Int Immunopharmacol Source Type: research

Long noncoding RNA ZFAS1 silencing alleviates rheumatoid arthritis via blocking miR-296-5p-mediated down-regulation of MMP-15.
Abstract Rheumatoid arthritis (RA), a chronic inflammatory disease, deprives patients' walking ability and reduces their life quality worldwide. Though recent studies have indicated the role of long noncoding RNA (lncRNA) ZFAS1 in several diseases, however, its role in RA remains uncharacterized. The present study aimed to unravel the the effect of ZFAS1 on RA. Herein, the RA mouse model and the human RA synoviocyte MH7A cell lines stimulated with TNF-α were established. ZFAS1 was next determined to be highly expressed in the mice with RA-like symptoms and TNF-α-stimulated MH7A cells while inhibiting Z...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Zheng J, Zeng P, Zhang H, Zhou Y, Liao J, Zhu W, Jia N, Lin L Tags: Int Immunopharmacol Source Type: research

Cytokine imbalance at materno-embryonic interface as a potential immune mechanism for recurrent pregnancy loss.
Abstract Recurrent pregnancy loss (RPL) is a prominent reproductive disease that distresses about 2%-5% of couples. RPL is the loss of two or more successive spontaneous pregnancies prior to the 20th week of embryo development. The commencement of pregnancy necessitates implantation of the embryo into responsive maternal decidua synchronized with the process of placentation, decidual and myometrial trophoblast incursion as well as refashioning of spiral blood arteries of uterus. The collapse of any of the processes fundamental for pregnancy success may result into an array of pregnancy problems including spontaneo...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Ali S, Majid S, Ali MN, Taing S, Rehman MU, Arafah A Tags: Int Immunopharmacol Source Type: research

Annexin A3 upregulates the infiltrated neutrophil-lymphocyte ratio to remodel the immune microenvironment in hepatocellular carcinoma.
Abstract Accumulating evidence has indicated that inflammation is required for the initiation and progression of hepatocellular carcinoma (HCC). The annexin family protein, which has a highly similar structure, has been demonstrated to participate in pro- or anti-inflammatory regulation in the developing of tumours. However, the potential effects of ANXA3 in the immune microenvironment of HCC remain unknown. In present study, we found that increased ANXA3 expression is associated with a higher infiltrated neutrophil-lymphocyte ratio (iNLR) in HCC. Moreover, HCC patients with a high iNLR and high ANXA3 expression c...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Zhu Q, Pan QZ, Zhong AL, Hu H, Zhao JJ, Tang Y, Hu WM, Li M, Weng DS, Chen MY, Ma G, Xia JC Tags: Int Immunopharmacol Source Type: research

Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
CONCLUSIONS: MitoQ attenuates inflammation, mucus hypersecretion, and oxidative stress induced by CS. It may exert these effects in part by modulating mitochondrial function and the NF-κB signal pathway. PMID: 33191175 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 12, 2020 Category: Allergy & Immunology Authors: Yang D, Xu D, Wang T, Yuan Z, Liu L, Shen Y, Wen F Tags: Int Immunopharmacol Source Type: research

Sunitinib malate inhibits intestinal tumor development in male ApcMin/+ mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3.
Sunitinib malate inhibits intestinal tumor development in male ApcMin/+ mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3. Int Immunopharmacol. 2020 Nov 12;:107128 Authors: Chen L, Xu P, Xiao Q, Chen L, Li S, Jian JM, Zhong YB Abstract Sunitinib is a tyrosine kinase inhibitor for many tumors. Inflammation is one of the most important factors in the development of intestinal tumors. Many inflammation-related factors are regulated by tyrosine kinase receptors. It is reasonable to hypothesize that sunitinib can regulat...
Source: International Immunopharmacology - November 12, 2020 Category: Allergy & Immunology Authors: Chen L, Xu P, Xiao Q, Chen L, Li S, Jian JM, Zhong YB Tags: Int Immunopharmacol Source Type: research

Comprehensive analysis of tumour mutation burden and the immune microenvironment in hepatocellular carcinoma.
Abstract Tumour mutation burden (TMB) and the immune microenvironment (IME) are reportedly associated with immunotherapy responses, but this relationship remains unclear in hepatocellular carcinoma (HCC). We classified HCC patients in the liver hepatocellular carcinoma cohort from The Cancer Genome Atlas into low- and high-TMB groups and evaluated differences in immune infiltrates. Additionally, differentially expressed genes in the low- and high-TMB groups were identified, and functional analyses were conducted. A risk score model was constructed based on three differentially expressed immune genes (DEIGs). The T...
Source: International Immunopharmacology - November 11, 2020 Category: Allergy & Immunology Authors: Xie F, Bai Y, Yang X, Long J, Mao J, Lin J, Wang D, Song Y, Xun Z, Huang H, Yang X, Zhang L, Mao Y, Sang X, Zhao H Tags: Int Immunopharmacol Source Type: research