Gypenoside XLIX alleviates acute liver injury: Emphasis on NF- κB/PPAR-α/NLRP3 pathways
In this study, we used cecum ligation and puncture (CLP) was used to induce in vivo mice hepatic injury, and lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells, evaluated whether Gypenoside XLIX could have a palliative effect on sepsis-induced acute liver injury via NF-κB/PPAR-α/NLRP3. In order to gain insight into these mechanisms, six groups were created in vivo: the Contol group, the Sham group, the CLP group, the CLP + XLIX group (40 mg/kg) and the Sham + XLIX (40 mg/kg) group, and the CLP + DEX (2 mg/kg) group. Three groups were created in vitro: Control, LPS, LPS + XLIX (40 μM). The analytical methods...
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Mengyuan Zhou Yu Cao Shaocheng Xie Yannan Xiang Mengxin Li Haitao Yang Zibo Dong Source Type: research

Novel insights into macrophage immunometabolism in nonalcoholic steatohepatitis
Int Immunopharmacol. 2024 Mar 18;131:111833. doi: 10.1016/j.intimp.2024.111833. Online ahead of print.ABSTRACTNonalcoholic steatohepatitis (NASH), an inflammatory subtype of nonalcoholic fatty liver disease (NAFLD), is characterized by liver steatosis, inflammation, hepatocellular injury and different degrees of fibrosis, and has been becoming the leading cause of liver-related morbidity and mortality worldwide. Unfortunately, the pathogenesis of NASH has not been completely clarified, and there are no approved therapeutic drugs. Recent accumulated evidences have revealed the involvement of macrophage in the regulation of ...
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Yali Yuan Ye Zhang Xinyu Lu Junxiang Li Muyuan Wang Wenji Zhang Mengyu Zheng Zhongmei Sun Yunqi Xing Yitong Li Yingdi Qu Yao Jiao Haixiao Han Chune Xie Tangyou Mao Source Type: research

Irbesartan ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing NLRP3 inflammasomes in vivo and in vitro
CONCLUSIONS: Our results suggested that IRB ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing the NLRP3 inflammasomes in vivo and in vitro. These findings provide new therapeutic strategies of diabetic nephropathy.PMID:38503013 | DOI:10.1016/j.intimp.2024.111844 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Yuan Li Weihong Long Haifeng Zhang Meng Zhao Menghan Gao Weiying Guo Lu Yu Source Type: research

Ischemia and reperfusion-injured liver-derived exosomes elicit acute lung injury through miR-122-5p regulated alveolar macrophage polarization
Int Immunopharmacol. 2024 Mar 18;131:111853. doi: 10.1016/j.intimp.2024.111853. Online ahead of print.ABSTRACTAcute lung injury (ALI) is a common postoperative complication, particularly in pediatric patients after liver transplantation. Hepatic ischemia-reperfusion (HIR) increases the release of exosomes (IR-Exos) in peripheral circulation. However, the role of IR-Exos in the pathogenesis of ALI induced by HIR remains unclear. Here, we explored the role of exosomes derived from the HIR-injured liver in ALI development. Intravenous injection of IR-Exos caused lung inflammation in naive rats, whereas pretreatment with an in...
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Jingshu Lyu Mingwei Sheng Yingli Cao Lili Jia Chen Zhang Yiqi Weng Wenli Yu Source Type: research

Immunoenhancement effect of cinobufagin on macrophages and the cyclophosphamide-induced immunosuppression mouse model
This study provides a theoretical basis for developing CBG immune enhancers and opens up new ideas for the comprehensive utilization and development of CBG in factories.PMID:38503015 | DOI:10.1016/j.intimp.2024.111885 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Yue-Zhu Zhao Yi-Lun Wang Yang Yu Source Type: research

Local thiamet-G delivery by a thermosensitive hydrogel confers ischemic cardiac repair via myeloid M2-like activation in a STAT6 O-GlcNAcylation-dependent manner
Int Immunopharmacol. 2024 Mar 18;131:111883. doi: 10.1016/j.intimp.2024.111883. Online ahead of print.ABSTRACTInfarct healing requires a dynamic and orchestrated inflammatory reaction following myocardial infarction (MI). While an uncontrolled excessive inflammatory response exaggerates ischemic injury post-MI, M2-like reparative macrophages may facilitate inflammation regression and promote myocardial healing. However, how protein post-translational modification regulates post-MI cardiac repair and dynamic myeloid activation remains unknown. Here we show that M2-like reparative, but not M1-like inflammatory activation, is...
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Wenjing Zhou Qingsong Tang Shengnan Wang Liang Ding Ming Chen Hongman Liu Yong Wu Xiwen Xiong Zhenya Shen Weiqian Chen Source Type: research

Interleukin-2/anti-interleukin-2 complex attenuates inflammation in a mouse COPD model by expanding CD4 < sup > + < /sup > CD25 < sup > + < /sup > Foxp3 < sup > + < /sup > regulatory T cells
CONCLUSIONS AND IMPLICATIONS: IL-2C is a potential therapeutic agent for alleviating excessive inflammation in the lungs of patients with COPD.PMID:38503017 | DOI:10.1016/j.intimp.2024.111849 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Ruirui Duan Ke Huang Tao Yu Chenli Chang Xu Chu Yuhang Huang Zhoude Zheng Linxi Ma Baicun Li Ting Yang Source Type: research

Dynamic ctDNA-based analysis of drug-resistant gene alterations at RAS/BRAF wild-type metastatic colorectal cancer patients after cetuximab plus chemotherapy as the first-line treatment
CONCLUSIONS: Resistant gene mutations caused by anti-EGFR drugs in RAS/BRAF wild-type mCRC patients can be observed by dynamic ctDNA analysis. TP53 and AMER1 mutations, tumor mutational burden (TMB) levels, and TP53/AMER1 co-mutation may predict the efficacy of the first-line cetuximab-contained treatment. Situations of genetic mutations were differentiated from first-line PD to second-line PD, which indicated that mutation detection may contribute to predict prognosis of mCRC patients.PMID:38503018 | DOI:10.1016/j.intimp.2024.111887 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Yu-Wen Zhou Xin Zhao Lu Ni Peng Cao Wei-Bing Leng Qing Zhu Hong-Feng Gou Jiao Zhang Xiao-Fen Li Meng Qiu Source Type: research

Neutrophil accumulation raises defence against Streptococcus equi ssp. zooepidemicus in the absence of Gasdermin D
This study aimed to investigate the role of GSDMD in host against SEZ. Mice were administrated with SEZ via intranasal intubation for 24 h (3 × 106CFU), GSDMD protein expression significantly increased in the lung tissue of mice infected with SEZ. For further research on the role of GSDMD during SEZ infection, GSDMD-/- mice and WT mice were treated with SEZ via intranasal intubation for 24 h (3 × 106CFU). GSDMD-/- mice showed less severe lung tissue due to fewer bacteria colonization. Numerous neutrophils were recruited into lung tissues in GSDMD-/- mice, related to the release of CXCL1 and CXCL2 regulated by p65 phospho...
Source: International Immunopharmacology - March 18, 2024 Category: Allergy & Immunology Authors: Yajuan Li Zihua Lin Jingyu Yu Yuxuan Liu Shun Li Yunfei Huang Oladejo Ayodele Olaolu Qiang Fu Source Type: research

Neutrophil accumulation raises defence against Streptococcus equi ssp. zooepidemicus in the absence of Gasdermin D
This study aimed to investigate the role of GSDMD in host against SEZ. Mice were administrated with SEZ via intranasal intubation for 24 h (3 × 106CFU), GSDMD protein expression significantly increased in the lung tissue of mice infected with SEZ. For further research on the role of GSDMD during SEZ infection, GSDMD-/- mice and WT mice were treated with SEZ via intranasal intubation for 24 h (3 × 106CFU). GSDMD-/- mice showed less severe lung tissue due to fewer bacteria colonization. Numerous neutrophils were recruited into lung tissues in GSDMD-/- mice, related to the release of CXCL1 and CXCL2 regulated by p65 phospho...
Source: International Immunopharmacology - March 18, 2024 Category: Allergy & Immunology Authors: Yajuan Li Zihua Lin Jingyu Yu Yuxuan Liu Shun Li Yunfei Huang Oladejo Ayodele Olaolu Qiang Fu Source Type: research

Targeting the "tumor microenvironment": RNA-binding proteins in the spotlight in colorectal cancer therapy
Int Immunopharmacol. 2024 Mar 16;131:111876. doi: 10.1016/j.intimp.2024.111876. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate among cancers. The development of CRC involves both genetic and epigenetic abnormalities, and recent research has focused on exploring the ex-transcriptome, particularly post-transcriptional modifications. RNA-binding proteins (RBPs) are emerging epigenetic regulators that play crucial roles in post-transcriptional events. Dysregulation of RBPs can result in aberrant expression of downstream target genes, thereby affec...
Source: International Immunopharmacology - March 17, 2024 Category: Allergy & Immunology Authors: Yiwei Zhang Yujun Zhang Jingjing Song Xifu Cheng Chulin Zhou Shuo Huang Wentao Zhao Zhen Zong Lingling Yang Source Type: research

Clinicopathological features and mucosal microbiota in gastric mucosal damage between nodular and non-nodular gastritis in children with Helicobacter pylori infection
In conclusion, NG group exhibited significant severe inflammation and reduced abundance levels of several bacterial genera compared to the non-NG group. However, individuals with NG did not have a dysregulated microbial community with genotoxic potential.PMID:38493689 | DOI:10.1016/j.intimp.2024.111813 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 17, 2024 Category: Allergy & Immunology Authors: Wei Zheng Yongjie Gan Yaofeng Yang Kerong Peng Fubang Li Hong Zhao Weizhong Gu Mizu Jiang Source Type: research

Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis
CONCLUSION: Dupilumab treatment tends to help shift the gut microbial dysbiosis in AD patients to a healthier state, along with improved intestinal tryptophan metabolism, suggesting the gut flora and its metabolites may mediate part of the synergistic therapeutic effects on the host.PMID:38493690 | DOI:10.1016/j.intimp.2024.111867 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 17, 2024 Category: Allergy & Immunology Authors: Liu Yang Danqi Li Shuomin Sun Danping Liu Yi Wang Xiaohuan Liu Bin Zhou Wenjia Nie Lu Li Yifei Wang Shanshan Sha Yan Li Chen Shen Juan Tao Source Type: research

Sophoricoside improved Crohn's disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K/AKT signaling
CONCLUSIONS: SOP can reduce IECs apoptosis through the inhibition of the PI3K/AKT signaling pathway, thereby protecting the intestinal barrier. This study is the first to illustrate how SOP ameliorates colitis and protects the intestinal barrier, suggesting SOP has potential clinical application in treating CD.PMID:38493691 | DOI:10.1016/j.intimp.2024.111886 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 17, 2024 Category: Allergy & Immunology Authors: Qingqing Li Jing Li Lixia Yin Ju Huang Xinyue Liu Jinran Shi Zhijun Geng Xue Song Lian Wang Yueyue Wang Xiaofeng Zhang Lugen Zuo Jianguo Hu Source Type: research

Prussian blue analogues improves the microenvironment after spinal cord injury by regulating Zn
This study provides a good prospect for the application of spinal cord injury treatment. It also provides an important feasibility for subsequent clinical conversions.PMID:38493692 | DOI:10.1016/j.intimp.2024.111868 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 17, 2024 Category: Allergy & Immunology Authors: Jinpeng Gao ShuRui Chen Sen Lin Xifan Mei Source Type: research