Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition
CONCLUSION: This study shows that NR and RV have therapeutic promise in treating diabetic wounds by addressing UPR dysregulation, and pyroptosis. The combination therapy is a viable strategy to improving the healing process, providing a multimodal intervention for diabetic skin ulcers. These findings pave the way for additional investigation and possible therapeutic applications, giving hope for better outcomes in diabetic wound care.PMID:38583241 | DOI:10.1016/j.intimp.2024.112013 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Mohammad Hasan Maleki Morvarid Siri Amirhossein Jafarabadi Mahsa Rajabi Seyed Amirhossein Mazhari Zahra Noori Farhad Koohpeyma Amirreza Dehghanian Nafiseh Esmaeili Zeinab Aryanian Sanaz Dastghaib Source Type: research
Galectin-3 inhibition ameliorates alveolar epithelial cell pyroptosis in phosgene-induced acute lung injury
Int Immunopharmacol. 2024 Apr 6;132:111965. doi: 10.1016/j.intimp.2024.111965. Online ahead of print.ABSTRACTPhosgene is a type of poisonous gas that can cause acute lung injury (ALI) upon accidental exposure. Casualties still occur due to phosgene-induced acute lung injury (P-ALI) from accidents resulting from improper operations. The pathological mechanisms of P-ALI are still understudied. Thus, we performed scRNA-seq on cells isolated from all subpopulations of the BALF in P-ALI and found that Gal3 expression was significantly higher in the gas group than in the control group. Further analysis revealed a ligand-receptor...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Obulkasim Memet Chao Cao Hanbing Hu Yu Dun Xuanrong Bao Fuli Liu Lin Zhang Jian Zhou Jie Shen Source Type: research
Deciphering and overcoming Anti-PD-1 resistance in Melanoma: A comprehensive review of Mechanisms, biomarker Developments, and therapeutic strategies
Int Immunopharmacol. 2024 Apr 6;132:111989. doi: 10.1016/j.intimp.2024.111989. Online ahead of print.ABSTRACTWorldwide, tens of thousands of people die from melanoma each year, making it the most frequently fatal form of cutaneous cancer. Immunotherapeutic advancements, particularly with anti-PD-1 medications, have significantly enhanced treatment outcomes over recent decades. With the broad application of anti-PD-1 therapies, insights into the mechanisms of resistance have evolved. Despite the development of combination treatments and early predictive biomarkers, a comprehensive synthesis of these advancements is absent i...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Ruoqi Wang Yanbin Chen Yongyi Xie Xin Ma Yeqiang Liu Source Type: research
Modulating the phenotype and function of bone marrow-derived macrophages via mandible and femur osteoblasts
In conclusion, our investigation showed that MOBs and FOBs have the ability to modulate MØ phenotype and function, with MOBs exhibiting a stronger regulatory potential. These findings provide a new direction for improving therapeutic strategies for bone regeneration in autologous bone grafts from the perspective of the immune microenvironment.PMID:38583238 | DOI:10.1016/j.intimp.2024.112000 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Li Li Yijuan Liu Xueshen Qian Ling Zhou Yujie Fan Xue Yang Kai Luo Yuling Chen Source Type: research
Expressions of CXCR3 and PD-1 on T cells and their clinical relevance in colorectal cancer
CONCLUSION: Expressions of CXCR3 and PD-1 on tumor-infiltrating T lymphocytes are related to the development of CRC and metastasis, providing clues for exploring the pathogenesis of CRC and developing new strategies for tumor immunotherapy.PMID:38583239 | DOI:10.1016/j.intimp.2024.111988 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Sen Wang Yangyang Zhang Guangyu Chen Peng Zhao Xiaoming Wang Benling Xu Long Yuan Source Type: research
Novel insights into the role of ubiquitination in osteoarthritis
Int Immunopharmacol. 2024 Apr 6;132:112026. doi: 10.1016/j.intimp.2024.112026. Online ahead of print.ABSTRACTUbiquitination (Ub) and deubiquitination are crucial post-translational modifications (PTMs) that precisely regulate protein degradation. Under the catalysis of a cascade of E1-E2-E3 ubiquitin enzymes, ubiquitination extensively regulates protein degradation exerting direct impact on various cellular processes, while deubiquitination opposes the effect of ubiquitination and prevents proteins from degradation. Notably, such dynamic modifications have been widely investigated to be implicated in cell cycle, transcript...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Yuzhe Lin Shide Jiang Jingyue Su Wenqing Xie Masoud Rahmati Yuxiang Wu Shengwu Yang Qin Ru Yusheng Li Zhenhan Deng Source Type: research
Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition
CONCLUSION: This study shows that NR and RV have therapeutic promise in treating diabetic wounds by addressing UPR dysregulation, and pyroptosis. The combination therapy is a viable strategy to improving the healing process, providing a multimodal intervention for diabetic skin ulcers. These findings pave the way for additional investigation and possible therapeutic applications, giving hope for better outcomes in diabetic wound care.PMID:38583241 | DOI:10.1016/j.intimp.2024.112013 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Mohammad Hasan Maleki Morvarid Siri Amirhossein Jafarabadi Mahsa Rajabi Seyed Amirhossein Mazhari Zahra Noori Farhad Koohpeyma Amirreza Dehghanian Nafiseh Esmaeili Zeinab Aryanian Sanaz Dastghaib Source Type: research
Galectin-3 inhibition ameliorates alveolar epithelial cell pyroptosis in phosgene-induced acute lung injury
Int Immunopharmacol. 2024 Apr 6;132:111965. doi: 10.1016/j.intimp.2024.111965. Online ahead of print.ABSTRACTPhosgene is a type of poisonous gas that can cause acute lung injury (ALI) upon accidental exposure. Casualties still occur due to phosgene-induced acute lung injury (P-ALI) from accidents resulting from improper operations. The pathological mechanisms of P-ALI are still understudied. Thus, we performed scRNA-seq on cells isolated from all subpopulations of the BALF in P-ALI and found that Gal3 expression was significantly higher in the gas group than in the control group. Further analysis revealed a ligand-receptor...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Obulkasim Memet Chao Cao Hanbing Hu Yu Dun Xuanrong Bao Fuli Liu Lin Zhang Jian Zhou Jie Shen Source Type: research
Deciphering and overcoming Anti-PD-1 resistance in Melanoma: A comprehensive review of Mechanisms, biomarker Developments, and therapeutic strategies
Int Immunopharmacol. 2024 Apr 6;132:111989. doi: 10.1016/j.intimp.2024.111989. Online ahead of print.ABSTRACTWorldwide, tens of thousands of people die from melanoma each year, making it the most frequently fatal form of cutaneous cancer. Immunotherapeutic advancements, particularly with anti-PD-1 medications, have significantly enhanced treatment outcomes over recent decades. With the broad application of anti-PD-1 therapies, insights into the mechanisms of resistance have evolved. Despite the development of combination treatments and early predictive biomarkers, a comprehensive synthesis of these advancements is absent i...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Ruoqi Wang Yanbin Chen Yongyi Xie Xin Ma Yeqiang Liu Source Type: research
PDCD4-induced oxidative stress through FGR/NF- κB axis in rectal cancer radiotherapy-induced AKI
This study aimed to investigate the molecular mechanism of the effect of PDCD4 on radiotherapy-induced acute kidney injury (AKI) in rectal cancer through the regulation of FGR/NF-κB signaling. Differentially expressed genes were identified using Gene Expression Omnibus (GEO) datasets (GSE90627 for rectal cancer and GSE145085 for AKI) and R software. The human renal tubular epithelial cell line, HK-2, was used to establish an in vitro model of radiotherapy-induced AKI. RT-qPCR and western blotting were used to detect gene and protein expression levels, respectively. Cell proliferation and apoptosis were assessed using the ...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Qiang Ma Lu Zheng Hao Cheng Xiaoyang Li Zhining Liu Peng Gong Source Type: research
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKC α-HuR axis in rheumatoid arthritis
In conclusion, our findings unveil a novel regulatory mechanism involved in the pathogenesis of RA and suggest that targeting TRPM7 might be a potential strategy for the prevention and treatment of RA.PMID:38581988 | DOI:10.1016/j.intimp.2024.111933 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yi Lin Yong Chen Weirong Hu Xingyu Liu Wenjuan Hao Jing Xing Jie Ding Yucai Xu Feng Yao Yingjie Zhao Ke Wang Shufang Li Qiuxia Yu Wei Hu Renpeng Zhou Source Type: research
Enhancement of antitumor response of staphylococcal enterotoxin C2 mutant 2M-118 by promoting cell-mediated antitumor immunity
CONCLUSION: 2M-118 promotes immune function and enhances antitumor response. This indicates that 2M-118 could potentially be developed as a novel anti-tumor drug with-highefficiencyandlowtoxicity.PMID:38581989 | DOI:10.1016/j.intimp.2024.111943 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Xinlin Chen Yuguo Liu Bohai Du Mingjie Shi Zeheng Lin Hongyi Li Juyu Chen Meifen Wu Ming Shi Source Type: research
The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment
In conclusion, our results suggest that the anti-PD-L1&CXCR4 bispecific nanobody exerts an antitumor immune response by changing the pancreatic tumour microenvironment. Hence, the anti-PD-L1&CXCR4 bispecific nanobody is a potential candidate for pancreatic cancer treatment.PMID:38581990 | DOI:10.1016/j.intimp.2024.111944 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yaxian Li Yuejiang Zheng Shuyi Xu Hai Hu Liyun Peng Jianwei Zhu Mingyuan Wu Source Type: research
Role of immunotherapies and stem cell therapy in the management of liver cancer: A comprehensive review
Int Immunopharmacol. 2024 Apr 5;132:112011. doi: 10.1016/j.intimp.2024.112011. Online ahead of print.ABSTRACTLiver cancer (LC) is the sixth most common disease and the third most common cause of cancer-related mortality. The WHO predicts that more than 1 million deaths will occur from LC by 2030. Hepatocellular carcinoma (HCC) is a common form of primary LC. Today, the management of LC involves multiple disciplines, and multimodal therapy is typically selected on an individual basis, considering the intricate interactions between the patient's overall health, the stage of the tumor, and the degree of underlying liver disea...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Fares E M Ali Islam M Ibrahim Hanan S Althagafy Emad H M Hassanein Source Type: research
Endotoxin tolerance ameliorates lipopolysaccharide/D-galactosamine-induced acute liver failure by negative regulation of the NF- κB/NLRP3 and activation of Nrf2/HO-1 via Sitr1
Int Immunopharmacol. 2024 Apr 5;132:111994. doi: 10.1016/j.intimp.2024.111994. Online ahead of print.ABSTRACTAcute liver failure (ALF) is a potentially fatal disorder characterized by extensive hepatocyte necrosis and rapid decline in liver function. Numerous factors, including oxidative stress, cell death, and inflammatory responses, are associated with its pathogenesis. Endotoxin tolerance (ET) refers to the phenomenon in which the body or cells exhibit low or no response to high-dose lipopolysaccharide (LPS) stimulation after pre-stimulation with low-dose LPS. However, the specific mechanism through which ET regulates L...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Huifang Shi Xueting Xie Sijie Zheng Hong Chen Chenyi Liu Shu Li Mingqin Lu Source Type: research
