Advances in traditional herbal formulation based nano-vaccine for cancer immunotherapy: Unraveling the enigma of complex tumor environment and multidrug resistance
Int Immunopharmacol. 2024 Mar 29;132:111948. doi: 10.1016/j.intimp.2024.111948. Online ahead of print.ABSTRACTCancer is attributed to uncontrolled cell growth and is among the leading causes of death with no known effective treatment while complex tumor microenvironment (TME) and multidrug resistance (MDR) are major challenges for developing an effective therapeutic strategy. Advancement in cancer immunotherapy has been limited by the over-activation of the host immune response that ultimately affects healthy tissues or organs and leads to a feeble response of the patient's immune system against tumor cells. Besides, tradi...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Yasmeen Saeed Ruimin Zhong Zhanghua Sun Source Type: research
Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist
Int Immunopharmacol. 2024 Mar 29;132:111909. doi: 10.1016/j.intimp.2024.111909. Online ahead of print.ABSTRACTAdjuvants enhance the body's immune response to a vaccine, often leading to better protection against diseases. Monophosphoryl lipid A analogues (MPLA, TLR4 agonists), α-galactosylceramide analogues (NKT cell agonists), and imidazoquinoline compounds (TLR7/8 agonists) are emerging novel adjuvants on market or under clinical trials. Despite significant interest in these adjuvants, a direct comparison of their adjuvant activities remains unexplored. We initially assessed the activities of various adjuvants from thre...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Xiongyan Meng Ying Xu Jing Yang Shuai Meng Ning Ding Tiantian Sun Chengli Zong Source Type: research
The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress following ischemic acute kidney injury
CONCLUSION: The involvement of mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H/GRP78 and CHOP axis is significant in the development of ischemic AKI. Moreover, hsa_circ_0075663 has potential as an early diagnostic biomarker.PMID:38554447 | DOI:10.1016/j.intimp.2024.111956 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Qiang Zheng Xiaozhou Li Xuan Xu Xianming Tang Bacha Hammad Jihong Xing Dongshan Zhang Source Type: research
Prognostic impact of age in advanced non-small cell lung cancer patients undergoing first-line checkpoint inhibitor immunotherapy and chemotherapy treatment
CONCLUSION: Age may not be the primary factor influencing the efficacy of immunotherapy combined with chemotherapy, but particular attention should be given to the elderly population.PMID:38554448 | DOI:10.1016/j.intimp.2024.111901 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Xiaoya Huang Shichao Wu Shubin Chen Moqin Qiu Yun Zhao Jiang Wei Jianbo He Wenhua Zhao Liping Tan Cuiyun Su Shaozhang Zhou Source Type: research
Immune effector dysfunction signatures predict outcomes in patients with colorectal cancer
CONCLUSION: CCR9, ISG20, ICOS, and CACNA2D2 were optimal IED signatures for predicting the outcomes of CRC patients, which might be a potential biomarker for prognostic stratification and designing novel CRC therapy.PMID:38552290 | DOI:10.1016/j.intimp.2024.111949 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Haifeng Tang Hongsheng Wu Yueju Jian Tengfei Ji Biwen Wu Yong Wu Peipei Wang Tiansheng Cao Source Type: research
Unveiling biomarkers and therapeutic targets in IgA nephropathy through large-scale blood transcriptome analysis
CONCLUSION: Key DEGs, particularly VISIG4, KLRC1, and C1QB, emerge as potential specific markers for IgAN, paving the way for future targeted personalized treatment options.PMID:38552291 | DOI:10.1016/j.intimp.2024.111905 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Ting Gan Lu-Xi Qu Shu Qu Yuan-Yuan Qi Yue-Miao Zhang Yan-Na Wang Yang Li Li-Jun Liu Su-Fang Shi Ji-Cheng Lv Hong Zhang Yi-Jie Peng Xu-Jie Zhou Source Type: research
Spermidine attenuates monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting purine metabolism and polyamine synthesis-associated vascular remodeling
Int Immunopharmacol. 2024 Mar 28;132:111946. doi: 10.1016/j.intimp.2024.111946. Online ahead of print.ABSTRACTEnsuring the homeostatic integrity of pulmonary artery endothelial cells (PAECs) is essential for combatting pulmonary arterial hypertension (PAH), as it equips the cells to withstand microenvironmental challenges. Spermidine (SPD), a potent facilitator of autophagy, has been identified as a significant contributor to PAECs function and survival. Despite SPD's observed benefits, a comprehensive understanding of its protective mechanisms has remained elusive. Through an integrated approach combining metabolomics and...
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Yu-Jing Chen Han-Fei Li Fan-Rong Zhao Miao Yu Si-Yu Pan Wen-Ze Sun Yan-Yan Yin Tian-Tian Zhu Source Type: research
Cyclosporine a inhibits bone regeneration and induces bone loss in a rat model
We examined the interventions of CSA on osteoblast progenitor cells MC3T3-E1 and assessed their effects on biological function using RT-qPCR, CCK-8 assay, alizarin red staining, and alkaline phosphatase staining. Furthermore, we evaluated the effects of CSA on bone regeneration and bone mass in both OVX rat models and femoral diaphysis bone defect models. The results from the CCK-8 experiment indicated a positive influence of experimental doses of CSA on osteogenic differentiation of MC3T3-E1 cells. ALP expression levels and calcified nodules were also evaluated, suggesting that CSA intervention promoted osteogenic differe...
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Zhou-Shan Tao Tao Ma Min Yang Source Type: research
Urine-derived exosomes and their role in modulating uroepithelial cells to prevent hypospadias
CONCLUSION: This study reveals the therapeutic potential of Urine-Exos in hypospadias, mediated by the SDC1/β-catenin axis. Urine-Exos promote UEC proliferation and migration, thereby inhibiting the progression of hypospadias. These findings offer new insights and potential therapeutic targets for the management of congenital malformations.PMID:38552294 | DOI:10.1016/j.intimp.2024.111828 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Shibo Zhu Jinhua Hu Guifang Chen Wen Fu Jin Zhang Wei Jia Source Type: research
Rapamycin alleviates mitochondrial dysfunction in anti-NMDAR encephalitis mice
Int Immunopharmacol. 2024 Mar 28;132:111910. doi: 10.1016/j.intimp.2024.111910. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is one of the most prevalent forms of autoimmune encephalitis, characterized by a series of neurological and psychiatric symptoms, including cognitive impairment, seizures and psychosis. The underlying mechanism of anti-NMDAR encephalitis remains unclear. In the current study, the mouse model of anti-NMDAR encephalitis with active immunization was performed. We first uncovered excessive mitochondrial fission in the hippocampus and temporal cortex of anti-NMDAR...
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Liangbo Kong Xiaxin Yang Anqi Sun Xue Yang Xiuhe Zhao Shengjun Wang Source Type: research
Real-world treatment patterns and outcomes for patients with advanced hepatocellular carcinoma initially treated with PD-1 inhibitors
CONCLUSIONS: Our findings provided insights into potential therapeutic strategies of PD-1 inhibitors in first-line settings for advanced HCC in real-world practice in China. It was recommended to consider patient characteristics associated with therapeutic options when making clinical decisions. Prospective randomized controlled studies with larger sample sizes and longer follow-up times were warranted further to verify the potential clinical benefits of PD-1 inhibitors.PMID:38552296 | DOI:10.1016/j.intimp.2024.111947 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Huimin Zou Ying Ge Wenge Chen Dongning Yao Carolina Oi Lam Ung Yunfeng Lai Hao Hu Source Type: research
Fully human anti-B7-H3 recombinant antibodies inhibited tumor growth by increasing T cell infiltration
In this study, the fully human anti-B7H3 single-chain antibodies (scFvs) were isolated and screened from the fully human phage immune library with B7H3 as the target. The antibodies screened from a fully human phage library had low immunogenicity and high affinity, which was more beneficial for clinical application. Leveraging B7-H3 scFvs as a foundation, we constructed two distinct recombinant antibody formats, scFv-Fc and IgG1, characterized by elevated affinity and a prolonged half-life. The results demonstrated that the recombinant antibodies had high specificity and affinity for the B7-H3 antigen and inhibited tumor c...
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Lin Li Siji Nian Qin Liu Bo Zhang Wulemo Jimu Chengwen Li Zhanwen Huang Qiaosen Hu Yuanshuai Huang Qing Yuan Source Type: research
Erratum to "Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis" [Int. Immunopharmacol. 123 (2023) 110710]
Int Immunopharmacol. 2024 Mar 28:111756. doi: 10.1016/j.intimp.2024.111756. Online ahead of print.NO ABSTRACTPMID:38553334 | DOI:10.1016/j.intimp.2024.111756 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Yifei Hou Huimin Zhang Yangzhuangzhuang Zhu Xufeng He Wen Li Lin Su Mingxi Liu Xi Chen Fang Shen Xiao Chen Wencheng Jiang Chunpu Zou Zihang Xu Source Type: research
Immune effector dysfunction signatures predict outcomes in patients with colorectal cancer
CONCLUSION: CCR9, ISG20, ICOS, and CACNA2D2 were optimal IED signatures for predicting the outcomes of CRC patients, which might be a potential biomarker for prognostic stratification and designing novel CRC therapy.PMID:38552290 | DOI:10.1016/j.intimp.2024.111949 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Haifeng Tang Hongsheng Wu Yueju Jian Tengfei Ji Biwen Wu Yong Wu Peipei Wang Tiansheng Cao Source Type: research
Unveiling biomarkers and therapeutic targets in IgA nephropathy through large-scale blood transcriptome analysis
CONCLUSION: Key DEGs, particularly VISIG4, KLRC1, and C1QB, emerge as potential specific markers for IgAN, paving the way for future targeted personalized treatment options.PMID:38552291 | DOI:10.1016/j.intimp.2024.111905 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Ting Gan Lu-Xi Qu Shu Qu Yuan-Yuan Qi Yue-Miao Zhang Yan-Na Wang Yang Li Li-Jun Liu Su-Fang Shi Ji-Cheng Lv Hong Zhang Yi-Jie Peng Xu-Jie Zhou Source Type: research
