Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition

CONCLUSION: This study shows that NR and RV have therapeutic promise in treating diabetic wounds by addressing UPR dysregulation, and pyroptosis. The combination therapy is a viable strategy to improving the healing process, providing a multimodal intervention for diabetic skin ulcers. These findings pave the way for additional investigation and possible therapeutic applications, giving hope for better outcomes in diabetic wound care.PMID:38583241 | DOI:10.1016/j.intimp.2024.112013

Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Mohammad Hasan Maleki Morvarid Siri Amirhossein Jafarabadi Mahsa Rajabi Seyed Amirhossein Mazhari Zahra Noori Farhad Koohpeyma Amirreza Dehghanian Nafiseh Esmaeili Zeinab Aryanian Sanaz Dastghaib Source Type: research