Most Parents Unaware Flu Vaccine More Important This Year Most Parents Unaware Flu Vaccine More Important This Year
"This is the year we need child health providers to...be more proactive in trying to reach their patients who aren't scheduled for those fall preventive visits," one expert said.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 29, 2020 Category: Allergy & Immunology Tags: Pediatrics News Source Type: news

Exposing Babies to Wheat Very Early Might Prevent Celiac Disease: Study
TUESDAY, Sept. 29, 2020 -- Childhood risk for developing the allergic/autoimmune disorder known as celiac disease might be eliminated if infants were exposed to gluten as early as 4 months of age, new British research suggests. The observation is... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 29, 2020 Category: General Medicine Source Type: news

FDA warns about serious problems with high doses of the allergy medicine diphenhydramine (Benadryl)
Listen to FDA Drug Safety Podcast on Drug Safety Communication titled "FDA warns about serious Problems with high doses of the allergy medicine diphenhydramine (Bendaryl). (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 29, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Is this the answer for threatening allergic reactions?
The transparent wafer, which is placed under the tongue at the first sign of a dangerous allergic reaction (called anaphylaxis), could stop life-threatening allergic reactions in their tracks. (Source: the Mail online | Health)
Source: the Mail online | Health - September 29, 2020 Category: Consumer Health News Source Type: news

FDA OKs Mepolizumab (Nucala) for Hypereosinophilic Syndrome FDA OKs Mepolizumab (Nucala) for Hypereosinophilic Syndrome
Mepolizumab is indicated for adults and children aged 12 years and older with HES for 6 months or longer without an identifiable nonhematologic secondary cause.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 29, 2020 Category: Allergy & Immunology Tags: Hematology-Oncology News Alert Source Type: news

Private Health Plans Pay Hospitals 247 Percent of Medicare
Relative prices average 231, 267 percent of what Medicare would pay for inpatient, outpatient services (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - September 29, 2020 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

Flu Vaccine Important, but Will GBS Patients Believe You? Flu Vaccine Important, but Will GBS Patients Believe You?
Influenza vaccination will be critically important this season. Dr Paauw reviews the literature that should help you convince your post-GBS patients to get it.Medscape Internal Medicine (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 28, 2020 Category: Allergy & Immunology Tags: Internal Medicine Clinical Case Source Type: news

UCLA researchers ’ efforts to combat melanoma gets $13M boost from NIH
UCLA researchers have received a $13 million grant from the National Institutes of Health to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies.There have been significant advancements in the past decade using targeted therapies and immunotherapies for treating people withadvanced forms of this deadliest type of skin cancer, but the treatments still only work in some people. Tumors can — and oftendo— become resistant to these drugs.“While these therapies have transformed the way people with melanoma are treated, only about 40% to 50% of peopl...
Source: UCLA Newsroom: Health Sciences - September 28, 2020 Category: Universities & Medical Training Source Type: news

Strong activation of anti-bacterial T cells linked to severe COVID-19
A type of anti-bacterial T cells, so-called MAIT cells, are strongly activated in people with moderate to severe COVID-19 disease, according to a study by researchers at Karolinska Institutet in Sweden that is published in the journal Science Immunology. The findings contribute to increased understanding about how our immune system responds against COVID-19 infection. (Source: World Pharma News)
Source: World Pharma News - September 28, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Strong activation of anti-bacterial T cells linked to severe COVID-19
(Karolinska Institutet) A type of anti-bacterial T cells, so-called MAIT cells, are strongly activated in people with moderate to severe COVID-19 disease, according to a study by researchers at Karolinska Institutet in Sweden that is published in the journal Science Immunology. The findings contribute to increased understanding about how our immune system responds against COVID-19 infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 28, 2020 Category: Infectious Diseases Source Type: news

Researchers discover a new method to regulate cell plasticity
(Institute for Research in Biomedicine (IRB Barcelona)) Researchers at IRB Barcelona's Cellular Plasticity and Disease Laboratory propose a more efficient way to limit cell plasticity without causing cell damage.The new method sheds light on processes in which cell plasticity is important, such as cancer and immunology.The study has been published in the journal Nature Cell Biology and has been supported by " la Caixa " Foundation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 28, 2020 Category: International Medicine & Public Health Source Type: news

Cases of Nut Anaphylaxis Spike in Children at Halloween and Easter Cases of Nut Anaphylaxis Spike in Children at Halloween and Easter
The number of children showing up in emergency departments with anaphylaxis may spike during Halloween and Easter, a new study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 25, 2020 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Benadryl Warning: FDA Investigates Reports Of Teen Injuries, Deaths Linked To TikTok Challenge
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 25, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston Benadryl CNN FDA TikTok Source Type: news

Scientists Sequence Genome of Mold That Produced First Penicillin
Title: Scientists Sequence Genome of Mold That Produced First PenicillinCategory: Health NewsCreated: 9/25/2020 12:00:00 AMLast Editorial Review: 9/25/2020 12:00:00 AM (Source: MedicineNet Allergies General)
Source: MedicineNet Allergies General - September 25, 2020 Category: Allergy & Immunology Source Type: news

This is why Covid-19 could be life-threatening for some patients
“It looks like this virus has one big trick,” said Shane Crotty, a professor in the Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology in California. (Source: The Economic Times)
Source: The Economic Times - September 25, 2020 Category: Consumer Health News Source Type: news

Uch é Blackstock, One of the Great Young Activists in Medicine Uch é Blackstock, One of the Great Young Activists in Medicine
Eric Topol and Abraham Verghese talk with emergency medicine physician Uch é Blackstock about the real changes that could bring about health equity.'I'm hopeful,'she says.Medscape (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 24, 2020 Category: Allergy & Immunology Tags: Internal Medicine Expert Interview Source Type: news

Benadryl (diphenhydramine): Drug Safety Communication - Serious Problems with High Doses of the Allergy Medicine
FDA is warning that taking higher than recommended doses of the common over-the-counter (OTC) allergy medicine Benadryl (diphenhydramine) can lead to serious heart problems, seizures, coma, or even death. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 24, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Scientists discover genetic and immunologic underpinnings of some cases of severe COVID-19
NIH investigator co-led international research effort. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 24, 2020 Category: American Health Source Type: news

FDA warns about serious problems with high doses of the allergy medicine diphenhydramine (Benadryl)
FDA warns against taking higher than recommended doses of over-the-counter Benadryl, which can lead to serious problems and death. We are aware of news reports of teens misusing the drug after participating in “Benadryl Challenge” on TikTok (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 24, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Cooked carrots can trigger allergic reactions
(Universit ä t Bayreuth) The consumption of raw carrots triggers allergic reactions in many people. Contrary to popular belief, cooked carrots can also have this effect. This was recently discovered by a research team at the University of Bayreuth. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 24, 2020 Category: International Medicine & Public Health Source Type: news

A step toward helping patients breathe deeply
(La Jolla Institute for Immunology) In a new study, researchers at La Jolla Institute for Immunology (LJI) report that a protein called TL1A drives fibrosis in several mouse models, triggering tissue remodeling, and making it harder for lungs and airways to function normally. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 24, 2020 Category: International Medicine & Public Health Source Type: news

Scientists Discover Genetic and Immunologic Underpinnings of Some Cases of Severe COVID-19
(NIH/National Institute of Allergy and Infectious Diseases) New findings by scientists at the National Institutes of Health and their collaborators help explain why some people with COVID-19 develop severe disease. The findings also may provide the first molecular explanation for why more men than women die from COVID-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 24, 2020 Category: Infectious Diseases Source Type: news

St. Jude immunologist Thirumala-Devi Kanneganti, Ph.D., receives NCI award
(St. Jude Children's Research Hospital) The National Cancer Institute award provides extended support for researchers to pursue projects with groundbreaking cancer research potential. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

The science and medicine of human immunology
Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer. (Source: ScienceNOW)
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Pulendran, B., Davis, M. M. Tags: Immunology, Online Only review Source Type: news

Succination inactivates gasdermin D and blocks pyroptosis
Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs’ cycle intermediates that alter transcription of immune response genes. We extended these observations by defining fumarate as an inhibitor of pyroptotic cell death. We found that dimethyl fumarate (DMF) delivered to cells or endogenous fumarate reacts with gasdermin D (GSDMD) at critical cysteine residues to form S-(2-succinyl)-cysteine. GSDMD succination prevents its interaction with caspases, limiting its processing, oligomerization, and capacity to induce cell death. In mice, the administration of DMF protects against lipop...
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Humphries, F., Shmuel-Galia, L., Ketelut-Carneiro, N., Li, S., Wang, B., Nemmara, V. V., Wilson, R., Jiang, Z., Khalighinejad, F., Muneeruddin, K., Shaffer, S. A., Dutta, R., Ionete, C., Pesiridis, S., Yang, S., Thompson, P. R., Fitzgerald, K. A. Tags: Biochemistry, Immunology reports Source Type: news

The immunogenetics of sexual parasitism
Sexual parasitism has evolved as a distinctive mode of reproduction among deep-sea anglerfishes. The permanent attachment of males to host females observed in these species represents a form of anatomical joining, which is otherwise unknown in nature. Pronounced modifications to immune facilities are associated with this reproductive trait. The genomes of species with temporarily attaching males lack functional aicda genes that underpin affinity maturation of antibodies. Permanent attachment is associated with additional alterations, culminating in the loss of functional rag genes in some species, abolishing somatic divers...
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Swann, J. B., Holland, S. J., Petersen, M., Pietsch, T. W., Boehm, T. Tags: Evolution, Immunology r-articles Source Type: news

Fumarate targets pyroptosis
(Source: ScienceNOW)
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Scanlon, S. T. Tags: Biochemistry, Immunology twis Source Type: news

Immunology through a human lens
(Source: ScienceNOW)
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Kelly, P. N. Tags: Immunology twis Source Type: news

Reconfiguring an immune response
(Source: ScienceNOW)
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Vignieri, S. Tags: Evolution, Immunology twis Source Type: news

Preventing pores and inflammation
(Source: ScienceNOW)
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Pickering, R. J., Bryant, C. E. Tags: Immunology perspective Source Type: news

J & J ’ s One-Shot COVID-19 Vaccine Advances to Phase 3 Testing J & J ’ s One-Shot COVID-19 Vaccine Advances to Phase 3 Testing
Johnson& Johnson has advanced its one-shot COVID-19 vaccine into phase 3 testing. The National Institute of Allergy and Infectious Diseases describes this as the fourth candidate to reach this stage.Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - September 23, 2020 Category: Primary Care Tags: Infectious Diseases News Source Type: news

Guts and brains: How microbes in a mother ’s intestines affect fetal neurodevelopment
During pregnancy in mice, the billions of bacteria and other microbes that live in a mother ’s intestines regulate key metabolites, small molecules that are important for healthy fetal brain development,UCLA biologists report Sept. 23 in the journal Nature.While the maternal gut microbiota has been associated with abnormalities in the brain function and behavior of offspring — often in response to factors like infection, a high-fat diet or stress during pregnancy — scientists had not known until now whether it influenced brain development during critical prenatal periods and in the absence of such environ...
Source: UCLA Newsroom: Health Sciences - September 23, 2020 Category: Universities & Medical Training Source Type: news

J & J ’s COVID-19 Vaccine Will Enter Phase 3 Testing, the Fourth To Reach That Stage
Johnson & Johnson announced today (Sept. 23) that it is launching a large-scale Phase 3 test of its COVID-19 vaccine candidate, which was developed based on science supported by the National Institutes of Health. The vaccine, being tested through the company’s Janssen Pharmaceuticals arm, will be the fourth to enter late stage studies, following candidates from Moderna, Pfizer-BioNTech and AstraZeneca. Unlike those vaccine candidates, which all require two shots, J&J’s vaccine involves a single injection. That means it could require half the number of doses to immunize the same number of people. J&J...
Source: TIME: Health - September 23, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Johnson & Johnson ’ s Coronavirus Vaccine Enters Phase 3 Trial With Beth Israel
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 23, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Beth Israel Deacones Medical Center Coronavirus Johnson & Johnson Source Type: news

Johnson & Johnson Initiates Pivotal Global Phase 3 Clinical Trial of Janssen ’s COVID-19 Vaccine Candidate
NEW BRUNSWICK, N.J., September 23, 2020 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced the launch of its large-scale, pivotal, multi-country Phase 3 trial (ENSEMBLE) for its COVID-19 vaccine candidate, JNJ-78436735, being developed by its Janssen Pharmaceutical Companies. The initiation of the ENSEMBLE trial follows positive interim results from the Company’s Phase 1/2a clinical study, which demonstrated that the safety profile and immunogenicity after a single vaccination were supportive of further development. These results have been submitted to medRxiv and are due to be published online i...
Source: Johnson and Johnson - September 23, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

Donor-conceived adults have higher incidence of immunology diseases
(Flinders University) Adults conceived through sperm donation reported higher frequencies of allergies, type 1 diabetes and other autoimmune conditions. Donor sperm conceived adults had seven times more type 1 diabetes diagnoses; double the incidence of thyroid disease, acute bronchitis and sleep apnoea; and 10% more reported allergies. The study looked at 272 donor-conceived adult participants compared to 877 conceived naturally, from around the world with most from Australia, US, UK, Belgium and Netherlands. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 23, 2020 Category: Biology Source Type: news

Fourth large-scale COVID-19 vaccine trial begins in the United States
(NIH/National Institute of Allergy and Infectious Diseases) A fourth Phase 3 clinical trial evaluating an investigational vaccine for coronavirus disease 2019 (COVID-19) has begun enrolling adult volunteers. The trial is designed to evaluate if the investigational Janssen COVID-19 vaccine (JNJ-78436725) can prevent symptomatic COVID-19 after a single dose regimen. Up to 60,000 volunteers will be enrolled in the trial at up to nearly 215 clinical research sites in the United States and internationally. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 23, 2020 Category: Infectious Diseases Source Type: news

NIH Public Affairs Specialist Turns Out To Be Covid-19 Coronavirus Conspiracy Theorist Blogger
Apparently, "streiff, ” who has been highly critical of Anthony Fauci, MD, is the pseudonym for a staff member at the National Institute of Allergy and Infectious Diseases (NIAID), which Fauci directs. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 23, 2020 Category: Pharmaceuticals Authors: Bruce Y. Lee, Senior Contributor Tags: Healthcare /healthcare Innovation /innovation Business /business Media /media pharma Source Type: news

EMA Panel Backs Baricitinib for Moderate-to-Severe Atopic Dermatitis EMA Panel Backs Baricitinib for Moderate-to-Severe Atopic Dermatitis
Baricitinib (Olumiant) would be the first JAK inhibitor (and oral medicine) indicated for adults with moderate-to-severe atopic dermatitis who are candidates for systemic therapy.International Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 23, 2020 Category: Allergy & Immunology Tags: Dermatology News Alert Source Type: news

Perrigo Asthma Inhalers Recalled Due to Clog Risk
Some of the recalled albuterol sulfate inhalers stop working after several uses (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - September 23, 2020 Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Allergy, Emergency Medicine, Pharmacy, Pulmonology, Institutional, Source Type: news

CDC Prepares States for COVID-19 Rollout Vaccine if Approved CDC Prepares States for COVID-19 Rollout Vaccine if Approved
The agency instructed states to submit plans for vaccine distribution by October 16, but an advisory committee member suggested that the deadline may be premature.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 22, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

COVID-19 May Damage Blood Marrow Immune Cells COVID-19 May Damage Blood Marrow Immune Cells
The coronavirus may damage blood marrow cells in patients with severe COVID-19, according to a new study published in the journal Science Immunology.WebMD Health News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - September 22, 2020 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news

Tragic Math: The U.S. Exceeds 200,000 COVID-19 Deaths
Body count has long been the yardstick by which we measure calamity. There were the 58,000 U.S. lives lives lost in the Vietnam war; the 1,496 souls who perished on the Titanic. In the hours after the September 11 attacks, when the death toll was not known, then-New York Mayor Rudy Giuliani famously said, “The number of casualties will be more than any of us can bear, ultimately.” We are, once again, trying to bear the unbearable as the U.S. today surpassed 200,000 deaths caused in the still-rampaging COVID-19 pandemic. We remain, as we have long been, the world’s hardest-hit country, with just 4% of the ...
Source: TIME: Health - September 22, 2020 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized COVID-19 Source Type: news

High Prevalence of SARS-CoV-2 Antibodies in Mass. Community High Prevalence of SARS-CoV-2 Antibodies in Mass. Community
Nearly a third of residents tested in one Massachusetts community were positive for anti-SARS-CoV-2 antibodies, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 22, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Holidays Can Be a Fright for Kids With Food Allergies
A new study found that serious allergic reactions (anaphylaxis) triggered by peanuts jumped 85% when kids were trick or treating. (Source: WebMD Health)
Source: WebMD Health - September 21, 2020 Category: Consumer Health News Source Type: news

Safety Concern With Fingolimod to Ocrelizumab Switch in MS Safety Concern With Fingolimod to Ocrelizumab Switch in MS
A new study has suggested that some patients who make this switch may experience"double immunosuppression" – very low levels of both T and B cells, and therefore be at increased risk for infection.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 21, 2020 Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news

Cystic Fibrosis: The Cribsiders' Update Cystic Fibrosis: The Cribsiders' Update
Presentation of CF, airway clearance regimens, diabetes in CF, and other highlights from the cystic fibrosis episode of The Cribsiders podcast.Medscape Pediatrics (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 21, 2020 Category: Allergy & Immunology Tags: Pediatrics Commentary Source Type: news

Holidays Can Be a Fright for Kids With Food Allergies
MONDAY, Sept. 21, 2020 -- Parents of kids with food allergies probably won't be surprised to hear that Halloween is an especially risky time for their youngsters. A new study found that serious allergic reactions (anaphylaxis) triggered by peanuts... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 21, 2020 Category: General Medicine Source Type: news

Holidays Can Be a Fright for Kids With Food Allergies
Title: Holidays Can Be a Fright for Kids With Food AllergiesCategory: Health NewsCreated: 9/21/2020 12:00:00 AMLast Editorial Review: 9/21/2020 12:00:00 AM (Source: MedicineNet Allergies General)
Source: MedicineNet Allergies General - September 21, 2020 Category: Allergy & Immunology Source Type: news

Intestinal Microbiota and Child Health Intestinal Microbiota and Child Health
A better understanding of the role of the intestinal microbiota in the development of chronic health issues in children could have important implications for prevention and treatment.Pediatric Nursing (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 21, 2020 Category: Allergy & Immunology Tags: Pediatrics Journal Article Source Type: news