Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer
Conditions: Locally Advanced Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Endoscopic Ultrasound; Drug: Fluorouracil; Drug: Irinotecan; Drug: Leucovorin; Procedure: Lymph Node Biopsy; Procedure: Magnetic Resonance Imaging; Drug: Oxaliplatin; Biological: Pembrolizumab; Drug: Photodynamic Therapy; Procedure: Positron Emission Tomography; Other: Questi...
Source: ClinicalTrials.gov - April 24, 2024 Category: Research Source Type: clinical trials

Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Food Allergy
Conditions: Food Allergy; Cow Milk Allergy Interventions: Other: Implementation of cow ' s milk in decreasingly heated forms; Other: Implementation of heated cow ' s milk; Other: No intervention Sponsors: Universitaire Ziekenhuizen KU Leuven Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 24, 2024 Category: Research Source Type: clinical trials

FDA Approves Clinical Trial for GFH925 Monotherapy in Phase III Registrational Study Treating Metastatic Colorectal Cancer
SHANGHAI, April 19, 2024. GenFleet Therapeutics, a clinical-stage biotechnology company focusing on cutting-edge therapies in oncology and immunology, announced US Food and Drug Administration (FDA) has granted the clinical trial approval for GFH925... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - April 22, 2024 Category: Pharmaceuticals Source Type: clinical trials

Sinonasal Risk Factors for Occurrence of Unilateral Versus Bilateral Allergic Fungal Rhinosinusitis .
Conditions: Allergic Fungal Rhinosinusitis Interventions: Diagnostic Test: functional endoscopic sinus surgery Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 19, 2024 Category: Research Source Type: clinical trials

Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial
DiscussionChildren with sensitization against food allergens with unknown clinical relevance often have to avoid the corresponding foods for several months until an OFC is performed. Therefore, the “window of opportunity” for an early preventive introduction of allergenic foods might be missed. This trial will assess whether an introduction of small allergen amounts will favor tolerance development in these children.Trial registrationGerman Clinical Trials Register DRKS00032769. Registered on 02 October 2023. (Source: Trials)
Source: Trials - April 19, 2024 Category: Research Source Type: clinical trials

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
Conditions: Antiphospholipid Syndrome (APS); Bullous Pemphigoid (BP); Beh çet ' s Syndrome (BS); Dermatomyositis (DM); Immune-mediated Necrotizing Myopathy (IMNM); Immune Thrombocytopenia (ITP) Interventions: Drug: RAY121 Sponsors: Chugai Pharmaceutical Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials

Short-Term Linvoseltamab Treatment, on Top of Chronic Dupilumab Treatment, for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy
Conditions: Food Allergy Interventions: Drug: linvoseltamab; Drug: dupilumab Sponsors: Regeneron Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials

Washed Microbiota Transplantation for Allergic Rhinitis
Conditions: Rhinitis, Allergic Interventions: Drug: Washed Microbiota Transplantation; Drug: Placebo Sponsors: The Second Hospital of Nanjing Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials

Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery
Conditions: Obesity; Liver Disease Parenchymal Interventions: Other: Nutritional Approach; Other: Surgery Approach Sponsors: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis; Notarnicola Maria; Cozzolongo Raffaele; Shahini Endrit; De Pergola Giovanni; Lippolis Giuseppe Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials

One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole in Chronic Fascioliasis
Conditions: Fascioliasis Interventions: Drug: Oxfendazole; Drug: Triclabendazole Sponsors: Universidad Peruana Cayetano Heredia; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2024 Category: Research Source Type: clinical trials

ASIA-Mesh: a Pilot Study for Diagnostics and Treatment on ASIA Syndrome Caused by Polypropylene Mesh Implantation
Conditions: Autoimmunity; Inguinal Hernia; Stress Urinary Incontinence; Pelvic Organ Prolapse; Implant Complication; Systemic Autoimmune Disease Interventions: Diagnostic Test: mesh allergy test; Diagnostic Test: blood tests; Procedure: Mesh removal Sponsors: Maxima Medical Center; Amsterdam UMC; Maastricht University Medical Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials

Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated With Imiquimod
Conditions: HSIL, High-Grade Squamous Intraepithelial Lesions; Vaginal Microbiome; Biomarkers Interventions: Drug: Imiquimod; Procedure: Loop Electrosurgical Excision Procedure Sponsors: Barretos Cancer Hospital; Funda ção de Amparo à Pesquisa do Estado de São Paulo; Farmoquimica S.A.; Hospital de Cancer de Barretos - Fundacao Pio XII Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials

Characterization of Visual Characteristics in Allergic Contact Dermatitis Using the Skincam ® Tool
Conditions: Allergic Contact Dermatitis Interventions: Other: The patch under study is photographed using the SkinCam ® Sponsors: Hospices Civils de Lyon Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials

Efficacy and Safety of Bismuth Quadruple Therapy Containing Cefuroxime and Tetracycline as First-line Therapy for Eradicating Helicobacter Pylori in Patients Allergic to Penicillin
Conditions: Helicobacter Pylori Infection Interventions: Drug: 14-day bismuth quadruple regimen containing cefuroxime and tetracycline; Drug: 14-day bismuth quadruple regimen containing cefuroxime and levofloxacin Sponsors: Qilu Hospital of Shandong University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials

A Clinical Study of Omalizumab in the Treatment of Allergic Asthma(ESSENCE)
Conditions: Moderate to Severe Allergic Asthma Interventions: Drug: IgE monoclonal antibody Sponsors: The First Affiliated Hospital with Nanjing Medical University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 4, 2024 Category: Research Source Type: clinical trials