Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profiles
ConclusionsJGP intervention improves ILI by restoring gut microbiota and modifying its metabolic profiles. These results provide a novel insight into the mechanism of JGP in treating ILI and the scientific basis to support its clinical application. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer
ConclusionWe identified ERLIN2 and CDK5RAP3 as ERS-related genes with important prognostic and immunologic values, and classified patients between high- and low-risk subgroups, which provided new prognostic markers, immunotherapeutic targets, and basis for prognostic assessments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
GSE172387 Loss of retinoic acid signaling drives immune escape in IDH mutant gliomas
Contributors : Anthony R Cillo ; Aparna Rao ; Xiaoran Zhang ; Tullia C Bruno ; Dario A Vignali ; Nduka AmankulorSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusGliomas are immunologically cold tumors that can be broken into several categories based on either RNA expression profiles or methylation profiles, with isocitrate dehydrogenase (IDH) mutations defining a major segregration between types. IDH mutant gliomas often exhibit defects in the retinoic acid pathway. We treated mice harboring IDH mutant gliomas with all-trans retinoic acid, and found that this treatment cause...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
Factors Determining Course of IgE-Mediated Cow ’s Milk Allergy
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - April 19, 2024 Category: Pediatrics Source Type: research
Evaluating an e-device to monitor the type 2 high unified airway response to dupilumab
Patients with unified airways disease (UAD) who have asthma and concomitant chronic rhinosinusitis with nasal polyps (CRSwNP) are often difficult to manage and have a higher burden of type 2 (T2) inflammation as compared to those with asthma or nasal polyps (NP) alone.1 Few studies have prospectively looked in detail at concomitant upper and lower airway outcomes in patients with T2 high UAD in response to biologics.2 Evaluating the clinical burden of upper and lower airway disease in response to treatment can be challenging using conventional analogue paper diary recordings of peak nasal inspiratory flow (PNIF) and peak e...
Source: Annals of Allergy, Asthma and Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth Tags: Letters Source Type: research
Cancers, Vol. 16, Pages 1572: The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors
In conclusion, this study provides new insights into the unique molecular profiles of HRASmt tumors that may help to identify new targets and guide future clinical trial design. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Samuel A. Kareff Asaad Trabolsi Harris B. Krause Timothy Samec Andrew Elliott Estelamari Rodriguez Coral Olazagasti Dionysios C. Watson Matias A. Bustos Dave S. B. Hoon Stephanie L. Graff Emmanuel S. Antonarakis Sanjay Goel George Sledge Gilberto Lopes Tags: Article Source Type: research
Antigen-specific immunotherapy via delivery of tolerogenic dendritic cells for multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 19, 2024 Category: Allergy & Immunology Authors: Vivien Li, Michele Binder, Anthony W. Purcell, Trevor J. Kilpatrick Tags: Review Article Source Type: research
Evaluation and Modification of a Shared Decision-Making Tool for Peanut Allergy Management
This study refined the decision aid ’s content to better reflect patients’ and caregivers’ lived experience.Recent FindingsCurrent standard of care for peanut allergy is avoidance, although peanut oral immunotherapy has been approved by the Food and Drug Administration for use in patients 4 –17 years old.SummaryAn advisory board of allergy therapy experts (n = 3) and patient advocates (n = 3) informed modifications to the decision aid. The revised tool underwent cognitive debriefing interviews (CDIs) among adolescents (12–17 years old) with peanut allergy and caregivers of patients 4–17 years old with p...
Source: Current Allergy and Asthma Reports - April 19, 2024 Category: Allergy & Immunology Source Type: research
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
AbstractThis systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases in children, focusing on specific pollutants, timing of exposure, and associated diseases. We searched PubMed, Scopus, and Web of Science for English articles until May 1, 2023, examining maternal exposure to outdoor air pollutants (PM1, PM2.5, PM10, NO, NO2, SO2, CO, and O3) during pregnancy and child allergic diseases (atopic dermatitis (AD), food allergy (FA), asthma (AT) and allergic rhinitis (AR)/hay fever (HF)). The final 38 eligible studies were included in the meta-analysis. Exposure ...
Source: Clinical Reviews in Allergy and Immunology - April 19, 2024 Category: Allergy & Immunology Source Type: research
LncRNA SNHG1 overexpression alleviates osteoarthritis via activating PI3K/Akt signal pathway and suppressing autophagy
Immunobiology. 2024 Apr 6;229(3):152799. doi: 10.1016/j.imbio.2024.152799. Online ahead of print.ABSTRACTWe hereby intend to further explore and confirm the underlying mechanism of Small nucleolar RNA Host Gene 1 (SNHG1) in osteoarthritis (OA). For in vitro assays, OA was induced in primary chondrocytes with interleukin-1β (IL-1β) treatment; while for in vivo tests, OA model was established in mice using the destabilization of the medial meniscus (DMM) method. Cell viability and apoptosis were assessed with MTT and flow cytometry assays, respectively. Cartilage tissue was stained by Safranin-O/Fast Green Staining. The mR...
Source: Immunobiology - April 18, 2024 Category: Allergy & Immunology Authors: Qiushi Wang Jie Yang Rui Pan Zhengang Zha Source Type: research
Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7
In this study, we report that zebrafish ubiquitin-specific protease 8 (USP8) promotes IRF7 degradation through an autophagy-lysosome-dependent pathway to inhibit IFN production. First, zebrafish usp8 is induced upon spring viremia of carp virus (SVCV) infection and polyinosinic/polycytidylic acid (poly I:C) stimulation. Second, overexpression of USP8 suppresses SVCV or poly I:C-mediated IFN expression. Mechanistically, USP8 interacts with IRF7 and promotes its degradation via an autophagy-lysosome-dependent pathway. Finally, USP8 significantly suppresses cellular antiviral responses and enhances SVCV proliferation. In summ...
Source: Developmental and Comparative Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Chu-Jing Zhou Can Zhang Long-Feng Lu Shun Li Source Type: research
Study on anti-BmNPV mechanism of branched-chain amino acid aminotransferases in silkworm
In this study, the four midgut tissue samples of the resistance strain NB (NB) and susceptible strain 306 (306) and the NB and 306 continuously infected with BmNPV for 96 hours are used for whole transcriptome sequencing to analyze the differences in the genetic background of NB and 306 and the differences after inoculation of BmNPV, and the significantly different mRNA, miRNA and lnRNA between NB and 306 after BmNPV inoculation were screened. By comparing NB and 306, 2,651 significantly different mRNAs, 57 significantly different miRNAs and 198 significantly different lncRNAs were screened. By comparing NB and 306 after B...
Source: Developmental and Comparative Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Can Chen Liang Chen Xiaoyong Liu Shangshang Ma Keping Chen Source Type: research
Galectin-8-like isoform X1 mediates antibacterial, antiviral, and antioxidant responses in red-lip mullet (Planiliza haematocheilus) through positive modulation of pro-inflammatory cytokine, chemokine, and enzymatic antioxidant activity
This study identified Galectin-8-like isoform X1 (PhGal8X1) from red-lip mullet (Planiliza haematocheilus) and investigated its role in regulating fish immunity. The open reading frame of PhGal8X1 was 918bp, encoding a soluble protein of 305 amino acids. The protein had a theoretical isoelectric (pI) point of 7.7 and an estimated molecular weight of 34.078 kDa. PhGal8X1 was expressed in various tissues of the fish, with prominent levels in the brain, stomach, and intestine. PhGal8X1 expression was significantly (p<0.05) induced in the blood and spleen upon challenge with different immune stimuli, including polyinosinic:...
Source: Developmental and Comparative Immunology - April 18, 2024 Category: Allergy & Immunology Authors: W A D L R Warnakula H M V Udayantha D S Liyanage E M T Tharanga W K M Omeka M A H Dilshan H A C R Hanchapola J D H E Jayasinghe Taehyug Jeong Qiang Wan Jehee Lee Source Type: research
Heat shock protein 71 restricts mutation of porcine reproductive and respiratory syndrome virus nsp2 in vitro
In this study, the binding of PRRSV nsp2 to HSP71 protein was detected by using the IP/MS technique. And the inhibitory effect of HSP71 on nsp2 antagonistic activity was validated by measuring NF-kB luciferase reporter. According to stress from inhibitory effects, the amino acid variation profile of PRRSV nsp2 under HSP71 stress was further analyzed using second-generation sequencing. Surprisingly, the results indicated that HSP71 pressure limits the random mutations of PRRSV nsp2 and maintains the dominant PRRSV strain within the population. Mutant strain showed weaker antagonistic activity and replication capability in c...
Source: Comparative immunology, microbiology and infectious diseases. - April 18, 2024 Category: Allergy & Immunology Authors: Fengyu Xie Lei Kang Mengli Chen Tong Zhang Zongjie Li Donghua Shao Beibei Li Jianchao Wei Yafeng Qiu Manxiang Li Zhiyong Ma Ke Liu Source Type: research
Multi-locus sequence analysis of Anaplasma bovis in goats and ticks from Thailand, with the initial identification of an uncultured Anaplasma species closely related to Anaplasma phagocytophilum-like 1
This study aimed to undertake a genetic analysis of A. bovis and determine its prevalence in goats and ticks utilizing three genetic markers (16S rRNA, gltA, groEL). A total of 601 goat blood and 118 tick samples were collected from 12 sampling sites throughout Thailand. Two tick species, Haemaphysalis bispinosa (n = 109), and Rhipicephalus microplus (n = 9) were identified. The results herein showed that 13.8 % (83/601) of goats at several farms and 5 % (1/20) of ticks were infected with A. bovis. Among infected ticks, A. bovis and an uncultured Anaplasma sp. which are closely related to A. phagocytophilum-like 1, were de...
Source: Comparative immunology, microbiology and infectious diseases. - April 18, 2024 Category: Allergy & Immunology Authors: Aung Aung Duriyang Narapakdeesakul Apinya Arnuphapprasert Yudhi Ratna Nugraheni Chaiyawan Wattanachant Winai Kaewlamun Morakot Kaewthamasorn Source Type: research
