TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKC α-HuR axis in rheumatoid arthritis

In conclusion, our findings unveil a novel regulatory mechanism involved in the pathogenesis of RA and suggest that targeting TRPM7 might be a potential strategy for the prevention and treatment of RA.PMID:38581988 | DOI:10.1016/j.intimp.2024.111933

Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yi Lin Yong Chen Weirong Hu Xingyu Liu Wenjuan Hao Jing Xing Jie Ding Yucai Xu Feng Yao Yingjie Zhao Ke Wang Shufang Li Qiuxia Yu Wei Hu Renpeng Zhou Source Type: research