The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential
Sepsis is a potentially fatal condition caused by dysregulation of the body ' s immune response to an infection. Sepsis-induced liver injury is considered a strong independent prognosticator of death in the critical care unit, and there is anatomic and accumulating epidemiologic evidence that demonstrates intimate cross talk between the gut and the liver. Intestinal barrier disruption and gut microbiota dysbiosis during sepsis result in translocation of intestinal pathogen-associated molecular patterns and damage-associated molecular patterns into the liver and systemic circulation. The liver is essential for regulating im...
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news

Translocation of an Anteater Infected With Rabies Translocation of an Anteater Infected With Rabies
This case demonstrates the possibility of rabies translocation by human movement of captive mammals, even in species in which rabies has not been previously reported.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 6, 2022 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

The role of bacterial translocation in sepsis: a new target for therapy P
Sepsis is a leading cause of death in critically ill patients, primarily due to multiple organ failures. It is associated with a systemic inflammatory response that plays a role in the pathogenesis of the disease. Intestinal barrier dysfunction and bacterial translocation (BT) play pivotal roles in the pathogenesis of sepsis and associated organ failure. In this review, we describe recent advances in understanding the mechanisms by which the gut microbiome and BT contribute to the pathogenesis of sepsis. We also discuss several potential treatment modalities that target the microbiome as therapeutic tools for patients with...
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news

Translocation of an Anteater (Tamandua tetradactyla) Infected with Rabies from Virginia to Tennessee Resulting in Multiple Human Exposures, 2021
This report describes a case of rabies virus in a tamandua leading to exposure among multiple people. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - April 14, 2022 Category: American Health Tags: Diseases & Conditions MMWR Morbidity Mortality Weekly Report Public Health Rabies Rabies Vaccine Wildlife diseases Source Type: news

What are Some of the Complications of Short Bowel Syndrome?
Discussion Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in neonates. Mortality rates are from 0-45% depending on infant weight and gestation with more premature and smaller infants having greater mortality. NEC usually occurs in premature infants but it also occurs in term infants. The etiology is unknown but is probably multifactorial with ischemia and/or reperfusion playing some role. There are ‘outbreaks’ of NEC but no causative organism has been identified. Regardless of the originating cause, inflammation of the intestine and release of inflammatory mediators causes variou...
Source: PediatricEducation.org - August 30, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Researchers identify a molecule critical to functional brain rejuvenation
(Advanced Science Research Center, GC/CUNY) A new study from a CUNY ASRC Neuroscience Initiative team has identified a molecule called ten-eleven-translocation 1 (TET1) as a necessary component in the repair of myelin, which protects nerves and facilitates accurate transmission of electrical signals. The discovery could have important implications in treating neurodegenerative diseases and for molecular rejuvenation of aging brains in healthy individuals. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 7, 2021 Category: International Medicine & Public Health Source Type: news

Genomics-informed decisions can help save species from extinction
(Lund University) Researchers in Lund, Copenhagen and Norwich have shown that harmful mutations present in the DNA play an important - yet neglected - role in the conservation and translocation programs of threatened species. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 4, 2021 Category: Biology Source Type: news

Accurate evaluation of CRISPR genome editing
(Bar-Ilan University) A multidisciplinary team of researchers from the Interdisciplinary Center Herzliya and Bar-Ilan University report in the May 24th issue of the journal Nature Communications the development of a new software tool to detect, evaluate and quantify off-target editing activity, including adverse translocation events that can cause cancer. The software is based on input taken from a standard measurement assay, involving multiplexed PCR amplification and Next-Generation Sequencing (NGS). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 24, 2021 Category: International Medicine & Public Health Source Type: news

Getting to the core of HIV replication
(University of Texas at Austin, Texas Advanced Computing Center) Mechanism found for how HIV-1 virus imports nucleotides into its core that fuel DNA synthesis, a key step in its replication. Supercomputer molecular dynamics simulations helped test translocation and free energy calculations. Research supported by the NSF-funded XSEDE through TACC Stampede2 and PSC Bridges. HIV-1 capsid research provides potential for new drug targets for therapeutic development such as improved anti-retroviral drugs. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 31, 2021 Category: Biology Source Type: news

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells
Innate immune responses to Gram-negative bacteria depend on the recognition of lipopolysaccharide (LPS) by a receptor complex that includes CD14 and TLR4. In dendritic cells (DCs), CD14 enhances the activation not only of TLR4 but also that of the NFAT family of transcription factors, which suppresses cell survival and promotes the production of inflammatory mediators. NFAT activation requires Ca2+ mobilization. In DCs, Ca2+ mobilization in response to LPS depends on phospholipase C 2 (PLC2), which produces inositol 1,4,5-trisphosphate (IP3). Here, we showed that the IP3 receptor 3 (IP3R3) and ITPKB, a kinase that converts...
Source: Signal Transduction Knowledge Environment - March 30, 2021 Category: Science Authors: Marongiu, L., Mingozzi, F., Cigni, C., Marzi, R., Di Gioia, M., Garre, M., Parazzoli, D., Sironi, L., Collini, M., Sakaguchi, R., Morii, T., Crosti, M., Moro, M., Schurmans, S., Catelani, T., Rotem, R., Colombo, M., Shears, S., Prosperi, D., Zanoni, I., G Tags: STKE Research Articles Source Type: news

Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action is mediated by NAADP-binding protein(s) of unknown identity that confer NAADP sensitivity to TPCs. Here, we used a "clickable" NAADP-based photoprobe to isolate human NAADP-binding proteins and identified Jupiter microtubule-associated homolog 2 (JPT2) as a TPC accessory protein required for endogenous NAADP-evoked Ca2+ signaling. JPT2 was also required for the translocation of a severe acute respir...
Source: Signal Transduction Knowledge Environment - March 23, 2021 Category: Science Authors: Gunaratne, G. S., Brailoiu, E., He, S., Unterwald, E. M., Patel, S., Slama, J. T., Walseth, T. F., Marchant, J. S. Tags: STKE Research Articles Source Type: news

Genetic Mutations May Add to Racial Disparity in Child B - ALL
Increased incidence of IKZF1 deletion and IGH - CRLF2 translocation seen in Hispanic/Latino children with B - ALL (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 19, 2021 Category: Cancer & Oncology Tags: Oncology, Pathology, Pediatrics, Journal, Source Type: news

Genetic Mutations May Add to Racial Disparity in Child B-ALL
FRIDAY, Feb. 19, 2021 -- Hispanic/Latino (H/L) children with B-cell acute lymphoblastic leukemia (B-ALL) have an increased incidence of IKZF1 deletion and IGH-CRLF2 translocation, according to a letter to the editor published online Feb. 2 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 19, 2021 Category: Pharmaceuticals Source Type: news

Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2
Spliceosome remodeling, executed by conserved adenosine triphosphatase (ATPase)/helicases including Prp2, enables precursor messenger RNA (pre-mRNA) splicing. However, the structural basis for the function of the ATPase/helicases remains poorly understood. Here, we report atomic structures of Prp2 in isolation, Prp2 complexed with its coactivator Spp2, and Prp2-loaded activated spliceosome and the results of structure-guided biochemical analysis. Prp2 weakly associates with the spliceosome and cannot function without Spp2, which stably associates with Prp2 and anchors on the spliceosome, thus tethering Prp2 to the activate...
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Bai, R., Wan, R., Yan, C., Jia, Q., Lei, J., Shi, Y. Tags: Biochemistry, Online Only r-articles Source Type: news

Novel method identifies areas most suitable for conservation of black lion tamarin
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) The researchers used modeling to show which areas are suitable in terms of forest cover and climate for occupation by the endangered species, which is endemic to the state of S ã o Paulo. Their study is a contribution to translocation initiatives that move groups of these animals to areas from which the species has disappeared. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 5, 2021 Category: Biology Source Type: news