ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3
Int Immunopharmacol. 2024 Apr 24;133:112123. doi: 10.1016/j.intimp.2024.112123. Online ahead of print.ABSTRACTThe NOD-like receptor family protein 3 (NLRP3) inflammasome is a crucial complex for the host to establish inflammatory immune responses and plays vital roles in a series of disorders, including Alzheimer's disease and acute peritonitis. However, its regulatory mechanism remains largely unclear. Zinc finger antiviral protein (ZAP), also known as zinc finger CCCH-type antiviral protein 1 (ZC3HAV1), promotes viral RNA degradation and plays vital roles in host antiviral immune responses. However, the role of ZAP in in...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Danhui Qin Caiwei Wang Rongzhen Yan Ying Qin Zhendong Ying Hongyi Kong Wei Zhao Lei Zhang Hui Song Source Type: research
The quantity, function and anti-tumor effect of Mucosal associated invariant T cells in patients with bladder cancer
CONCLUSIONS: This study sheds light on the role of MAIT cells in BC. While the quantity of MAIT cells showed no significant change in BC patients, their functional attributes and association with tumor characteristics suggest their potential as an immunotherapy target in BC treatment.PMID:38663315 | DOI:10.1016/j.intimp.2024.111892 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Baodan Zhang Pengcheng Chen Jie Zhu Yongyong Lu Source Type: research
Cope with copper: From molecular mechanisms of cuproptosis to copper-related kidney diseases
Int Immunopharmacol. 2024 Apr 24;133:112075. doi: 10.1016/j.intimp.2024.112075. Online ahead of print.ABSTRACTCuproptosis has recently been identified as a novel regulatory mechanism of cell death. It is characterized by the accumulation of copper in mitochondria and its binding to acylated proteins. These characteristics lead to the downregulation of iron-sulfur cluster proteins and protein toxicity stress, ultimately resulting in cell death. Cuproptosis is distinct from other types of cell death, including necrosis, apoptosis, ferroptosis, and pyroptosis. Cu induces oxidative stress damage, protein acylation, and the oli...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yurong Zou Shukun Wu Xingli Xu Xiaoqiu Tan Shuang Yang Tangting Chen Jiong Zhang Shengqiang Li Wei Li Fang Wang Source Type: research
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibrosis. Our results showed that intraperitoneal injection of an NLRP3 inhibitor MCC950 or use of NLRP3-/- mice inhibited cardiac pyroptosis mediated by NLRP3 inflammasome in VMC. CXCL4 is a chemokine that has been reported to have pro-inflammatory and pro-fibrotic functions. In VMC, we further found that pyroptosis of Mouse myocardial fibroblasts (MCF) promoted the secretion of CXCL4 by activating Wnt/β-Catenin signaling. Subsequently, the transcriptome sequencing data showed that CXCL4 could promot...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jing Wei Ming Yu Peng Sai Nan Wang Hong Xiang Lu Source Type: research
Immune targeting of filarial glutaredoxin through a multi-epitope peptide-based vaccine: A reverse vaccinology approach
Int Immunopharmacol. 2024 Apr 23;133:112120. doi: 10.1016/j.intimp.2024.112120. Online ahead of print.ABSTRACTDespite the efforts of global programme to eliminate lymphatic filariasis (GPELF), the threat of lymphatic filariasis (LF) still looms over humanity in terms of long-term disabilities, and morbidities across the globe. In light of this situation, investigators have chosen to focus on the development of immunotherapeutics targeting the physiologically important filarial-specific proteins. Glutaredoxin (16.43 kDa) plays a pivotal role in filarial redox biology, serving as a vital contributor. In the context of the in...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nabarun Chandra Das Sampa Gorai Parth Sarthi Sen Gupta Saroj Kumar Panda Malay Kumar Rana Suprabhat Mukherjee Source Type: research
A phytosphingosine derivative mYG-II-6 inhibits histamine-mediated TRPV1 activation and MRGPRX2-dependent mast cell degranulation
CONCLUSIONS: Our findings show that mYG-II-6 can alleviate histamine-induced itch sensation through dual mechanisms. This underscores its potential as a versatile treatment for various pruritic conditions.PMID:38657498 | DOI:10.1016/j.intimp.2024.112113 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nisha Adhikari Wook-Joo Lee Soojun Park Sanghee Kim Won-Sik Shim Source Type: research
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model
Int Immunopharmacol. 2024 Apr 23;133:112125. doi: 10.1016/j.intimp.2024.112125. Online ahead of print.ABSTRACTBone fracture as a consequence of colorectal cancer (CRC) and associated osteoporosis (OP) is considered a risk factor for increasing the mortality rate among CRC patients. SNHG16/ miRNA-146a/ TRAF6 signaling pathway is a substantial contributor to neoplastic evolution, progression, and metastasis. Here, we investigated the effect of zoledronate (ZOL) on the growth of CRC and associated OP in a mouse model. Thirty Balb/c mice were divided into Naïve, azoxymethane (AOM)/dextran sodium sulfate (DSS), and ZOL groups....
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Amany Helmy Mohamed Ahmed Noureldin Hassan Nesma Hussein Abdel Hay Manar Fouad Ahmed Marwa M El Sawy Mohamed M Sonbol Reham Hussein Mohamed Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung
Int Immunopharmacol. 2024 Apr 23;133:112012. doi: 10.1016/j.intimp.2024.112012. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) seed in lung during embryogenesis and become mature in perinatal period. Establishment of acclimatization to environmental challenges is important, whereas the detailed mechanisms that drive metabolic adaptation of AMs remains to be elucidated. Here, we showed that energy metabolism of AMs was transformed from glycolysis prenatally to oxidative phosphorylation (OXPHOS) postnatally accompanied by up-regulated expression of mitochondrial transcription factor A (TFAM). TFAM deficiency distur...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jun Zhang Yu Peng Haosen Song Siqi Liu Chuanwei Li Yi Zhang Xiaowei Shi Huifang Guo Yingping Xu Source Type: research
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibrosis. Our results showed that intraperitoneal injection of an NLRP3 inhibitor MCC950 or use of NLRP3-/- mice inhibited cardiac pyroptosis mediated by NLRP3 inflammasome in VMC. CXCL4 is a chemokine that has been reported to have pro-inflammatory and pro-fibrotic functions. In VMC, we further found that pyroptosis of Mouse myocardial fibroblasts (MCF) promoted the secretion of CXCL4 by activating Wnt/β-Catenin signaling. Subsequently, the transcriptome sequencing data showed that CXCL4 could promot...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jing Wei Ming Yu Peng Sai Nan Wang Hong Xiang Lu Source Type: research
Immune targeting of filarial glutaredoxin through a multi-epitope peptide-based vaccine: A reverse vaccinology approach
Int Immunopharmacol. 2024 Apr 23;133:112120. doi: 10.1016/j.intimp.2024.112120. Online ahead of print.ABSTRACTDespite the efforts of global programme to eliminate lymphatic filariasis (GPELF), the threat of lymphatic filariasis (LF) still looms over humanity in terms of long-term disabilities, and morbidities across the globe. In light of this situation, investigators have chosen to focus on the development of immunotherapeutics targeting the physiologically important filarial-specific proteins. Glutaredoxin (16.43 kDa) plays a pivotal role in filarial redox biology, serving as a vital contributor. In the context of the in...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nabarun Chandra Das Sampa Gorai Parth Sarthi Sen Gupta Saroj Kumar Panda Malay Kumar Rana Suprabhat Mukherjee Source Type: research
A phytosphingosine derivative mYG-II-6 inhibits histamine-mediated TRPV1 activation and MRGPRX2-dependent mast cell degranulation
CONCLUSIONS: Our findings show that mYG-II-6 can alleviate histamine-induced itch sensation through dual mechanisms. This underscores its potential as a versatile treatment for various pruritic conditions.PMID:38657498 | DOI:10.1016/j.intimp.2024.112113 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nisha Adhikari Wook-Joo Lee Soojun Park Sanghee Kim Won-Sik Shim Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung
Int Immunopharmacol. 2024 Apr 23;133:112012. doi: 10.1016/j.intimp.2024.112012. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) seed in lung during embryogenesis and become mature in perinatal period. Establishment of acclimatization to environmental challenges is important, whereas the detailed mechanisms that drive metabolic adaptation of AMs remains to be elucidated. Here, we showed that energy metabolism of AMs was transformed from glycolysis prenatally to oxidative phosphorylation (OXPHOS) postnatally accompanied by up-regulated expression of mitochondrial transcription factor A (TFAM). TFAM deficiency distur...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jun Zhang Yu Peng Haosen Song Siqi Liu Chuanwei Li Yi Zhang Xiaowei Shi Huifang Guo Yingping Xu Source Type: research
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model
Int Immunopharmacol. 2024 Apr 23;133:112125. doi: 10.1016/j.intimp.2024.112125. Online ahead of print.ABSTRACTBone fracture as a consequence of colorectal cancer (CRC) and associated osteoporosis (OP) is considered a risk factor for increasing the mortality rate among CRC patients. SNHG16/ miRNA-146a/ TRAF6 signaling pathway is a substantial contributor to neoplastic evolution, progression, and metastasis. Here, we investigated the effect of zoledronate (ZOL) on the growth of CRC and associated OP in a mouse model. Thirty Balb/c mice were divided into Naïve, azoxymethane (AOM)/dextran sodium sulfate (DSS), and ZOL groups....
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Amany Helmy Mohamed Ahmed Noureldin Hassan Nesma Hussein Abdel Hay Manar Fouad Ahmed Marwa M El Sawy Mohamed M Sonbol Reham Hussein Mohamed Source Type: research
