TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKC α-HuR axis in rheumatoid arthritis
In conclusion, our findings unveil a novel regulatory mechanism involved in the pathogenesis of RA and suggest that targeting TRPM7 might be a potential strategy for the prevention and treatment of RA.PMID:38581988 | DOI:10.1016/j.intimp.2024.111933 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yi Lin Yong Chen Weirong Hu Xingyu Liu Wenjuan Hao Jing Xing Jie Ding Yucai Xu Feng Yao Yingjie Zhao Ke Wang Shufang Li Qiuxia Yu Wei Hu Renpeng Zhou Source Type: research
Enhancement of antitumor response of staphylococcal enterotoxin C2 mutant 2M-118 by promoting cell-mediated antitumor immunity
CONCLUSION: 2M-118 promotes immune function and enhances antitumor response. This indicates that 2M-118 could potentially be developed as a novel anti-tumor drug with-highefficiencyandlowtoxicity.PMID:38581989 | DOI:10.1016/j.intimp.2024.111943 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Xinlin Chen Yuguo Liu Bohai Du Mingjie Shi Zeheng Lin Hongyi Li Juyu Chen Meifen Wu Ming Shi Source Type: research
The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment
In conclusion, our results suggest that the anti-PD-L1&CXCR4 bispecific nanobody exerts an antitumor immune response by changing the pancreatic tumour microenvironment. Hence, the anti-PD-L1&CXCR4 bispecific nanobody is a potential candidate for pancreatic cancer treatment.PMID:38581990 | DOI:10.1016/j.intimp.2024.111944 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yaxian Li Yuejiang Zheng Shuyi Xu Hai Hu Liyun Peng Jianwei Zhu Mingyuan Wu Source Type: research
Role of immunotherapies and stem cell therapy in the management of liver cancer: A comprehensive review
Int Immunopharmacol. 2024 Apr 5;132:112011. doi: 10.1016/j.intimp.2024.112011. Online ahead of print.ABSTRACTLiver cancer (LC) is the sixth most common disease and the third most common cause of cancer-related mortality. The WHO predicts that more than 1 million deaths will occur from LC by 2030. Hepatocellular carcinoma (HCC) is a common form of primary LC. Today, the management of LC involves multiple disciplines, and multimodal therapy is typically selected on an individual basis, considering the intricate interactions between the patient's overall health, the stage of the tumor, and the degree of underlying liver disea...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Fares E M Ali Islam M Ibrahim Hanan S Althagafy Emad H M Hassanein Source Type: research
Endotoxin tolerance ameliorates lipopolysaccharide/D-galactosamine-induced acute liver failure by negative regulation of the NF- κB/NLRP3 and activation of Nrf2/HO-1 via Sitr1
Int Immunopharmacol. 2024 Apr 5;132:111994. doi: 10.1016/j.intimp.2024.111994. Online ahead of print.ABSTRACTAcute liver failure (ALF) is a potentially fatal disorder characterized by extensive hepatocyte necrosis and rapid decline in liver function. Numerous factors, including oxidative stress, cell death, and inflammatory responses, are associated with its pathogenesis. Endotoxin tolerance (ET) refers to the phenomenon in which the body or cells exhibit low or no response to high-dose lipopolysaccharide (LPS) stimulation after pre-stimulation with low-dose LPS. However, the specific mechanism through which ET regulates L...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Huifang Shi Xueting Xie Sijie Zheng Hong Chen Chenyi Liu Shu Li Mingqin Lu Source Type: research
Arginase inhibitor reduces fungal dissemination in murine pulmonary cryptococcosis by promoting anti-cryptococcal immunity
Int Immunopharmacol. 2024 Apr 5;132:111995. doi: 10.1016/j.intimp.2024.111995. Online ahead of print.ABSTRACTElevation of arginase enzyme activity in the lung contributes to the pathogenesis of various chronic inflammatory diseases and infections. Inhibition of arginase expression and activity is able to alleviate those effects. Here, we investigated the immunomodulatory effect of arginase inhibitor in C. neoformans infection. In the pulmonary cryptococcosis model that was shown to recapitulate human infection, we found arginase expression was excessively induced in the lung during the late stage of infection. To inhibit t...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Adithap Hansakon Pornpimon Angkasekwinai Source Type: research
Tacrolimus alleviates pulmonary fibrosis progression through inhibiting the activation and interaction of ILC2 and monocytes
This study will reveal the specific process of tacrolimus alleviating pulmonary fibrosis by regulating type II immunity, and explore the potential feasibility of tacrolimus combined with nintedanib in the treatment of pulmonary fibrosis. This project will provide new ideas for clinical optimization of anti-pulmonary fibrosis drug strategies.PMID:38581994 | DOI:10.1016/j.intimp.2024.111999 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Bowen Liu Qiuyan Jiang Ruxuan Chen Huizhe Zhang Qin Xia Chi Shao Xiangning Liu Mengqi Wang Yujie Shi Jingyan Zhu Ruixi Zhao Haixia Jiang Shaoyan Gao Xiaohe Li Honggang Zhou Cheng Yang Hui Huang Source Type: research
Impact of Drp1-regulated changes in T cell activity on the combined antitumor effects of PARPi and PD-1 inhibitors
This study aimed to investigate the influence of dynamin-related protein 1 (Drp1)-regulated T cells on the antitumor effects of poly (ADP-ribose) polymerase inhibitors (PARPi) combined with programmed cell death protein 1 (PD-1) inhibitors to identify potential targets for enhancing immunotherapy efficacy. We found that T cells with high expression of Drp1 promoted the inhibitory and killing effects of the PARPi and PD-1 inhibitor combination on lung cancer cells in vivo and in vitro. This synergistic mechanism involves Drp1-regulated promotion of activation, migration, and intratumor infiltration of effector T cells; inhi...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Jietao Ma Jun Song Xiaofang Yi Shuling Zhang Letian Huang Li Sun Ruolin Gao Chengbo Han Source Type: research
Targeting BRD4 with PROTAC degrader ameliorates LPS-induced acute lung injury by inhibiting M1 alveolar macrophage polarization
CONCLUSION: Our study suggested that targeting BRD4 using ARV-825 is a potential therapeutic approach for ALI.PMID:38581996 | DOI:10.1016/j.intimp.2024.111991 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Difei Li Yao Deng Guanxi Wen Lingwei Wang Xing Shi Shanze Chen Rongchang Chen Source Type: research
Corrigendum to "GTS-21 attenuates ACE/ACE2 ratio and glycocalyx shedding in lipopolysaccharide-induced acute lung injury by targeting macrophage polarization derived ADAM-17" [Int. Immunopharmacol. 129 (2024) 111603]
Int Immunopharmacol. 2024 Apr 5:111914. doi: 10.1016/j.intimp.2024.111914. Online ahead of print.NO ABSTRACTPMID:38582738 | DOI:10.1016/j.intimp.2024.111914 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Weiwei Zhu Fengyun Wang Chang Hu Qiuyue Zhao Dandan Zhang Xiaozhi Wang Bo Hu Jianguo Li Source Type: research
The effect of Bruton's tyrosine kinase (BTK) inhibitor in the eosinophilic asthma model of mouse
This study aims to investigate the potential of BTK inhibitor in eosinophilic asthma mouse model. BALB/c mice were sensitized with ovalbumin (OVA) via intraperitoneal injections and followed by OVA nebulizations. The mice were treated with 250 µg/ml or 500 µg/ml of ibrutinib before the second intraperitoneal injection and the first nebulization. Two days after the last OVA challenge, airway hyperresponsiveness (AHR) was assessed with methacholine, and differential cell count in bronchoalveolar lavage fluid (BALF) was performed. The cytokines were measured in BALF, and serum OVA-specific IgE and IgG antibody levels were e...
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: YeJi Choi Seo-Hee Kim Seung Jun Shin Hae-Sim Park Yoo Seob Shin Source Type: research
Integrative analyses of whole-transcriptome sequencing reveals CeRNA regulatory network in pulmonary hypertension treated with FGF21
Int Immunopharmacol. 2024 Apr 3;132:111925. doi: 10.1016/j.intimp.2024.111925. Online ahead of print.ABSTRACTNoncoding RNAs have been shown to play essential roles in hypoxic pulmonary hypertension (HPH). Our preliminary data showed that HPH is attenuated by fibroblast growth factor 21 (FGF21) administration. Therefore, we further investigated the whole transcriptome RNA expression patterns and interactions in a mice HPH model treated with FGF21. By whole-transcriptome sequencing, differentially expressed mRNAs, miRNAs, lncRNAs, and circRNAs were successfully identified in normoxia (Nx) vs. hypoxia (Hx) and Hx vs. hypoxia ...
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Xiuchun Li Lanlan Song Ziyi Lu Shuolan Tong Chi Zhang Yaxin Zhang Xinghong Wang Haijian Cai Jianhao Zhang Jin Lin Liangxing Wang Jian Wang Xiaoying Huang Source Type: research
ω3-PUFA alleviates neuroinflammation by upregulating miR-107 targeting PIEZO1/NFκB p65
CONCLUSION: The miR-107/PIEZO1/NFκB p65 pathway represents a novel mechanism underlying the improvement of neuroinflammation by ω3-PUFA.PMID:38579563 | DOI:10.1016/j.intimp.2024.111996 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Hailin Liu Lian Zhou Pengcheng Yi Fenfang Zhan Lanqian Zhou Yao Dong Yanhong Xiong Fuzhou Hua Guohai Xu Source Type: research
Neutrophils display distinct post-translational modifications in response to varied pathological stimuli
Int Immunopharmacol. 2024 Apr 3;132:111950. doi: 10.1016/j.intimp.2024.111950. Online ahead of print.ABSTRACTNeutrophils play a vital role in the innate immunity by perform effector functions through phagocytosis, degranulation, and forming extracellular traps. However, over-functioning of neutrophils has been associated with sterile inflammation such as Type 2 Diabetes, atherosclerosis, cancer and autoimmune disorders. Neutrophils exhibiting phenotypical and functional heterogeneity in both homeostatic and pathological conditions suggests distinct signaling pathways are activated in disease-specific stimuli and alter neut...
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Pooja Yedehalli Thimmappa Aswathy S Nair Sian D'silva Anjana Aravind Sandeep Mallya Sreelakshmi Pathappillil Soman Kanive Parashiva Guruprasad Shamee Shastry Rajesh Raju Thottethodi Subrahmanya Keshava Prasad Manjunath B Joshi Source Type: research
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis
CONCLUSIONS: The findings demonstrated that PAL improved DSS-induced experimental colitis. This effect was associated with inhibiting FTO expression and regulating m6A methylation.PMID:38579565 | DOI:10.1016/j.intimp.2024.111968 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Wanli Ji Yan Huo Yifan Zhang Xiaojing Qian Yi Ren Cheng Hu Jiaqi Zhang Source Type: research
