Geniposide alleviates imiquimod-induced psoriasis-like skin lesions in mice via inhibition of angiogenesis
In this study, we aimed to evaluate the protective effect of geniposide (GEN) on imiquimod (IMQ)-induced psoriasis-like skin lesions in mice. Firstly, visual changes of psoriatic skin lesions were observed and the severity was recorded using psoriasis area and severity index (PASI) score. Histological changes were assessed by HE staining for epidermal thickness and Masson's staining for collagen fibers. Then, photographs of microvascular inside the skin were taken for macroscopic observation, and microscopic changes associated with angiogenesis were evaluated. Furthermore, expression of angiogenic factors were analyzed by ...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Jiaojiao Chen Yuan Liu Nina Yin Min Zhao Xuan Sun Yanhong Zhang Zhigang Wang Source Type: research
Adjudin protects blood-brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice
In this study, we investigated the effects of adjudin on brain injury in a mouse ICH model and explored its underlying mechanisms. ICH was induced in male C57BL/6 mice by injecting collagenase into the right striatum. Mice received adjudin treatment (50 mg/kg/day) for 3 days before euthanization and the perihematomal tissues were collected for further analysis. Adjudin significantly reduced hematoma volume and improved neurological function compared with the vehicle group. Western blot showed that Adjudin markedly decreased the expression of MMP-9 and increased the expression of tight junctions (TJs) proteins, Occludin and...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Qiuyang Su Chunhe Su Yan Zhang Yan Guo Yang Liu Yuanyuan Liu V Wee Yong Mengzhou Xue Source Type: research
IGF2 promotes alveolar bone regeneration in murine periodontitis via inhibiting cGAS/STING-mediated M1 macrophage polarization
This study evaluated the role of insulin-like growth factor 2 (IGF2) in periodontitis by inhibiting the polarization of M1 macrophages via the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway. IGF2 was enriched in the gingival tissue of murine periodontitis model identified by RNA sequencing. IGF2 application alleviated the expression of pro-inflammatory factors and promoted osteogenesis and the expression of related genes and proteins in a dose-dependent manner in periodontitis. The result of micro-CT verified this finding. Both in vivo and in vitro results revealed that IGF2 decreased the pol...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Tairan Wang Yi Tang Yuxing Xia Qian Zhang Shaokang Cao Miaomiao Bie Feiwu Kang Source Type: research
The skin circadian clock gene F3 as a potential marker for psoriasis severity and its bidirectional relationship with IL-17 signaling in keratinocytes
CONCLUSION: Our research revealed a bidirectional link between the skin circadian gene F3 and the IL-17 signaling pathway in psoriasis, suggesting that F3 may interact with the IL-17 pathway by activating JAK-STAT within keratinocytes and inducing abnormal intracellular inflammation.PMID:38565044 | DOI:10.1016/j.intimp.2024.111993 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Xiuqing Yuan Caixin Ou Xinhui Li Zhe Zhuang Yongfeng Chen Source Type: research
Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation
Int Immunopharmacol. 2024 Apr 1;132:111942. doi: 10.1016/j.intimp.2024.111942. Online ahead of print.ABSTRACTEndometriosis (EM) is a gynecological inflammatory disease often accompanied by stress, chronic pelvic pain (CPP), anxiety, and depression, leading to a diminished quality of life. This review aims to discuss the relationship between systemic and local inflammatory responses in the central nervous system (CNS), focusing on glial dysfunctions (astrocytes and microglia) as in critical brain regions involved in emotion, cognition, pain processing, anxiety, and depression. The review presents that EM is connected to inc...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Tahmineh Mokhtari Elnaz Irandoost Fatemeh Sheikhbahaei Source Type: research
Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions
Int Immunopharmacol. 2024 Mar 31;132:111932. doi: 10.1016/j.intimp.2024.111932. Online ahead of print.ABSTRACTUric acid is a product of purine degradation, and uric acid may have multiple physiologic roles, including the beneficial effects as an antioxidant and neuroprotector, maintenance of blood pressure during low salt ingestion, and modulation of immunity. However, overproduction of metabolic uric acid, and/or imbalance of renal uric acid secretion and reabsorption, and/or underexcretion of extrarenal uric acid, e.g. gut, will contribute to hyperuricemia, which is a common metabolic disease. Long-lasting hyperuricemia ...
Source: International Immunopharmacology - April 1, 2024 Category: Allergy & Immunology Authors: Shuangling Yang Haimei Liu Xian-Ming Fang Fuman Yan Yaxing Zhang Source Type: research
Sacubitril/valsartan alleviates sunitinib-induced cardiac fibrosis and oxidative stress via improving TXNIP/TRX system and downregulation of NF- ĸB/Wnt/β-catenin/SOX9 signaling
Int Immunopharmacol. 2024 Mar 31;132:111963. doi: 10.1016/j.intimp.2024.111963. Online ahead of print.ABSTRACTWe aimed in this study to investigate the possible cardioprotective effects of sacubitril/valsartan against sunitinib-induced cardiac fibrosis (CF) and oxidative stress via targeting thioredoxin-interacting protein/thioredoxin (TXNIP/TRX) system and nuclear factor-kappa B (NF-κB)/Wingless-related MMTV integration site (Wnt)/β-catenin/Sex-determining region Y box 9 (SOX9) signaling. CF was induced in male Wistar albino rats by cumulative dose of sunitinib (300 mg/kg, given over 4 weeks as: 25 mg/kg orally, three t...
Source: International Immunopharmacology - April 1, 2024 Category: Allergy & Immunology Authors: Hoda E Mohamad Mervat E Askar Mohamed A Shaheen Nourhan M Baraka Yasmin K Mahmoud Source Type: research
Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions
Int Immunopharmacol. 2024 Mar 31;132:111932. doi: 10.1016/j.intimp.2024.111932. Online ahead of print.ABSTRACTUric acid is a product of purine degradation, and uric acid may have multiple physiologic roles, including the beneficial effects as an antioxidant and neuroprotector, maintenance of blood pressure during low salt ingestion, and modulation of immunity. However, overproduction of metabolic uric acid, and/or imbalance of renal uric acid secretion and reabsorption, and/or underexcretion of extrarenal uric acid, e.g. gut, will contribute to hyperuricemia, which is a common metabolic disease. Long-lasting hyperuricemia ...
Source: International Immunopharmacology - April 1, 2024 Category: Allergy & Immunology Authors: Shuangling Yang Haimei Liu Xian-Ming Fang Fuman Yan Yaxing Zhang Source Type: research
Sacubitril/valsartan alleviates sunitinib-induced cardiac fibrosis and oxidative stress via improving TXNIP/TRX system and downregulation of NF- ĸB/Wnt/β-catenin/SOX9 signaling
Int Immunopharmacol. 2024 Mar 31;132:111963. doi: 10.1016/j.intimp.2024.111963. Online ahead of print.ABSTRACTWe aimed in this study to investigate the possible cardioprotective effects of sacubitril/valsartan against sunitinib-induced cardiac fibrosis (CF) and oxidative stress via targeting thioredoxin-interacting protein/thioredoxin (TXNIP/TRX) system and nuclear factor-kappa B (NF-κB)/Wingless-related MMTV integration site (Wnt)/β-catenin/Sex-determining region Y box 9 (SOX9) signaling. CF was induced in male Wistar albino rats by cumulative dose of sunitinib (300 mg/kg, given over 4 weeks as: 25 mg/kg orally, three t...
Source: International Immunopharmacology - April 1, 2024 Category: Allergy & Immunology Authors: Hoda E Mohamad Mervat E Askar Mohamed A Shaheen Nourhan M Baraka Yasmin K Mahmoud Source Type: research
Emodin ameliorates acute radiation proctitis in mice by regulating AKT/MAPK/NF- κB/VEGF pathways
CONCLUSION: These results suggest that emodin attenuates ARP in mice, and the underlying mechanism might involve inhibition of the AKT/ERK/NF-κB/VEGF pathways and the induction of apoptosis mediated by JNK and p38.PMID:38555816 | DOI:10.1016/j.intimp.2024.111945 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Jinsheng Gao Yousong Li Jiaohua Chen Wen Feng Jianchen Bu Zixuan Lu Jiandong Wang Source Type: research
LAMP1 controls CXCL10-CXCR3 axis mediated inflammatory regulation of macrophage polarization during inflammatory stimulation
In conclusion, CXCL10-CXCR3 axis differentially directs macrophage polarization in inflammatory and non-inflammatory states, and autophagy protein LAMP1 acts as the switch controlling the direction of macrophage polarization by CXCL10-CXCR3.PMID:38555817 | DOI:10.1016/j.intimp.2024.111929 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Yingying Ye Lexing Li Hu Kang Ziyu Wan Mengjie Zhang Baocai Gang Jie Liu Guoquan Liu Wei Gu Source Type: research
Decrypting the multi-genome data for chimeric vaccine designing against the antibiotic resistant Yersinia pestis
In this study, vaccinomics-assisted immunoinformatics techniques were used to find possible vaccine candidates by utilizing the core proteome prepared from 58 complete genomes of Y. pestis. Human non-homologous, pathogen-essential, virulent, and extracellular and membrane proteins are potential vaccine targets. Two antigenic proteins were prioritized for the prediction of lead epitopes by utilizing reverse vaccinology approaches. Four vaccine designs were formulated using the selected B- and T-cell epitopes coupled with appropriate linkers and adjuvant sequences capable of inducing potent immune responses. The HLA allele p...
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Asifa Sarfraz Sayyada Qurrat-Ul-Ain Fatima Muhammad Shehroz Iqra Ahmad Aqal Zaman Umar Nishan Muhammad Tayyab None Sheheryar Arlindo Alencar Moura Riaz Ullah Essam A Ali Mohibullah Shah Source Type: research
The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
CONCLUSION: Cu(sal)phen has the potential to induce ICD in tumors and activate the adaptive immune response to achieve anti-tumor effects. This makes Cu(sal)phen a promising candidate for the treatment of CRC.PMID:38555819 | DOI:10.1016/j.intimp.2024.111980 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Ming Chen Dong Wang Limei Fan Dongqin Niu Jinhua Xu Yuchen Liu Yunyi Liu Source Type: research
Single-cell sequencing unveils T-cell characteristic in acute myeloid leukemia
In this study, we conducted a comparative analysis of transcriptome profiles in T cells derived from bone marrow samples of three leukemia patients, both before and after treatment, as well as from a relapse sample. This analysis was facilitated through the utilization of single-cell RNA sequencing. The T cell population was subcategorized into CD4 + T cells and CD8 + T cells. Intriguingly, the composition of CD8 + T cells exhibited a relatively stable pattern before and after treatment, while a substantial difference in composition was observed in CD4 + T cells, notably in Th17 and Treg cell populations. Pseudotime trajec...
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Gelan Zhu Wenjing Lang Wanbin Fu Lan Xu Jiayi Cai Hua Zhong Source Type: research
The novel vaccines targeting interleukin-1 receptor type I
CONCLUSION: The vaccines targeting the IL-1R1 would be a novel and promising treatment for the atherosclerosis and myocardial infarction.PMID:38554439 | DOI:10.1016/j.intimp.2024.111941 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Yanzhao Zhou Jianwu Huang Wuqian Mai Wenlong Kuang Xin Li Dingyang Shi Yulu Yang Jiacheng Wu Zhijie Wu Yuhua Liao Zihua Zhou Zhihua Qiu Source Type: research
