A phytosphingosine derivative mYG-II-6 inhibits histamine-mediated TRPV1 activation and MRGPRX2-dependent mast cell degranulation

CONCLUSIONS: Our findings show that mYG-II-6 can alleviate histamine-induced itch sensation through dual mechanisms. This underscores its potential as a versatile treatment for various pruritic conditions.PMID:38657498 | DOI:10.1016/j.intimp.2024.112113
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research