Genetically predicted hypotaurine levels mediate the relationship between immune cells and intracerebral hemorrhage
In this study, our objective was to investigate the connections between immune cell characteristics and plasma metabolites, as well as the links between plasma components and ICH. Our investigation uncovered that the levels of hypotaurine play a key role in the advancement of ICH, influencing the ratio of switched memory B cells among lymphocytes. Thus, our findings provide novel insights into the potential biological mechanisms underlying immune cell-mediated ICH.PMID:38608476 | DOI:10.1016/j.intimp.2024.112049 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Liang Cao Wenjun Pi Yi Zhang Leiluo Yang Qing Li V Wee Yong Mengzhou Xue Source Type: research
Staphylococcus aureus acquires resistance to glycopeptide antibiotic vancomycin via CXCL10
CONCLUSION: SA upregulates the expression of CXCL10 in urethral epithelial cells, thereby activating the TLR signaling pathway and promoting resistance to glycopeptide antibiotics in SA.PMID:38603853 | DOI:10.1016/j.intimp.2024.111780 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Xu Wang Peng Zhan Qiushuang Zhang Ranwei Li Haitao Fan Source Type: research
Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis
CONCLUSION: The combination of HDW and AP targets 16 key genes to impede the development of NPC, primarily by modulating AKT1 and VEGFA pathways.PMID:38603854 | DOI:10.1016/j.intimp.2024.111866 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Chengyu Ye Baofan Zhang Zhongjie Tang Cuiping Zheng Qiongzhang Wang Xiangmin Tong Source Type: research
Glycolysis, a driving force of rheumatoid arthritis
Int Immunopharmacol. 2024 Apr 9;132:111913. doi: 10.1016/j.intimp.2024.111913. Online ahead of print.ABSTRACTResident synoviocytes and synovial microvasculature, together with immune cells from circulation, contribute to pannus formation, the main pathological feature of rheumatoid arthritis (RA), leading to destruction of adjacent cartilage and bone. Seeds, fibroblast-like synoviocytes (FLSs), macrophages, dendritic cells (DCs), B cells, T cells and endothelial cells (ECs) seeds with high metabolic demands undergo metabolic reprogramming from oxidative phosphorylation to glycolysis in response to poor soil of RA synovium ...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Pei-Rong Gan Hong Wu Yu-Long Zhu Yin Shu Yi Wei Source Type: research
NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
Int Immunopharmacol. 2024 Apr 10;132:111964. doi: 10.1016/j.intimp.2024.111964. Online ahead of print.ABSTRACTThe link between neuroinflammation and depression is a subject of growing interest in neuroscience and psychiatry; meanwhile, the precise mechanisms are still being unrevealed. However, glial cell activation, together with cytokine level elevation, suggests a connection between neuroinflammation and the development or exacerbation of depression. Glial cells (astrocytes) communicate with neurons via their extracellular neurotransmitter receptors, including glutamate receptors NMDARs. However, these receptor roles ar...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Ruyan Gao Tahir Ali Zizhen Liu Axiang Li Kaiwu He Canyu Yang Jinxing Feng Shupeng Li Source Type: research
Semaphorins in tumor microenvironment: Biological mechanisms and therapeutic progress
Int Immunopharmacol. 2024 Apr 9;132:112035. doi: 10.1016/j.intimp.2024.112035. Online ahead of print.ABSTRACTHallmark features of the tumor microenvironment include immune cells, stromal cells, blood vessels, and extracellular matrix (ECM), providing a conducive environment for the growth and survival of tumors. Recent advances in the understanding of cancer biology have highlighted the functional role of semaphorins (SEMAs). SEMAs are a large and diverse family of widely expressed secreted and membrane-binding proteins, which were initially implicated in axon guidance and neural development. However, it is now clear that ...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Tianyi Chen Shazhou Li Lufang Wang Source Type: research
Cyp2e1 protects against OVA-induced allergic rhinitis through the inhibition of Th2 cell activation and differentiation: Mediated by MAFB
Int Immunopharmacol. 2024 Apr 10;132:112003. doi: 10.1016/j.intimp.2024.112003. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is a common allergic disease. Cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) is a member of the cytochrome P450 family of enzymes, while its role in AR is still unveiled. In AR mice, T cell-specific overexpression of Cyp2e1 relieved the AR symptoms. Overexpressed-Cyp2e1 restrained the infiltration of eosinophils and mast cells in the nasal mucosa of mice, and the inflammatory cells in nasal lavage fluid (NALF). Cyp2e1 overexpressed mice exhibited decreased goblet cell hyperpla...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Weiliang Bai Hui Su Shengqun Xu Zhao Gao Ziwen Chang Xun Sun Tiancong Liu Source Type: research
The association between expression of CD200 on B lymphocytes and the count of eosinophils and basophils in atopic dermatitis patients with and without dupilumab therapy - Pilot study
CONCLUSION: The higher association between eosinophils and expression of CD200 molecule on memory, naive and non switched B lymphocytes in AD patients under dupilumab therapy suggests that activation of B lymphocytes is caused by IL-4, whose production involves eosinophils and the CD200 molecule on B lymphocytes.PMID:38603859 | DOI:10.1016/j.intimp.2024.112023 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: J Čelakovská E Čermákova P Boudkov á C Andr ýs J Krejsek Source Type: research
Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs
CONCLUSIONS: Our data indicated that ZGS II attenuated bone loss in OVX mice by relieving inflammation and regulating gut microbiota and SCFAs.PMID:38603860 | DOI:10.1016/j.intimp.2024.112027 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Yilin Zhou Yingtong Zhang Yafei Qian Lin Tang Tianyu Zhou Youhong Xie Li Hu Chenghong Ma Qunwei Dong Ping Sun Source Type: research
Minimally invasive vagus nerve stimulation modulates mast cell degranulation via the microbiota-gut-brain axis to ameliorate blood-brain barrier and intestinal barrier damage following ischemic stroke
Int Immunopharmacol. 2024 Apr 10;132:112030. doi: 10.1016/j.intimp.2024.112030. Online ahead of print.ABSTRACTMast cells (MCs) play a significant role in various diseases, and their activation and degranulation can trigger inflammatory responses and barrier damage. Several studies have indicated that vagus nerve stimulation (VNS) exerts ameliorates neurological injury, and regulates gut MC degranulation. However, there is limited research on the modulatory effect of VNS on MCs in both the gut and brain in brain ischemia-reperfusion (I/R) injury in this process. We aim to develop a minimally invasive, targeted and convenien...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Yanan Wang Qianqian Tan Mingdong Pan Jiaying Yu Shaoqi Wu Wenzhan Tu Ming Li Songhe Jiang Source Type: research
β-glucan mitigates ovalbumin-induced airway inflammation by preventing oxidative stress and CD8 < sup > + < /sup > T cell infiltration
CONCLUSION: The findings revealed the role of CD8+ T cells in the pathogenesis of asthma and the role of BG as a potential therapeutic agent for asthma management through the suppression of airway inflammation and oxidative stress.PMID:38603862 | DOI:10.1016/j.intimp.2024.111985 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Islam Ahmed Abdelmawgood Mohamed A Kotb Hamid Ashry Bassam W Ebeed Noha A Mahana Ayman Saber Mohamed Jehane I Eid Marwa A Ramadan Nahla S Rabie Mariam Y Mohamed Nermeen Th Saed Nada Yasser Dina Essam Youssef Y Zaki Samar Saeed Asmaa Mahmoud Marwan M Elada Source Type: research
Staphylococcus aureus acquires resistance to glycopeptide antibiotic vancomycin via CXCL10
CONCLUSION: SA upregulates the expression of CXCL10 in urethral epithelial cells, thereby activating the TLR signaling pathway and promoting resistance to glycopeptide antibiotics in SA.PMID:38603853 | DOI:10.1016/j.intimp.2024.111780 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Xu Wang Peng Zhan Qiushuang Zhang Ranwei Li Haitao Fan Source Type: research
Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis
CONCLUSION: The combination of HDW and AP targets 16 key genes to impede the development of NPC, primarily by modulating AKT1 and VEGFA pathways.PMID:38603854 | DOI:10.1016/j.intimp.2024.111866 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Chengyu Ye Baofan Zhang Zhongjie Tang Cuiping Zheng Qiongzhang Wang Xiangmin Tong Source Type: research
Glycolysis, a driving force of rheumatoid arthritis
Int Immunopharmacol. 2024 Apr 9;132:111913. doi: 10.1016/j.intimp.2024.111913. Online ahead of print.ABSTRACTResident synoviocytes and synovial microvasculature, together with immune cells from circulation, contribute to pannus formation, the main pathological feature of rheumatoid arthritis (RA), leading to destruction of adjacent cartilage and bone. Seeds, fibroblast-like synoviocytes (FLSs), macrophages, dendritic cells (DCs), B cells, T cells and endothelial cells (ECs) seeds with high metabolic demands undergo metabolic reprogramming from oxidative phosphorylation to glycolysis in response to poor soil of RA synovium ...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Pei-Rong Gan Hong Wu Yu-Long Zhu Yin Shu Yi Wei Source Type: research
NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
Int Immunopharmacol. 2024 Apr 10;132:111964. doi: 10.1016/j.intimp.2024.111964. Online ahead of print.ABSTRACTThe link between neuroinflammation and depression is a subject of growing interest in neuroscience and psychiatry; meanwhile, the precise mechanisms are still being unrevealed. However, glial cell activation, together with cytokine level elevation, suggests a connection between neuroinflammation and the development or exacerbation of depression. Glial cells (astrocytes) communicate with neurons via their extracellular neurotransmitter receptors, including glutamate receptors NMDARs. However, these receptor roles ar...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Ruyan Gao Tahir Ali Zizhen Liu Axiang Li Kaiwu He Canyu Yang Jinxing Feng Shupeng Li Source Type: research
