Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota
In conclusion, TP and its derivative peptides ameliorated DSS-induced ulcerative colitis by inhibiting the expression of inflammatory factors and modulating the composition of the intestinal microbiota; this study provides a theoretical basis for the application of TP and its derivative peptides for their anti-inflammatory activity.PMID:38608475 | DOI:10.1016/j.intimp.2024.112024 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Hai-Xiang Guo Bing-Bing Wang Hong-Yu Wu Hao-Yuan Feng Hong-Yi Zhang Wei Gao Bao Yuan Source Type: research
Genetically predicted hypotaurine levels mediate the relationship between immune cells and intracerebral hemorrhage
In this study, our objective was to investigate the connections between immune cell characteristics and plasma metabolites, as well as the links between plasma components and ICH. Our investigation uncovered that the levels of hypotaurine play a key role in the advancement of ICH, influencing the ratio of switched memory B cells among lymphocytes. Thus, our findings provide novel insights into the potential biological mechanisms underlying immune cell-mediated ICH.PMID:38608476 | DOI:10.1016/j.intimp.2024.112049 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Liang Cao Wenjun Pi Yi Zhang Leiluo Yang Qing Li V Wee Yong Mengzhou Xue Source Type: research
Establishment and validation of a tumor-infiltrating γδT cell related prognostic gene signature in head and neck squamous cell carcinoma
In this study, we utilized the TCGA HNSCC database to evaluate the infiltration of γδT cells and the association between γδT cells and clinicopathological factors by related gene signature, which were then validated by a total of 100 collected tumor samples from HNSCC patient cohort. Heterogeneity and functional characteristics of distinct infiltrating γδT cell profiles in HNSCC were then investigated based on the scRNA-seq data from the GEO database. We found higher γδT cell gene signature score was significantly associated with longer survival. Cox regression models showed that γδT cell gene signature could ser...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Yanwen Lu Zhuqin Xiang Wenjin Wang Bokai Yun Chen Yi Ming Zhang Nan Xie Cheng Wang Zehang Zhuang Source Type: research
The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease
Int Immunopharmacol. 2024 Apr 11;132:112015. doi: 10.1016/j.intimp.2024.112015. Online ahead of print.ABSTRACTCXC chemokine receptor 6 (CXCR6), a seven-transmembrane domain G-protein-coupled receptor, plays a pivotal regulatory role in inflammation and tissue damage through its interaction with CXC chemokine ligand 16 (CXCL16). This axis is implicated in the pathogenesis of various fibrotic diseases and correlates with clinical parameters that indicate disease severity, activity, and prognosis in organ fibrosis, including afflictions of the liver, kidney, lung, cardiovascular system, skin, and intestines. Soluble CXCL16 (s...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Fang-Tao Wang Tian-Qi Wu Yin Lin Yi-Ran Jiao Ji-Yuan Li Yu Ruan Lu Yin Chun-Qiu Chen Source Type: research
Gut microbiome-mediated monocytes promote liver metastasis
In this study, we found that fecal microbiome transplantation (FMT) from the stool of patients with liver metastasis (LM) significantly promoted liver metastasis compared with healthy donors (HD). Monocytes were upregulated in liver tissues by the CCL2/CCR2 axis in LM patients' stool transplanted mouse model. CCL2/CCR2 inhibition and monocyte depletion significantly suppress liver metastasis. FMT using LM patients' stool enhanced the plasma lipopolysaccharides (LPS) concentration. The LPS/TLR4 signaling pathway is crucial for gut microbiome-mediated liver metastasis. These results indicated that monocytes contribute to liv...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Wenzhong Zhang Jie Ling Baiying Xu Jie Wang Zexu Chen Gang Li Source Type: research
Inhibition of Drp1-mediated mitochondrial fission improves contrast-induced acute kidney injury by targeting the mROS-TXNIP-NLRP3 inflammasome axis
Int Immunopharmacol. 2024 Apr 11;133:112001. doi: 10.1016/j.intimp.2024.112001. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a critical complication known for their extremely high mortality rate and lack of effective clinical therapy. Disorders in mitochondrial dynamics possess a pivotal role in the occurrence and progression of contrast-induced nephropathy (CIN) by activating NLRP3 inflammasome. The activation of dynamin-related protein-1 (Drp1) can trigger mitochondrial dynamic disorders by regulating excessive mitochondrial fission. However, the precise role of Drp1 during CIN has not been clarified. In vi...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Jiong Zhang Qian Wei Shu-Kun Wu Fang Wang Tong-Ling Yuan Jia Wang Source Type: research
Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis
In conclusion, HMGCS1 downregulation improved psoriasis in vitro and in vivo through the STAT3/IL-23 axis.PMID:38608446 | DOI:10.1016/j.intimp.2024.112033 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Lin Chen Danqi Huang Zhongzhou Huang Xiuting Liu Mingjie He Minqing Luo Zengqi Tang Guozhen Tan Qing Guo Hui Xiong Source Type: research
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1 β-induced IL-8 production
We report here that STAT3 inhibitors Stattic and Niclosamide up-regulated IL-1β-induced IL-8 production in C33A, CaSki, and Siha cervical cancer cells. As expected, IL-1β-induced IL-8 production was also up-regulated through the molecular inhibition of STAT3 by use of CRISPR/Cas9 technology. Unexpectedly, IL-1β induced IL-8 production via activating ERK and P38 signal pathways, but neither STAT3 inhibitors nor STAT3 knockout affected IL-1β-induced signal transduction, suggesting that STAT3 decreases IL-8 production not via inhibition of signal transduction. To our surprise, STAT3 inhibition increased the stabilization,...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Jiangwen Long Wang Zhao Yangen Xiang Yufei Wang Wei Xiang Xueting Liu Manli Jiang Yinghui Song Jinyue Hu Source Type: research
Potential therapeutic options for celiac Disease: An update on Current evidence from Gluten-Free diet to cell therapy
Int Immunopharmacol. 2024 Apr 11;133:112020. doi: 10.1016/j.intimp.2024.112020. Online ahead of print.ABSTRACTCeliac disease (CD) is a chronic autoimmune enteropathy and multifactorial disease caused by inappropriate immune responses to gluten in the small intestine. Weight loss, anemia, osteoporosis, arthritis, and hepatitis are among the extraintestinal manifestations of active CD. Currently, a strict lifelong gluten-free diet (GFD) is the only safe, effective, and available treatment. Despite the social burden, high expenses, and challenges of following a GFD, 2 to 5 percent of patients do not demonstrate clinical or pa...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Effat Noori Nader Hashemi Delsuz Rezaee Reza Maleki Forough Shams Bahram Kazemi Mojgan Bandepour Fardin Rahimi Source Type: research
Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis
CONCLUSION: The data suggested that corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis.PMID:38608471 | DOI:10.1016/j.intimp.2024.111939 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Mingming Jin Jingjing Li Liying Zheng Mi Huang Yue Wu Qingqing Huang Gang Huang Source Type: research
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis
CONCLUSION: Our findings highlight that downregulation of SIRT1-modulated FAO facilitated by the SP1/SIRT1/ACLY axis in the kidney increases IRI, suggesting SIRT1 to be a potential therapeutic target for renal fibrosis induced by renal IRI.PMID:38608473 | DOI:10.1016/j.intimp.2024.112002 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Huailiang Wu Liyan Wang Peng Kang Xiangjun Zhou Wei Li Zhongyuan Xia Source Type: research
Esculin suppresses the PERK-eIF2 α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model
CONCLUSION: Our results suggest the potential therapeutic value of Esculin on osteoarthritis. It probably inhibits the PERK-eIF2α-ATF4-CHOP pathway by upregulating SIRT1, thereby mitigating endoplasmic reticulum stress and protecting chondrocytes from apoptosis.PMID:38608474 | DOI:10.1016/j.intimp.2024.112061 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Zhihua Cheng Zheyuan Liu Chao Liu Aoxiang Yang Haichuan Miao Xizhuang Bai Source Type: research
Establishment and validation of a tumor-infiltrating γδT cell related prognostic gene signature in head and neck squamous cell carcinoma
In this study, we utilized the TCGA HNSCC database to evaluate the infiltration of γδT cells and the association between γδT cells and clinicopathological factors by related gene signature, which were then validated by a total of 100 collected tumor samples from HNSCC patient cohort. Heterogeneity and functional characteristics of distinct infiltrating γδT cell profiles in HNSCC were then investigated based on the scRNA-seq data from the GEO database. We found higher γδT cell gene signature score was significantly associated with longer survival. Cox regression models showed that γδT cell gene signature could ser...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Yanwen Lu Zhuqin Xiang Wenjin Wang Bokai Yun Chen Yi Ming Zhang Nan Xie Cheng Wang Zehang Zhuang Source Type: research
The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease
Int Immunopharmacol. 2024 Apr 11;132:112015. doi: 10.1016/j.intimp.2024.112015. Online ahead of print.ABSTRACTCXC chemokine receptor 6 (CXCR6), a seven-transmembrane domain G-protein-coupled receptor, plays a pivotal regulatory role in inflammation and tissue damage through its interaction with CXC chemokine ligand 16 (CXCL16). This axis is implicated in the pathogenesis of various fibrotic diseases and correlates with clinical parameters that indicate disease severity, activity, and prognosis in organ fibrosis, including afflictions of the liver, kidney, lung, cardiovascular system, skin, and intestines. Soluble CXCL16 (s...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Fang-Tao Wang Tian-Qi Wu Yin Lin Yi-Ran Jiao Ji-Yuan Li Yu Ruan Lu Yin Chun-Qiu Chen Source Type: research
Mitochondrial dysfunction of peripheral blood mononuclear cells is associated with lung carcinogenesis
Int Immunopharmacol. 2024 Apr 11;133:111958. doi: 10.1016/j.intimp.2024.111958. Online ahead of print.ABSTRACTThe composition, quantity, and function of peripheral blood mononuclear cells (PBMCs) are closely correlated with tumorigenesis. However, the mechanisms of PBMCs in lung cancer are not clear. Mitochondria are energy factories of cells, and almost all cellular functions rely on their energy metabolism level. The present study aimed to test whether the mitochondrial function of PBMCs directly determines their tumor immune monitoring function. We recruited 211 subjects, including 105 healthy controls and 106 patients ...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Weili Liu Hua Li Yuan Gao Xuelian Zhang Zilin Wei Dong Yang Min Jin Zhigang Qiu Zhiqiang Shen Zhaoli Chen Yamei Qiao Lingling Pu Changqing Yan Shuang Zhang Xinxing Wang Junwen Li Source Type: research
