Esculin suppresses the PERK-eIF2 α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model

CONCLUSION: Our results suggest the potential therapeutic value of Esculin on osteoarthritis. It probably inhibits the PERK-eIF2α-ATF4-CHOP pathway by upregulating SIRT1, thereby mitigating endoplasmic reticulum stress and protecting chondrocytes from apoptosis.PMID:38608474 | DOI:10.1016/j.intimp.2024.112061
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research