The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis

CONCLUSION: Our findings highlight that downregulation of SIRT1-modulated FAO facilitated by the SP1/SIRT1/ACLY axis in the kidney increases IRI, suggesting SIRT1 to be a potential therapeutic target for renal fibrosis induced by renal IRI.PMID:38608473 | DOI:10.1016/j.intimp.2024.112002

Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Huailiang Wu Liyan Wang Peng Kang Xiangjun Zhou Wei Li Zhongyuan Xia Source Type: research