Advances in traditional herbal formulation based nano-vaccine for cancer immunotherapy: Unraveling the enigma of complex tumor environment and multidrug resistance
Int Immunopharmacol. 2024 Mar 29;132:111948. doi: 10.1016/j.intimp.2024.111948. Online ahead of print.ABSTRACTCancer is attributed to uncontrolled cell growth and is among the leading causes of death with no known effective treatment while complex tumor microenvironment (TME) and multidrug resistance (MDR) are major challenges for developing an effective therapeutic strategy. Advancement in cancer immunotherapy has been limited by the over-activation of the host immune response that ultimately affects healthy tissues or organs and leads to a feeble response of the patient's immune system against tumor cells. Besides, tradi...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Yasmeen Saeed Ruimin Zhong Zhanghua Sun Source Type: research
Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist
Int Immunopharmacol. 2024 Mar 29;132:111909. doi: 10.1016/j.intimp.2024.111909. Online ahead of print.ABSTRACTAdjuvants enhance the body's immune response to a vaccine, often leading to better protection against diseases. Monophosphoryl lipid A analogues (MPLA, TLR4 agonists), α-galactosylceramide analogues (NKT cell agonists), and imidazoquinoline compounds (TLR7/8 agonists) are emerging novel adjuvants on market or under clinical trials. Despite significant interest in these adjuvants, a direct comparison of their adjuvant activities remains unexplored. We initially assessed the activities of various adjuvants from thre...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Xiongyan Meng Ying Xu Jing Yang Shuai Meng Ning Ding Tiantian Sun Chengli Zong Source Type: research
The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress following ischemic acute kidney injury
CONCLUSION: The involvement of mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H/GRP78 and CHOP axis is significant in the development of ischemic AKI. Moreover, hsa_circ_0075663 has potential as an early diagnostic biomarker.PMID:38554447 | DOI:10.1016/j.intimp.2024.111956 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Qiang Zheng Xiaozhou Li Xuan Xu Xianming Tang Bacha Hammad Jihong Xing Dongshan Zhang Source Type: research
Prognostic impact of age in advanced non-small cell lung cancer patients undergoing first-line checkpoint inhibitor immunotherapy and chemotherapy treatment
CONCLUSION: Age may not be the primary factor influencing the efficacy of immunotherapy combined with chemotherapy, but particular attention should be given to the elderly population.PMID:38554448 | DOI:10.1016/j.intimp.2024.111901 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Xiaoya Huang Shichao Wu Shubin Chen Moqin Qiu Yun Zhao Jiang Wei Jianbo He Wenhua Zhao Liping Tan Cuiyun Su Shaozhang Zhou Source Type: research
The novel vaccines targeting interleukin-1 receptor type I
CONCLUSION: The vaccines targeting the IL-1R1 would be a novel and promising treatment for the atherosclerosis and myocardial infarction.PMID:38554439 | DOI:10.1016/j.intimp.2024.111941 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Yanzhao Zhou Jianwu Huang Wuqian Mai Wenlong Kuang Xin Li Dingyang Shi Yulu Yang Jiacheng Wu Zhijie Wu Yuhua Liao Zihua Zhou Zhihua Qiu Source Type: research
F1 fraction isolated from Mesobuthus eupeus scorpion venom induces macrophage polarization toward M1 phenotype and exerts anti-tumoral effects on the CT26 tumor cell line
In conclusion, our findings demonstrated the potential of Mesobuthus eupeus venom in M2-to-M1 macrophage polarization as a promising therapeutic approach against proliferation and metastasis of colon cancer cells.PMID:38554440 | DOI:10.1016/j.intimp.2024.111960 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Mahvash Sadeghi Afshin Amari Ali Asadirad Mohammad Nemati Ali Khodadadi Source Type: research
Dioon rzedowskii: An antioxidant, antibacterial and anticancer plant extract with multi-faceted effects on cell growth and molecular signaling
This study investigated the antioxidant, anticancer, antibacterial properties of Dioon rzedowskii extract, which had not been previously explored. We aimed to determine the extract's effect on liver and breast cancer cell lines and on solid Ehrlich carcinoma (SEC) mouse model to investigate the underlying molecular mechanisms. Three female albino mice groups were established: a tumor control group, a group treated with 100 mg/kg of the extract (D100), and a group treated with 200 mg/kg of the extract (D200) for 16 days after tumor development. Results showed that the D. rzedowskii extract inhibited cell growth in both MCF-...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Walaa A Negm Engy Elekhnawy Sebaey Mahgoub Hanaa A Ibrahim Aya Ibrahim Elberri Hend E Abo Mansour Esraa M Mosalam Ehssan Moglad Fatma Alzahraa Mokhtar Source Type: research
Ononin triggers ferroptosis-mediated disruption in the triple negative breast cancer both in vitro and in vivo
In this study, we aimed to investigate whether a natural flavonoid compound called ononin could be effective in treating TNBC by triggering ferroptosis in MDA-MB-231 and 4 T1 cell lines, and MDA-MB-231-xenograft nude mice model. Ononin inhibited TNBC through ferroptosis, which was determined by MTT assay, flow cytometry, RT-PCR, immunofluorescence, transmission electron microscopy, histological analysis, western blot and bioluminescence assay. Our results showed that treatment with ononin led to increased levels of malondialdehyde and reactive oxygen species and decreased activity of superoxide dismutase, which are indicat...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Guowei Gong Yukai Wan Yaqun Liu Zhenxia Zhang Yuzhong Zheng Source Type: research
PD-1 Receptor (+) T cells are associated with the efficacy of the combined treatment with regulatory t cells and rituximab in type 1 diabetes children via regulatory t cells suppressive activity amelioration
Int Immunopharmacol. 2024 Mar 29;132:111919. doi: 10.1016/j.intimp.2024.111919. Online ahead of print.ABSTRACTAn imbalance between exaggerated autoaggressive T cell responses, primarily CD8 + T cells, and impaired tolerogenic mechanisms underlie the development of type 1 diabetes mellitus. Disease-modifying strategies, particularly immunotherapy focusing on FoxP3 + T regulatory cells (Treg), and B cells facilitating antigen presentation for T cells, show promise. Selective depletion of B cells may be achieved with an anti-CD20 monoclonal antibody (mAb). In a 2-year-long flow cytometry follow-up, involving 32 peripheral blo...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Maciej Zieli ński Justyna Sakowska Dorota Iwaszkiewicz-Grze ś Mateusz Gliwi ński Matylda Hennig Magdalena Żalińska Anna Wo łoszyn-Durkiewicz Anna Ja źwińska-Curyłło Halla Kami ńska Rados ław Owczuk Wojciech M łynarski Przemys ława Jarosz-Cho Source Type: research
Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
Int Immunopharmacol. 2024 Mar 29;132:111954. doi: 10.1016/j.intimp.2024.111954. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is a serious kidney disorder driven by diabetes and affects people all over the world. One of the mechanisms promoting NF-κB-induced renal inflammation and injury has been theorized to be ATM signaling. On the other hand, AMPK, which can be activated by the naturally occurring alkaloid harmine (HAR), has been proposed to stop that action. As a result, the goal of this study was to evaluate the therapeutic effectiveness of HAR against streptozotocin (STZ)-induced DN in rats through AMPK-me...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Manar Mohammed El Tabaa Maram Mohammed El Tabaa Eman Rashad Mohammed Salah Elballal Ola Elazazy Source Type: research
Advances in traditional herbal formulation based nano-vaccine for cancer immunotherapy: Unraveling the enigma of complex tumor environment and multidrug resistance
Int Immunopharmacol. 2024 Mar 29;132:111948. doi: 10.1016/j.intimp.2024.111948. Online ahead of print.ABSTRACTCancer is attributed to uncontrolled cell growth and is among the leading causes of death with no known effective treatment while complex tumor microenvironment (TME) and multidrug resistance (MDR) are major challenges for developing an effective therapeutic strategy. Advancement in cancer immunotherapy has been limited by the over-activation of the host immune response that ultimately affects healthy tissues or organs and leads to a feeble response of the patient's immune system against tumor cells. Besides, tradi...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Yasmeen Saeed Ruimin Zhong Zhanghua Sun Source Type: research
Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist
Int Immunopharmacol. 2024 Mar 29;132:111909. doi: 10.1016/j.intimp.2024.111909. Online ahead of print.ABSTRACTAdjuvants enhance the body's immune response to a vaccine, often leading to better protection against diseases. Monophosphoryl lipid A analogues (MPLA, TLR4 agonists), α-galactosylceramide analogues (NKT cell agonists), and imidazoquinoline compounds (TLR7/8 agonists) are emerging novel adjuvants on market or under clinical trials. Despite significant interest in these adjuvants, a direct comparison of their adjuvant activities remains unexplored. We initially assessed the activities of various adjuvants from thre...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Xiongyan Meng Ying Xu Jing Yang Shuai Meng Ning Ding Tiantian Sun Chengli Zong Source Type: research
The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress following ischemic acute kidney injury
CONCLUSION: The involvement of mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H/GRP78 and CHOP axis is significant in the development of ischemic AKI. Moreover, hsa_circ_0075663 has potential as an early diagnostic biomarker.PMID:38554447 | DOI:10.1016/j.intimp.2024.111956 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Qiang Zheng Xiaozhou Li Xuan Xu Xianming Tang Bacha Hammad Jihong Xing Dongshan Zhang Source Type: research
Prognostic impact of age in advanced non-small cell lung cancer patients undergoing first-line checkpoint inhibitor immunotherapy and chemotherapy treatment
CONCLUSION: Age may not be the primary factor influencing the efficacy of immunotherapy combined with chemotherapy, but particular attention should be given to the elderly population.PMID:38554448 | DOI:10.1016/j.intimp.2024.111901 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Xiaoya Huang Shichao Wu Shubin Chen Moqin Qiu Yun Zhao Jiang Wei Jianbo He Wenhua Zhao Liping Tan Cuiyun Su Shaozhang Zhou Source Type: research
Immune effector dysfunction signatures predict outcomes in patients with colorectal cancer
CONCLUSION: CCR9, ISG20, ICOS, and CACNA2D2 were optimal IED signatures for predicting the outcomes of CRC patients, which might be a potential biomarker for prognostic stratification and designing novel CRC therapy.PMID:38552290 | DOI:10.1016/j.intimp.2024.111949 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Haifeng Tang Hongsheng Wu Yueju Jian Tengfei Ji Biwen Wu Yong Wu Peipei Wang Tiansheng Cao Source Type: research
