Identification of idiopathic pulmonary fibrosis hub genes and exploration of the mechanisms of action of Jinshui Huanxian formula
In conclusion, a series of IPF hub genes was identified, and validated in an independent dataset, mice with PF, and MRC-5 cells. Moreover, the abnormal gene expression was normalized by JHF. These findings provide guidance for further exploration of the pathogenesis and treatment of IPF.PMID:38593509 | DOI:10.1016/j.intimp.2024.112048 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Qingzhou Guan Zhenzhen Zhang Peng Zhao Lidong Huang Ruilong Lu Chunlei Liu Yakun Zhao Xuejie Shao Yange Tian Jiansheng Li Source Type: research
Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy
CONCLUSIONS: We constructed a TGCP model, which demonstrates satisfactory predictive accuracy. Out of 9 prognostic genes, TAP1 was validated as a synergistic target for Oxaliplatin and PDL1 inhibitors, offering a genetic-level explanation for the synergy observed in GC treatment involving Oxaliplatin in combination with PDL1 inhibitors.PMID:38593510 | DOI:10.1016/j.intimp.2024.111998 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Yupeng Zhao Ziyuan Liu Kaiyuan Deng Huiheng Qu Qing Zhang Peng Zhou Mengqi Yang Xiao Yang Hao Wang Ranran Li Jiazeng Xia Source Type: research
New insights of acylation stimulating protein in modulating the pathological progression of metabolic syndromes
Int Immunopharmacol. 2024 Apr 7;132:112018. doi: 10.1016/j.intimp.2024.112018. Online ahead of print.ABSTRACTObesity is associated with insulin resistance, hypertension, and coronary artery diseases which are grouped as metabolic syndrome. Rather than being a storage for energy, the adipocytes could synthesis and secret diverse hormones and molecules, named as adipokines. Under obese status, the adipocytes are dysfunctional with excessively producing the inflammatory related cytokines, such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor α (TNF-α). Concerning on the vital role of adipokines, it is proposed that ...
Source: International Immunopharmacology - April 8, 2024 Category: Allergy & Immunology Authors: Xi Lian Ye Cheng Huiyuan Kang Source Type: research
Identification and validation of regulatory T cell-associated gene signatures to predict colon adenocarcinoma prognosis
This study used the TCGA data set, clinical information and RNA-seq data of COAD patients to construct a Tregs-related risk score (TRS) through methods such as WGCNA, single-factor Cox, multi-factor Cox and random survival forest (RSF). Moreover, we also used the TCGA test set and internal validation set to verify the predictive ability of TRS, and used functional enrichment analysis and somatic mutation analysis to mine genes related to TRS, such as like thrombin/trypsin receptor 2 (F2RL2), inhibin subunit beta B (INHBB) and melanoma antigen family A12 (MAGEA12). Moreover, this study confirmed the expression of these prog...
Source: International Immunopharmacology - April 8, 2024 Category: Allergy & Immunology Authors: Xiaomeng Zhao Xuanwen Li Zhi Miao Source Type: research
New insights of acylation stimulating protein in modulating the pathological progression of metabolic syndromes
Int Immunopharmacol. 2024 Apr 7;132:112018. doi: 10.1016/j.intimp.2024.112018. Online ahead of print.ABSTRACTObesity is associated with insulin resistance, hypertension, and coronary artery diseases which are grouped as metabolic syndrome. Rather than being a storage for energy, the adipocytes could synthesis and secret diverse hormones and molecules, named as adipokines. Under obese status, the adipocytes are dysfunctional with excessively producing the inflammatory related cytokines, such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor α (TNF-α). Concerning on the vital role of adipokines, it is proposed that ...
Source: International Immunopharmacology - April 8, 2024 Category: Allergy & Immunology Authors: Xi Lian Ye Cheng Huiyuan Kang Source Type: research
Identification and validation of regulatory T cell-associated gene signatures to predict colon adenocarcinoma prognosis
This study used the TCGA data set, clinical information and RNA-seq data of COAD patients to construct a Tregs-related risk score (TRS) through methods such as WGCNA, single-factor Cox, multi-factor Cox and random survival forest (RSF). Moreover, we also used the TCGA test set and internal validation set to verify the predictive ability of TRS, and used functional enrichment analysis and somatic mutation analysis to mine genes related to TRS, such as like thrombin/trypsin receptor 2 (F2RL2), inhibin subunit beta B (INHBB) and melanoma antigen family A12 (MAGEA12). Moreover, this study confirmed the expression of these prog...
Source: International Immunopharmacology - April 8, 2024 Category: Allergy & Immunology Authors: Xiaomeng Zhao Xuanwen Li Zhi Miao Source Type: research
Modulating the phenotype and function of bone marrow-derived macrophages via mandible and femur osteoblasts
In conclusion, our investigation showed that MOBs and FOBs have the ability to modulate MØ phenotype and function, with MOBs exhibiting a stronger regulatory potential. These findings provide a new direction for improving therapeutic strategies for bone regeneration in autologous bone grafts from the perspective of the immune microenvironment.PMID:38583238 | DOI:10.1016/j.intimp.2024.112000 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Li Li Yijuan Liu Xueshen Qian Ling Zhou Yujie Fan Xue Yang Kai Luo Yuling Chen Source Type: research
Expressions of CXCR3 and PD-1 on T cells and their clinical relevance in colorectal cancer
CONCLUSION: Expressions of CXCR3 and PD-1 on tumor-infiltrating T lymphocytes are related to the development of CRC and metastasis, providing clues for exploring the pathogenesis of CRC and developing new strategies for tumor immunotherapy.PMID:38583239 | DOI:10.1016/j.intimp.2024.111988 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Sen Wang Yangyang Zhang Guangyu Chen Peng Zhao Xiaoming Wang Benling Xu Long Yuan Source Type: research
Novel insights into the role of ubiquitination in osteoarthritis
Int Immunopharmacol. 2024 Apr 6;132:112026. doi: 10.1016/j.intimp.2024.112026. Online ahead of print.ABSTRACTUbiquitination (Ub) and deubiquitination are crucial post-translational modifications (PTMs) that precisely regulate protein degradation. Under the catalysis of a cascade of E1-E2-E3 ubiquitin enzymes, ubiquitination extensively regulates protein degradation exerting direct impact on various cellular processes, while deubiquitination opposes the effect of ubiquitination and prevents proteins from degradation. Notably, such dynamic modifications have been widely investigated to be implicated in cell cycle, transcript...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Yuzhe Lin Shide Jiang Jingyue Su Wenqing Xie Masoud Rahmati Yuxiang Wu Shengwu Yang Qin Ru Yusheng Li Zhenhan Deng Source Type: research
Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition
CONCLUSION: This study shows that NR and RV have therapeutic promise in treating diabetic wounds by addressing UPR dysregulation, and pyroptosis. The combination therapy is a viable strategy to improving the healing process, providing a multimodal intervention for diabetic skin ulcers. These findings pave the way for additional investigation and possible therapeutic applications, giving hope for better outcomes in diabetic wound care.PMID:38583241 | DOI:10.1016/j.intimp.2024.112013 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Mohammad Hasan Maleki Morvarid Siri Amirhossein Jafarabadi Mahsa Rajabi Seyed Amirhossein Mazhari Zahra Noori Farhad Koohpeyma Amirreza Dehghanian Nafiseh Esmaeili Zeinab Aryanian Sanaz Dastghaib Source Type: research
Galectin-3 inhibition ameliorates alveolar epithelial cell pyroptosis in phosgene-induced acute lung injury
Int Immunopharmacol. 2024 Apr 6;132:111965. doi: 10.1016/j.intimp.2024.111965. Online ahead of print.ABSTRACTPhosgene is a type of poisonous gas that can cause acute lung injury (ALI) upon accidental exposure. Casualties still occur due to phosgene-induced acute lung injury (P-ALI) from accidents resulting from improper operations. The pathological mechanisms of P-ALI are still understudied. Thus, we performed scRNA-seq on cells isolated from all subpopulations of the BALF in P-ALI and found that Gal3 expression was significantly higher in the gas group than in the control group. Further analysis revealed a ligand-receptor...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Obulkasim Memet Chao Cao Hanbing Hu Yu Dun Xuanrong Bao Fuli Liu Lin Zhang Jian Zhou Jie Shen Source Type: research
Deciphering and overcoming Anti-PD-1 resistance in Melanoma: A comprehensive review of Mechanisms, biomarker Developments, and therapeutic strategies
Int Immunopharmacol. 2024 Apr 6;132:111989. doi: 10.1016/j.intimp.2024.111989. Online ahead of print.ABSTRACTWorldwide, tens of thousands of people die from melanoma each year, making it the most frequently fatal form of cutaneous cancer. Immunotherapeutic advancements, particularly with anti-PD-1 medications, have significantly enhanced treatment outcomes over recent decades. With the broad application of anti-PD-1 therapies, insights into the mechanisms of resistance have evolved. Despite the development of combination treatments and early predictive biomarkers, a comprehensive synthesis of these advancements is absent i...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Ruoqi Wang Yanbin Chen Yongyi Xie Xin Ma Yeqiang Liu Source Type: research
Modulating the phenotype and function of bone marrow-derived macrophages via mandible and femur osteoblasts
In conclusion, our investigation showed that MOBs and FOBs have the ability to modulate MØ phenotype and function, with MOBs exhibiting a stronger regulatory potential. These findings provide a new direction for improving therapeutic strategies for bone regeneration in autologous bone grafts from the perspective of the immune microenvironment.PMID:38583238 | DOI:10.1016/j.intimp.2024.112000 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Li Li Yijuan Liu Xueshen Qian Ling Zhou Yujie Fan Xue Yang Kai Luo Yuling Chen Source Type: research
Expressions of CXCR3 and PD-1 on T cells and their clinical relevance in colorectal cancer
CONCLUSION: Expressions of CXCR3 and PD-1 on tumor-infiltrating T lymphocytes are related to the development of CRC and metastasis, providing clues for exploring the pathogenesis of CRC and developing new strategies for tumor immunotherapy.PMID:38583239 | DOI:10.1016/j.intimp.2024.111988 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Sen Wang Yangyang Zhang Guangyu Chen Peng Zhao Xiaoming Wang Benling Xu Long Yuan Source Type: research
Novel insights into the role of ubiquitination in osteoarthritis
Int Immunopharmacol. 2024 Apr 6;132:112026. doi: 10.1016/j.intimp.2024.112026. Online ahead of print.ABSTRACTUbiquitination (Ub) and deubiquitination are crucial post-translational modifications (PTMs) that precisely regulate protein degradation. Under the catalysis of a cascade of E1-E2-E3 ubiquitin enzymes, ubiquitination extensively regulates protein degradation exerting direct impact on various cellular processes, while deubiquitination opposes the effect of ubiquitination and prevents proteins from degradation. Notably, such dynamic modifications have been widely investigated to be implicated in cell cycle, transcript...
Source: International Immunopharmacology - April 7, 2024 Category: Allergy & Immunology Authors: Yuzhe Lin Shide Jiang Jingyue Su Wenqing Xie Masoud Rahmati Yuxiang Wu Shengwu Yang Qin Ru Yusheng Li Zhenhan Deng Source Type: research
