Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages
CONCLUSION: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.PMID:38466071 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 11, 2024 Category: Complementary Medicine Authors: Qian Liu Yuanyuan Li Junqing Li Junying Zhou Source Type: research
Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages
CONCLUSION: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.PMID:38466071 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 11, 2024 Category: Complementary Medicine Authors: Qian Liu Yuanyuan Li Junqing Li Junying Zhou Source Type: research
Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages
CONCLUSION: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.PMID:38466071 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 11, 2024 Category: Complementary Medicine Authors: Qian Liu Yuanyuan Li Junqing Li Junying Zhou Source Type: research
Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages
CONCLUSION: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.PMID:38466071 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 11, 2024 Category: Complementary Medicine Authors: Qian Liu Yuanyuan Li Junqing Li Junying Zhou Source Type: research
Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages
CONCLUSION: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.PMID:38466071 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 11, 2024 Category: Complementary Medicine Authors: Qian Liu Yuanyuan Li Junqing Li Junying Zhou Source Type: research
Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages
CONCLUSION: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.PMID:38466071 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 11, 2024 Category: Complementary Medicine Authors: Qian Liu Yuanyuan Li Junqing Li Junying Zhou Source Type: research
Saikosaponin d protects pancreatic acinar cells against cerulein ‐induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS‐STING pathway
In conclusion, SSd protected PACs against cerulein-induced pyroptosis by alleviating mitochondrial damage and inhibiting the cGAS-STING pathway, and it could be a therapeutic candidate for acute pancreatitis. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 11, 2024 Category: Toxicology Authors: Hui Chen,
Xirong Lu,
Beiqi Xu,
Gang Cheng,
Yuyi Li,
Dan Xie Tags: RESEARCH ARTICLE Source Type: research
Type I Interferon Signalling and Ischemic Stroke: Mechanisms and Therapeutic Potentials
AbstractType I interferon (IFN-I) signalling is intricately involved in the pathogenesis of multiple infectious diseases, autoimmune diseases, and neurological diseases. Acute ischemic stroke provokes overactivation of IFN-I signalling within the injured brain, particularly in microglia. Following cerebral ischemia, damage-associated molecular patterns (DAMPs) released from injured neural cells elicit marked proinflammatory episodes within minutes. Among these, self-nucleic acids, including nuclear DNA and mitochondrial DNA (mtDNA), have been recognized as a critical alarm signal to fan the flames of neuroinflammation, pre...
Source: Translational Stroke Research - March 11, 2024 Category: Neurology Source Type: research
IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - March 11, 2024 Category: Cytology Authors: Xibao Shi Menglu Wei Yuwen Feng Yuanhao Yang Xiaozhuan Zhang Hao Chen Yuqi Xing Keqi Wang Wensheng Wang Li Wang Aiping Wang Gaiping Zhang Source Type: research
Delivery of STING agonists for cancer immunotherapy
Curr Opin Biotechnol. 2024 Mar 9;87:103105. doi: 10.1016/j.copbio.2024.103105. Online ahead of print.ABSTRACTAgonists of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway, a critical mediator of innate immune response to foreign invaders with DNA, have gained significant interest in cancer immunotherapy. STING agonists are envisioned as a way of complementing the antitumor activity of the patient's immune system and immune checkpoint blockade therapy. However, their clinical development has been challenging due to the poor pharmacokinetic and physicoch...
Source: Current Opinion in Biotechnology - March 10, 2024 Category: Biotechnology Authors: Jianping Wang Fanfei Meng Yoon Yeo Source Type: research
Delivery of STING agonists for cancer immunotherapy
Curr Opin Biotechnol. 2024 Mar 9;87:103105. doi: 10.1016/j.copbio.2024.103105. Online ahead of print.ABSTRACTAgonists of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway, a critical mediator of innate immune response to foreign invaders with DNA, have gained significant interest in cancer immunotherapy. STING agonists are envisioned as a way of complementing the antitumor activity of the patient's immune system and immune checkpoint blockade therapy. However, their clinical development has been challenging due to the poor pharmacokinetic and physicoch...
Source: Current Opinion in Biotechnology - March 10, 2024 Category: Biotechnology Authors: Jianping Wang Fanfei Meng Yoon Yeo Source Type: research
The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases
CONCLUSION: The cGAS-STING signaling plays an important role in the pathogenesis of NDs. Inhibiting the cGAS-STING signaling may provide new measures in the treatment of NDs.PMID:38459658 | DOI:10.1111/cns.14671 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Xiaofeng Guo Lin Yang Jiawei Wang You Wu Yi Li Lixia Du Ling Li Zongping Fang Xijing Zhang Source Type: research
The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment
In conclusion, these data suggest that chronic inflammation after cigarette smoke exposure is associated with AIM2 activation, which could lead towards cigarette smoke-associated lung diseases.PMID:38460301 | DOI:10.1016/j.intimp.2024.111832 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 9, 2024 Category: Allergy & Immunology Authors: Chiara Colarusso Anna Falanga Simone Di Caprio Michela Terlizzi Aldo Pinto Piera Maiolino Rosalinda Sorrentino Source Type: research
The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases
CONCLUSION: The cGAS-STING signaling plays an important role in the pathogenesis of NDs. Inhibiting the cGAS-STING signaling may provide new measures in the treatment of NDs.PMID:38459658 | PMC:PMC10924111 | DOI:10.1111/cns.14671 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Xiaofeng Guo Lin Yang Jiawei Wang You Wu Yi Li Lixia Du Ling Li Zongping Fang Xijing Zhang Source Type: research
The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment
In conclusion, these data suggest that chronic inflammation after cigarette smoke exposure is associated with AIM2 activation, which could lead towards cigarette smoke-associated lung diseases.PMID:38460301 | DOI:10.1016/j.intimp.2024.111832 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 9, 2024 Category: Allergy & Immunology Authors: Chiara Colarusso Anna Falanga Simone Di Caprio Michela Terlizzi Aldo Pinto Piera Maiolino Rosalinda Sorrentino Source Type: research
