Traumatic brain injury.
PMID: 32452140 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 28, 2020 Category: Neuroscience Authors: Bailes JE, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury.
CONCLUSIONS: In summary, these results suggest that overexpression of the transcription factors OCT4 and KLF4 could induce astrocyte reprogramming, which subsequently improves remyelination and functional recovery after SCI. PMID: 32449258 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 25, 2020 Category: Neuroscience Authors: Huang X, Wang C, Zhou X, Wang J, Xia K, Yang B, Gong Z, Ying L, Yu C, Shi K, Shu J, Cheng F, Han B, Liang C, Li F, Chen Q Tags: CNS Neurosci Ther Source Type: research

Perihematomal brain tissue iron concentration measurement by MRI in patients with intracerebral hemorrhage.
CONCLUSIONS: These results demonstrate the feasibility of measuring perihematomal iron in ICH patients which may be important for monitoring treatment strategies and assessing efficacy noninvasively. PMID: 32436273 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2020 Category: Neuroscience Authors: Wei J, Novakovic N, Chenevert TL, Xi G, Keep RF, Pandey AS, Chaudhary N Tags: CNS Neurosci Ther Source Type: research

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
CONCLUSION: These findings expand our understanding of how STK24 involved in the excitatory synaptic transmission in epilepsy and lay a foundation for exploring the possibility of STK24 as a drug target. PMID: 32436359 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2020 Category: Neuroscience Authors: Yang J, Jiang Q, Yu X, Xu T, Wang Y, Deng J, Liu Y, Chen Y Tags: CNS Neurosci Ther Source Type: research

Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1  year.
Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year. CNS Neurosci Ther. 2020 May 21;: Authors: You Z, Wu YY, Wu R, Xu ZX, Wu X, Wang XP Abstract OBJECTIVE: To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of variance, and chi-square ...
Source: CNS Neuroscience and Therapeutics - May 21, 2020 Category: Neuroscience Authors: You Z, Wu YY, Wu R, Xu ZX, Wu X, Wang XP Tags: CNS Neurosci Ther Source Type: research

Abnormal dynamic functional connectivity in Alzheimer's disease.
CONCLUSION: Our findings suggest abnormal dynamic FC in AD patients, which provides novel insights for understanding the pathophysiological mechanisms of AD. PMID: 32378335 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 6, 2020 Category: Neuroscience Authors: Gu Y, Lin Y, Huang L, Ma J, Zhang J, Xiao Y, Dai Z, Alzheimer's Disease Neuroimaging Initiative Tags: CNS Neurosci Ther Source Type: research

Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction.
Abstract AIMS: To investigate the relationship between peripheral leukocyte dynamics and the outcome of large hemispheric infarction (LHI) patients. METHODS: Patients with acute LHI admitted to the neuro-intensive care unit of Xuanwu Hospital from 2013 to 2017 were prospectively enrolled and followed up for 6 months after LHI. RESULTS: A total of 84 LHI patients were included, 38 patients suffered brain herniation and 20 patients died from stroke. Compared to patients with benign course, LHI patients with fatal outcome showed larger infarcts and more severe brain edema (P 
Source: CNS Neuroscience and Therapeutics - May 6, 2020 Category: Neuroscience Authors: Cui LL, Zhang Y, Chen ZY, Su YY, Liu Y, Boltze J Tags: CNS Neurosci Ther Source Type: research

The significance of leptomeningeal collaterals in moyamoya disease.
PMID: 32358863 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2020 Category: Neuroscience Authors: Yu J, Zhang J, Chen J Tags: CNS Neurosci Ther Source Type: research

Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury.
Abstract Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death and secondary cell death closely model disease progression and worsen outcomes. Mounting evidence indicates that long-term neuroinflammation extensively exacerbates the secondary deterioration of brain structure and function. Due to their immunomodulatory and regenerative properties, mesenchymal stem cell transplants have emerged as a promising approach to treating this facet of stroke and TBI pathology. In this review, we summ...
Source: CNS Neuroscience and Therapeutics - May 1, 2020 Category: Neuroscience Authors: Bonsack B, Corey S, Shear A, Heyck M, Cozene B, Sadanandan N, Zhang H, Gonzales-Portillo B, Sheyner M, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Immunization with neural-derived peptides increases neurogenesis in rats with chronic spinal cord injury.
CONCLUSIONS: These findings suggest that INDP has a neurogenic effect that could improve motor and sensitive recovery in the chronic stage of SCI. Moreover, our results also envision the use of INDP as a possible therapeutic strategy for other trauma-related disorders like traumatic brain injury. PMID: 32352656 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 30, 2020 Category: Neuroscience Authors: Rodríguez-Barrera R, Flores-Romero A, García E, Fernández-Presas AM, Incontri-Abraham D, Navarro-Torres L, García-Sánchez J, Juárez-Vignon Whaley JJ, Madrazo I, Ibarra A Tags: CNS Neurosci Ther Source Type: research

A comparative evaluation of dexmedetomidine and midazolam in pediatric sedation: A meta-analysis of randomized controlled trials with trial sequential analysis.
CONCLUSIONS: Given that more satisfactory sedation at separation from parents and less incidence of emergence agitation, dexmedetomidine is preferred for pediatric sedation. However, compared with midazolam, the superiority of dexmedetomidine in providing adequate sedation at mask induction and postoperative analgesic effects has not yet been defined. PMID: 32347647 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 29, 2020 Category: Neuroscience Authors: Lang B, Zhang L, Zhang W, Lin Y, Fu Y, Chen S Tags: CNS Neurosci Ther Source Type: research

Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.
Abstract AIMS: The involvement of pyroptosis in ischemic stroke remains to be established. Therefore, we used the specific pyroptosis inhibitor Vx765 as an experimental intervention target in a murine model of stroke. METHODS: A total of 564 C57BL/6 mice were subjected to photothrombotic procedures and treated via gavage with Vx765 at 1-hour post-ischemia. We subsequently assessed the expression of Gasdermin D (GSDMD), inflammasomes, caspase-1, and interleukin-1β (IL-1β) using immunofluorescence (IF) and Western blot (WB) analyses. We also examined ultrastructural changes of cortical neurons with tr...
Source: CNS Neuroscience and Therapeutics - April 28, 2020 Category: Neuroscience Authors: Li J, Hao JH, Yao D, Li R, Li XF, Yu ZY, Luo X, Liu XH, Wang MH, Wang W Tags: CNS Neurosci Ther Source Type: research

miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4.
CONCLUSION: miR-322/NOX4 plays a crucial role in apoptosis-induced NTD formation, which may provide a new understanding of the mechanism of embryonic NTDs and a basis for potential therapeutic target against NTDs. PMID: 32329577 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 24, 2020 Category: Neuroscience Authors: Liu YS, Gu H, Huang TC, Wei XW, Ma W, Liu D, He YW, Luo WT, Huang JT, Zhao D, Jia SS, Wang F, Zhang T, Bai YZ, Wang WL, Yuan ZW Tags: CNS Neurosci Ther Source Type: research

RGS16 promotes glioma progression and serves as a prognostic factor.
CONCLUSIONS: RGS16 plays an important role in glioma progression and serves as an independent prognostic factor, especially in GBM patients. PMID: 32319728 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2020 Category: Neuroscience Authors: Huang R, Li G, Zhao Z, Zeng F, Zhang K, Liu Y, Wang K, Hu H Tags: CNS Neurosci Ther Source Type: research

Clinical features and outcome of Wilson's disease with generalized epilepsy in Chinese patients.
CONCLUSIONS: We firstly described WD patients with generalized epilepsy in the Chinese population. WD patients with aggravation of neuropsychiatric symptoms are prone to occur epilepsy; thus, brain MRI should be performed regularly in those patients. Cortical abnormality in brain MRI is a warning sign of epilepsy. Irregular use of copper-chelation drugs and excessive copper deposition in the brain may be the cause of seizures. Long-term standardized treatment for WD can effectively prevent the extensive brain damage and reduce the incidence of epilepsy in WD patients. PMID: 32281751 [PubMed - as supplied by publisher]...
Source: CNS Neuroscience and Therapeutics - April 13, 2020 Category: Neuroscience Authors: Wang RM, Yu H, Yang GM, Xu WQ, Xia N, Zhang Y, Ni W, Dong Y, Wu ZY Tags: CNS Neurosci Ther Source Type: research

Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.
CONCLUSION: These findings highlight the therapeutic effects of EPI-NCSCs transplantation, probably through simultaneous induction of neuronal and glial formation, as well as Bdnf over-expression in a rat model of ischemic stroke. PMID: 32281225 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 12, 2020 Category: Neuroscience Authors: Salehi MS, Pandamooz S, Safari A, Jurek B, Tamadon A, Namavar MR, Dianatpour M, Dargahi L, Azarpira N, Fattahi S, Shid Moosavi SM, Keshavarz S, Khodabandeh Z, Zare S, Nazari S, Heidari M, Izadi S, Poursadeghfard M, Borhani-Haghighi A Tags: CNS Neurosci Ther Source Type: research

Neurological manifestations in COVID-19 caused by SARS-CoV-2.
PMID: 32266761 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 7, 2020 Category: Neuroscience Authors: Baig AM Tags: CNS Neurosci Ther Source Type: research

Predicting conversion to Alzheimer's disease among individual high-risk patients using the Characterizing AD Risk Events index model.
This study aims to determine whether the Characterizing AD Risk Events (CARE) index model can effectively predict conversion in individuals at high risk for AD development either in an independent aMCI population or in an rLOD population. METHODS: The CARE index model was constructed based on the event-based probabilistic framework fusion of AD biomarkers to differentiate individuals progressing to AD from cognitively stable individuals in the aMCI population (27 stable subjects, 6 progressive subjects) and rLOD population (29 stable subjects, 10 progressive subjects) during the follow-up period. RESULTS: AD diag...
Source: CNS Neuroscience and Therapeutics - April 3, 2020 Category: Neuroscience Authors: Lu X, Chen J, Shu H, Wang Z, Shi YM, Yuan YG, Xie CM, Liao WX, Su F, Shi YC, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Elevation of CXCL1 indicates poor prognosis and radioresistance by inducing mesenchymal transition in glioblastoma.
Abstract INTRODUCTION: Glioblastoma (GBM) is identified as a lethal malignant tumor derived from the nervous system. Despite the standard clinical strategy including maximum surgical resection, temozolomide (TMZ) chemotherapy, and radiotherapy, the median survival of GBM patients remains
Source: CNS Neuroscience and Therapeutics - March 19, 2020 Category: Neuroscience Authors: Alafate W, Li X, Zuo J, Zhang H, Xiang J, Wu W, Xie W, Bai X, Wang M, Wang J Tags: CNS Neurosci Ther Source Type: research

Myeleterosis in an ALPS5 patient with primary immune dysregulation syndrome.
PMID: 32181586 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 17, 2020 Category: Neuroscience Authors: Long H, Chen Z, Xiao B, Tang B, Jiang H Tags: CNS Neurosci Ther Source Type: research

Stem cell therapy and FUS[1-359]-transgenic mice: A recent study highlighting a promising ALS model and a promising therapy.
PMID: 32181601 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 17, 2020 Category: Neuroscience Authors: Ninkina N Tags: CNS Neurosci Ther Source Type: research

Alpha-lipoic acid downregulates TRPV1 receptor via NF- κB and attenuates neuropathic pain in rats with diabetes.
CONCLUSION: Our findings demonstrated that ALA may alleviate neuropathic pain in diabetes by regulating TRPV1 expression via affecting NF-κB. PMID: 32175676 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 16, 2020 Category: Neuroscience Authors: Zhang BY, Zhang YL, Sun Q, Zhang PA, Wang XX, Xu GY, Hu J, Zhang HH Tags: CNS Neurosci Ther Source Type: research

Potential of mesenchymal stem cells alone, or in combination, to treat traumatic brain injury.
Abstract Traumatic brain injury (TBI) causes death and disability in the United States and around the world. The traumatic insult causes the mechanical injury of the brain and primary cellular death. While a comprehensive pathological mechanism of TBI is still lacking, the focus of the TBI research is concentrated on understanding the pathophysiology and developing suitable therapeutic approaches. Given the complexities in pathophysiology involving interconnected immunologic, inflammatory, and neurological cascades occurring after TBI, the therapies directed to a single mechanism fail in the clinical trials. This ...
Source: CNS Neuroscience and Therapeutics - March 10, 2020 Category: Neuroscience Authors: Willing AE, Das M, Howell M, Mohapatra SS, Mohapatra S Tags: CNS Neurosci Ther Source Type: research

P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis.
CONCLUSION: Our results indicate that P2Y6 receptor-mediated microglial phagocytosis plays a beneficial role during the acute stage of ischemic stroke, which can be a therapeutic target for ischemic stroke. PMID: 32154670 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 10, 2020 Category: Neuroscience Authors: Wen RX, Shen H, Huang SX, Wang LP, Li ZW, Peng P, Mamtilahun M, Tang YH, Shen FX, Tian HL, Yang GY, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

2019 Overview.
PMID: 32125098 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 1, 2020 Category: Neuroscience Authors: Borlongan C, Dorandeu F, Di Giovanni G, Lin JS, Hu G, Boltze J, Wu J, Hu X, Luo Y Tags: CNS Neurosci Ther Source Type: research

Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.
CONCLUSION: Collectively, these data suggest that ApoE promotes axonal regeneration partially through the Dab1 pathway, thereby contributing to functional recovery following TBI. PMID: 32115899 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 1, 2020 Category: Neuroscience Authors: Huang ZJ, Cao F, Wu Y, Peng JH, Zhong JJ, Jiang Y, Yin C, Guo ZD, Sun XC, Jiang L, Cheng CJ Tags: CNS Neurosci Ther Source Type: research

Cerebral organoids transplantation improves neurological motor function in rat brain injury.
CONCLUSIONS: This study revealed 55 d-CO as better transplantation donor and demonstrated the feasibility and efficacy of COs transplantation in TBI, hoping to provide first-hand preclinical evidence of COs transplantation for brain injury. PMID: 32087606 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2020 Category: Neuroscience Authors: Wang Z, Wang SN, Xu TY, Hong C, Cheng MH, Zhu PX, Lin JS, Su DF, Miao CY Tags: CNS Neurosci Ther Source Type: research

Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence.
CONCLUSIONS: Level I evidence already exists for the efficacy of 10 kHz SCS in treating CBLP, supported by real-world clinical experience. Other studies demonstrate the potential of the therapy across a range of chronic pain etiologies, although larger confirmatory studies are recommended. Overall, the literature suggests that the therapy is associated with improved QOL as well as reduced opioid consumption. PMID: 32087613 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2020 Category: Neuroscience Authors: Sayed D, Kallewaard JW, Rotte A, Jameson J, Caraway D Tags: CNS Neurosci Ther Source Type: research

Potential microglia-based interventions for stroke.
Abstract A large number of families worldwide suffer from the physical and mental burden posed by stroke. An increasing number of studies aimed at the prevention and treatment of stroke have been conducted. Specifically, manipulating the immune response to stroke is under intense investigation. Microglia are the principal immune cells in the brain and are the first line of defense against the pathophysiology induced by stroke. Increasing evidence has suggested that microglia play diverse roles that depend on dynamic interactions with neurons, astrocytes, and other neighboring cells both in the normal brain and und...
Source: CNS Neuroscience and Therapeutics - February 16, 2020 Category: Neuroscience Authors: Li LZ, Huang YY, Yang ZH, Zhang SJ, Han ZP, Luo YM Tags: CNS Neurosci Ther Source Type: research

Expression and prognostic role of E2F transcription factors in high-grade glioma.
CONCLUSIONS: E2Fs (except for E2F3 and E2F5) are highly expressed in HGG and indicate adverse outcome. E2F7 and E2F8 were identified as novel potential prognostic markers in HGG. E2F7 was further validated to be closely associated with radioresistance of HGG and a critical transcriptional regulator of EZH2. PMID: 32064771 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 16, 2020 Category: Neuroscience Authors: Yu H, Li Z, Wang M Tags: CNS Neurosci Ther Source Type: research

Natural history and genotype-phenotype correlation of pantothenate kinase-associated neurodegeneration.
Abstract AIMS: To investigate the natural history and genotype-phenotype correlation of pantothenate kinase-associated neurodegeneration. METHODS: We collected data of patients with PKAN by searching from available publications in English and Chinese. Patients diagnosed in our center (Peking University First Hospital) were also included. The difference in natural history and genotype between early-onset (
Source: CNS Neuroscience and Therapeutics - February 11, 2020 Category: Neuroscience Authors: Chang X, Zhang J, Jiang Y, Wang J, Wu Y Tags: CNS Neurosci Ther Source Type: research

The amygdala via the paraventricular nucleus regulates asthma attack in rats.
CONCLUSIONS: Asthma attack could induce neural activities in the MeA and CeA, and OT neurons in the PVN may be involved in the process of asthma attack. PMID: 32011093 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 3, 2020 Category: Neuroscience Authors: Chen Z, Liu NN, Xiao J, Wang YH, Dong R Tags: CNS Neurosci Ther Source Type: research

Nicotinamide riboside rescues angiotensin --induced cerebral small vessel disease in mice.
CONCLUSION: Our results indicated that NR administration alleviated Ang --induced CSVD by protecting BBB integrity, vascular remodeling, neuroinflammation, and white matter injury (WMI)-associated cognitive impairment. PMID: 31943833 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 14, 2020 Category: Neuroscience Authors: Li CC, Chen WX, Wang J, Xia M, Jia ZC, Guo C, Tang XQ, Li MX, Yin Y, Liu X, Feng H Tags: CNS Neurosci Ther Source Type: research

Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment.
CONCLUSIONS: Changes in the properties of DTI may be the potential mechanism of WMH-related MCI, especially the right IFOF and the right ILF, which may become imaging markers for predicting WMH-related cognitive dysfunction. PMID: 31901155 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 4, 2020 Category: Neuroscience Authors: Chen HF, Huang LL, Li HY, Qian Y, Yang D, Qing Z, Luo CM, Li MC, Zhang B, Xu Y Tags: CNS Neurosci Ther Source Type: research

Clinical characteristics and leptomeningeal collateral  status in pediatric and adult patients with ischemic moyamoya disease.
Clinical characteristics and leptomeningeal collateral status in pediatric and adult patients with ischemic moyamoya disease. CNS Neurosci Ther. 2020 Jan;26(1):14-20 Authors: Liu ZW, Han C, Wang H, Zhang Q, Li SJ, Bao XY, Zhang ZS, Duan L Abstract AIM: Previous studies have found significant differences in clinical characteristics between pediatric and adult moyamoya disease (MMD) patients, but few studies have focused on the factors underlying these differences. We aimed to investigate the differences in leptomeningeal collateral (LMC) status between pediatric and adult MMD patients and to ...
Source: CNS Neuroscience and Therapeutics - December 27, 2019 Category: Neuroscience Authors: Liu ZW, Han C, Wang H, Zhang Q, Li SJ, Bao XY, Zhang ZS, Duan L Tags: CNS Neurosci Ther Source Type: research

Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice.
CONCLUSION: The neuropathology in FUS-tg mice is sensitive to standard ALS treatments and Neuro-Cells infusion. The latter improves motor outcomes in two ALS models possibly by suppressing microglial activation. PMID: 31867846 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 23, 2019 Category: Neuroscience Authors: de Munter JPJM, Shafarevich I, Liundup A, Pavlov D, Wolters EC, Gorlova A, Veniaminova E, Umriukhin A, Kalueff A, Svistunov A, Kramer BW, Lesch KP, Strekalova T Tags: CNS Neurosci Ther Source Type: research

microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3.
CONCLUSION: Taken together, the miR cluster MC-let-7a-1 ~ let-7d promotes glioma cell autophagy and apoptosis by repressing STAT3. The current study highlights the potential of the miR cluster MC-let-7a-1 ~ let-7d as biomarkers and promising treatment strategies for glioma. PMID: 31868319 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 23, 2019 Category: Neuroscience Authors: Yang ZY, Wang Y, Liu Q, Wu M Tags: CNS Neurosci Ther Source Type: research

Dentate nNOS accounts for stress-induced 5-HT1A receptor deficiency: Implication in anxiety behaviors.
CONCLUSIONS: These findings uncovered an important role of nNOS-5-HT1A receptor pathway in the DG of the hippocampus in chronic stress-induced anxiety. Accordingly, we developed a "dentate nNOS-5-HT1A receptor closed-loop" theory (stress-glucocorticoids-nNOS-Nitric oxide-ONOO•-5-HT1A receptor -nNOS) of stress-related anxiety. PMID: 31863649 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 21, 2019 Category: Neuroscience Authors: Zhu LJ, Xu C, Ren J, Chang L, Zhu XH, Sun N, Meng GL, Liu MY, Zhang J, Li YY, Tang YL, Zhou QG Tags: CNS Neurosci Ther Source Type: research

Activated Schwann cells and increased inflammatory cytokines IL-1 β, IL-6, and TNF-α in patients' sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson's disease.
CONCLUSION: Our study results suggest that peripheral sensory nerve injury exists in PD patients, accompanied by Schwann cell activation and inflammation, thus demonstrate peripheral nerve inflammation participates in the pathophysiological process of PD but it is not necessarily related to the patient's sensory disturbance. PMID: 31828965 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 11, 2019 Category: Neuroscience Authors: Zhang H, Wu J, Shen FF, Yuan YS, Li X, Ji P, Zhu L, Sun L, Ding J, Niu Q, Zhang KZ Tags: CNS Neurosci Ther Source Type: research

(-)-Phenserine tartrate (PhenT) as a treatment for traumatic brain injury.
CONCLUSION: In the light of its tolerability in AD clinical trials, PhenT is an agent that can be fast-tracked for evaluation in not only civilian TBI, but also as a potentially protective agent in battlefield conditions where TBI and chemical weapon exposure are increasingly jointly occurring. PMID: 31828969 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 11, 2019 Category: Neuroscience Authors: Greig NH, Lecca D, Hsueh SC, Nogueras-Ortiz C, Kapogiannis D, Tweedie D, Glotfelty EJ, Becker RE, Chiang YH, Hoffer BJ Tags: CNS Neurosci Ther Source Type: research

Reversible Parkinsonism caused by Influenza B-associated encephalitis affecting bilateral basal ganglia: A case report.
PMID: 31823469 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 10, 2019 Category: Neuroscience Authors: Zhu YL, Guo XM, Qin ZB, Zhou ZJ, Cao J, Wu JM, Pu JL Tags: CNS Neurosci Ther Source Type: research

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.
CONCLUSION: Our study suggested that lnc-MKRN2-42:1 may be involved in the occurrence and development of PD. PMID: 31814304 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 8, 2019 Category: Neuroscience Authors: Wang Q, Han CL, Wang KL, Sui YP, Li ZB, Chen N, Fan SY, Shimabukuro M, Wang F, Meng FG Tags: CNS Neurosci Ther Source Type: research

Remote ischemic conditioning for the treatment of ischemic moyamoya disease.
This study investigated the safety and efficacy of remote ischemic conditioning (RIC) on ameliorating the sequelae of ischemic moyamoya disease (iMMD). METHODS: A total of 30 iMMD patients underwent long-term RIC and were followed up at 0.5, 1, and 2 years for clinical outcomes, including frequency of stroke recurrence, Patient Global Impression of Change (PGIC) scale, peak systolic velocities (PSV), and cerebral perfusion. RESULTS: During the whole RIC treatment process, no RIC-related adverse event occurred. Only one of 30 patients suffered a onetime infarction (3.3%), and the ratios of acceptable PGIC wer...
Source: CNS Neuroscience and Therapeutics - December 8, 2019 Category: Neuroscience Authors: Ding JY, Shang SL, Sun ZS, Asmaro K, Li WL, Yang Q, Ding YC, Ji XM, Meng R Tags: CNS Neurosci Ther Source Type: research

The Sphkl/SlP pathway regulates angiogenesis via NOS/NO synthesis following cerebral ischemia-reperfusion.
CONCLUSIONS: Based on these results, we therefore postulate that Sphk1/S1P signaling is able to mediate angiogenesis following cerebral IRI via the regulation of eNOS activity and NO production. As such, targeting these pathways may potentially represent a novel means of improving patient prognosis in those suffering from cerebral IRI. PMID: 31814336 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 8, 2019 Category: Neuroscience Authors: Lv MH, Li S, Jiang YJ, Zhang W Tags: CNS Neurosci Ther Source Type: research

Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway.
CONCLUSION: Melatonin treatment ameliorates brain damage at least partially through shifting microglia phenotype from pro-inflammatory to anti-inflammatory polarity in a STAT3-dependent manner. PMID: 31793209 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 1, 2019 Category: Neuroscience Authors: Liu ZJ, Ran YY, Qie SY, Gong WJ, Gao FH, Ding ZT, Xi JN Tags: CNS Neurosci Ther Source Type: research

Microglia/macrophage diversities in central nervous system physiology and pathology.
PMID: 31793210 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 1, 2019 Category: Neuroscience Authors: Xie D, He M, Hu X Tags: CNS Neurosci Ther Source Type: research

Aging alters Hv1-mediated microglial polarization and enhances neuroinflammation after peripheral surgery.
Abstract Perioperative neurocognitive disorders have been widely recognized as common adverse events after surgical intervention. Aging is one of the most important independent risk factors for worsened cognitive outcome, and this deterioration is linked to exacerbated microglia-mediated neuroinflammation in the aged brain. Under pathological stimulation, microglia are capable of polarizing toward proinflammatory M1 and anti-inflammatory M2 phenotypes. In the present study, we examined how aging affects microglial responses and neuroinflammation following peripheral surgery. Adult (2-3 months) and aged (18&nb...
Source: CNS Neuroscience and Therapeutics - November 27, 2019 Category: Neuroscience Authors: Zhang ZJ, Zheng XX, Zhang XY, Zhang Y, Huang BY, Luo T Tags: CNS Neurosci Ther Source Type: research

Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke.
CONCLUSIONS: RSG treatment protects against BBB damage and ameliorates HT in delayed tPA-treated stroke mice by activating PPAR-γ and favoring microglial polarization toward anti-inflammatory phenotype. PMID: 31756041 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 22, 2019 Category: Neuroscience Authors: Li Y, Zhu ZY, Lu BW, Huang TT, Zhang YM, Zhou NY, Xuan W, Chen ZA, Wen DX, Yu WF, Li PY Tags: CNS Neurosci Ther Source Type: research

microRNA-139-5p confers sensitivity to antiepileptic drugs in refractory epilepsy by inhibition of MRP1.
CONCLUSION: Collectively, these results suggest an important role of miR-139-5p/MRP1 axis in reducing the resistance of refractory epilepsy to antiepileptic drugs. PMID: 31750616 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 21, 2019 Category: Neuroscience Authors: Wang L, Song L, Chen X, Suo J, Ma Y, Shi J, Liu K, Chen G Tags: CNS Neurosci Ther Source Type: research

Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China.
CONCLUSION: An essential tremor SNP (rs3794087 of SLC1A2) is associated with a decreased risk of PD in the Eastern Han Chinese population, while rs9652490 (LINGO1) and rs17590046 (PPARGC1A) do not show an association. PMID: 31755235 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 21, 2019 Category: Neuroscience Authors: Gao T, Wu J, Zheng R, Fang Y, Jin CY, Ruan Y, Cao J, Tian J, Pu JL, Zhang BR Tags: CNS Neurosci Ther Source Type: research