Benefit of endovascular treatment for primary versus secondary medium vessel occlusion: A multi-center experience
CONCLUSION: In MeVO patients who received EVT, there was a higher likelihood of poor outcomes in patients with secondary versus primary MeVO.PMID:38497517 | DOI:10.1111/cns.14687 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 18, 2024 Category: Neuroscience Authors: Hai-Zhou Hu Yong-Gang Zhao Xin Liu Xian-Hui Sun Thanh N Nguyen Hui-Sheng Chen Source Type: research

Isolation and usage of exosomes in central nervous system diseases
CONCLUSION: The varying isolation methods result in differences in the concentration, purity, and size of exosomes. The efficient separation of exosomes facilitates their widespread application, particularly in the diagnosis and treatment of CNS diseases.PMID:38497529 | DOI:10.1111/cns.14677 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 18, 2024 Category: Neuroscience Authors: Wenjing Wang Hong Sun Huijuan Duan Gang Sheng Na Tian Dingyi Liu Zhaogang Sun Source Type: research

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study
CONCLUSION: DON patients altered node properties and connectivity in the DMN, auditory network, FPN-L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.PMID:38497532 | DOI:10.1111/cns.14579 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 18, 2024 Category: Neuroscience Authors: Qian Wei Si-Min Lin San-Hua Xu Jie Zou Jun Chen Min Kang Jin-Yu Hu Xu-Lin Liao Hong Wei Qian Ling Yi Shao Yao Yu Source Type: research

Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night
CONCLUSION: There is a bidirectional relationship between the pathogenesis of PD and sleep disorders which might be due to GABA deregulation.PMID:38491789 | PMC:PMC10943276 | DOI:10.1111/cns.14521 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 16, 2024 Category: Neuroscience Authors: Hayder M Al-Kuraishy Ali I Al-Gareeb Ali K Albuhadily Yaser Hosny Ali Elewa Ammar Al-Farga Faisal Aqlan Mahmoud Hosny Zahran Gaber El-Saber Batiha Source Type: research

Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night
CONCLUSION: There is a bidirectional relationship between the pathogenesis of PD and sleep disorders which might be due to GABA deregulation.PMID:38491789 | DOI:10.1111/cns.14521 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 16, 2024 Category: Neuroscience Authors: Hayder M Al-Kuraishy Ali I Al-Gareeb Ali K Albuhadily Yaser Hosny Ali Elewa Ammar Al-Farga Faisal Aqlan Mahmoud Hosny Zahran Gaber El-Saber Batiha Source Type: research

Real-time field-programmable gate array-based closed-loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia
CONCLUSION: Our real-time FPGA-based DCN-DBS system could be a potential clinical strategy for alleviating cerebellar ataxia and other movement disorders.PMID:38488445 | PMC:PMC10941591 | DOI:10.1111/cns.14638 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Gajendra Kumar Zhanhong Zhou Zhihua Wang Kin Ming Kwan Chung Tin Chi Him Eddie Ma Source Type: research

Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the β-common receptor in mice with cerebral ischemic stroke
CONCLUSION: ARA290 provided a neuroprotective effect via βCR in cerebral ischemic mice without causing erythropoiesis. This study provides novel insights into the role of ARA290 in ischemic stroke intervention.PMID:38488446 | PMC:PMC10941562 | DOI:10.1111/cns.14676 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Rong-Liang Wang Zhen-Hong Yang Yu-You Huang Yue Hu Yi-Lin Wang Feng Yan Yang-Min Zheng Zi-Ping Han Jun-Fen Fan Zhen Tao Hai-Ping Zhao Si-Jie Li Yu-Min Luo Source Type: research

Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia
CONCLUSION: This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.PMID:38488453 | PMC:PMC10941502 | DOI:10.1111/cns.14675 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Fuyang Cao Yongxin Guo Shuting Guo Xinyu Hao Lujia Yang Jiangbei Cao Zhikang Zhou Weidong Mi Li Tong Source Type: research

Real-time field-programmable gate array-based closed-loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia
CONCLUSION: Our real-time FPGA-based DCN-DBS system could be a potential clinical strategy for alleviating cerebellar ataxia and other movement disorders.PMID:38488445 | DOI:10.1111/cns.14638 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Gajendra Kumar Zhanhong Zhou Zhihua Wang Kin Ming Kwan Chung Tin Chi Him Eddie Ma Source Type: research

Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the β-common receptor in mice with cerebral ischemic stroke
CONCLUSION: ARA290 provided a neuroprotective effect via βCR in cerebral ischemic mice without causing erythropoiesis. This study provides novel insights into the role of ARA290 in ischemic stroke intervention.PMID:38488446 | DOI:10.1111/cns.14676 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Rong-Liang Wang Zhen-Hong Yang Yu-You Huang Yue Hu Yi-Lin Wang Feng Yan Yang-Min Zheng Zi-Ping Han Jun-Fen Fan Zhen Tao Hai-Ping Zhao Si-Jie Li Yu-Min Luo Source Type: research

Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia
CONCLUSION: This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.PMID:38488453 | DOI:10.1111/cns.14675 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Fuyang Cao Yongxin Guo Shuting Guo Xinyu Hao Lujia Yang Jiangbei Cao Zhikang Zhou Weidong Mi Li Tong Source Type: research

Theory and application of TTFields in newly diagnosed glioblastoma
CONCLUSION: This review summarizes mechanisms of TTFields in the treatment of ndGBM, and describes the current clinical application of TTFields in ndGBM. Through the understanding of its principle and application status, we believe that TTFields still has the potential to further prolong the survival of ndGBM patients. Thus,research is still needed to explore new ways to combine TTFields with other therapies and optimize the use of TTFields to realize its full potential in ndGBM patients.PMID:38481068 | PMC:PMC10938032 | DOI:10.1111/cns.14563 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 14, 2024 Category: Neuroscience Authors: Ao Yu Juan Zeng Jinhui Yu Shuo Cao Ailin Li Source Type: research

Theory and application of TTFields in newly diagnosed glioblastoma
CONCLUSION: This review summarizes mechanisms of TTFields in the treatment of ndGBM, and describes the current clinical application of TTFields in ndGBM. Through the understanding of its principle and application status, we believe that TTFields still has the potential to further prolong the survival of ndGBM patients. Thus,research is still needed to explore new ways to combine TTFields with other therapies and optimize the use of TTFields to realize its full potential in ndGBM patients.PMID:38481068 | DOI:10.1111/cns.14563 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 14, 2024 Category: Neuroscience Authors: Ao Yu Juan Zeng Jinhui Yu Shuo Cao Ailin Li Source Type: research

Long term for patients with futile endovascular reperfusion after stroke
CONCLUSIONS: Futile recanalization accounts for a large proportion of stroke patients after thrombectomy. This study on the long-term prognosis of such patients is beneficial to the formulation of treatment plans and the prediction of therapeutic effects.PMID:38475869 | DOI:10.1111/cns.14588 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 13, 2024 Category: Neuroscience Authors: Mengke Zhang Ruiwen Che Jiali Xu Wenting Guo Xi Chen Wenbo Zhao Changhong Ren Milan Jia Xunming Ji Source Type: research

Intermittent hypoxia preconditioning can attenuate acute hypoxic injury after a sustained normobaric hypoxic exposure: A randomized clinical trial
CONCLUSION: The short-term moderate IH improved the tolerance to hypoxia and exerted protection against acute hypoxic injury induced by exposure to sustained normobaric hypoxia, which provided a novel method and randomized controlled trial evidence to develop treatments for hypoxia-related disease.PMID:38477221 | PMC:PMC10934266 | DOI:10.1111/cns.14662 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 13, 2024 Category: Neuroscience Authors: Yuan Wang Qihan Zhang Qingfeng Ma Qing Wang Dan Huang Xunming Ji Source Type: research