Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model.
CONCLUSION: All these findings indicate that HS may serve as a potential therapeutic candidate for the treatment of ALS. PMID: 31318169 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 18, 2019 Category: Neuroscience Authors: Shang HY, Zhang JJ, Fu ZF, Liu YF, Li S, Chen S, Le WD Tags: CNS Neurosci Ther Source Type: research

Combined elevation of TRIB2 and MAP3K1 indicates poor prognosis and chemoresistance to temozolomide in glioblastoma.
CONCLUSION: Combined elevation of TRIB2 and MAP3K1 could be novel prognostic biomarkers and potential therapeutic targets to evaluate the malignancy and long-term outcomes of GBM. PMID: 31318172 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 18, 2019 Category: Neuroscience Authors: Wang J, Zuo J, Wahafu A, Wang MD, Li RC, Xie WF Tags: CNS Neurosci Ther Source Type: research

A DTI study of leukoaraiosis and the differential diagnosis between leukoaraiosis and acute lacunar infarction.
PMID: 31297957 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 11, 2019 Category: Neuroscience Authors: Zhao DQ, Wang ZW, Cheng Y, Yuan Z, Rene F, Liu H, Pliss A, Luan P Tags: CNS Neurosci Ther Source Type: research

Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin-induced diabetic rats.
CONCLUSION: Our results demonstrate that the exposure to RH leads to metabolomics alterations in the hippocampus of insulin-treated streptozotocin-diabetic rats. Understanding how RH affects hippocampal metabolism may help attenuate the adverse effects of RH on hippocampal functions. PMID: 31282100 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 7, 2019 Category: Neuroscience Authors: Dewan N, Shukla V, Rehni AK, Koronowski KB, Klingbeil KD, Stradecki-Cohan H, Garrett TJ, Rundek T, Perez-Pinzon MA, Dave KR Tags: CNS Neurosci Ther Source Type: research

Effect of exosomes from adipose-derived stem cells on the apoptosis of Schwann cells in peripheral nerve injury.
CONCLUSION: Our results present a novel exosome-mediated mechanism for ADSC-SC cross talk that reduces the apoptosis and promotes the proliferation of SCs and may have therapeutic potential in the future. PMID: 31278850 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 6, 2019 Category: Neuroscience Authors: Liu CY, Yin G, Sun YD, Lin YF, Xie Z, English AW, Li QF, Lin HD Tags: CNS Neurosci Ther Source Type: research

Progressive brain atrophy in Parkinson's disease patients who convert to mild cognitive impairment.
CONCLUSION: Early atrophy in temporal lobes and progressive atrophy in frontal lobes might be a biomarker for developing multidomain impairment of cognition and converting to PD-MCI. Furthermore, cognition-related temporal atrophy might be associated with dopaminergic deficit reflected by DAT scan but independent of CSF proteins in patients with PD who convert to PD-MCI. PMID: 31278861 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 6, 2019 Category: Neuroscience Authors: Zhou C, Guan XJ, Guo T, Zeng QL, Gao T, Huang PY, Xuan M, Gu QQ, Xu XJ, Zhang MM Tags: CNS Neurosci Ther Source Type: research

Mitochondria in neurodegenerative diseases.
PMID: 31197947 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 16, 2019 Category: Neuroscience Authors: Lin F, Luo SQ Tags: CNS Neurosci Ther Source Type: research

KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders.
Abstract The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision therapeutics acting on well-characterized targets. Although the identification of genes responsible for neurodevelopmental and neuropsychiatric disorders remains a major obstacle, the few causally associated genes are ripe for discovery by focusing efforts to dissect their mechanisms. Here, we make a case for del...
Source: CNS Neuroscience and Therapeutics - June 16, 2019 Category: Neuroscience Authors: Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM Tags: CNS Neurosci Ther Source Type: research

Molecular and clinical characterization of TMEM71 expression at the transcriptional level in glioma.
CONCLUSION: In summary, TMEM71 expression was increased in GBM and associated with immune response. Our study suggests that TMEM71 may function as an oncogene and serve as a new effective therapeutic target for the treatment of glioma. PMID: 31180187 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 10, 2019 Category: Neuroscience Authors: Wang KY, Huang RY, Tong XZ, Zhang KN, Liu YW, Zeng F, Hu HM, Jiang T Tags: CNS Neurosci Ther Source Type: research

Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats.
CONCLUSION: Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder. PMID: 31179640 [PubMed - as supplied by publisher] (Source: CNS ...
Source: CNS Neuroscience and Therapeutics - June 9, 2019 Category: Neuroscience Authors: Deng J, Xu T, Yang J, Zhang KM, Li Q, Yu XY, Li R, Fu J, Jiang Q, Ma JX, Chen YM Tags: CNS Neurosci Ther Source Type: research

Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury.
CONCLUSIONS: Concertedly, parameters of the CAPs offer a novel functional assessment strategy for cerebral white matter injury in rodent models. PMID: 31140740 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 29, 2019 Category: Neuroscience Authors: Mu HF, Gao XG, Li SC, Wei PJ, Zhao YF, Zhang WT, Wang Y, Gao YQ Tags: CNS Neurosci Ther Source Type: research

Increased frontal gray matter volume in individuals with prodromal psychosis.
CONCLUSION: Our results provide evidence of increased frontal GMV in prodromal individuals. A combination of GMV values in the two frontal brain areas may serve as potential markers to discriminate prodromal individuals from healthy controls. The results thus highlight the importance of the frontal regions in the pathophysiology of psychosis. PMID: 31129924 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 25, 2019 Category: Neuroscience Authors: Shan XX, Ou YP, Pan P, Ding YD, Zhao J, Liu F, Chen JD, Guo WB, Zhao JP Tags: CNS Neurosci Ther Source Type: research

Effect of Fasudil on remyelination following cuprizone-induced demyelination.
CONCLUSION: These results provide evidence for the therapeutic potential of Fasudil in CPZ-induced demyelination. However, how Fasudil acts on microglia, astrocytes, and immune cells remains to be further explored. PMID: 31124292 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 23, 2019 Category: Neuroscience Authors: Wang J, Sui RX, Miao Q, Wang Q, Song LJ, Yu JZ, Li YH, Xiao BG, Ma CG Tags: CNS Neurosci Ther Source Type: research

Functional study and pathogenicity classification of PRRT2 missense variants in PRRT2-related disorders.
CONCLUSIONS: The pathogenicity of eight uncertain significance variants needs further investigation. C-terminal of PRRT2 is crucial for its physiological function. PMID: 31124310 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 23, 2019 Category: Neuroscience Authors: Zhao SY, Li LX, Chen YL, Chen YJ, Liu GL, Dong HL, Chen DF, Li HF, Wu ZY Tags: CNS Neurosci Ther Source Type: research

Cervical spondylotic internal jugular venous compression syndrome.
CONCLUSIONS: This study proposes cervical spondylotic internal jugular venous compression syndrome as a brand-new cervical spondylotic subtype. A better understanding of this disease entity can be of great relevance to clinicians in making a proper diagnosis. PMID: 31119898 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 22, 2019 Category: Neuroscience Authors: Ding JY, Zhou D, Pan LQ, Ya JY, Liu C, Yan F, Fan CQ, Ding YC, Ji XM, Meng R Tags: CNS Neurosci Ther Source Type: research

LncRNA FOXD1-AS1 acts as a potential oncogenic biomarker in glioma.
CONCLUSIONS: These data indicated that FOXD1-AS1, a miR339/342 target, affected biological processes via protein eIF5a; thus, it might be considered as a new therapeutic target for glioblastoma. PMID: 31102349 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2019 Category: Neuroscience Authors: Gao YF, Liu JY, Mao XY, He ZW, Zhu T, Wang ZB, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ Tags: CNS Neurosci Ther Source Type: research

Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress.
CONCLUSION: Ciproxifan improved contextual memory retrieval both in stress and nonstress conditions without exacerbating behavioral and endocrine responses to stress. Overall, these data suggest potential usefulness of H3 receptor antagonists as cognitive enhancer both in nonstress and stress conditions. PMID: 31094061 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 15, 2019 Category: Neuroscience Authors: Chauveau F, De Job E, Poly-Thomasson B, Cavroy R, Thomasson J, Fromage D, Beracochea D Tags: CNS Neurosci Ther Source Type: research

Transplantation of Nurr1-overexpressing neural stem cells and microglia for treating parkinsonian rats.
CONCLUSIONS: The results suggested that transplantation of Nurr1-overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be  a new potential strategy for the cell replacement therapy in PD. PMID: 31087449 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2019 Category: Neuroscience Authors: Qian Y, Chen XX, Wang W, Li JJ, Wang XP, Tang ZW, Xu JT, Lin H, Yang ZY, Li LY, Song XB, Guo JZ, Bian LG, Zhou L, Lu D, Deng XL Tags: CNS Neurosci Ther Source Type: research

Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway.
CONCLUSIONS: Leonurine exerted neuroprotective effects, promoted antioxidant responses, and upregulated VEGF expression by activating the Nrf-2 pathway. PMID: 31087454 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2019 Category: Neuroscience Authors: Xie YZ, Zhang XJ, Zhang C, Yang Y, He JN, Chen YX Tags: CNS Neurosci Ther Source Type: research

Optimal response to dimethyl fumarate is mediated by a reduction of Th1-like Th17 cells after 3  months of treatment.
CONCLUSION: The optimal response to DMF is mediated by a shift to antiinflammatory and immunoregulatory profile, which puts forward Th1-like Th17 lymphocytes as a potential early biomarker of treatment response. PMID: 31066225 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 7, 2019 Category: Neuroscience Authors: Mansilla MJ, Navarro-Barriuso J, Presas-Rodríguez S, Teniente-Serra A, Quirant-Sánchez B, Ramo-Tello C, Martínez-Cáceres EM Tags: CNS Neurosci Ther Source Type: research

Mechanisms and roles of mitophagy in neurodegenerative diseases.
Abstract Mitochondria are double-membrane-encircled organelles existing in most eukaryotic cells and playing important roles in energy production, metabolism, Ca2+ buffering, and cell signaling. Mitophagy is the selective degradation of mitochondria by autophagy. Mitophagy can effectively remove damaged or stressed mitochondria, which is essential for cellular health. Thanks to the implementation of genetics, cell biology, and proteomics approaches, we are beginning to understand the mechanisms of mitophagy, including the roles of ubiquitin-dependent and receptor-dependent signals on damaged mitochondria in trigge...
Source: CNS Neuroscience and Therapeutics - May 2, 2019 Category: Neuroscience Authors: Wang Y, Liu N, Lu B Tags: CNS Neurosci Ther Source Type: research

Deep brain stimulation in post-traumatic dystonia: A case series study.
CONCLUSIONS: Deep brain stimulation may be an effective and safe treatment for medically refractory PTD, but this needs to be confirmed by further studies. PMID: 31033189 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 29, 2019 Category: Neuroscience Authors: Li HX, He L, Zhang CC, Eisinger R, Pan YX, Wang T, Sun BM, Wu YW, Li DY Tags: CNS Neurosci Ther Source Type: research

Phosphoregulation on mitochondria: Integration of cell and organelle responses.
Abstract Mitochondria are highly integrated organelles that are crucial to cell adaptation and mitigating adverse physiology. Recent studies demonstrate that fundamental signal transduction pathways incorporate mitochondrial substrates into their biological programs. Reversible phosphorylation is emerging as a useful mechanism to modulate mitochondrial function in accordance with cellular changes. Critical serine/threonine protein kinases, such as the c-Jun N-terminal kinase (JNK), protein kinase A (PKA), PTEN-induced kinase-1 (PINK1), and AMP-dependent protein kinase (AMPK), readily translocate to the outer mitoc...
Source: CNS Neuroscience and Therapeutics - April 25, 2019 Category: Neuroscience Authors: Lucero M, Suarez AE, Chambers JW Tags: CNS Neurosci Ther Source Type: research

Secukinumab attenuates reactive astrogliosis via IL-17RA/(C/EBP β)/SIRT1 pathway in a rat model of germinal matrix hemorrhage.
CONCLUSION: Secukinumab attenuated reactive astrogliosis and reduced neurological deficits after GMH, partly by regulating IL-17RA/(C/EBPβ)/SIRT1 pathways. Secukinumab may provide a promising therapeutic strategy for GMH patients. PMID: 31020769 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 24, 2019 Category: Neuroscience Authors: Liu SP, Huang L, Flores J, Ding Y, Li P, Peng J, Zuo G, Zhang JH, Lu J, Tang JP Tags: CNS Neurosci Ther Source Type: research

A five-CpG signature of microRNA methylation in non-G-CIMP glioblastoma.
CONCLUSION: The five-CpG signature of miRNA methylation was biologically relevant and was of potential prognostic and predictive value for GBMs. It might be of help for improving individualized treatment. PMID: 31016891 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 23, 2019 Category: Neuroscience Authors: Kang EM, Yin AA, He YL, Chen WJ, Etcheverry A, Aubry M, Barnholtz-Sloan J, Mosser J, Zhang W, Zhang X Tags: CNS Neurosci Ther Source Type: research

Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.
CONCLUSION: Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients. PMID: 31004399 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 19, 2019 Category: Neuroscience Authors: Park CI, Hwang SS, Kim HW, Kang JI, Lee SH, Kim SJ Tags: CNS Neurosci Ther Source Type: research

Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo.
CONCLUSION: Urolithin A protected against ischemic neuronal injury by reinforcing autophagy rather than mitophagy. Autophagy activation by Uro-A attenuated ischemic neuronal death by suppressing ER stress. PMID: 30972969 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 11, 2019 Category: Neuroscience Authors: Ahsan A, Zheng YR, Wu XL, Tang WD, Liu MR, Ma SJ, Jiang L, Hu WW, Zhang XN, Chen Z Tags: CNS Neurosci Ther Source Type: research

Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer.
Abstract AIMS: Hyperbaric oxygen therapy (HBOT) has been widely used as postinjury treatment; however, we investigate its ability to mitigate potential damage as a preconditioning option. Here, we tested the hypothesis that HBOT preconditioning mitigates cell death in primary rat neuronal cells (PRNCs) through the transfer of mitochondria from astrocytes. METHODS: Primary rat neuronal cells were subjected to a 90-minute HBOT treatment at 2.5 absolute atmospheres prior to either tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) injury to simulate the inflammation-plagued secondary cell death ...
Source: CNS Neuroscience and Therapeutics - April 11, 2019 Category: Neuroscience Authors: Lippert T, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Development and validation of a new score for predicting functional outcome of neurocritically ill patients: The INCNS score.
CONCLUSION: We developed an INCNS score with superior predictive power for functional outcome of neurocritically ill patients. PMID: 30968580 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 10, 2019 Category: Neuroscience Authors: Gao Q, Yuan F, Yang XA, Zhu JW, Song L, Bi LJ, Jiao ZY, Kang XG, Yang F, Jiang W Tags: CNS Neurosci Ther Source Type: research

Olanzapine induced autophagy through suppression of NF- κB activation in human glioma cells.
CONCLUSIONS: Our findings identify a pathway by which olanzapine induces autophagy by depressing NF-κB in a glioma cell line, providing evidence which supports the use of olanzapine as a potential anticancer drug. PMID: 30955240 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 7, 2019 Category: Neuroscience Authors: Zhu Y, Zhao YF, Liu RS, Xiong YJ, Shen X, Wang Y, Liang ZQ Tags: CNS Neurosci Ther Source Type: research

CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model.
CONCLUSION: We demonstrate that the CXCL12/CXCR4 signaling pathway contributes to the development and maintenance of neuropathic pain via central sensitization mechanisms. Importantly, intervening with CXCL12/CXCR4 presents an effective therapeutic approach to treat the neuropathic pain. PMID: 30955244 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 7, 2019 Category: Neuroscience Authors: Liu ZY, Song ZW, Guo SW, He JS, Wang SY, Zhu JG, Yang HL, Liu JB Tags: CNS Neurosci Ther Source Type: research

Thrombin disrupts vascular endothelial-cadherin and leads to hydrocephalus via protease-activated receptors-1 pathway.
CONCLUSIONS: Our results suggested that the thrombin-induced hydrocephalus was associated with the inhibition of VE-cadherin via the PAR1/p-Src/p-PAK1 pathway. PMID: 30955248 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 7, 2019 Category: Neuroscience Authors: Hao XD, Le CS, Zhang HM, Shang DS, Tong LS, Gao F Tags: CNS Neurosci Ther Source Type: research

Harnessing brain activity at adolescence prevents later schizophrenia development.
PMID: 30941905 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 2, 2019 Category: Neuroscience Authors: Zhou DS, Yuan TF Tags: CNS Neurosci Ther Source Type: research

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury.
CONCLUSION: The activation of TNFR2 in the spinal cord following contusive injury leads to enhanced locomotion and better cortical responses to hindlimb stimulation. PMID: 30941924 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 2, 2019 Category: Neuroscience Authors: Gerald MJ, Bracchi-Ricard V, Ricard J, Fischer R, Nandakumar B, Blumenthal GH, Williams R, Kontermann RE, Pfizenmaier K, Moxon KA, Bethea JR Tags: CNS Neurosci Ther Source Type: research

Astrocyte morphology: Diversity, plasticity, and role in neurological diseases.
Abstract Astrocytes are the most abundant glial cells in the central nervous system (CNS) and participate in synaptic, circuit, and behavioral functions. The well-developed protoplasmic astrocytes contain numerous processes forming well-delineated bushy territories that overlap by as little as 5% at their boundaries. This highly complex morphology, with up to approximately 80% of the cell's membrane constituted by fine processes with dimensions on the tens of nanometer scale and high surface area to volume ratios, comes in contact with synapses, blood vessels, and other glial cells. Recent progress is challenging ...
Source: CNS Neuroscience and Therapeutics - March 30, 2019 Category: Neuroscience Authors: Zhou B, Zuo YX, Jiang RT Tags: CNS Neurosci Ther Source Type: research

Long noncoding RNA ENST00000413528 sponges microRNA-593-5p to modulate human glioma growth via polo-like kinase 1.
CONCLUSION: lncRNA ENST00000413528 is closely related to the development of glioma via the miR-593-5p/PLK1 pathway. PMID: 30924320 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2019 Category: Neuroscience Authors: Zhang R, Wei RL, Du W, Zhang LW, Du T, Geng YD, Wei XT Tags: CNS Neurosci Ther Source Type: research

Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction.
Abstract OBJECTIVE: To investigate the relationship between tumor characteristics and the preoperative counts of immune cells in peripheral blood test in glioma patients. METHODS: We included 260 WHO grades II-IV patients who had preoperative peripheral blood test result from Sanbo hospital as training set. The 66 patients from Tiantan hospital was obtained for validation. RNA sequencing data from CGGA and TCGA datasets were used to evaluate the features of neutrophil subtype and lymphocyte subtype in glioma. RESULTS: We revealed that the count of preoperative lymphocytes, eosinophils and neutrophils wer...
Source: CNS Neuroscience and Therapeutics - March 26, 2019 Category: Neuroscience Authors: Wang ZL, Zhang CB, Liu YQ, Wang Z, Jiang T Tags: CNS Neurosci Ther Source Type: research

Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders.
Abstract Axonal mitochondrial quality is essential for neuronal health and functions. Compromised mitochondrial quality, reflected by loss of membrane potential, collapse of ATP production, abnormal morphology, burst of reactive oxygen species generation, and impaired Ca2+ buffering capacity, can alter mitochondrial transport. Mitochondrial transport in turn maintains axonal mitochondrial homeostasis in several ways. Newly generated mitochondria are anterogradely transported along with axon from soma to replenish axonal mitochondrial pool, while damaged mitochondria undergo retrograde transport for repair or degra...
Source: CNS Neuroscience and Therapeutics - March 21, 2019 Category: Neuroscience Authors: Zheng YR, Zhang XN, Chen Z Tags: CNS Neurosci Ther Source Type: research

The absence of NIPA2 enhances neural excitability through BK (big potassium) channels.
CONCLUSION: The results indicate that the absence of NIPA2 enhances neural excitability through BK channels. Zonisamide is probably a potential treatment for NIPA2 mutation-induced epilepsy, which may provide a basis for the development of new treatment strategies for epilepsy. PMID: 30895737 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 20, 2019 Category: Neuroscience Authors: Liu NN, Xie H, Xiang-Wei WS, Gao K, Wang TS, Jiang YW Tags: CNS Neurosci Ther Source Type: research

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure.
Abstract Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria in aging and neurodegenerative diseases, and the signaling pathways leading to mitochondrial biogenesis (including PGC-1 family proteins, SIRT1, AMPK) and mitophagy (parkin-Pink1 pathway). Understanding the regulation of these mitochondrial pathways may be beneficial in finding pharmacological approaches or lifestyle changes (caloric restrict or exercise) to modulate mitochondrial biogenesis and/or to activate mitophagy for the removal of damaged mitochond...
Source: CNS Neuroscience and Therapeutics - March 19, 2019 Category: Neuroscience Authors: Wang Y, Xu E, Musich PR, Lin F Tags: CNS Neurosci Ther Source Type: research

Bilateral anterior capsulotomy enhances medication compliance in patients with epilepsy and psychiatric comorbidities.
CONCLUSION: Anterior capsulotomy seems to be a safe and effective treatment for epilepsy patients with otherwise intractable comorbid psychotic symptoms and aggression. Moreover, this neurosurgical treatment may improve the patients' social function, quality of life, and compliance with anti-epilepsy medication regimens. PMID: 30868752 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 13, 2019 Category: Neuroscience Authors: Huang P, Zheng-Dao D, Sun BM, Pan YX, Zhang J, Wang T, Liu W, Jin HY, Zhan SK Tags: CNS Neurosci Ther Source Type: research

Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway.
CONCLUSION: Running exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway. PMID: 30864262 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2019 Category: Neuroscience Authors: Huang J, Wang X, Zhu Y, Li Z, Zhu YT, Wu JC, Qin ZH, Xiang M, Lin F Tags: CNS Neurosci Ther Source Type: research

Shared genes between Alzheimer's disease and ischemic stroke.
CONCLUSIONS: The observation that AD and IS had shared disease-associated genes offered mechanistic insights into their common pathogenesis, predominantly involving the immune system. More importantly, our findings have important implications for future research directions, which are encouraged to verify the involvement of these candidates in AD and IS and interpret the exact molecular mechanisms of action. PMID: 30859738 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 11, 2019 Category: Neuroscience Authors: Wei CJ, Cui P, Li H, Lang WJ, Liu GY, Ma XF Tags: CNS Neurosci Ther Source Type: research

Pregabalin: A range of misuse-related unanswered questions.
PMID: 30834646 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 4, 2019 Category: Neuroscience Authors: Schifano F, Chiappini S Tags: CNS Neurosci Ther Source Type: research

Immunosuppressive and monoclonal antibody treatment for myasthenia gravis: A network meta-analysis.
CONCLUSION: These findings demonstrated that ECZ represented the most effective and tolerable therapeutic alternative to be recommended for refractory MG. TAC may be a beneficial therapy to treat MG extensively while the efficacy of CsA and cyclophosphamide may be limited by their multiple or severe AEs. PMID: 30809966 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 26, 2019 Category: Neuroscience Authors: Wang L, Huan X, Xi JY, Wu H, Zhou L, Lu JH, Zhang TS, Zhao CB Tags: CNS Neurosci Ther Source Type: research

Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.
Abstract INTRODUCTION: Dl-3-N-butylphthalide (NBP), a small molecule drug used clinically in the acute phase of ischemic stroke, has been shown to improve functional recovery and promote angiogenesis and collateral vessel circulation after experimental cerebral ischemia. However, the underlying molecular mechanism is unknown. AIMS: To explore the potential molecular mechanism of angiogenesis induced by NBP after cerebral ischemia. RESULTS: NBP treatment attenuated body weight loss, reduced brain infarct volume, and improved neurobehavioral outcomes during focal ischemia compared to the control rats (P 
Source: CNS Neuroscience and Therapeutics - February 19, 2019 Category: Neuroscience Authors: Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ, Yang GY Tags: CNS Neurosci Ther Source Type: research

Clinical or neuroimaging profiles in the assessment of genetic variants associated with neurodegenerative diseases.
;as-Guiu JA PMID: 30779312 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 18, 2019 Category: Neuroscience Authors: Matías-Guiu J, Torre-Fuentes L, Gomez-Pinedo U, Matías-Guiu JA Tags: CNS Neurosci Ther Source Type: research

Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis.
CONCLUSION: Our results indicate that intranasal delivery of Fasudil-modified MNCs have therapeutic potential in EAE, providing a safe and effective cell therapeutic strategy to MS and/or other related disorders. PMID: 30779332 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 18, 2019 Category: Neuroscience Authors: Guo SD, Liu CY, Yu JW, Chai Z, Wang Q, Mi XT, Song GB, Li YH, Yang PW, Feng L, Xiao BG, Ma CG Tags: CNS Neurosci Ther Source Type: research

Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker.
CONCLUSIONS: This study analyzed the differential lncRNA profile in cryptococcal meningitis patients and revealed DPY19L1p1 could be used for treatment evaluation and disease diagnosis. PMID: 30767376 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 14, 2019 Category: Neuroscience Authors: Zhang L, Fang WJ, Zhang KM, Jiang WW, Chen M, Liao WQ, Pan WH Tags: CNS Neurosci Ther Source Type: research

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.
Abstract AIM: To examine whether the velocity of saccadic eye movements in internuclear ophthalmoparesis (INO) improves with fampridine treatment in patients with multiple sclerosis (MS). METHODS: Randomized, double-blind, placebo-controlled, cross-over trial with fampridine in patients with MS and INO. Horizontal saccades were recorded at baseline and at multiple time points post-dose. Main outcome measures were the change of peak velocity versional dysconjugacy index (PV-VDI) and first-pass amplitude VDI (FPA-VDI). Both parameters were compared between fampridine and placebo using a mixed model analysis of ...
Source: CNS Neuroscience and Therapeutics - February 12, 2019 Category: Neuroscience Authors: Kanhai KMS, Nij Bijvank JA, Wagenaar YL, Klaassen ES, Lim K, Bergheanu SC, Petzold A, Verma A, Hesterman J, Wattjes MP, Uitdehaag BMJ, van Rijn LJ, Groeneveld GJ Tags: CNS Neurosci Ther Source Type: research