CHD4 variants are associated with childhood idiopathic epilepsy with sinus arrhythmia
CONCLUSIONS: CHD4 was potentially a candidate pathogenic gene of childhood idiopathic epilepsy with arrhythmia. The molecular sub-regional effect of CHD4 mutations helped explaining the mechanisms underlying phenotypic variations.PMID:34109749 | DOI:10.1111/cns.13692 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 10, 2021 Category: Neuroscience Authors: Xiao-Rong Liu Ting-Ting Ye Wen-Jun Zhang Xuan Guo Jie Wang Shao-Ping Huang Long-Shan Xie Xing-Wang Song Wei-Wen Deng Bing-Mei Li Na He Qian-Yi Wu Min-Zhi Zhuang Meng Xu Yi-Wu Shi Tao Su Yong-Hong Yi Wei-Ping Liao China Epilepsy Gene 1.0 Project Source Type: research

Spinal microglial β-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain
CONCLUSION: This suggests that spinal microglial expression of β-endorphin mediates IL-10- and exenatide-induced inhibition of glutamatergic transmission and pain hypersensitivity via presynaptic and postsynaptic MORs in spinal dorsal horn.PMID:34111331 | DOI:10.1111/cns.13694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 10, 2021 Category: Neuroscience Authors: Le Ma Shiyu Peng Jinbao Wei Mengjing Zhao Khalil Ali Ahmad Jinghong Chen Yong-Xiang Wang Source Type: research

CHD4 variants are associated with childhood idiopathic epilepsy with sinus arrhythmia
CONCLUSIONS: CHD4 was potentially a candidate pathogenic gene of childhood idiopathic epilepsy with arrhythmia. The molecular sub-regional effect of CHD4 mutations helped explaining the mechanisms underlying phenotypic variations.PMID:34109749 | DOI:10.1111/cns.13692 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 10, 2021 Category: Neuroscience Authors: Xiao-Rong Liu Ting-Ting Ye Wen-Jun Zhang Xuan Guo Jie Wang Shao-Ping Huang Long-Shan Xie Xing-Wang Song Wei-Wen Deng Bing-Mei Li Na He Qian-Yi Wu Min-Zhi Zhuang Meng Xu Yi-Wu Shi Tao Su Yong-Hong Yi Wei-Ping Liao China Epilepsy Gene 1.0 Project Source Type: research

Spinal microglial β-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain
CONCLUSION: This suggests that spinal microglial expression of β-endorphin mediates IL-10- and exenatide-induced inhibition of glutamatergic transmission and pain hypersensitivity via presynaptic and postsynaptic MORs in spinal dorsal horn.PMID:34111331 | DOI:10.1111/cns.13694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 10, 2021 Category: Neuroscience Authors: Le Ma Shiyu Peng Jinbao Wei Mengjing Zhao Khalil Ali Ahmad Jinghong Chen Yong-Xiang Wang Source Type: research

Potential surgical therapies for drug-resistant focal epilepsy
CNS Neurosci Ther. 2021 Jun 7. doi: 10.1111/cns.13690. Online ahead of print.ABSTRACTDrug-resistant focal epilepsy (DRFE), defined by failure of two antiepileptic drugs, affects 30% of epileptic patients. Epilepsy surgeries are alternative options for this population. Preoperative evaluation is critical to include potential candidates, and to choose the most appropriate procedure to maximize efficacy and simultaneously minimize side effects. Traditional procedures involve open skull surgeries and epileptic focus resection. Alternatively, neuromodulation surgeries use peripheral nerve or deep brain stimulation to reduce the...
Source: CNS Neuroscience and Therapeutics - June 8, 2021 Category: Neuroscience Authors: Wei Shan Xuewei Mao Xiu Wang Robert E Hogan Qun Wang Source Type: research

Potential surgical therapies for drug-resistant focal epilepsy
CNS Neurosci Ther. 2021 Jun 7. doi: 10.1111/cns.13690. Online ahead of print.ABSTRACTDrug-resistant focal epilepsy (DRFE), defined by failure of two antiepileptic drugs, affects 30% of epileptic patients. Epilepsy surgeries are alternative options for this population. Preoperative evaluation is critical to include potential candidates, and to choose the most appropriate procedure to maximize efficacy and simultaneously minimize side effects. Traditional procedures involve open skull surgeries and epileptic focus resection. Alternatively, neuromodulation surgeries use peripheral nerve or deep brain stimulation to reduce the...
Source: CNS Neuroscience and Therapeutics - June 8, 2021 Category: Neuroscience Authors: Wei Shan Xuewei Mao Xiu Wang Robert E Hogan Qun Wang Source Type: research

Potential surgical therapies for drug-resistant focal epilepsy
CNS Neurosci Ther. 2021 Jun 7. doi: 10.1111/cns.13690. Online ahead of print.ABSTRACTDrug-resistant focal epilepsy (DRFE), defined by failure of two antiepileptic drugs, affects 30% of epileptic patients. Epilepsy surgeries are alternative options for this population. Preoperative evaluation is critical to include potential candidates, and to choose the most appropriate procedure to maximize efficacy and simultaneously minimize side effects. Traditional procedures involve open skull surgeries and epileptic focus resection. Alternatively, neuromodulation surgeries use peripheral nerve or deep brain stimulation to reduce the...
Source: CNS Neuroscience and Therapeutics - June 8, 2021 Category: Neuroscience Authors: Wei Shan Xuewei Mao Xiu Wang Robert E Hogan Qun Wang Source Type: research

Corrigendum
CNS Neurosci Ther. 2021 Jun 7. doi: 10.1111/cns.13652. Online ahead of print.NO ABSTRACTPMID:34097351 | DOI:10.1111/cns.13652 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 7, 2021 Category: Neuroscience Source Type: research

Chronic Toxoplasma gondii infection and sleep-wake alterations in mice
CONCLUSION: We demonstrated for the first time the direct consequences of Tg infection on sleep-wake states. The persistently increased wakefulness and reduced sleep fit with the parasite's strategy to enhance dissemination through host predation and are of significance in understanding the neurodegenerative and neuropsychiatric disorders reported in infected patients.PMID:34085752 | DOI:10.1111/cns.13650 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 4, 2021 Category: Neuroscience Authors: Damien Dupont Jian-Sheng Lin Fran çois Peyron Hideo Akaoka Martine Wallon Source Type: research

Chronic Toxoplasma gondii infection and sleep-wake alterations in mice
CONCLUSION: We demonstrated for the first time the direct consequences of Tg infection on sleep-wake states. The persistently increased wakefulness and reduced sleep fit with the parasite's strategy to enhance dissemination through host predation and are of significance in understanding the neurodegenerative and neuropsychiatric disorders reported in infected patients.PMID:34085752 | DOI:10.1111/cns.13650 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 4, 2021 Category: Neuroscience Authors: Damien Dupont Jian-Sheng Lin Fran çois Peyron Hideo Akaoka Martine Wallon Source Type: research

Chronic Toxoplasma gondii infection and sleep-wake alterations in mice
CONCLUSION: We demonstrated for the first time the direct consequences of Tg infection on sleep-wake states. The persistently increased wakefulness and reduced sleep fit with the parasite's strategy to enhance dissemination through host predation and are of significance in understanding the neurodegenerative and neuropsychiatric disorders reported in infected patients.PMID:34085752 | DOI:10.1111/cns.13650 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 4, 2021 Category: Neuroscience Authors: Damien Dupont Jian-Sheng Lin Fran çois Peyron Hideo Akaoka Martine Wallon Source Type: research

Chronic Toxoplasma gondii infection and sleep-wake alterations in mice
CONCLUSION: We demonstrated for the first time the direct consequences of Tg infection on sleep-wake states. The persistently increased wakefulness and reduced sleep fit with the parasite's strategy to enhance dissemination through host predation and are of significance in understanding the neurodegenerative and neuropsychiatric disorders reported in infected patients.PMID:34085752 | DOI:10.1111/cns.13650 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 4, 2021 Category: Neuroscience Authors: Damien Dupont Jian-Sheng Lin Fran çois Peyron Hideo Akaoka Martine Wallon Source Type: research

TROAP regulates cell cycle and promotes tumor progression through Wnt/ β-Catenin signaling pathway in glioma cells
CONCLUSION: The present study found that TROAP accelerated the progression of gliomagenesis through Wnt/β-Catenin pathway, and TROAP might be considered as a novel target for glioma therapy.PMID:34077623 | DOI:10.1111/cns.13688 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 2, 2021 Category: Neuroscience Authors: Zong-Qing Zhao Xiu-Jie Wu Yan-Hao Cheng Yun-Fei Zhou Xi-Meng Ma Jian Zhang Xue-Yuan Heng Fan Feng Source Type: research

TROAP regulates cell cycle and promotes tumor progression through Wnt/ β-Catenin signaling pathway in glioma cells
CONCLUSION: The present study found that TROAP accelerated the progression of gliomagenesis through Wnt/β-Catenin pathway, and TROAP might be considered as a novel target for glioma therapy.PMID:34077623 | DOI:10.1111/cns.13688 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 2, 2021 Category: Neuroscience Authors: Zong-Qing Zhao Xiu-Jie Wu Yan-Hao Cheng Yun-Fei Zhou Xi-Meng Ma Jian Zhang Xue-Yuan Heng Fan Feng Source Type: research

Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/ β-catenin signaling following ischemic stroke
CONCLUSIONS: The BBB protection induced by upregulation of endothelial Wnt/β-catenin signaling may be not interfered by the normalization of non-canonical Wnt signalings in the early stage of ischemic stroke.PMID:34056869 | DOI:10.1111/cns.13661 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 31, 2021 Category: Neuroscience Authors: Ya-Bin Ji Tian-Xi Wang Qiang Gao Xiao-Wen Huang Junlei Chang Source Type: research

Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/ β-catenin signaling following ischemic stroke
CONCLUSIONS: The BBB protection induced by upregulation of endothelial Wnt/β-catenin signaling may be not interfered by the normalization of non-canonical Wnt signalings in the early stage of ischemic stroke.PMID:34056869 | DOI:10.1111/cns.13661 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 31, 2021 Category: Neuroscience Authors: Ya-Bin Ji Tian-Xi Wang Qiang Gao Xiao-Wen Huang Junlei Chang Source Type: research

Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/ β-catenin signaling following ischemic stroke
CONCLUSIONS: The BBB protection induced by upregulation of endothelial Wnt/β-catenin signaling may be not interfered by the normalization of non-canonical Wnt signalings in the early stage of ischemic stroke.PMID:34056869 | DOI:10.1111/cns.13661 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 31, 2021 Category: Neuroscience Authors: Ya-Bin Ji Tian-Xi Wang Qiang Gao Xiao-Wen Huang Junlei Chang Source Type: research

Microvascular decompression for hemifacial spasm involving the vertebral artery: A modified effective technique using a gelatin sponge with a FuAiLe medical adhesive
CNS Neurosci Ther. 2021 May 28. doi: 10.1111/cns.13662. Online ahead of print.ABSTRACTMicrovascular Decompression for Hemifacial Spasm Involving the Vertebral Artery (VA): A Modified Effective Technique Using a Gelatin Sponge with a FuAiLe Medical Adhesive. (a)The VA pushes the anterior inferior cerebellar artery (AICA) which compressed the root exit zone (REZ) of the facial nerve. (b) The VA was adhered to the petrous dura, and the AICA was decompressed from the REZ by a Teflon pad.PMID:34050606 | DOI:10.1111/cns.13662 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 29, 2021 Category: Neuroscience Authors: Fei Xue Zhaoli Shen Yuhai Wang Sze Chai Kwok Jia Yin Source Type: research

Microvascular decompression for hemifacial spasm involving the vertebral artery: A modified effective technique using a gelatin sponge with a FuAiLe medical adhesive
CNS Neurosci Ther. 2021 May 28. doi: 10.1111/cns.13662. Online ahead of print.ABSTRACTMicrovascular Decompression for Hemifacial Spasm Involving the Vertebral Artery (VA): A Modified Effective Technique Using a Gelatin Sponge with a FuAiLe Medical Adhesive. (a)The VA pushes the anterior inferior cerebellar artery (AICA) which compressed the root exit zone (REZ) of the facial nerve. (b) The VA was adhered to the petrous dura, and the AICA was decompressed from the REZ by a Teflon pad.PMID:34050606 | DOI:10.1111/cns.13662 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 29, 2021 Category: Neuroscience Authors: Fei Xue Zhaoli Shen Yuhai Wang Sze Chai Kwok Jia Yin Source Type: research

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
CONCLUSION: Naltrexone reduced TBI-mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non-MOR and MOR mechanisms.PMID:34018697 | DOI:10.1111/cns.13655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2021 Category: Neuroscience Authors: Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu Source Type: research

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
CONCLUSION: Naltrexone reduced TBI-mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non-MOR and MOR mechanisms.PMID:34018697 | DOI:10.1111/cns.13655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2021 Category: Neuroscience Authors: Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu Source Type: research

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
CONCLUSION: Naltrexone reduced TBI-mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non-MOR and MOR mechanisms.PMID:34018697 | DOI:10.1111/cns.13655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2021 Category: Neuroscience Authors: Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu Source Type: research

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
CONCLUSION: Naltrexone reduced TBI-mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non-MOR and MOR mechanisms.PMID:34018697 | DOI:10.1111/cns.13655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2021 Category: Neuroscience Authors: Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu Source Type: research

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
CONCLUSION: Naltrexone reduced TBI-mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non-MOR and MOR mechanisms.PMID:34018697 | DOI:10.1111/cns.13655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2021 Category: Neuroscience Authors: Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu Source Type: research

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
CONCLUSION: Naltrexone reduced TBI-mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non-MOR and MOR mechanisms.PMID:34018697 | DOI:10.1111/cns.13655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2021 Category: Neuroscience Authors: Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu Source Type: research

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease
CONCLUSIONS: Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.PMID:33987940 | DOI:10.1111/cns.13659 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2021 Category: Neuroscience Authors: Hao Wang Jian-Jun Lv Yu Zhao Hao-Lin Wei Tian-Jiao Zhang Hai-Jiao Yang Zhi-Nan Chen Jian-Li Jiang Source Type: research

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease
CONCLUSIONS: Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.PMID:33987940 | DOI:10.1111/cns.13659 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2021 Category: Neuroscience Authors: Hao Wang Jian-Jun Lv Yu Zhao Hao-Lin Wei Tian-Jiao Zhang Hai-Jiao Yang Zhi-Nan Chen Jian-Li Jiang Source Type: research

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease
CONCLUSIONS: Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.PMID:33987940 | DOI:10.1111/cns.13659 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2021 Category: Neuroscience Authors: Hao Wang Jian-Jun Lv Yu Zhao Hao-Lin Wei Tian-Jiao Zhang Hai-Jiao Yang Zhi-Nan Chen Jian-Li Jiang Source Type: research

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease
CONCLUSIONS: Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.PMID:33987940 | DOI:10.1111/cns.13659 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2021 Category: Neuroscience Authors: Hao Wang Jian-Jun Lv Yu Zhao Hao-Lin Wei Tian-Jiao Zhang Hai-Jiao Yang Zhi-Nan Chen Jian-Li Jiang Source Type: research

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease
CONCLUSIONS: Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.PMID:33987940 | DOI:10.1111/cns.13659 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2021 Category: Neuroscience Authors: Hao Wang Jian-Jun Lv Yu Zhao Hao-Lin Wei Tian-Jiao Zhang Hai-Jiao Yang Zhi-Nan Chen Jian-Li Jiang Source Type: research

Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia
CONCLUSION: Our results demonstrate that 5-HT neurons in the DRN play a regulative role of general anesthesia, and activation of serotonergic neurons could facilitate emergence from general anesthesia partly through 5-HT 1A and 2C receptors.PMID:33973716 | DOI:10.1111/cns.13656 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2021 Category: Neuroscience Authors: Ao Li Rui Li Pengrong Ouyang Huihui Li Sa Wang Xinxin Zhang Dan Wang Mingzi Ran Guangchao Zhao Qianzi Yang Zhenghua Zhu Hailong Dong Haopeng Zhang Source Type: research

Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia
CONCLUSION: Our results demonstrate that 5-HT neurons in the DRN play a regulative role of general anesthesia, and activation of serotonergic neurons could facilitate emergence from general anesthesia partly through 5-HT 1A and 2C receptors.PMID:33973716 | DOI:10.1111/cns.13656 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2021 Category: Neuroscience Authors: Ao Li Rui Li Pengrong Ouyang Huihui Li Sa Wang Xinxin Zhang Dan Wang Mingzi Ran Guangchao Zhao Qianzi Yang Zhenghua Zhu Hailong Dong Haopeng Zhang Source Type: research

Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia
CONCLUSION: Our results demonstrate that 5-HT neurons in the DRN play a regulative role of general anesthesia, and activation of serotonergic neurons could facilitate emergence from general anesthesia partly through 5-HT 1A and 2C receptors.PMID:33973716 | DOI:10.1111/cns.13656 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2021 Category: Neuroscience Authors: Ao Li Rui Li Pengrong Ouyang Huihui Li Sa Wang Xinxin Zhang Dan Wang Mingzi Ran Guangchao Zhao Qianzi Yang Zhenghua Zhu Hailong Dong Haopeng Zhang Source Type: research

Ferroptosis-related gene signature predicts prognosis and immunotherapy in glioma
CONCLUSION: A novel FRGs-related risk score can predict prognosis and immunotherapy in glioma patients.PMID:33969928 | DOI:10.1111/cns.13654 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 10, 2021 Category: Neuroscience Authors: Rong-Jun Wan Wang Peng Qin-Xuan Xia Hong-Hao Zhou Xiao-Yuan Mao Source Type: research

Ferroptosis-related gene signature predicts prognosis and immunotherapy in glioma
CONCLUSION: A novel FRGs-related risk score can predict prognosis and immunotherapy in glioma patients.PMID:33969928 | DOI:10.1111/cns.13654 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 10, 2021 Category: Neuroscience Authors: Rong-Jun Wan Wang Peng Qin-Xuan Xia Hong-Hao Zhou Xiao-Yuan Mao Source Type: research

Impact of beta-2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment
CONCLUSIONS: We conclude that B2M levels are critical for the survival times of glioma patients, at least in part due to mediating high immune infiltration.PMID:33960680 | DOI:10.1111/cns.13649 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 7, 2021 Category: Neuroscience Authors: Feng Tang Yu-Hang Zhao Qing Zhang Wei Wei Su-Fang Tian Chen Li Jie Yao Ze-Fen Wang Zhi-Qiang Li Source Type: research

Impact of beta-2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment
CONCLUSIONS: We conclude that B2M levels are critical for the survival times of glioma patients, at least in part due to mediating high immune infiltration.PMID:33960680 | DOI:10.1111/cns.13649 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 7, 2021 Category: Neuroscience Authors: Feng Tang Yu-Hang Zhao Qing Zhang Wei Wei Su-Fang Tian Chen Li Jie Yao Ze-Fen Wang Zhi-Qiang Li Source Type: research

Impact of beta-2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment
CONCLUSIONS: We conclude that B2M levels are critical for the survival times of glioma patients, at least in part due to mediating high immune infiltration.PMID:33960680 | DOI:10.1111/cns.13649 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 7, 2021 Category: Neuroscience Authors: Feng Tang Yu-Hang Zhao Qing Zhang Wei Wei Su-Fang Tian Chen Li Jie Yao Ze-Fen Wang Zhi-Qiang Li Source Type: research

Inhibition of hyperactivity of the dorsal raphe 5-HTergic neurons ameliorates hippocampal seizure
CONCLUSION: Inhibition of hyperactivity of DR 5-HTergic neuron may present promising anti-seizure effect and the DR may be a potential DBS target for the therapy of TLE.PMID:33955651 | DOI:10.1111/cns.13648 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 6, 2021 Category: Neuroscience Authors: Heming Cheng Yingbei Qi Nanxi Lai Lin Yang Cenglin Xu Shuang Wang Yi Guo Zhong Chen Yi Wang Source Type: research

Inhibition of hyperactivity of the dorsal raphe 5-HTergic neurons ameliorates hippocampal seizure
CONCLUSION: Inhibition of hyperactivity of DR 5-HTergic neuron may present promising anti-seizure effect and the DR may be a potential DBS target for the therapy of TLE.PMID:33955651 | DOI:10.1111/cns.13648 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 6, 2021 Category: Neuroscience Authors: Heming Cheng Yingbei Qi Nanxi Lai Lin Yang Cenglin Xu Shuang Wang Yi Guo Zhong Chen Yi Wang Source Type: research

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway
CONCLUSION: Zinc promoted the degradation of oxidative stress products and lipid peroxides through the NRF2/HO-1 and GPX4 signaling pathways to inhibit ferroptosis in neurons.PMID:33951302 | DOI:10.1111/cns.13657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 5, 2021 Category: Neuroscience Authors: Ming-Hao Ge He Tian Liang Mao Dao-Yong Li Jia-Quan Lin Heng-Shuo Hu Shuo-Cheng Huang Chuan-Jie Zhang Xi-Fan Mei Source Type: research

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway
CONCLUSION: Zinc promoted the degradation of oxidative stress products and lipid peroxides through the NRF2/HO-1 and GPX4 signaling pathways to inhibit ferroptosis in neurons.PMID:33951302 | DOI:10.1111/cns.13657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 5, 2021 Category: Neuroscience Authors: Ming-Hao Ge He Tian Liang Mao Dao-Yong Li Jia-Quan Lin Heng-Shuo Hu Shuo-Cheng Huang Chuan-Jie Zhang Xi-Fan Mei Source Type: research

Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice
CONCLUSION: Our findings provide evidence that galectin-1 may inhibit IRAK1 expression, thus suppressing inflammatory response, inhibiting neuroinflammation, and improving ensuing cognitive dysfunction. Collectively, these findings unveil that galectin-1 may elicit protective effects on surgery-induced neuroinflammation and neurocognitive disorders.PMID:33942523 | DOI:10.1111/cns.13645 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Zhiwen Shen Hui Xu Wen Song Chuwen Hu Mingyan Guo Jinfeng Li Junhua Li Source Type: research

Magnetoencephalography for epileptic focus localization based on Tucker decomposition with ripple window
CONCLUSION: Tucker estimation of MEG for source imaging by ripple window is a promising approach toward the presurgical evaluation of epileptics.PMID:33942534 | DOI:10.1111/cns.13643 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Li-Juan Shi Bo-Xuan Wei Lu Xu Yi-Cong Lin Yu-Ping Wang Ji-Cong Zhang Source Type: research

Use of a panel of four microRNAs in CSF as a predicted biomarker for postoperative neoangiogenesis in moyamoya disease
CONCLUSION: The 4-miRNA signature is a good model to predict angiogenesis after indirect bypass surgery and help the surgeon to select a appreciate bypass strategy.PMID:33942536 | DOI:10.1111/cns.13646 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Gang Wang Yunyu Wen Siyuan Chen Guozhong Zhang Mingzhou Li Shichao Zhang Songtao Qi Wenfeng Feng Source Type: research

BAPTA, a calcium chelator, neuroprotects injured neurons in vitro and promotes motor recovery after spinal cord transection in vivo
CONCLUSION: This study shows for the first time that local/immediate application of Ca++ chelator BAPTA is strongly neuroprotective after severe spinal cord injury.PMID:33942993 | DOI:10.1111/cns.13651 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Kyu-Ree Kang Jin Kim Bokyeong Ryu Seul-Gi Lee Min-Seok Oh Jieun Baek Xiaoping Ren Sergio Canavero C-Yoon Kim Hyung Min Chung Source Type: research

The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population
CONCLUSION: Our findings broaden the mutational spectrum of NOTCH3 and validate the pathogenic role of NOTCH3 mutations in SVaD, but do not support the notion that NOTCH3 variation influences the risk of AD.PMID:33942994 | DOI:10.1111/cns.13647 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Lina Guo Bin Jiao Xinxin Liao Xuewen Xiao Weiwei Zhang Zhenhua Yuan Xixi Liu Lu Zhou Xin Wang Yuan Zhu Qijie Yang Junling Wang Beisha Tang Lu Shen Source Type: research

Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature
CNS Neurosci Ther. 2021 May 4. doi: 10.1111/cns.13653. Online ahead of print.ABSTRACTDementia accompanied by memory loss is considered one of the most common neurodegenerative diseases worldwide, and its prevalence is gradually increasing. Known risk factors for dementia include genetic background, certain lifestyle and dietary patterns, smoking, iron overload, insulin resistance, and impaired glucose metabolism in the brain. Here, we review recent evidence on the regulatory role of lipocalin 2 (LCN2) in dementia from various perspectives. LCN2 is a neutrophil gelatinase-associated protein that influences diverse cellular ...
Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Daejin Lim Jae-Ho Jeong Juhyun Song Source Type: research

Juvenile idiopathic inflammatory myopathies with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in a Chinese cohort
CONCLUSIONS: Our study indicates that anti-HMGCR antibodies may not be rare in Chinese JIIM. These anti-HMGCR-positive JIIMs were characterized by acute onset, substantially elevated creatine kinase level, and skin lesions without perifascicular changes in muscle pathology. The treatment outcome is generally favorable with the combination of steroid and immunosuppressant.PMID:33932258 | DOI:10.1111/cns.13658 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2021 Category: Neuroscience Authors: Ying Hou Kai Shao Bing Zhao Tingjun Dai Qinzhou Wang Yuying Zhao Chuanzhu Yan Yaping Yan Xiaotian Ma Wei Li Source Type: research

Juvenile idiopathic inflammatory myopathies with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in a Chinese cohort
CONCLUSIONS: Our study indicates that anti-HMGCR antibodies may not be rare in Chinese JIIM. These anti-HMGCR-positive JIIMs were characterized by acute onset, substantially elevated creatine kinase level, and skin lesions without perifascicular changes in muscle pathology. The treatment outcome is generally favorable with the combination of steroid and immunosuppressant.PMID:33932258 | DOI:10.1111/cns.13658 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2021 Category: Neuroscience Authors: Ying Hou Kai Shao Bing Zhao Tingjun Dai Qinzhou Wang Yuying Zhao Chuanzhu Yan Yaping Yan Xiaotian Ma Wei Li Source Type: research