Combinations of four or more CpGs methylation present equivalent predictive value for MGMT expression and temozolomide therapeutic prognosis in gliomas.
Abstract AIMS: The pyrosequencing (PSQ) has been regarded as the gold standard for MGMT promoter methylation testing in gliomas. However, various CpG combinations are currently used in clinical practice. We aimed to clarify how and how many CpGs combined is robust enough to predict MGMT mRNA expression and therapeutic prognosis of patients. METHODS: Total 223 patients with WHO III/IV gliomas were enrolled from Chinese Glioma Genome Atlas, including two independent cohorts, the eight-site cohort (with CpGs 75-82 tested) and the seven-site cohort (with CpGs 72-78 tested). Spearman's correlation and ROC curves w...
Source: CNS Neuroscience and Therapeutics - August 16, 2018 Category: Neuroscience Authors: Chai RC, Zhang KN, Liu YQ, Wu F, Zhao Z, Wang KY, Jiang T, Wang YZ Tags: CNS Neurosci Ther Source Type: research

Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.
CONCLUSION: The well-reproducible results showed the good performance of the combinatorial approach, and the remaining five new targets could be a good starting point for our understanding of the pathogenesis and drug discovery of AD. Moreover, this study supported validity of the combinatorial approach integrating ontology inference with network analysis in the discovery of novel drug target for neurological diseases. PMID: 30106219 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 14, 2018 Category: Neuroscience Authors: Han ZJ, Xue WW, Tao L, Zhu F Tags: CNS Neurosci Ther Source Type: research

Motor neuron disease-like phenotype associated with anti-IgLON5 disease.
PMID: 30105827 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 13, 2018 Category: Neuroscience Authors: Tao QQ, Wei Q, Song SJ, Yin XZ Tags: CNS Neurosci Ther Source Type: research

Costimulatory checkpoint SLAMF8 is an independent prognosis factor in glioma.
CONCLUSION: Our study highlighted the important role of SLAMF8 in malignancy progression, shortened survival, and immune disorders. Further research on SLAMF8 in immunosuppression and inflammation response to glioma cells could aid immunotherapy for glioma. PMID: 30105842 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 13, 2018 Category: Neuroscience Authors: Zou CY, Guan GF, Zhu C, Liu TQ, Guo Q, Cheng W, Wu AH Tags: CNS Neurosci Ther Source Type: research

SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms.
CONCLUSION: Our results show that siRNA-mediated silencing of SRPK1 gene inhibits VSMC apoptosis, and increases VSMCs proliferation and vascular remodeling in IA via the PI3 K/Akt signaling pathway. Our findings provide a novel intervention target for the molecular treatment of IA. PMID: 30101479 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 12, 2018 Category: Neuroscience Authors: Li XG, Wang YB Tags: CNS Neurosci Ther Source Type: research

Pronounced antiepileptic activity of the subtype-selective GABAA -positive allosteric modulator PF-06372865 in the GAERS absence epilepsy model.
CONCLUSIONS: PF-06372865 demonstrated robust efficacy in suppressing SWDs in the GAERS model of absence epilepsy. To our knowledge, this is the first demonstration of antiepileptic activity of an α2/3/5-subtype-selective GABAA PAM in a model of absence epilepsy. Further study of the antiepileptic properties of PF-06372865 is warranted in patients with absence seizures. PMID: 30101518 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 12, 2018 Category: Neuroscience Authors: Duveau V, Buhl DL, Evrard A, Ruggiero C, Mandé-Niedergang B, Roucard C, Gurrell R Tags: CNS Neurosci Ther Source Type: research

Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?
Abstract Alzheimer's disease (AD) is characterized by extensive neurodegeneration and inflammation in selective brain areas, linked to severely disabling cognitive deficits. Before full manifestation, different stages appear with progressively increased brain pathology and cognitive impairment. This significantly extends the time lag between initial molecular triggers and appearance of detectable symptoms. Notably, a number of studies in the last decade have revealed that in the early stage of mild cognitive impairment, events that appear in contrast with neuronal distress may occur. These have been reproduced in ...
Source: CNS Neuroscience and Therapeutics - August 12, 2018 Category: Neuroscience Authors: Merlo S, Spampinato SF, Sortino MA Tags: CNS Neurosci Ther Source Type: research

Do heterozygous HTRA1 mutations carriers form a distinct clinical entity?
PMID: 30084173 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 6, 2018 Category: Neuroscience Authors: Bougea A Tags: CNS Neurosci Ther Source Type: research

The delta-opioid receptor and Parkinson's disease.
Abstract Parkinson's disease (PD) is a common degenerative neurological disease leading to a series of familial, medical, and social problems. Although it is known that the major characteristics of PD pathophysiology are the dysfunction of basal ganglia due to injury/loss of dopaminergic neurons in the substantia nigra pars compacta dopaminergic and exhaustion of corpus striatum dopamine, therapeutic modalities for PD are limited in clinical settings up to date. It is of utmost importance to better understand PD pathophysiology and explore new solutions for this serious neurodegenerative disorder. Our recent work ...
Source: CNS Neuroscience and Therapeutics - August 3, 2018 Category: Neuroscience Authors: Huang JZ, Ren Y, Xu Y, Chen T, Xia TC, Li ZR, Zhao JN, Hua F, Sheng S, Xia Y Tags: CNS Neurosci Ther Source Type: research

Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine.
CONCLUSION: Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one. PMID: 30076687 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 3, 2018 Category: Neuroscience Authors: Liu CB, Yang DG, Zhang X, Zhang WH, Li DP, Zhang C, Qin C, Du LJ, Li J, Gao F, Zhang J, Zuo ZT, Yang ML, Li JJ Tags: CNS Neurosci Ther Source Type: research

Interdisciplinary approaches for neuropathology.
PMID: 30009529 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 18, 2018 Category: Neuroscience Authors: Di Giovanni G, Crunelli V, Rizzolatti G Tags: CNS Neurosci Ther Source Type: research

Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex.
CONCLUSION: These results suggest that the reduction in GABAergic inhibition in the PBN and VLPO may be involved in sleep disorders that are induced by STZ. Our novel findings encourage further studies that investigate mechanisms of sleep regulation in sporadic AD. PMID: 30014576 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 16, 2018 Category: Neuroscience Authors: Cui SY, Song JZ, Cui XY, Hu X, Ma YN, Shi YT, Luo Y, Ge YR, Ding H, Ye H, Zhang YH Tags: CNS Neurosci Ther Source Type: research

Mitochondrial ataxia is genetically and phenotypically heterogeneous.
PMID: 29998495 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 11, 2018 Category: Neuroscience Authors: Finsterer J, Zarrouk-Mahjoub S Tags: CNS Neurosci Ther Source Type: research

Clinical characteristics associated with therapeutic nonadherence of the patients with major depressive disorder: A report on the National Survey on Symptomatology of Depression in China.
CONCLUSION: Clinical characteristics may play an important role in predicting nonadherence. Doctors may have to pay much attention on patients with these factors and should keep on discussing them with patients. PMID: 29998606 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 11, 2018 Category: Neuroscience Authors: Zhou Q, Wu ZG, Wang Y, Liu XH, Chen J, Wang Y, Su YS, Zhang C, Peng DH, Hong W, Fang YR Tags: CNS Neurosci Ther Source Type: research

Inaccuracy in meta-analysis on safety of eleven drugs for the treatment of Parkinson's disease.
PMID: 29978947 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 6, 2018 Category: Neuroscience Authors: Chen XW Tags: CNS Neurosci Ther Source Type: research

MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric A β25-35 -induced anxiety and cognitive deficits in a mouse model.
CONCLUSIONS: These results reveal MGCD0103 could be a potential therapeutic agent against AD. PMID: 29978554 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 5, 2018 Category: Neuroscience Authors: Huang HJ, Huang HY, Hsieh-Li HM Tags: CNS Neurosci Ther Source Type: research

Pifithrin- μ modulates microglial activation and promotes histological recovery following spinal cord injury.
CONCLUSIONS: Our results indicate that a small molecule reagent PFT-μ has sustained immunomodulatory effects following a single dose after injury. PMID: 29962076 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 2, 2018 Category: Neuroscience Authors: Caponegro MD, Torres LF, Rastegar C, Rath N, Anderson ME, Robinson JK, Tsirka SE Tags: CNS Neurosci Ther Source Type: research

Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors.
Abstract The Mirror Neuron System (MNS) plays a crucial role in action perception and imitative behavior, which is suggested to be impaired in Autism Spectrum Disorders (ASDs). In this review, we discuss the plausibility and empirical evidence of a neural interaction between the MNS, action perception, empathy, imitative behavior, and their impact on social decision making in ASDs. To date, there is no consensus regarding a particular theory in ASDs and its underlying mechanisms. Some theories have completely focused on social difficulties, others have emphasized sensory aspects. Based on the current studies, we s...
Source: CNS Neuroscience and Therapeutics - July 2, 2018 Category: Neuroscience Authors: Khalil R, Tindle R, Boraud T, Moustafa AA, Karim AA Tags: CNS Neurosci Ther Source Type: research

Metabolic syndrome emerges after artificial selection for low baroreflex sensitivity.
CONCLUSION: Our study demonstrated that intrinsic low BRS induced hypertension and metabolic disorder. Restoration of impaired BRS might be a potent target of therapeutic intervention in metabolic syndrome. PMID: 29962085 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 1, 2018 Category: Neuroscience Authors: Zhang LL, Zhang Y, Cheng YQ, Zhang JM, Liu HQ, Wang WZ, Mehta JL, Xiong ZG, Su DF, Liu AJ Tags: CNS Neurosci Ther Source Type: research

A within-subject consideration of the psychotic spectrum disorder concept in a patient in remission associated with cortical gray matter recovery.
CONCLUSIONS: The 3 discrete periods of psychopathology support the diagnosis of PSD. The unusual course and outcome, including remarkable improvement, in executive function and enhanced cortical gray matter in selective brain regions may have been the result of unique endogenous genetic and epigenetic factors and effect of medication. PMID: 29898284 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2018 Category: Neuroscience Authors: Meltzer HY, Sim MY, Anderson A, Cannistraci C, Jayathilake K, Share DB, Lee M Tags: CNS Neurosci Ther Source Type: research

Emerging and evolving concepts in the pathobiology and treatment of psychosis.
PMID: 29898285 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2018 Category: Neuroscience Authors: Zhen XC, Waddington J Tags: CNS Neurosci Ther Source Type: research

Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod.
PMID: 29898493 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 13, 2018 Category: Neuroscience Authors: Evangelopoulos ME, Miclea A, Schrewe L, Briner M, Salmen A, Engelhardt B, Huwiler A, Chan A, Hoepner R Tags: CNS Neurosci Ther Source Type: research

Direct activation of tachykinin receptors within baroreflex afferent pathway and neurocontrol of blood pressure regulation.
CONCLUSION: The estrogen-dependent NKRs' expression in baroreflex afferent pathway participates at least partially in sexual-dimorphic and SP-mediated BP regulation under physiological and hypertensive conditions. PMID: 29900692 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 13, 2018 Category: Neuroscience Authors: Yuan M, Ma MN, Wang TY, Feng Y, Chen P, He C, Liu S, Guo YX, Wang Y, Fan Y, Wang LQ, E XQ, Qiao GF, Li BY Tags: CNS Neurosci Ther Source Type: research

The Basal Ganglia: More than just a switching device.
Abstract The basal ganglia consist of a variety of subcortical nuclei engaged in motor control and executive functions, such as motor learning, behavioral control, and emotion. The striatum, a major basal ganglia component, is particularly useful for cognitive planning of purposive motor acts owing to its structural features and the neuronal circuitry established with the cerebral cortex. Recent data indicate emergent functions played by the striatum. Indeed, cortico-striatal circuits carrying motor information are paralleled by circuits originating from associative and limbic territories, which are functionally i...
Source: CNS Neuroscience and Therapeutics - June 7, 2018 Category: Neuroscience Authors: Florio TM, Scarnati E, Rosa I, Di Censo D, Ranieri B, Cimini A, Galante A, Alecci M Tags: CNS Neurosci Ther Source Type: research

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.
CONCLUSION: Taken together, our findings suggest that DHM prevents progression of AD-like pathology through inhibition of NLRP3 inflammasome-based microglia-mediated neuroinflammation and may be a promising therapeutic drug for treating AD. PMID: 29869390 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 4, 2018 Category: Neuroscience Authors: Feng J, Wang J, Du Y, Liu Y, Zhang W, Chen J, Liu Y, Zheng M, Wang K, He G Tags: CNS Neurosci Ther Source Type: research

Intravenous immunoglobulin treatment in multiple sclerosis: A prospective, rater-blinded analysis of relapse rates during pregnancy and the postnatal period.
CONCLUSIONS: In MS patients, IVIg treatment during and/or after delivery is an option to reduce the incidence of relapses during pregnancy and the postnatal period. Surprisingly, untreated patients becoming pregnant showed an increase in the relapse rate in the first trimester compared with the pre-gestational period. How alterations of hormone status during pregnancy affect disease activity in MS has to be further investigated. PMID: 29858532 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 1, 2018 Category: Neuroscience Authors: Winkelmann A, Rommer PS, Hecker M, Zettl UK Tags: CNS Neurosci Ther Source Type: research

Novel mutation in SP2 in a Chinese pedigree with Neural tube defects.
PMID: 29855149 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 31, 2018 Category: Neuroscience Authors: Liu BH, Wang J, Li CM, Qi L, Song YH, Pan H, Li TY, Wang BB Tags: CNS Neurosci Ther Source Type: research

Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury.
CONCLUSION: Usage of aqueous sucrose solutions may be a feasible strategy, in combination with rehabilitation, to ameliorate ChABC-based treatments to promote the regeneration of central nervous system injuries. PMID: 29855151 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 31, 2018 Category: Neuroscience Authors: Raspa A, Bolla E, Cuscona C, Gelain F Tags: CNS Neurosci Ther Source Type: research

In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234.
F, Romero A PMID: 29808538 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 28, 2018 Category: Neuroscience Authors: Ramos E, Marco-Contelles J, López-Muñoz F, Romero A Tags: CNS Neurosci Ther Source Type: research

MiR-181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4.
CONCLUSION: MiR-181b could inhibit P38/JNK signaling pathway via targeting TLR4, thereby exerting protective roles in attenuating autophagy and apoptosis of KA-induced epileptic juvenile rats. PMID: 29808547 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 28, 2018 Category: Neuroscience Authors: Wang L, Song LF, Chen XY, Ma YL, Suo JF, Shi JH, Chen GH Tags: CNS Neurosci Ther Source Type: research

MicroRNA-219 decreases hippocampal long-term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing the NMDAR signaling pathway.
CONCLUSION: The findings from this study indicated that the upregulation of miR-219 decreases LTP inhibition and hippocampal neuronal cell apoptosis in T2DM mice by downregulating the NMDAR signaling pathway, therefore suggesting that MiR-219 might be a future therapeutic strategy for T2DM. PMID: 29804319 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Zhang L, Chen ZW, Yang SF, Shaer M, Wang Y, Dong JJ, Jiapaer B Tags: CNS Neurosci Ther Source Type: research

An epigenetic role for ascorbic acid in neurodegenerative diseases.
PMID: 29804320 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Peedicayil J Tags: CNS Neurosci Ther Source Type: research

Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies.
Abstract BACKGROUND: Previous review from randomized controlled trials (RCT) showed that patients with cryptogenic stroke may benefit from patent foramen ovale (PFO) closure. However, the findings from the systematic review were not clear when observational studies were also included. METHODS: We searched MEDLINE, Embase, and Cochrane databases. The primary endpoints were recurrent stroke or transient ischemic attack (TIA). The secondary outcomes were all-cause death, atrial fibrillation (AF), and hemorrhagic events. RESULTS: Five randomized trials and fourteen observational studies (6301 participants) w...
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Chen X, Chen SD, Dong Y, Dong Q Tags: CNS Neurosci Ther Source Type: research

Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke.
CONCLUSION: This study reveals potentially beneficial effects of a diet containing elevated amounts of anti-inflammatory nutrients on the recovery from ischemic brain damage. Therefore, dietary intervention can be considered as an adjuvant therapy for recovery from this brain pathology. PMID: 29804326 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Kurtys E, Casteels C, Real CC, Eisel ULM, Verkuyl JM, Broersen LM, Klein HC, Dierckx RAJO, Doorduin J, de Vries EFJ Tags: CNS Neurosci Ther Source Type: research

PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.
CONCLUSIONS: This PET study highlights an effect of α-syn modulation on the expression of the D2 receptor, whereas aggregated α-syn leads to overexpression of 5-HT1A receptor, as a pathophysiological signature. PMID: 29781098 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 20, 2018 Category: Neuroscience Authors: Levigoureux E, Bouillot C, Baron T, Zimmer L, Lancelot S Tags: CNS Neurosci Ther Source Type: research

Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid.
CONCLUSION: Taken together, these results thus defined a novel backbone structure for small molecule drug design targeting ASIC3 channels to treat pain-related diseases. PMID: 29781252 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 20, 2018 Category: Neuroscience Authors: Yan XG, Li WG, Qi X, Zhu JJ, Huang C, Han SL, Jiang Q, Xu TL, Liu JH Tags: CNS Neurosci Ther Source Type: research

Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
CONCLUSION: Our results indicated that Sirt3 is beneficial to neurovascular and functional recovery following chronic ischemic stroke. PMID: 29777578 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 18, 2018 Category: Neuroscience Authors: Yang X, Geng KY, Zhang YS, Zhang JF, Yang K, Shao JX, Xia WL Tags: CNS Neurosci Ther Source Type: research

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer's disease.
Abstract Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances. Approximately, 60%-80% of a...
Source: CNS Neuroscience and Therapeutics - May 16, 2018 Category: Neuroscience Authors: Jabir NR, Khan FR, Tabrez S Tags: CNS Neurosci Ther Source Type: research

Early increase of neutrophil-to-lymphocyte ratio predicts 30-day mortality in patients with spontaneous intracerebral hemorrhage.
Abstract AIMS: To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS: This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and September 2016 at the Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences in Shanghai, China. NLR was determined at admission (T1), at 24-48 hours (T2) and 5-7 days (T3). NLR and clinicopathologic features were compared between t...
Source: CNS Neuroscience and Therapeutics - May 16, 2018 Category: Neuroscience Authors: Wang F, Xu F, Quan Y, Wang L, Xia JJ, Jiang TT, Shen LJ, Kang WH, Ding Y, Mei LX, Ju XF, Hu SY, Wu X Tags: CNS Neurosci Ther Source Type: research

Organic psychosis: The pathobiology and treatment of delusions.
Abstract Organic or secondary psychosis can be seen in diverse conditions such as toxic/metabolic disorders, neurodegenerative disease, and stroke. Poststroke psychosis is a rare phenomenon, but its study has significantly contributed to the understanding of delusion formation. The evidence from case studies of patients with focal strokes shows that delusions develop following unilateral damage of the right hemisphere. The majority of patients with right hemisphere stroke do not develop delusions however, and advanced neuroimaging analysis has elucidated why this symptom develops in only a small proportion. Lesion...
Source: CNS Neuroscience and Therapeutics - May 15, 2018 Category: Neuroscience Authors: Joyce EM Tags: CNS Neurosci Ther Source Type: research

Hydroxychloroquine fails to attenuate lesion development in a mouse model of neuromyelitis optica.
PMID: 29761646 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2018 Category: Neuroscience Authors: Fang L, Wang Z, Song HH, Zhou YF, Chen C, Yan YP, Qiu W Tags: CNS Neurosci Ther Source Type: research

The effect of V-ATPase function defects in pathogenesis of Alzheimer's disease.
PMID: 29761665 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 14, 2018 Category: Neuroscience Authors: Zhao ZW, Yuan Z, Zhao DQ, Wang ZW, Zhu FQ, Luan P Tags: CNS Neurosci Ther Source Type: research

Genetic and clinical features of Chinese patients with mitochondrial ataxia identified by targeted next-generation sequencing.
CONCLUSIONS: Our results implicate that mitochondrial ataxia might not be as rare in Chinese as previously assumed. This study firstly defines the mutations of mitochondrial ataxia in a Chinese population by targeted NGS, which broadens the clinical spectrum of mtDNA mutations and highlights the importance of screening mtDNA and nDNA mutations among undefined ataxia patients. PMID: 29756269 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2018 Category: Neuroscience Authors: Dong HL, Ma Y, Li QF, Du YC, Yang L, Chen S, Wu ZY Tags: CNS Neurosci Ther Source Type: research

The novel atypical antipsychotic cariprazine demonstrates dopamine D2 receptor-dependent partial agonist actions on rat mesencephalic dopamine neuronal activity.
CONCLUSIONS: Cariprazine significantly modulates the number of spontaneously active VTA dopamine neurons and moderately suppresses midbrain dopamine neuronal activity. The contribution of dopamine D2 receptors to cariprazine's in vivo effects is prevalent and that of D3 receptors is less apparent. PMID: 29729086 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2018 Category: Neuroscience Authors: Delcourte S, Ashby CR, Rovera R, Kiss B, Adham N, Farkas B, Haddjeri N Tags: CNS Neurosci Ther Source Type: research

A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
CONCLUSION: Our results show that inhibition of PDE9 by C36D produces antidepressant- and anxiolytic-like behavioral effects and memory enhancement by activating cGMP/PKG signaling pathway. PDE9 inhibitors may have the potential as a novel class of drug to treat MDD. PMID: 29722134 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 2, 2018 Category: Neuroscience Authors: Huang XF, Jiang WT, Liu L, Song FC, Zhu X, Shi GL, Ding SM, Ke HM, Wang W, O'Donnell JM, Zhang HT, Luo HB, Wan YQ, Song GQ, Xu Y Tags: CNS Neurosci Ther Source Type: research

Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling.
te;rez AM, Gundlach AL Abstract The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin-3, which acts via the Gi/o -protein-coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into th...
Source: CNS Neuroscience and Therapeutics - May 2, 2018 Category: Neuroscience Authors: Olucha-Bordonau FE, Albert-Gascó H, Ros-Bernal F, Rytova V, Ong-Pålsson EKE, Ma S, Sánchez-Pérez AM, Gundlach AL Tags: CNS Neurosci Ther Source Type: research

Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry.
Abstract AIM: This 4-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring in individuals with Parkinson's disease (PD). METHODS: Twenty-eight outpatients with PD on stable levodopa treatment with dose intervals of ≤4 hour had their daytime doses of levodopa replaced with levodopa/carbidopa microtablets, 5/1.25 mg (LC-5) delivered from a dose dispenser device with programmable reminders. After 2 weeks, doses were adjusted based on ambulatory accelerometry and clinical mo...
Source: CNS Neuroscience and Therapeutics - April 15, 2018 Category: Neuroscience Authors: Johansson D, Ericsson A, Johansson A, Medvedev A, Nyholm D, Ohlsson F, Senek M, Spira J, Thomas I, Westin J, Bergquist F Tags: CNS Neurosci Ther Source Type: research

Overrated hedonic judgment of odors in patients with schizophrenia.
CONCLUSIONS: There is potential relationship between increased β-endorphin concentration and severity of negative symptoms. Patients with predominant negative symptoms tend to evaluate odors as significantly more pleasant. Individuals with this subtype of schizophrenia might present specific, altered pattern of smell identification and hedonic judgment. Presumably, β-endorphin has no direct influence on olfactory identification performance and hedonic judgment in schizophrenia. PMID: 29638031 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 11, 2018 Category: Neuroscience Authors: Urban-Kowalczyk M, Śmigielski J, Kotlicka-Antczak M Tags: CNS Neurosci Ther Source Type: research

Coping behavior in multiple sclerosis-complementary and alternative medicine: A cross-sectional study.
ettl UK Abstract MAIN PROBLEM: Treatment options for multiple sclerosis (MS) have enlarged tremendously over the last years. Nonetheless, lots of patients look for alternative treatment options. The use of complementary and alternative medicine (CAM) is widespread in MS, however, its scientific investigation is limited so far. The aim of the study is to analyse clinical and demographical differences of MS patients in dependency of their CAM utilization as coping strategy. METHODS: A total of 254 patients with a clinically definite MS were examined in a semistructured interview. Additional standardized questio...
Source: CNS Neuroscience and Therapeutics - April 10, 2018 Category: Neuroscience Authors: Rommer PS, König N, Sühnel A, Zettl UK Tags: CNS Neurosci Ther Source Type: research

Huntington's disease: From basic science to therapeutics.
PMID: 29582586 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 29, 2018 Category: Neuroscience Authors: Cepeda C, Tong XP Tags: CNS Neurosci Ther Source Type: research