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Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment.
CONCLUSIONS: We found an association between isoflurane exposure, impairment of spatial memory, decreasing level of NR2B, and increasing levels of A-beta and P-tau, presumably via the activation of the A1A receptor. PMID: 29345054 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 17, 2018 Category: Neuroscience Authors: Zuo CL, Wang CM, Liu J, Shen T, Zhou JP, Hao XR, Pan YZ, Liu HC, Lian QQ, Lin H Tags: CNS Neurosci Ther Source Type: research

Notch1 gain of function in skeletal muscles leads to neuromuscular junction formation defects and neonatal death.
PMID: 29345116 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 17, 2018 Category: Neuroscience Authors: Yang HH, Liu FJ, Wu Y, Zhu Q, Cheng JX, Fan M, Wu HT Tags: CNS Neurosci Ther Source Type: research

Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients.
CONCLUSION: NUSAP1 is a potential prognosis marker for glioma patients and therapeutic strategies targeting NUSAP1 might hold promise in improving glioma treatment. PMID: 29336114 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2018 Category: Neuroscience Authors: Zhu T, Xie P, Gao YF, Huang MS, Li X, Zhang W, Zhou HH, Liu ZQ Tags: CNS Neurosci Ther Source Type: research

The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference.
Abstract The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted...
Source: CNS Neuroscience and Therapeutics - January 9, 2018 Category: Neuroscience Authors: Sun YM, Chen RX, Li ZF, Spijker S, Zhai RW, Yang SC Tags: CNS Neurosci Ther Source Type: research

TAK-063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia.
Abstract The basal ganglia regulates motor, cognitive, and emotional behaviors. Dysfunction of dopamine system in this area is implicated in the pathophysiology of schizophrenia characterized by positive symptoms, negative symptoms, and cognitive deficits. Medium spiny neurons (MSNs) are principal output neurons of striatum in the basal ganglia. Similar to current antipsychotics with dopamine D2 receptor antagonism or partial agonism, phosphodiesterase 10A (PDE10A) inhibitors activate indirect pathway MSNs, leading to the expectation of therapeutic potential for the treatment of psychosis. PDE10A inhibitors also a...
Source: CNS Neuroscience and Therapeutics - January 9, 2018 Category: Neuroscience Authors: Suzuki K, Kimura H Tags: CNS Neurosci Ther Source Type: research

Divalproex sodium modulates nuclear localization of ataxin-3 and prevents cellular toxicity caused by expanded ataxin-3.
CONCLUSION: Our study provides novel insights into the mechanisms of action of divalproex sodium as a possible treatment for SCA3, beyond the known regulation of transcription. PMID: 29318784 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 9, 2018 Category: Neuroscience Authors: Wang ZJ, Hanet A, Weishäupl D, Martins IM, Sowa AS, Riess O, Schmidt T Tags: CNS Neurosci Ther Source Type: research

Fingolimod-improved axonal and myelin integrity of white matter tracts associated with multiple sclerosis-related functional impairments.
CONCLUSION: The observed results suggest increased microstructural integrity and decreased demyelination of damaged WM tracts and support the possible direct mechanism of fingolimod action. PMID: 29316271 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 5, 2018 Category: Neuroscience Authors: Gurevich M, Waknin R, Stone E, Achiron A Tags: CNS Neurosci Ther Source Type: research

MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway.
CONCLUSION: MicroRNA-21 might promote cell proliferation and inhibit cell senescence and apoptosis of human glioma cells by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. PMID: 29316313 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 5, 2018 Category: Neuroscience Authors: Chai C, Song LJ, Han SY, Li XQ, Li M Tags: CNS Neurosci Ther Source Type: research

Transcriptome profiling of peripheral blood immune cell populations in multiple sclerosis patients before and during treatment with a sphingosine-1-phosphate receptor modulator.
CONCLUSION: Our study corroborates changes in the composition of circulating immune cells in response to fingolimod and delineates the respective implications at the RNA level. Our data may be valuable for comparing the effects of novel S1P receptor modulating agents, which may be a therapeutic option for patients with secondary progressive MS as well. PMID: 29314605 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 3, 2018 Category: Neuroscience Authors: Angerer IC, Hecker M, Koczan D, Roch L, Friess J, Rüge A, Fitzner B, Boxberger N, Schröder I, Flechtner K, Thiesen HJ, Winkelmann A, Meister S, Zettl UK Tags: CNS Neurosci Ther Source Type: research

Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.
CONCLUSION: The results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS. PMID: 29314714 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 3, 2018 Category: Neuroscience Authors: Santangelo A, Bortolato M, Mosher LJ, Crescimanno G, Di Giovanni G, Cassioli E, Ricca V, Casarrubea M Tags: CNS Neurosci Ther Source Type: research

Visual field impairment predicts recurrent stroke after acute posterior circulation stroke and transient ischemic attack.
CONCLUSIONS: VFI is an independent predictor of recurrent VB stroke and TIA. PMID: 29293287 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 2, 2018 Category: Neuroscience Authors: Deng YM, Chen DD, Wang LY, Gao F, Sun X, Liu L, Lei K, Wang SR, Mo DP, Ma N, Song LG, Huo XC, Xu XT, Yan TY, Miao ZR Tags: CNS Neurosci Ther Source Type: research

Two-year observational study of deferiprone in superficial siderosis.
Abstract INTRODUCTION: Superficial siderosis is a rare, neurodegenerative disease caused by toxic accumulation of hemosiderin on the surface of the brain and the spinal cord, most commonly from chronic subarachnoid hemorrhage. AIMS: The aim of this study was to assess the clinical and radiological outcomes of superficial siderosis patients using deferiprone, a cell permeant iron chelator. Subjects obtained pre- and post-treatment brain MRIs and weekly laboratory tests. Osirix software was used to develop a method of quantifying hemosiderin deposition. Three-dimensional whole brain images of gradient echo imag...
Source: CNS Neuroscience and Therapeutics - December 28, 2017 Category: Neuroscience Authors: Kessler RA, Li X, Schwartz K, Huang H, Mealy MA, Levy M Tags: CNS Neurosci Ther Source Type: research

Enriched physical environment reverses spatial cognitive impairment of socially isolated APPswe/PS1dE9 transgenic mice before amyloidosis onset.
CONCLUSION: These results suggest that the enriched physical environment may serve as a nonpharmacological intervention for delaying the onset of AD accompanied with social isolation. PMID: 29274291 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 23, 2017 Category: Neuroscience Authors: Cao M, Hu PP, Zhang YL, Yan YX, Shields CB, Zhang YP, Hu G, Xiao M Tags: CNS Neurosci Ther Source Type: research

Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Cav 2.3 voltage-gated calcium channel.
GA Abstract INTRODUCTION: The relationship between blood metabolites and hemoglobin degradation products (BMHDPs) formed in the cerebrospinal fluid and the development of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been the focus of several previous studies, but their molecular and cellular targets remain to be elucidated. METHODS: Because BMHDP-induced changes in Cav 2.3 channel function are thought to contribute to DCI after aSAH, we studied their modulation by unconjugated bilirubin (UCB) in an organotypical neuronal network from wild-type (WT) and Cav...
Source: CNS Neuroscience and Therapeutics - December 23, 2017 Category: Neuroscience Authors: Albanna W, Neumaier F, Lüke JN, Kotliar K, Conzen C, Lindauer U, Hescheler J, Clusmann H, Schneider T, Schubert GA Tags: CNS Neurosci Ther Source Type: research

The neurobiological mechanisms of physical exercise in methamphetamine addiction.
Abstract Methamphetamine (METH) is the primary drug within amphetamine-type stimulants which are the second most abused group of drugs worldwide. There is no pharmacological treatment addressed specifically to METH addiction, and behavioral therapy is shadowed by poor long-term recovery and relapse. Therefore, novel approaches to manage METH addiction are an urgent need. This review aims to describe the current state of physical exercise use on methamphetamine addiction management. The following searching terms in PubMed were used: ("physical exercise" OR "exercise") AND "methamphetamine.&...
Source: CNS Neuroscience and Therapeutics - December 20, 2017 Category: Neuroscience Authors: Morais APD, Pita IR, Fontes-Ribeiro CA, Pereira FC Tags: CNS Neurosci Ther Source Type: research

CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.
CONCLUSION: A positive allosteric modulator of GluN2C/D-containing NMDARs rescues LTP and forelimb-use asymmetry in a mouse model of PD. This study proposes GluN2D as a potential candidate for therapeutic intervention in PD. PMID: 29230960 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 11, 2017 Category: Neuroscience Authors: Nouhi M, Zhang X, Yao N, Chergui K Tags: CNS Neurosci Ther Source Type: research

Effective network of deep brain stimulation of subthalamic nucleus with bimodal positron emission tomography/functional magnetic resonance imaging in Parkinson's disease.
CONCLUSION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) may deactivate the motor cortex as a remote and network effect, affecting the target and the neighboring subcortical areas. These areas may constitute an effective network of STN-DBS modulation. Our results shed light on the mechanisms of STN-DBS treatment from a network perspective and highlight the potential therapeutic benefits of targeted network modulation. PMID: 29222835 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 8, 2017 Category: Neuroscience Authors: Chen HM, Sha ZQ, Ma HZ, He Y, Feng T Tags: CNS Neurosci Ther Source Type: research

Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats.
CONCLUSION: These results suggest that finasteride inhibits dopaminergic system and open-field behaviors in adolescent male rats by inhibiting the conversion of testosterone to dihydrotestosterone, and imply finasteride as a potential therapeutic option for neuropsychiatric disorders associated with hyperactivities of dopaminergic system and androgen. PMID: 29214729 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 6, 2017 Category: Neuroscience Authors: Li L, Kang YX, Ji XM, Li YK, Li SC, Zhang XJ, Cui HX, Shi GM Tags: CNS Neurosci Ther Source Type: research

Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses.
CONCLUSION: Taken together, this study shows that MCT1 plays a role in the responses of OPCs and OLs to metabolic and ischemic stresses and suggests that redistribution of energy substrates is a determinant in white matter injury. PMID: 29205833 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 4, 2017 Category: Neuroscience Authors: Zhou P, Guan T, Jiang Z, Namaka M, Huang QJ, Kong JM Tags: CNS Neurosci Ther Source Type: research

No effect of transcranial direct current stimulation of the dorsolateral prefrontal cortex on short-term memory.
CONCLUSIONS: These results did not provide evidence for the enhancement of short-term memory by tDCS of the left DLPFC in healthy subjects, but it suggested an importance of administration time for visual short-term memory. Further studies are required to taking into account the baseline performance of subjects and time-dependence feature of tDCS. PMID: 29171169 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 23, 2017 Category: Neuroscience Authors: Wang J, Wen J, Li X Tags: CNS Neurosci Ther Source Type: research

Advances in chronic cerebral circulation insufficiency.
Abstract Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long-term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress of CCCI, mainly focusing on epidemiology, experimental research, pathophysiology, etiology, clinical manifestations, imaging presentation, diagnosis, ...
Source: CNS Neuroscience and Therapeutics - November 15, 2017 Category: Neuroscience Authors: Zhou D, Meng R, Li SJ, Ya JY, Ding JY, Shang SL, Ding YC, Ji XM Tags: CNS Neurosci Ther Source Type: research

Does the Serotonin2C receptor segregate circuits of the basal ganglia responding to cingulate cortex stimulation?
egrave;re P PMID: 29143496 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 15, 2017 Category: Neuroscience Authors: Lagière M, Bosc M, Whitestone S, Manem J, Elboukhari H, Benazzouz A, Di Giovanni G, De Deurwaerdère P Tags: CNS Neurosci Ther Source Type: research

Ginsenoside Rb1 improves leptin sensitivity in the prefrontal cortex in obese mice.
CONCLUSION: These results indicate that Rb1 reverses central leptin resistance and improves leptin-BDNF-neurite outgrowth and synaptogenesis in the prefrontal cortical neurons. Thus, Rb1 supplementation may be a beneficial avenue to treat obesity-associated neurodegenerative disorders. PMID: 29130652 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 11, 2017 Category: Neuroscience Authors: Wu Y, Huang XF, Bell C, Yu Y Tags: CNS Neurosci Ther Source Type: research

Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice.
CONCLUSION: Environmental enrichment and MgT may synergistically improve recognition and spatial memory by reducing synaptic loss and restoring the NMDAR signaling pathway in AD mice, which suggests that combination of EE and MgT may be a novel therapeutic strategy for AD. PMID: 29125684 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 10, 2017 Category: Neuroscience Authors: Huang Y, Huang X, Zhang L, Han F, Pang KL, Li X, Shen JY Tags: CNS Neurosci Ther Source Type: research

Impaired long contact white matter fibers integrity is related to depression in Parkinson's disease.
CONCLUSIONS: This study suggested depression in PD was related to impaired white matter integrity especially the long contact fibers in the left hemisphere. These findings may be helpful for further understanding the potential mechanisms underlying depression in PD. PMID: 29125694 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 10, 2017 Category: Neuroscience Authors: Wu JY, Zhang Y, Wu WB, Hu G, Xu Y Tags: CNS Neurosci Ther Source Type: research

Th2 axis-related cytokines in patients with neuromyelitis optica spectrum disorders.
CONCLUSION: We found higher serum levels of IL-25, IL-31, and IL-33 in patient with NMOSD as compared to healthy controls. The serum level of IL-33 during acute phase was associated with more past attacks in patients with NMOSD. PMID: 29110391 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 6, 2017 Category: Neuroscience Authors: Zhang Y, Yao XY, Gao MC, Ding J, Hong RH, Huang H, Zhuang L, Wang YG, Hao Y, Guan YT Tags: CNS Neurosci Ther Source Type: research

Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats.
CONCLUSION: In conclusion, our study suggests that the neuroprotective effects of acupuncture in VD are mediated through reducing expression of TXNIP-associated oxidative stress and inflammation. PMID: 29110407 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 6, 2017 Category: Neuroscience Authors: Du SQ, Wang XR, Zhu W, Ye Y, Yang JW, Ma SM, Ji CS, Liu CZ Tags: CNS Neurosci Ther Source Type: research

Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy-prone rat.
CONCLUSIONS: These findings suggest that the TRPV1 channel is a promising molecular target for seizure suppression, with female GEPR-3s exhibiting higher sensitivity than male GEPR-3s. PMID: 29105300 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 3, 2017 Category: Neuroscience Authors: Cho SJ, Vaca MA, Miranda CJ, N'Gouemo P Tags: CNS Neurosci Ther Source Type: research

A β exacerbates α-synuclein-induced neurotoxicity through impaired insulin signaling in α-synuclein-overexpressed human SK-N-MC neuronal cells.
CONCLUSIONS: This raised the possibility that insulin resistance could be one of the causative factors of αSyn toxicity, and the strategies for insulin sensitization may have therapeutic potential for synucleinopathies including DLB. PMID: 29092095 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 1, 2017 Category: Neuroscience Authors: Chang CC, Li HH, Chang YT, Ho YJ, Hsieh LJ, Chiu PY, Cheng YS, Lin CL, Lai TJ Tags: CNS Neurosci Ther Source Type: research

Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke.
This study explored the association between enlarged perivascular spaces (EPVS) and the health-related quality of life (HRQoL) in patients with acute ischemic stroke. METHODS: This was an observational study of consecutively screened patients with acute ischemic stroke from March 2010 to March 2015. EPVS were rated in the basal ganglia and the centrum semiovale with a validated scale. The HRQoL was assessed 3 months after the stroke onset using the Stroke-Specific Quality of Life (SSQoL). Linear regression models were used to study the association between EPVS and HRQoL. RESULTS: The study included 648 patie...
Source: CNS Neuroscience and Therapeutics - October 20, 2017 Category: Neuroscience Authors: Liang Y, Deng M, Chen YK, Mok V, Wang DF, Ungvari GS, Chu CW, Berge E, Tang WK Tags: CNS Neurosci Ther Source Type: research

Expression of aromatase in the rostral ventromedial medulla and its role in the regulation of visceral pain.
CONCLUSIONS: Our observations confirmed the expression of aromatase in the RVM, a pivotal brain region in descending modulation of pain and opioid analgesia. The results support the hypothesis that locally produced estrogens in the RVM may be involved in the maintenance of chronic visceral hyperalgesia and the downstream signaling may involve phosphorylation of MOR. PMID: 29047208 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 18, 2017 Category: Neuroscience Authors: Gao P, Ding XW, Dong L, Luo P, Zhang GH, Rong WF Tags: CNS Neurosci Ther Source Type: research

Endoplasmic reticulum stress regulates oxygen-glucose deprivation-induced parthanatos in human SH-SY5Y cells via improvement of intracellular ROS.
CONCLUSION: Endoplasmic reticulum stress regulates OGD-induced parthanatos in human SH-SY5Y cells via improvement of intracellular ROS. PMID: 29045036 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 16, 2017 Category: Neuroscience Authors: Wang HF, Wang ZQ, Ding Y, Piao MH, Feng CS, Chi GF, Luo YN, Ge PF Tags: CNS Neurosci Ther Source Type: research

Pooled efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Data from four double-blind placebo-controlled pivotal phase III clinical studies.
Abstract PURPOSE: Pooled evaluation of the key efficacy and safety profile of eslicarbazepine acetate (ESL) added-on to stable antiepileptic therapy in adults with focal-onset seizures. METHODS: Data from 1703 patients enrolled in four phase III double-blind, randomized, placebo-controlled studies were pooled and analyzed. Following a 2 week titration period, ESL was administered at 400 mg, 800 mg, and 1200 mg once-daily doses for 12 weeks (maintenance period). Pooled efficacy variable was standardized (/4 weeks) seizure frequency (SSF) analyzed over the maintenance period as red...
Source: CNS Neuroscience and Therapeutics - October 13, 2017 Category: Neuroscience Authors: Elger C, Koepp M, Trinka E, Villanueva V, Chaves J, Ben-Menachen E, Kowacs PA, Gil-Nagel A, Moreira J, Gama H, Rocha JF, Soares-da-Silva P Tags: CNS Neurosci Ther Source Type: research

Sigma-1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage-gated calcium ions channels.
CONCLUSION: Sig-1R activation can enhance axon outgrowth and may have a substantial influence on neurogenesis and neurodegenerative diseases. PMID: 28990373 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 8, 2017 Category: Neuroscience Authors: Li D, Zhang SZ, Yao YH, Xiang Y, Ma XY, Wei XL, Yan HT, Liu XY Tags: CNS Neurosci Ther Source Type: research

Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases.
Abstract In this review, we summarize the involvement of ascorbic acid in neurodegenerative diseases by presenting available evidence on the behavioral and biochemical effects of this compound in animal models of neurodegeneration as well as the use of ascorbic acid as a therapeutic approach to alleviate neurodegenerative progression in clinical studies. Ascorbate, a reduced form of vitamin C, has gained interest for its multiple functions and mechanisms of action, contributing to the homeostasis of normal tissues and organs as well as to tissue regeneration. In the brain, ascorbate exerts neuromodulatory function...
Source: CNS Neuroscience and Therapeutics - October 4, 2017 Category: Neuroscience Authors: Moretti M, Fraga DB, Rodrigues ALS Tags: CNS Neurosci Ther Source Type: research

Effectiveness of repetitive transcranial magnetic stimulation (rTMS) after acute stroke: A one-year longitudinal randomized trial.
CONCLUSION: rTMS facilitates motor recovery of acute stroke patients, and the effect can last to 1 month, except the function improvement on upper extremities could last for 1 year. A single course of rTMS in the acute stage may induce the improvement of upper extremities function lasted for 1 year. PMID: 28971620 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 2, 2017 Category: Neuroscience Authors: Guan YZ, Li J, Zhang XW, Wu S, Du H, Cui LY, Zhang WH Tags: CNS Neurosci Ther Source Type: research

Prenatal alcohol exposure enhances the susceptibility to NMDA-induced generalized tonic-clonic seizures in developing rats.
CONCLUSIONS: The PAE animal model of GTCS may provide a new opportunity to investigate the mechanisms that underlie neuronal hyperexcitability in developing animals prenatally-exposed to alcohol. PMID: 28884976 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 10, 2017 Category: Neuroscience Authors: Cho SJ, Lovinger DM, N'Gouemo P Tags: CNS Neurosci Ther Source Type: research

Organoid technology for brain and therapeutics research.
Abstract Brain is one of the most complex organs in human. The current brain research is mainly based on the animal models and traditional cell culture. However, the inherent species differences between humans and animals as well as the gap between organ level and cell level make it difficult to study human brain development and associated disorders through traditional technologies. Recently, the brain organoids derived from pluripotent stem cells have been reported to recapitulate many key features of human brain in vivo, for example recapitulating the zone of putative outer radial glia cells. Brain organoids off...
Source: CNS Neuroscience and Therapeutics - September 10, 2017 Category: Neuroscience Authors: Wang Z, Wang SN, Xu TY, Miao ZW, Su DF, Miao CY Tags: CNS Neurosci Ther Source Type: research

Response to Letter to the Editor: Can MR spectroscopy and muscle biopsy findings be correlated in MELAS and CPEO?
PMID: 28884978 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 10, 2017 Category: Neuroscience Authors: Niu FN, Meng HL, Liu RY, Zhang B, Xu Y Tags: CNS Neurosci Ther Source Type: research

Psychological status in depressive patients correlates with metabolic gene expression.
ndo JM, Bullón P PMID: 28879683 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 9, 2017 Category: Neuroscience Authors: Alcocer-Gómez E, Casas-Barquero N, Núñez-Vasco J, Navarro-Pando JM, Bullón P Tags: CNS Neurosci Ther Source Type: research

Adverse effects produced by different drugs used in the treatment of Parkinson's disease: A mixed treatment comparison.
CONCLUSIONS: This mixed treatment comparison showed that the drugs ropinirole, bromocriptine, and piribedil produced the highest incidence rates of nausea, dyskinesia, hallucination, dizziness, constipation, and somnolence symptoms. Thus, we conclude that as these three drugs produced the most frequent symptoms, they are not recommended for the treatment of patients with Parkinson's disease. PMID: 28872217 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 4, 2017 Category: Neuroscience Authors: Li BD, Bi ZY, Liu JF, Si WJ, Shi QQ, Xue LP, Bai J Tags: CNS Neurosci Ther Source Type: research

Paradoxical prognostic impact of TERT promoter mutations in gliomas depends on different histological and genetic backgrounds.
CONCLUSION: We describe the TERT promoter mutation spectrum according to the histological, genetic, and molecular subtypes of glioma, which may aid in glioma subtype classification and have clinical implications. PMID: 28868656 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 3, 2017 Category: Neuroscience Authors: You H, Wu Y, Chang K, Shi X, Chen XD, Yan W, Li R Tags: CNS Neurosci Ther Source Type: research

Can MR spectroscopy and muscle biopsy findings be correlated with MELAS and CPEO?
PMID: 28851043 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 29, 2017 Category: Neuroscience Authors: Finsterer J, Zarrouk-Mahjoub S Tags: CNS Neurosci Ther Source Type: research

Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting nitrosative stress and NLRP3 signaling in mice with bilateral carotid artery stenosis.
CONCLUSIONS: These data disclose novel findings about the therapeutic potential of DY-9836, and its encapsulated nanodrug delivery system significantly enhanced the cognitive function via inhibitory effect on nitrosative stress and NLRP3 signaling in VaD mice. PMID: 28851042 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 28, 2017 Category: Neuroscience Authors: Wang R, Yin YX, Mahmood Q, Wang XJ, Gao YP, Gou GJ, Ahmed MM, Kohji F, Du YZ, Han F Tags: CNS Neurosci Ther Source Type: research

Ethyl pyruvate does not require microglia for mediating neuroprotection after excitotoxic injury.
CONCLUSION: EP-mediated neuroprotection seems to be mediated by astrocytes and/or neurons. PMID: 28836378 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 23, 2017 Category: Neuroscience Authors: Pieroh P, Wagner DC, Ghadban C, Birkenmeier G, Dehghani F Tags: CNS Neurosci Ther Source Type: research

RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth.
CONCLUSIONS: These results suggest that astroglial-fibrotic scar formation and particularly the expression of aggrecan and versican could be mitigated by ephrin-B2 specific siRNA, thus improving the microenvironment for spinal axon regeneration. PMID: 28834283 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 21, 2017 Category: Neuroscience Authors: Li Y, Chen Y, Tan L, Pan JY, Lin WW, Wu J, Hu W, Chen X, Wang XD Tags: CNS Neurosci Ther Source Type: research

Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene.
CONCLUSION: Our results suggest significant alterations in hippocampal dendritic structure and synaptic function in Apoe4 mice, even at an early age. PMID: 28786172 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 7, 2017 Category: Neuroscience Authors: Sun GZ, He YC, Ma XK, Li ST, Chen DJ, Gao M, Qiu SF, Yin JX, Shi J, Wu J Tags: CNS Neurosci Ther Source Type: research

Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease.
CONCLUSION: Our observation further supports the pathogenic role of the heterozygous HTRA1 mutations in familial SVD. PMID: 28782182 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 6, 2017 Category: Neuroscience Authors: Di Donato I, Bianchi S, Gallus GN, Cerase A, Taglia I, Pescini F, Nannucci S, Battisti C, Inzitari D, Pantoni L, Zini A, Federico A, Dotti MT Tags: CNS Neurosci Ther Source Type: research

Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease.
CONCLUSION: Our data suggested that TXNIP blocked autophagic flux and induced α-synuclein accumulation through inhibition of ATP13A2, indicating TXNIP was a disease-causing protein in PD. PMID: 28755477 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 29, 2017 Category: Neuroscience Authors: Su CJ, Feng Y, Liu TT, Liu X, Bao JJ, Shi AM, Hu DM, Liu T, Yu YL Tags: CNS Neurosci Ther Source Type: research

Downregulation of DEC1 contributes to the neurotoxicity induced by MPP(+) by suppressing PI3K/Akt/GSK3 β pathway.
CONCLUSION: Downregulation of DEC1 contributes to MPP(+) -induced neurotoxicity by suppressing PI3K/Akt/GSK3β pathway. PMID: 28734031 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 21, 2017 Category: Neuroscience Authors: Zhu Z, Wang YW, Ge DH, Lu M, Liu W, Xiong J, Hu G, Li XP, Yang J Tags: CNS Neurosci Ther Source Type: research