DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
CONCLUSION: The results demonstrated that ferroptosis occurs via the Nedd4/DMT1 pathway during ICH, suggesting it potential as a valuable target to inhibit ferroptosis for the treatment of ICH.PMID:38634270 | PMC:PMC11024684 | DOI:10.1111/cns.14685 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 18, 2024 Category: Neuroscience Authors: Bingchen Lv Ping Fu Miao Wang Likun Cui Lei Bao Xingzhi Wang Lu Yu Chao Zhou Mengxin Zhu Fei Wang Ye Pang Suhua Qi Zuohui Zhang Guiyun Cui Source Type: research
Novel α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator LT-102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia
CONCLUSION: We conclude that LT-102 ameliorates cognitive impairments in a phencyclidine-induced model of schizophrenia by enhancing synaptic function, which could make it a potential therapeutic candidate for CIAS.PMID:38615362 | PMC:PMC11016348 | DOI:10.1111/cns.14713 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Xueyu Qi Xueli Yu Long Wei Han Jiang Jiangwen Dong Hongxing Li Yingying Wei Liansheng Zhao Wei Deng Wanjun Guo Xun Hu Tao Li Source Type: research
The promotion-like effect of the M1-STN hyperdirect pathway induced by ccPAS enhanced balance performances: From the perspective of brain connectivity
CONCLUSION: The ccPAS enhanced balance performance by promotion-like plasticity mechanisms through the hyperdirect pathway.PMID:38615363 | PMC:PMC11016345 | DOI:10.1111/cns.14710 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Yu-Lin Li Jia-Jia Wu Xu-Yun Hua Mou-Xiong Zheng Jian-Guang Xu Source Type: research
Brain white matter changes and their associations with non-motor dysfunction in orthostatic hypotension in α-synucleinopathy: A NODDI study
CONCLUSION: Patients with α-synucleinopathies experiencing OH exhibit distinctive patterns of microstructural damage in the WM as revealed by the NODDI model, and there is a correlation with the onset and progression of non-motor functional impairments.PMID:38615364 | PMC:PMC11016347 | DOI:10.1111/cns.14712 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Lin Lin Peilin Huang Yingzhe Cheng Shaofan Jiang Jiejun Zhang Man Li Jiahao Zheng Xiaodong Pan Yanping Wang Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
Metabolomics of cerebrospinal fluid reveals candidate diagnostic biomarkers to distinguish between spinal muscular atrophy type II and type III
CONCLUSION: This study identified metabolic markers are promising candidate prognostic factors for SMA. We also identified the metabolic pathways associated with the severity of SMA. These assessments can help predict the outcomes of screening SMA classification biomarkers.PMID:38615366 | PMC:PMC11016346 | DOI:10.1111/cns.14718 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mengnan Lu Xueying Wang Na Sun Shaoping Huang Lin Yang Dan Li Source Type: research
Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury
CONCLUSIONS: This study posits that the combination of AST IV and Lig has the potential to reduce the SUMO-1ylation of Drp1, augment the SUMO-2/3ylation of Drp1, and thereby exert a protective effect against CIRI.PMID:38615367 | PMC:PMC11016344 | DOI:10.1111/cns.14725 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Xiangyu Chen Tong Yang Yue Zhou Zhigang Mei Wenli Zhang Source Type: research
Novel α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator LT-102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia
CONCLUSION: We conclude that LT-102 ameliorates cognitive impairments in a phencyclidine-induced model of schizophrenia by enhancing synaptic function, which could make it a potential therapeutic candidate for CIAS.PMID:38615362 | PMC:PMC11016348 | DOI:10.1111/cns.14713 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Xueyu Qi Xueli Yu Long Wei Han Jiang Jiangwen Dong Hongxing Li Yingying Wei Liansheng Zhao Wei Deng Wanjun Guo Xun Hu Tao Li Source Type: research
The promotion-like effect of the M1-STN hyperdirect pathway induced by ccPAS enhanced balance performances: From the perspective of brain connectivity
CONCLUSION: The ccPAS enhanced balance performance by promotion-like plasticity mechanisms through the hyperdirect pathway.PMID:38615363 | PMC:PMC11016345 | DOI:10.1111/cns.14710 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Yu-Lin Li Jia-Jia Wu Xu-Yun Hua Mou-Xiong Zheng Jian-Guang Xu Source Type: research
Brain white matter changes and their associations with non-motor dysfunction in orthostatic hypotension in α-synucleinopathy: A NODDI study
CONCLUSION: Patients with α-synucleinopathies experiencing OH exhibit distinctive patterns of microstructural damage in the WM as revealed by the NODDI model, and there is a correlation with the onset and progression of non-motor functional impairments.PMID:38615364 | PMC:PMC11016347 | DOI:10.1111/cns.14712 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Lin Lin Peilin Huang Yingzhe Cheng Shaofan Jiang Jiejun Zhang Man Li Jiahao Zheng Xiaodong Pan Yanping Wang Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
Metabolomics of cerebrospinal fluid reveals candidate diagnostic biomarkers to distinguish between spinal muscular atrophy type II and type III
CONCLUSION: This study identified metabolic markers are promising candidate prognostic factors for SMA. We also identified the metabolic pathways associated with the severity of SMA. These assessments can help predict the outcomes of screening SMA classification biomarkers.PMID:38615366 | PMC:PMC11016346 | DOI:10.1111/cns.14718 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mengnan Lu Xueying Wang Na Sun Shaoping Huang Lin Yang Dan Li Source Type: research
Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury
CONCLUSIONS: This study posits that the combination of AST IV and Lig has the potential to reduce the SUMO-1ylation of Drp1, augment the SUMO-2/3ylation of Drp1, and thereby exert a protective effect against CIRI.PMID:38615367 | PMC:PMC11016344 | DOI:10.1111/cns.14725 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Xiangyu Chen Tong Yang Yue Zhou Zhigang Mei Wenli Zhang Source Type: research
Novel α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator LT-102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia
CONCLUSION: We conclude that LT-102 ameliorates cognitive impairments in a phencyclidine-induced model of schizophrenia by enhancing synaptic function, which could make it a potential therapeutic candidate for CIAS.PMID:38615362 | PMC:PMC11016348 | DOI:10.1111/cns.14713 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Xueyu Qi Xueli Yu Long Wei Han Jiang Jiangwen Dong Hongxing Li Yingying Wei Liansheng Zhao Wei Deng Wanjun Guo Xun Hu Tao Li Source Type: research
The promotion-like effect of the M1-STN hyperdirect pathway induced by ccPAS enhanced balance performances: From the perspective of brain connectivity
CONCLUSION: The ccPAS enhanced balance performance by promotion-like plasticity mechanisms through the hyperdirect pathway.PMID:38615363 | PMC:PMC11016345 | DOI:10.1111/cns.14710 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Yu-Lin Li Jia-Jia Wu Xu-Yun Hua Mou-Xiong Zheng Jian-Guang Xu Source Type: research
