Corrigendum.
Authors: PMID: 30417597 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 13, 2018 Category: Neuroscience Tags: CNS Neurosci Ther Source Type: research

Corrigendum.
Authors: PMID: 30417598 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 13, 2018 Category: Neuroscience Tags: CNS Neurosci Ther Source Type: research

Age-dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross-sectional study.
CONCLUSION: Our data demonstrate an age dependency of female preponderance in MS except for PPMS. This could be influenced by the lifecycle of sex hormone secretion in women. In PPMS, a male preponderance was observed in all age-groups, which might point to pathophysiological mechanisms being less influenced by sex hormones. PMID: 30411534 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 8, 2018 Category: Neuroscience Authors: Miclea A, Salmen A, Zoehner G, Diem L, Kamm CP, Chaloulos-Iakovidis P, Miclea M, Briner M, Kilidireas K, Stefanis L, Chan A, Evangelopoulos ME, Hoepner R Tags: CNS Neurosci Ther Source Type: research

Amyloid beta soluble forms and plasminogen activation system in Alzheimer's disease: Consequences on extracellular maturation of brain-derived neurotrophic factor and therapeutic implications.
a R, Hort J Abstract Soluble oligomeric forms of amyloid beta (Aβ) play an important role in causing the cognitive deficits in Alzheimer's disease (AD) by targeting and disrupting synaptic pathways. Thus, the present research is directed toward identifying the neuronal pathways targeted by soluble forms and, accordingly, develops alternative therapeutic strategies. The neurotrophin brain-derived neurotrophic factor (BDNF) is synthesized as a precursor (pro-BDNF) which is cleaved extracellularly by plasmin to release the mature form. The conversion from pro-BDNF to BDNF is an important process that regulates n...
Source: CNS Neuroscience and Therapeutics - November 6, 2018 Category: Neuroscience Authors: Angelucci F, Čechová K, Průša R, Hort J Tags: CNS Neurosci Ther Source Type: research

The peripheral immune response after stroke-A double edge sword for blood-brain barrier integrity.
Abstract The blood-brain barrier (BBB) is a highly regulated interface that separates the peripheral circulation and the brain. It plays a vital role in regulating the trafficking of solutes, fluid, and cells at the blood-brain interface and maintaining the homeostasis of brain microenvironment for normal neuronal activity. Growing evidence has led to the realization that ischemic stroke elicits profound immune responses in the circulation and the activation of multiple subsets of immune cells, which in turn affect both the early disruption and the later repair of the BBB after stroke. Distinct phenotypes or subse...
Source: CNS Neuroscience and Therapeutics - November 1, 2018 Category: Neuroscience Authors: Li Y, Zhu ZY, Huang TT, Zhou YX, Wang X, Yang LQ, Chen ZA, Yu WF, Li PY Tags: CNS Neurosci Ther Source Type: research

Imaging connectomics in depression.
PMID: 30315642 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 14, 2018 Category: Neuroscience Authors: Xia MR, Si TM, He Y Tags: CNS Neurosci Ther Source Type: research

Integrated profiling identifies caveolae-associated protein 1 as a prognostic biomarker of malignancy in glioblastoma patients.
CONCLUSIONS: We identified CAVIN1 as a prognostic biomarker and potential target for developing novel therapeutic strategies against GBM. PMID: 30311408 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 11, 2018 Category: Neuroscience Authors: Guo Q, Guan GF, Cheng W, Zou CY, Zhu C, Cheng P, Wu AH Tags: CNS Neurosci Ther Source Type: research

Complete but not partial inhibition of glutamate transporters exacerbates cortical excitability in the R6/2 mouse model of Huntington's disease.
CONCLUSIONS: R6/2 CPNs are more sensitive to glutamate accumulation during full inhibition of both glutamate transporters, and these neurons have homeostatic mechanisms to cope with inhibition of GLT-1 or GLAST by a mechanism that involves upregulation of either transporter when the other is deficient. PMID: 30311425 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 11, 2018 Category: Neuroscience Authors: Estrada-Sánchez AM, Castro D, Portillo-Ortiz K, Jang K, Nedjat-Haiem M, Levine MS, Cepeda C Tags: CNS Neurosci Ther Source Type: research

Oxytocin receptor gene variants are associated with emotion recognition and resilience, but not with false-belief reasoning performance in healthy young Korean volunteers.
CONCLUSIONS: Single makers or haplotypes at OXTR may contribute to individual differences in facial emotion recognition and psychological resilience. PMID: 30311451 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 11, 2018 Category: Neuroscience Authors: Kim HW, Kang JI, An SK, Kim SJ Tags: CNS Neurosci Ther Source Type: research

Bone marrow mesenchymal stem cells stimulated with low-intensity pulsed ultrasound: Better choice of transplantation treatment for spinal cord injury: Treatment for SCI by LIPUS-BMSCs transplantation.
Abstract Stem cell transplantation, especially treatment with bone marrow mesenchymal stem cells (BMSCs), has been considered a promising therapy for the locomotor and neurological recovery of spinal cord injury (SCI) patients. However, the clinical benefits of BMSCs transplantation remain limited because of the considerably low viability and inhibitory microenvironment. In our research, low-intensity pulsed ultrasound (LIPUS), which has been widely applied to clinical applications and fundamental research, was employed to improve the properties of BMSCs. The most suitable intensity of LIPUS stimulation was determ...
Source: CNS Neuroscience and Therapeutics - October 8, 2018 Category: Neuroscience Authors: Ning GZ, Song WY, Xu H, Zhu RS, Wu QL, Wu Y, Zhu SB, Li JQ, Wang M, Qu ZG, Feng SQ Tags: CNS Neurosci Ther Source Type: research

Metabolic covariance networks combining graph theory measuring aberrant topological patterns in mesial temporal lobe epilepsy.
CONCLUSION: From a metabolic point of view, we demonstrated the damaging effects with reduced contralateral intranetwork metrics properties and the compensatory effects in contralateral intranetworks with increased network properties. However, the import role of significant reduced interhemisphere connection has rarely been reported in other mTLE studies. Taken together, 18 F-FDG-PET MCN analysis provides new evidence that the mTLE is a system neurological disorder with disrupted networks. PMID: 30298594 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 8, 2018 Category: Neuroscience Authors: Wang KL, Hu W, Liu TH, Zhao XB, Han CL, Xia XT, Zhang JG, Wang F, Meng FG Tags: CNS Neurosci Ther Source Type: research

Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect.
In this study, we synthesized a series of modified compounds based on the FKBP12 binding moiety to as same as the binding structure of rapamycin and FK506 particularly. We removed the other binding regions of the complex that has the property of immunosuppression. We found that a novel small molecule named TH2849 from these derivative compounds has a significant binding connection with mTOR by comparing to calcineurin. The effects of TH2849 on calcineurin/NFAT were not as significant as FK506, and weak effects on IL2/p34cdc2 /cyclin signaling pathway were also found. Moreover, TH2849 also shows mitochondrial protective eff...
Source: CNS Neuroscience and Therapeutics - October 7, 2018 Category: Neuroscience Authors: Ding L, Nan WH, Zhu XB, Li XM, Zhou LY, Chen HJ, Yu L, Ullah Khan F, Zhong HB, Shi XJ Tags: CNS Neurosci Ther Source Type: research

Available and future treatments for atypical parkinsonism. A systematic review.
CONCLUSION: A detailed knowledge of the pathological mechanism underlying the disorders is needed, and disease-modifying therapies are required to offer better therapeutic options to physician and caregivers of APS patients. PMID: 30294976 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 7, 2018 Category: Neuroscience Authors: Moretti DV Tags: CNS Neurosci Ther Source Type: research

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study.
CONCLUSION: Acupuncture may serve as a promising clinical candidate for the treatment of vascular dementia via regulating oxidative stress, apoptosis, or synaptic functions. PMID: 30278105 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 2, 2018 Category: Neuroscience Authors: Yang JW, Wang XR, Zhang M, Xiao LY, Zhu W, Ji CS, Liu CZ Tags: CNS Neurosci Ther Source Type: research

The effects of Mindfulness Meditation on hallucination and delusion in severe schizophrenia patients with more than 20 years' medical history.
PMID: 30264927 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 28, 2018 Category: Neuroscience Authors: Sheng JL, Yan Y, Yang XH, Yuan TF, Cui DH Tags: CNS Neurosci Ther Source Type: research

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.
CONCLUSION: This study demonstrated an effective method with which to treat TBI by targeting ferroptosis. PMID: 30264934 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 28, 2018 Category: Neuroscience Authors: Xie BS, Wang YQ, Lin Y, Mao Q, Feng JF, Gao GY, Jiang JY Tags: CNS Neurosci Ther Source Type: research

A single factor induces neuronal differentiation to suppress glioma cell growth.
CONCLUSION: This study revealed that glioma cells can be reprogrammed into neuron-like cells using a single factor ZIC1, which may be a potential tumor suppressor gene for gliomas treatment. PMID: 30264483 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 27, 2018 Category: Neuroscience Authors: Fu JQ, Chen Z, Hu YJ, Fan ZH, Guo ZX, Liang JY, Ryu BM, Ren JL, Shi XJ, Li J, Jia S, Wang J, Ke XS, Ma X, Tan X, Zhang T, Chen XZ, Zhang C Tags: CNS Neurosci Ther Source Type: research

Effectiveness of dorsal root ganglion stimulation and dorsal column spinal cord stimulation in a model of experimental painful diabetic polyneuropathy.
Abstract AIMS: Conventional dorsal root ganglion stimulation (DRGS) is known to achieve better pain-paresthesia overlap of difficult-to-reach areas like the feet compared to dorsal column spinal cord stimulation (SCS). As in painful diabetic polyneuropathy (PDPN) pain is mostly present in the feet, we hypothesized that DRGS is more effective in relieving pain in PDPN when compared to SCS. METHODS: Diabetes was induced in female Sprague-Dawley rats with an intraperitoneal injection of 65 mg/kg of streptozotocin (STZ; n = 48). Rats with a significant decrease in mechanical paw withdrawal response...
Source: CNS Neuroscience and Therapeutics - September 23, 2018 Category: Neuroscience Authors: Koetsier E, Franken G, Debets J, van Kuijk SMJ, Perez RSGM, Linderoth B, Joosten EAJ, Maino P Tags: CNS Neurosci Ther Source Type: research

Discovery of a small molecule modulator of the Kv1.1/Kv β1 channel complex that reduces neuronal excitability and in vitro epileptiform activity.
CONCLUSIONS: This study describes a rational drug discovery approach for the identification of novel ligands that inhibit Kv1.1 channel inactivation and provides pharmacological evidence that such a mechanism translates into physiological effects by reducing in vitro epileptiform activity. PMID: 30242974 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 21, 2018 Category: Neuroscience Authors: Niespodziany I, Mullier B, André VM, Ghisdal P, Jnoff E, Moreno-Delgado D, Swinnen D, Sands Z, Wood M, Wolff C Tags: CNS Neurosci Ther Source Type: research

Impaired histaminergic neurotransmission in children with narcolepsy type 1.
Abstract OBJECTIVE: Narcolepsy is a sleep disorder characterized in humans by excessive daytime sleepiness and cataplexy. Greater than fifty percent of narcoleptic patients have an onset of symptoms prior to the age of 18. Current general agreement considers the loss of hypothalamic hypocretin (orexin) neurons as the direct cause of narcolepsy notably cataplexy. To assess whether brain histamine (HA) is also involved, we quantified the cerebrospinal fluid (CSF) levels of HA and tele-methylhistamine (t-MeHA), the direct metabolite of HA between children with orexin-deficient narcolepsy type 1 (NT1) and controls. ...
Source: CNS Neuroscience and Therapeutics - September 17, 2018 Category: Neuroscience Authors: Franco P, Dauvilliers Y, Inocente CO, Guyon A, Villanueva C, Raverot V, Plancoulaine S, Lin JS Tags: CNS Neurosci Ther Source Type: research

Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury.
Abstract AIMS: Neural stem cells (NSCs) in the adult mammalian spinal cord are activated in response to spinal cord injury (SCI); however, mechanisms modulating this process are not clear. Here, we noticed SCI elevated expression of vascular endothelial growth factor (VEGF) and we aimed to validate the roles of VEGF in NSCs activation after SCI and investigated the related signals during the process. METHODS: In vitro we detected whether VEGF promoted spinal cord NSCs proliferation and investigated the involved signals; In vivo, we injected VEGF into rat spinal cord to check the NSCs activation. RESULTS:...
Source: CNS Neuroscience and Therapeutics - August 29, 2018 Category: Neuroscience Authors: Liu SM, Xiao ZF, Li X, Zhao YN, Wu XM, Han J, Chen B, Li JY, Fan CX, Xu B, Xue XY, Xue WW, Yang Y, Dai JW Tags: CNS Neurosci Ther Source Type: research

Baseline assessment of physical frailty in neurological drug development.
PMID: 30146699 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 26, 2018 Category: Neuroscience Authors: Canevelli M, Bruno G, Vanacore N, Cesari M Tags: CNS Neurosci Ther Source Type: research

Machine learning in major depression: From classification to treatment outcome prediction.
CONCLUSIONS: We hope such efforts may highlight the need for an urgently needed paradigm shift in treatment, to guide personalized optimal clinical care. PMID: 30136381 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 23, 2018 Category: Neuroscience Authors: Gao S, Calhoun VD, Sui J Tags: CNS Neurosci Ther Source Type: research

DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high-glucose conditions, potentially through the SIRT1/HIF-1/VEGF pathway.
CONCLUSIONS: The protection of rBMVECs from hypoxia/high-glucose induced impairment by DPP-4 inhibitors may be mediated by the SIRT1/HIF-1α/VEGF pathway. PMID: 30136405 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 23, 2018 Category: Neuroscience Authors: Mi DH, Fang HJ, Zheng GH, Liang XH, Ding YR, Liu X, Liu LP Tags: CNS Neurosci Ther Source Type: research

Combinations of four or more CpGs methylation present equivalent predictive value for MGMT expression and temozolomide therapeutic prognosis in gliomas.
Abstract AIMS: The pyrosequencing (PSQ) has been regarded as the gold standard for MGMT promoter methylation testing in gliomas. However, various CpG combinations are currently used in clinical practice. We aimed to clarify how and how many CpGs combined is robust enough to predict MGMT mRNA expression and therapeutic prognosis of patients. METHODS: Total 223 patients with WHO III/IV gliomas were enrolled from Chinese Glioma Genome Atlas, including two independent cohorts, the eight-site cohort (with CpGs 75-82 tested) and the seven-site cohort (with CpGs 72-78 tested). Spearman's correlation and ROC curves w...
Source: CNS Neuroscience and Therapeutics - August 16, 2018 Category: Neuroscience Authors: Chai RC, Zhang KN, Liu YQ, Wu F, Zhao Z, Wang KY, Jiang T, Wang YZ Tags: CNS Neurosci Ther Source Type: research

Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.
CONCLUSION: The well-reproducible results showed the good performance of the combinatorial approach, and the remaining five new targets could be a good starting point for our understanding of the pathogenesis and drug discovery of AD. Moreover, this study supported validity of the combinatorial approach integrating ontology inference with network analysis in the discovery of novel drug target for neurological diseases. PMID: 30106219 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 14, 2018 Category: Neuroscience Authors: Han ZJ, Xue WW, Tao L, Zhu F Tags: CNS Neurosci Ther Source Type: research

Motor neuron disease-like phenotype associated with anti-IgLON5 disease.
PMID: 30105827 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 13, 2018 Category: Neuroscience Authors: Tao QQ, Wei Q, Song SJ, Yin XZ Tags: CNS Neurosci Ther Source Type: research

Costimulatory checkpoint SLAMF8 is an independent prognosis factor in glioma.
CONCLUSION: Our study highlighted the important role of SLAMF8 in malignancy progression, shortened survival, and immune disorders. Further research on SLAMF8 in immunosuppression and inflammation response to glioma cells could aid immunotherapy for glioma. PMID: 30105842 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 13, 2018 Category: Neuroscience Authors: Zou CY, Guan GF, Zhu C, Liu TQ, Guo Q, Cheng W, Wu AH Tags: CNS Neurosci Ther Source Type: research

SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms.
CONCLUSION: Our results show that siRNA-mediated silencing of SRPK1 gene inhibits VSMC apoptosis, and increases VSMCs proliferation and vascular remodeling in IA via the PI3 K/Akt signaling pathway. Our findings provide a novel intervention target for the molecular treatment of IA. PMID: 30101479 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 12, 2018 Category: Neuroscience Authors: Li XG, Wang YB Tags: CNS Neurosci Ther Source Type: research

Pronounced antiepileptic activity of the subtype-selective GABAA -positive allosteric modulator PF-06372865 in the GAERS absence epilepsy model.
CONCLUSIONS: PF-06372865 demonstrated robust efficacy in suppressing SWDs in the GAERS model of absence epilepsy. To our knowledge, this is the first demonstration of antiepileptic activity of an α2/3/5-subtype-selective GABAA PAM in a model of absence epilepsy. Further study of the antiepileptic properties of PF-06372865 is warranted in patients with absence seizures. PMID: 30101518 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 12, 2018 Category: Neuroscience Authors: Duveau V, Buhl DL, Evrard A, Ruggiero C, Mandé-Niedergang B, Roucard C, Gurrell R Tags: CNS Neurosci Ther Source Type: research

Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?
Abstract Alzheimer's disease (AD) is characterized by extensive neurodegeneration and inflammation in selective brain areas, linked to severely disabling cognitive deficits. Before full manifestation, different stages appear with progressively increased brain pathology and cognitive impairment. This significantly extends the time lag between initial molecular triggers and appearance of detectable symptoms. Notably, a number of studies in the last decade have revealed that in the early stage of mild cognitive impairment, events that appear in contrast with neuronal distress may occur. These have been reproduced in ...
Source: CNS Neuroscience and Therapeutics - August 12, 2018 Category: Neuroscience Authors: Merlo S, Spampinato SF, Sortino MA Tags: CNS Neurosci Ther Source Type: research

Do heterozygous HTRA1 mutations carriers form a distinct clinical entity?
PMID: 30084173 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 6, 2018 Category: Neuroscience Authors: Bougea A Tags: CNS Neurosci Ther Source Type: research

The delta-opioid receptor and Parkinson's disease.
Abstract Parkinson's disease (PD) is a common degenerative neurological disease leading to a series of familial, medical, and social problems. Although it is known that the major characteristics of PD pathophysiology are the dysfunction of basal ganglia due to injury/loss of dopaminergic neurons in the substantia nigra pars compacta dopaminergic and exhaustion of corpus striatum dopamine, therapeutic modalities for PD are limited in clinical settings up to date. It is of utmost importance to better understand PD pathophysiology and explore new solutions for this serious neurodegenerative disorder. Our recent work ...
Source: CNS Neuroscience and Therapeutics - August 3, 2018 Category: Neuroscience Authors: Huang JZ, Ren Y, Xu Y, Chen T, Xia TC, Li ZR, Zhao JN, Hua F, Sheng S, Xia Y Tags: CNS Neurosci Ther Source Type: research

Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine.
CONCLUSION: Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one. PMID: 30076687 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 3, 2018 Category: Neuroscience Authors: Liu CB, Yang DG, Zhang X, Zhang WH, Li DP, Zhang C, Qin C, Du LJ, Li J, Gao F, Zhang J, Zuo ZT, Yang ML, Li JJ Tags: CNS Neurosci Ther Source Type: research

Interdisciplinary approaches for neuropathology.
PMID: 30009529 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 18, 2018 Category: Neuroscience Authors: Di Giovanni G, Crunelli V, Rizzolatti G Tags: CNS Neurosci Ther Source Type: research

Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex.
CONCLUSION: These results suggest that the reduction in GABAergic inhibition in the PBN and VLPO may be involved in sleep disorders that are induced by STZ. Our novel findings encourage further studies that investigate mechanisms of sleep regulation in sporadic AD. PMID: 30014576 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 16, 2018 Category: Neuroscience Authors: Cui SY, Song JZ, Cui XY, Hu X, Ma YN, Shi YT, Luo Y, Ge YR, Ding H, Ye H, Zhang YH Tags: CNS Neurosci Ther Source Type: research

Mitochondrial ataxia is genetically and phenotypically heterogeneous.
PMID: 29998495 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 11, 2018 Category: Neuroscience Authors: Finsterer J, Zarrouk-Mahjoub S Tags: CNS Neurosci Ther Source Type: research

Clinical characteristics associated with therapeutic nonadherence of the patients with major depressive disorder: A report on the National Survey on Symptomatology of Depression in China.
CONCLUSION: Clinical characteristics may play an important role in predicting nonadherence. Doctors may have to pay much attention on patients with these factors and should keep on discussing them with patients. PMID: 29998606 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 11, 2018 Category: Neuroscience Authors: Zhou Q, Wu ZG, Wang Y, Liu XH, Chen J, Wang Y, Su YS, Zhang C, Peng DH, Hong W, Fang YR Tags: CNS Neurosci Ther Source Type: research

Inaccuracy in meta-analysis on safety of eleven drugs for the treatment of Parkinson's disease.
PMID: 29978947 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 6, 2018 Category: Neuroscience Authors: Chen XW Tags: CNS Neurosci Ther Source Type: research

MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric A β25-35 -induced anxiety and cognitive deficits in a mouse model.
CONCLUSIONS: These results reveal MGCD0103 could be a potential therapeutic agent against AD. PMID: 29978554 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 5, 2018 Category: Neuroscience Authors: Huang HJ, Huang HY, Hsieh-Li HM Tags: CNS Neurosci Ther Source Type: research

Pifithrin- μ modulates microglial activation and promotes histological recovery following spinal cord injury.
CONCLUSIONS: Our results indicate that a small molecule reagent PFT-μ has sustained immunomodulatory effects following a single dose after injury. PMID: 29962076 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 2, 2018 Category: Neuroscience Authors: Caponegro MD, Torres LF, Rastegar C, Rath N, Anderson ME, Robinson JK, Tsirka SE Tags: CNS Neurosci Ther Source Type: research

Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors.
Abstract The Mirror Neuron System (MNS) plays a crucial role in action perception and imitative behavior, which is suggested to be impaired in Autism Spectrum Disorders (ASDs). In this review, we discuss the plausibility and empirical evidence of a neural interaction between the MNS, action perception, empathy, imitative behavior, and their impact on social decision making in ASDs. To date, there is no consensus regarding a particular theory in ASDs and its underlying mechanisms. Some theories have completely focused on social difficulties, others have emphasized sensory aspects. Based on the current studies, we s...
Source: CNS Neuroscience and Therapeutics - July 2, 2018 Category: Neuroscience Authors: Khalil R, Tindle R, Boraud T, Moustafa AA, Karim AA Tags: CNS Neurosci Ther Source Type: research

Metabolic syndrome emerges after artificial selection for low baroreflex sensitivity.
CONCLUSION: Our study demonstrated that intrinsic low BRS induced hypertension and metabolic disorder. Restoration of impaired BRS might be a potent target of therapeutic intervention in metabolic syndrome. PMID: 29962085 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 1, 2018 Category: Neuroscience Authors: Zhang LL, Zhang Y, Cheng YQ, Zhang JM, Liu HQ, Wang WZ, Mehta JL, Xiong ZG, Su DF, Liu AJ Tags: CNS Neurosci Ther Source Type: research

A within-subject consideration of the psychotic spectrum disorder concept in a patient in remission associated with cortical gray matter recovery.
CONCLUSIONS: The 3 discrete periods of psychopathology support the diagnosis of PSD. The unusual course and outcome, including remarkable improvement, in executive function and enhanced cortical gray matter in selective brain regions may have been the result of unique endogenous genetic and epigenetic factors and effect of medication. PMID: 29898284 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2018 Category: Neuroscience Authors: Meltzer HY, Sim MY, Anderson A, Cannistraci C, Jayathilake K, Share DB, Lee M Tags: CNS Neurosci Ther Source Type: research

Emerging and evolving concepts in the pathobiology and treatment of psychosis.
PMID: 29898285 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2018 Category: Neuroscience Authors: Zhen XC, Waddington J Tags: CNS Neurosci Ther Source Type: research

Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod.
PMID: 29898493 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 13, 2018 Category: Neuroscience Authors: Evangelopoulos ME, Miclea A, Schrewe L, Briner M, Salmen A, Engelhardt B, Huwiler A, Chan A, Hoepner R Tags: CNS Neurosci Ther Source Type: research

Direct activation of tachykinin receptors within baroreflex afferent pathway and neurocontrol of blood pressure regulation.
CONCLUSION: The estrogen-dependent NKRs' expression in baroreflex afferent pathway participates at least partially in sexual-dimorphic and SP-mediated BP regulation under physiological and hypertensive conditions. PMID: 29900692 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 13, 2018 Category: Neuroscience Authors: Yuan M, Ma MN, Wang TY, Feng Y, Chen P, He C, Liu S, Guo YX, Wang Y, Fan Y, Wang LQ, E XQ, Qiao GF, Li BY Tags: CNS Neurosci Ther Source Type: research

The Basal Ganglia: More than just a switching device.
Abstract The basal ganglia consist of a variety of subcortical nuclei engaged in motor control and executive functions, such as motor learning, behavioral control, and emotion. The striatum, a major basal ganglia component, is particularly useful for cognitive planning of purposive motor acts owing to its structural features and the neuronal circuitry established with the cerebral cortex. Recent data indicate emergent functions played by the striatum. Indeed, cortico-striatal circuits carrying motor information are paralleled by circuits originating from associative and limbic territories, which are functionally i...
Source: CNS Neuroscience and Therapeutics - June 7, 2018 Category: Neuroscience Authors: Florio TM, Scarnati E, Rosa I, Di Censo D, Ranieri B, Cimini A, Galante A, Alecci M Tags: CNS Neurosci Ther Source Type: research

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.
CONCLUSION: Taken together, our findings suggest that DHM prevents progression of AD-like pathology through inhibition of NLRP3 inflammasome-based microglia-mediated neuroinflammation and may be a promising therapeutic drug for treating AD. PMID: 29869390 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 4, 2018 Category: Neuroscience Authors: Feng J, Wang J, Du Y, Liu Y, Zhang W, Chen J, Liu Y, Zheng M, Wang K, He G Tags: CNS Neurosci Ther Source Type: research

Intravenous immunoglobulin treatment in multiple sclerosis: A prospective, rater-blinded analysis of relapse rates during pregnancy and the postnatal period.
CONCLUSIONS: In MS patients, IVIg treatment during and/or after delivery is an option to reduce the incidence of relapses during pregnancy and the postnatal period. Surprisingly, untreated patients becoming pregnant showed an increase in the relapse rate in the first trimester compared with the pre-gestational period. How alterations of hormone status during pregnancy affect disease activity in MS has to be further investigated. PMID: 29858532 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 1, 2018 Category: Neuroscience Authors: Winkelmann A, Rommer PS, Hecker M, Zettl UK Tags: CNS Neurosci Ther Source Type: research