Pharmacokinetic changes for newer antiepileptic drugs and seizure control during pregnancy
CNS Neurosci Ther. 2022 Jan 17. doi: 10.1111/cns.13796. Online ahead of print.ABSTRACTOBJECTIVE: To investigate pharmacokinetic changes in newer antiepileptic drugs (AEDs) and assess seizure frequencies and risk factors of increased seizures during pregnancy in women with epilepsy (WWE).METHODS: A total of 56 pregnancies in 53 WWE who received newer antiepileptic drugs (AEDs) were enrolled. Data on seizure activity and types, daily dose, and AEDs blood levels were derived from routine clinical follow-up. Changes in AEDs clearance were compared between each trimester and nonpregnant baseline. The ratio of AED levels of each...
Source: CNS Neuroscience and Therapeutics - January 17, 2022 Category: Neuroscience Authors: Xiaotong Yin Yan Liu Yang Guo Limei Zhao Guofei Li Xiaoping Tan Source Type: research

Optimization and high-density array of stereoelectroencephalography-guided radiofrequency thermocoagulation for the treatment of pediatric tuberous sclerosis complex with epilepsy
CONCLUSION: Optimized high-density array of SEEG-guided RF-TC is a safe and highly effective approach and can be an alternative application applied for TSC patients with refractory epilepsy.PMID:35032101 | DOI:10.1111/cns.13804 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2022 Category: Neuroscience Authors: Tian Luo Xinhua Wang Ji Wang Rui Zhao Hao Li Yuanfeng Zhou Yi Wang Source Type: research

Optimization and high-density array of stereoelectroencephalography-guided radiofrequency thermocoagulation for the treatment of pediatric tuberous sclerosis complex with epilepsy
CONCLUSION: Optimized high-density array of SEEG-guided RF-TC is a safe and highly effective approach and can be an alternative application applied for TSC patients with refractory epilepsy.PMID:35032101 | DOI:10.1111/cns.13804 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2022 Category: Neuroscience Authors: Tian Luo Xinhua Wang Ji Wang Rui Zhao Hao Li Yuanfeng Zhou Yi Wang Source Type: research

Optimization and high-density array of stereoelectroencephalography-guided radiofrequency thermocoagulation for the treatment of pediatric tuberous sclerosis complex with epilepsy
CONCLUSION: Optimized high-density array of SEEG-guided RF-TC is a safe and highly effective approach and can be an alternative application applied for TSC patients with refractory epilepsy.PMID:35032101 | DOI:10.1111/cns.13804 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2022 Category: Neuroscience Authors: Tian Luo Xinhua Wang Ji Wang Rui Zhao Hao Li Yuanfeng Zhou Yi Wang Source Type: research

Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction
CONCLUSION: SMC neurocircuitry was selectively disrupted after chronic stroke and associated with diverse hand outcomes, which deepens the understanding of SMC reorganization.PMID:35005843 | DOI:10.1111/cns.13799 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 10, 2022 Category: Neuroscience Authors: FeiWen Liu ChangCheng Chen WenJun Hong ZhongFei Bai SiZhong Wang HanNa Lu QiXiang Lin ZhiYong Zhao ChaoZheng Tang Source Type: research

Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction
CONCLUSION: SMC neurocircuitry was selectively disrupted after chronic stroke and associated with diverse hand outcomes, which deepens the understanding of SMC reorganization.PMID:35005843 | DOI:10.1111/cns.13799 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 10, 2022 Category: Neuroscience Authors: FeiWen Liu ChangCheng Chen WenJun Hong ZhongFei Bai SiZhong Wang HanNa Lu QiXiang Lin ZhiYong Zhao ChaoZheng Tang Source Type: research

Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction
CONCLUSION: SMC neurocircuitry was selectively disrupted after chronic stroke and associated with diverse hand outcomes, which deepens the understanding of SMC reorganization.PMID:35005843 | DOI:10.1111/cns.13799 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 10, 2022 Category: Neuroscience Authors: FeiWen Liu ChangCheng Chen WenJun Hong ZhongFei Bai SiZhong Wang HanNa Lu QiXiang Lin ZhiYong Zhao ChaoZheng Tang Source Type: research

Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction
CONCLUSION: SMC neurocircuitry was selectively disrupted after chronic stroke and associated with diverse hand outcomes, which deepens the understanding of SMC reorganization.PMID:35005843 | DOI:10.1111/cns.13799 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 10, 2022 Category: Neuroscience Authors: FeiWen Liu ChangCheng Chen WenJun Hong ZhongFei Bai SiZhong Wang HanNa Lu QiXiang Lin ZhiYong Zhao ChaoZheng Tang Source Type: research

Emerging neurological symptoms after liver transplantation: A 6-year follow-up of an adolescent patient with Wilson's disease
CNS Neurosci Ther. 2022 Jan 7. doi: 10.1111/cns.13798. Online ahead of print.NO ABSTRACTPMID:34997703 | DOI:10.1111/cns.13798 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 8, 2022 Category: Neuroscience Authors: Wan-Qing Xu Rou-Min Wang Yi Dong Zhi-Ying Wu Source Type: research

Emerging neurological symptoms after liver transplantation: A 6-year follow-up of an adolescent patient with Wilson's disease
CNS Neurosci Ther. 2022 Jan 7. doi: 10.1111/cns.13798. Online ahead of print.NO ABSTRACTPMID:34997703 | DOI:10.1111/cns.13798 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 8, 2022 Category: Neuroscience Authors: Wan-Qing Xu Rou-Min Wang Yi Dong Zhi-Ying Wu Source Type: research

Neuroinflammation in perioperative neurocognitive disorders: From bench to the bedside
CNS Neurosci Ther. 2022 Jan 6. doi: 10.1111/cns.13794. Online ahead of print.ABSTRACTThe perioperative neurocognitive disorders (PNDs) are one of the most common complications in elderly patients characterized by various forms of cognitive decline after anesthesia and surgery. Although the etiology for PNDs remained unclear, neuroinflammation has been characterized as one of the major causes, especially in the elderly patients. The activation of glial cells including microglia and astrocytes plays a significant role in the inflammatory responses in central nerve system (CNS). Although carefully designed, clinical studies o...
Source: CNS Neuroscience and Therapeutics - January 6, 2022 Category: Neuroscience Authors: Yang Liu Huiqun Fu Tianlong Wang Source Type: research

Results from a multicenter, randomized, double-blind, placebo-controlled study of repository corticotropin injection for multiple sclerosis relapse that did not adequately respond to corticosteroids
CONCLUSION: RCI is safe and effective for MS relapse patients who do not respond to high-dose corticosteroids.PMID:34984839 | DOI:10.1111/cns.13789 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 5, 2022 Category: Neuroscience Authors: Daniel Wynn Lawrence Goldstick William Bauer Enxu Zhao Eva Tarau Jeffrey A Cohen Derrick Robertson Aaron Miller Source Type: research

Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway
CONCLUSION: Lira has anti-inflammation and anti-demyelination effect on EAE mice, and the protective effect of Lira in the EAE model may be related to regulation of pAMPK pathway, autophagy, and NLRP3 pathway. However, Lira treatment cannot significantly inhibit pyroptosis of BV2 cells in vitro. Our study provides Lira as a potential candidate for Multiple Sclerosis treatment.PMID:34985189 | DOI:10.1111/cns.13791 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 5, 2022 Category: Neuroscience Authors: Shuang Song Ruoyi Guo Arshad Mehmood Lu Zhang Bowen Yin Congcong Yuan Huining Zhang Li Guo Bin Li Source Type: research

Asymmetric distribution of enlarged perivascular spaces in centrum semiovale may be associated with epilepsy after acute ischemic stroke
CONCLUSIONS: Asymmetric distribution of EPVS in CS may be an independent risk factor and a novel imaging biomarker for the development of PSE. Further studies to understand the mechanisms of this association and confirmation with larger patient populations are warranted.PMID:34981639 | DOI:10.1111/cns.13786 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 4, 2022 Category: Neuroscience Authors: Nian Yu Benjamin Sinclair Lina Maria Garcia Posada Zhibin Chen Qing Di Xingjian Lin Scott Kolbe Gernot Hlauschek Patrick Kwan Meng Law Source Type: research

Glioblastoma multiforme with vertebral metastases: A case report
CNS Neurosci Ther. 2022 Feb;28(2):310-313. doi: 10.1111/cns.13785. Epub 2021 Dec 30.NO ABSTRACTPMID:34970850 | DOI:10.1111/cns.13785 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 31, 2021 Category: Neuroscience Authors: Hongyu Liu Chuanbiao Chen Fangye Li Yangrui Zheng Jialin Liu Xinguang Yu Ling Chen Source Type: research

Glioblastoma multiforme with vertebral metastases: A case report
CNS Neurosci Ther. 2021 Dec 30. doi: 10.1111/cns.13785. Online ahead of print.NO ABSTRACTPMID:34970850 | DOI:10.1111/cns.13785 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 31, 2021 Category: Neuroscience Authors: Hongyu Liu Chuanbiao Chen Fangye Li Yangrui Zheng Jialin Liu Xinguang Yu Ling Chen Source Type: research

Glioblastoma multiforme with vertebral metastases: A case report
CNS Neurosci Ther. 2021 Dec 30. doi: 10.1111/cns.13785. Online ahead of print.NO ABSTRACTPMID:34970850 | DOI:10.1111/cns.13785 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 31, 2021 Category: Neuroscience Authors: Hongyu Liu Chuanbiao Chen Fangye Li Yangrui Zheng Jialin Liu Xinguang Yu Ling Chen Source Type: research

Glioblastoma multiforme with vertebral metastases: A case report
CNS Neurosci Ther. 2021 Dec 30. doi: 10.1111/cns.13785. Online ahead of print.NO ABSTRACTPMID:34970850 | DOI:10.1111/cns.13785 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 31, 2021 Category: Neuroscience Authors: Hongyu Liu Chuanbiao Chen Fangye Li Yangrui Zheng Jialin Liu Xinguang Yu Ling Chen Source Type: research

Effect of axitinib regulating the pathological blood-brain barrier functional recovery for glioblastoma therapeutics
CONCLUSION: The mechanism of axitinib involved in BBB functional regulation in the treatment of GBM is first illuminated in this report; moreover, this is the first report first referring to regulating pathological BBB functional recovery for GBM effective therapeutics. Overall, the view of regulating pathological BBB functional recovery may offer a novel sight for other CNS diseases relating to BBB permeability effective therapeutics.PMID:34967104 | DOI:10.1111/cns.13788 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 30, 2021 Category: Neuroscience Authors: Fengtian Zhang Lijuan Wen Kai Wang Zhihua Huang Xiangyu Jin Ruiwen Xiong Shiying He Fuqiang Hu Source Type: research

Effect of axitinib regulating the pathological blood-brain barrier functional recovery for glioblastoma therapeutics
CONCLUSION: The mechanism of axitinib involved in BBB functional regulation in the treatment of GBM is first illuminated in this report; moreover, this is the first report first referring to regulating pathological BBB functional recovery for GBM effective therapeutics. Overall, the view of regulating pathological BBB functional recovery may offer a novel sight for other CNS diseases relating to BBB permeability effective therapeutics.PMID:34967104 | DOI:10.1111/cns.13788 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 30, 2021 Category: Neuroscience Authors: Fengtian Zhang Lijuan Wen Kai Wang Zhihua Huang Xiangyu Jin Ruiwen Xiong Shiying He Fuqiang Hu Source Type: research

Modulation of the rat hippocampal-cortex network and episodic-like memory performance following entorhinal cortex stimulation
CONCLUSION: EC-DBS caused a reversible modulation effect on functional connectivity in the hippocampal-cortex network and episodic-like memory performance.PMID:34964261 | DOI:10.1111/cns.13795 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 29, 2021 Category: Neuroscience Authors: Yin Jiang De-Feng Liu Xin Zhang Huan-Guang Liu Chao Zhang Jian-Guo Zhang Source Type: research

Role of lipoic acid in multiple sclerosis
In conclusion, this review provides evidence for the anti-inflammatory and antioxidative effects of LA in both in vitro and in vivo experiments; therefore, patients with MS may benefit from LA administration. Whether LA can be a routine supplementary therapy warrants further study.PMID:34964271 | DOI:10.1111/cns.13793 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 29, 2021 Category: Neuroscience Authors: Hongsheng Xie Xiufang Yang Yuan Cao Xipeng Long Huifang Shang Zhiyun Jia Source Type: research

Bradykinin-mediated estrogen-dependent depressor response by direct activation of female-specific distribution of myelinated Ah-type baroreceptor neurons in rats
CONCLUSION: These datasets have demonstrated for the first time that bradykinin mediates direct activation of baroreflex afferent function to trigger estrogen-dependent depressor response, which is due mainly to the direct activation/neuroexcitation of female-specific myelinated Ah-type baroreceptor neurons leading to a sexual dimorphism in parasympathetic domination of blood pressure regulation via activation of B2 R/B1 R expression in baroreflex afferent pathway.PMID:34964272 | DOI:10.1111/cns.13792 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 29, 2021 Category: Neuroscience Authors: Ke-Xin Li Yan Feng Xiong-Xiong Fan Xun Sun Ying Li Di Wu Li Liu Chang-Peng Cui Xue Xiong Hu-Die Li Meng Zhou Hai-Lan Ma Yang Liu Rong Zhang Bai-Yan Li Source Type: research

Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response
CONCLUSION: The attenuated alpha-gamma coupling in dual pathways indicated increased sensitivity to the negative emotional information and reduced moderated effect of the amygdala, which might cause insensitivity to antidepressant treatment and could be regarded as potential neural mechanisms for treatment response prediction.PMID:34953030 | DOI:10.1111/cns.13787 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Zhongpeng Dai Cong Pei Siqi Zhang Shui Tian Zhilu Chen Hongliang Zhou Qing Lu Zhijian Yao Source Type: research

Microvascular decompression and aneurysm clipping for a patient with hemifacial spasm and ipsilateral labyrinthine artery aneurysm: A rare case report and literature review
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13783. Online ahead of print.ABSTRACTPreoperative MRI results showed a vascular anomaly at the REZ of the left facial nerve (Figure A) and an anomaly at the internal auditory canal (Figure B). The left AICA was identified as the offending vessel compressing the left facial nerve at the REZ (Figure C). After the artery was dissociated and Teflon felt was placed between the involved vessel and the facial nerve (Figure D), electrophysiological monitoring indicated that the AMR had disappeared (Figure E).PMID:34953034 | DOI:10.1111/cns.13783 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Yufei Liu Fanfan Chen Zongyang Li Jihu Yang Xiejun Zhang Lei Chen Liwei Zhang Guodong Huang Source Type: research

Clinical and imaging characteristics of 4H syndrome: A case report
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13790. Online ahead of print.NO ABSTRACTPMID:34953043 | DOI:10.1111/cns.13790 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Chao Wang Shan Wang Huanhuan Xie Siyu Yang Source Type: research

Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response
CONCLUSION: The attenuated alpha-gamma coupling in dual pathways indicated increased sensitivity to the negative emotional information and reduced moderated effect of the amygdala, which might cause insensitivity to antidepressant treatment and could be regarded as potential neural mechanisms for treatment response prediction.PMID:34953030 | DOI:10.1111/cns.13787 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Zhongpeng Dai Cong Pei Siqi Zhang Shui Tian Zhilu Chen Hongliang Zhou Qing Lu Zhijian Yao Source Type: research

Microvascular decompression and aneurysm clipping for a patient with hemifacial spasm and ipsilateral labyrinthine artery aneurysm: A rare case report and literature review
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13783. Online ahead of print.ABSTRACTPreoperative MRI results showed a vascular anomaly at the REZ of the left facial nerve (Figure A) and an anomaly at the internal auditory canal (Figure B). The left AICA was identified as the offending vessel compressing the left facial nerve at the REZ (Figure C). After the artery was dissociated and Teflon felt was placed between the involved vessel and the facial nerve (Figure D), electrophysiological monitoring indicated that the AMR had disappeared (Figure E).PMID:34953034 | DOI:10.1111/cns.13783 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Yufei Liu Fanfan Chen Zongyang Li Jihu Yang Xiejun Zhang Lei Chen Liwei Zhang Guodong Huang Source Type: research

Clinical and imaging characteristics of 4H syndrome: A case report
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13790. Online ahead of print.NO ABSTRACTPMID:34953043 | DOI:10.1111/cns.13790 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Chao Wang Shan Wang Huanhuan Xie Siyu Yang Source Type: research

Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response
CONCLUSION: The attenuated alpha-gamma coupling in dual pathways indicated increased sensitivity to the negative emotional information and reduced moderated effect of the amygdala, which might cause insensitivity to antidepressant treatment and could be regarded as potential neural mechanisms for treatment response prediction.PMID:34953030 | DOI:10.1111/cns.13787 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Zhongpeng Dai Cong Pei Siqi Zhang Shui Tian Zhilu Chen Hongliang Zhou Qing Lu Zhijian Yao Source Type: research

Microvascular decompression and aneurysm clipping for a patient with hemifacial spasm and ipsilateral labyrinthine artery aneurysm: A rare case report and literature review
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13783. Online ahead of print.ABSTRACTPreoperative MRI results showed a vascular anomaly at the REZ of the left facial nerve (Figure A) and an anomaly at the internal auditory canal (Figure B). The left AICA was identified as the offending vessel compressing the left facial nerve at the REZ (Figure C). After the artery was dissociated and Teflon felt was placed between the involved vessel and the facial nerve (Figure D), electrophysiological monitoring indicated that the AMR had disappeared (Figure E).PMID:34953034 | DOI:10.1111/cns.13783 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Yufei Liu Fanfan Chen Zongyang Li Jihu Yang Xiejun Zhang Lei Chen Liwei Zhang Guodong Huang Source Type: research

Clinical and imaging characteristics of 4H syndrome: A case report
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13790. Online ahead of print.NO ABSTRACTPMID:34953043 | DOI:10.1111/cns.13790 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Chao Wang Shan Wang Huanhuan Xie Siyu Yang Source Type: research

Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response
CONCLUSION: The attenuated alpha-gamma coupling in dual pathways indicated increased sensitivity to the negative emotional information and reduced moderated effect of the amygdala, which might cause insensitivity to antidepressant treatment and could be regarded as potential neural mechanisms for treatment response prediction.PMID:34953030 | DOI:10.1111/cns.13787 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Zhongpeng Dai Cong Pei Siqi Zhang Shui Tian Zhilu Chen Hongliang Zhou Qing Lu Zhijian Yao Source Type: research

Microvascular decompression and aneurysm clipping for a patient with hemifacial spasm and ipsilateral labyrinthine artery aneurysm: A rare case report and literature review
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13783. Online ahead of print.ABSTRACTPreoperative MRI results showed a vascular anomaly at the REZ of the left facial nerve (Figure A) and an anomaly at the internal auditory canal (Figure B). The left AICA was identified as the offending vessel compressing the left facial nerve at the REZ (Figure C). After the artery was dissociated and Teflon felt was placed between the involved vessel and the facial nerve (Figure D), electrophysiological monitoring indicated that the AMR had disappeared (Figure E).PMID:34953034 | DOI:10.1111/cns.13783 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Yufei Liu Fanfan Chen Zongyang Li Jihu Yang Xiejun Zhang Lei Chen Liwei Zhang Guodong Huang Source Type: research

Clinical and imaging characteristics of 4H syndrome: A case report
CNS Neurosci Ther. 2021 Dec 24. doi: 10.1111/cns.13790. Online ahead of print.NO ABSTRACTPMID:34953043 | DOI:10.1111/cns.13790 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 25, 2021 Category: Neuroscience Authors: Chao Wang Shan Wang Huanhuan Xie Siyu Yang Source Type: research

CELSR3 variants are associated with febrile seizures and epilepsy with antecedent febrile seizures
CONCLUSIONS: CELSR3 variants are potentially associated with FS/EFS+.PMID:34951123 | DOI:10.1111/cns.13781 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 24, 2021 Category: Neuroscience Authors: Jia Li Si-Mei Lin Jing-Da Qiao Xiao-Rong Liu Jie Wang Mi Jiang Jing Zhang Min Zhong Xu-Qin Chen Jing Zhu Na He Tao Su Yi-Wu Shi Yong-Hong Yi Wei-Ping Liao China Epilepsy Gene 1.0 Project Source Type: research

Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice
CONCLUSION: EA alleviates POCD-mediated cognitive dysfunction associated with ameliorated neuroinflammation. Mechanistically, EA's treatment effects are dependent on NLRP3 inhibition.PMID:34951130 | DOI:10.1111/cns.13784 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 24, 2021 Category: Neuroscience Authors: Long Sun Yue Yong Pan Wei Yongqiang Wang He Li Yalan Zhou Wenqing Ruan Xing Li Jiangang Song Source Type: research

Development and validation of prediction models for neurocognitive disorders in adult patients admitted to the ICU with sleep disturbance
CONCLUSIONS: The LASSO prediction model showed better performance than the logistic prediction model and should be preferred for nomogram-assisted decisions on clinical risk management of NCDs among adult patients with sleep disturbance in the ICU.PMID:34951135 | DOI:10.1111/cns.13772 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 24, 2021 Category: Neuroscience Authors: Yun Li Lina Zhao Ye Wang Xizhe Zhang Jiannan Song Qi Zhou Yi Sun Chenyi Yang Haiyun Wang Source Type: research

CELSR3 variants are associated with febrile seizures and epilepsy with antecedent febrile seizures
CONCLUSIONS: CELSR3 variants are potentially associated with FS/EFS+.PMID:34951123 | DOI:10.1111/cns.13781 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 24, 2021 Category: Neuroscience Authors: Jia Li Si-Mei Lin Jing-Da Qiao Xiao-Rong Liu Jie Wang Mi Jiang Jing Zhang Min Zhong Xu-Qin Chen Jing Zhu Na He Tao Su Yi-Wu Shi Yong-Hong Yi Wei-Ping Liao China Epilepsy Gene 1.0 Project Source Type: research

Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice
CONCLUSION: EA alleviates POCD-mediated cognitive dysfunction associated with ameliorated neuroinflammation. Mechanistically, EA's treatment effects are dependent on NLRP3 inhibition.PMID:34951130 | DOI:10.1111/cns.13784 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 24, 2021 Category: Neuroscience Authors: Long Sun Yue Yong Pan Wei Yongqiang Wang He Li Yalan Zhou Wenqing Ruan Xing Li Jiangang Song Source Type: research

Development and validation of prediction models for neurocognitive disorders in adult patients admitted to the ICU with sleep disturbance
CONCLUSIONS: The LASSO prediction model showed better performance than the logistic prediction model and should be preferred for nomogram-assisted decisions on clinical risk management of NCDs among adult patients with sleep disturbance in the ICU.PMID:34951135 | DOI:10.1111/cns.13772 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 24, 2021 Category: Neuroscience Authors: Yun Li Lina Zhao Ye Wang Xizhe Zhang Jiannan Song Qi Zhou Yi Sun Chenyi Yang Haiyun Wang Source Type: research

Identifying epilepsy based on machine-learning technique with diffusion kurtosis tensor
CONCLUSION: Although the classification task for epileptic patients and normal controls discussed in this article did not directly achieve the location of epileptic foci and only identified epilepsy on certain brain region, the epileptic foci can be located with the results of identifying results on other brain regions.PMID:34939745 | DOI:10.1111/cns.13773 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 23, 2021 Category: Neuroscience Authors: Li Kang Jin Chen Jianjun Huang Tijiang Zhang Jiahui Xu Source Type: research

Retraction: Allopregnanolone restores the tyrosine hydroxylase-positive neurons and motor performance in a 6-OHDA-injected mouse model
CNS Neurosci Ther. 2021 Dec 17. doi: 10.1111/cns.13780. Online ahead of print.NO ABSTRACTPMID:34921506 | DOI:10.1111/cns.13780 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2021 Category: Neuroscience Authors: Zhi-Chi Chen Tong-Tong Wang Wei Bian Xin Ye Meng-Yi Li Juan-Juan Du Peng Zhou Huai-Rui Cui Yu-Qiang Ding Yan-Hua Ren Shuang-Shuang Qi Yuan-Yuan Yuan Min Liao Chen-You Sun Source Type: research

Retraction: Allopregnanolone restores the tyrosine hydroxylase-positive neurons and motor performance in a 6-OHDA-injected mouse model
CNS Neurosci Ther. 2021 Dec 17. doi: 10.1111/cns.13780. Online ahead of print.NO ABSTRACTPMID:34921506 | DOI:10.1111/cns.13780 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2021 Category: Neuroscience Authors: Zhi-Chi Chen Tong-Tong Wang Wei Bian Xin Ye Meng-Yi Li Juan-Juan Du Peng Zhou Huai-Rui Cui Yu-Qiang Ding Yan-Hua Ren Shuang-Shuang Qi Yuan-Yuan Yuan Min Liao Chen-You Sun Source Type: research

Retraction: Allopregnanolone restores the tyrosine hydroxylase-positive neurons and motor performance in a 6-OHDA-injected mouse model
CNS Neurosci Ther. 2021 Dec 17. doi: 10.1111/cns.13780. Online ahead of print.NO ABSTRACTPMID:34921506 | DOI:10.1111/cns.13780 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2021 Category: Neuroscience Authors: Zhi-Chi Chen Tong-Tong Wang Wei Bian Xin Ye Meng-Yi Li Juan-Juan Du Peng Zhou Huai-Rui Cui Yu-Qiang Ding Yan-Hua Ren Shuang-Shuang Qi Yuan-Yuan Yuan Min Liao Chen-You Sun Source Type: research

Retraction: Allopregnanolone restores the tyrosine hydroxylase-positive neurons and motor performance in a 6-OHDA-injected mouse model
CNS Neurosci Ther. 2021 Dec 17. doi: 10.1111/cns.13780. Online ahead of print.NO ABSTRACTPMID:34921506 | DOI:10.1111/cns.13780 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2021 Category: Neuroscience Authors: Zhi-Chi Chen Tong-Tong Wang Wei Bian Xin Ye Meng-Yi Li Juan-Juan Du Peng Zhou Huai-Rui Cui Yu-Qiang Ding Yan-Hua Ren Shuang-Shuang Qi Yuan-Yuan Yuan Min Liao Chen-You Sun Source Type: research

Retraction: Allopregnanolone restores the tyrosine hydroxylase-positive neurons and motor performance in a 6-OHDA-injected mouse model
CNS Neurosci Ther. 2021 Dec 17. doi: 10.1111/cns.13780. Online ahead of print.NO ABSTRACTPMID:34921506 | DOI:10.1111/cns.13780 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2021 Category: Neuroscience Authors: Zhi-Chi Chen Tong-Tong Wang Wei Bian Xin Ye Meng-Yi Li Juan-Juan Du Peng Zhou Huai-Rui Cui Yu-Qiang Ding Yan-Hua Ren Shuang-Shuang Qi Yuan-Yuan Yuan Min Liao Chen-You Sun Source Type: research

BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway
CONCLUSION: BMPER is a neuroprotective hormone that alleviates ischemic brain injury via activating the Smad3/Akt/Nrf2 pathway. These findings may provide potential therapeutic strategies for stroke.PMID:34904361 | DOI:10.1111/cns.13782 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 14, 2021 Category: Neuroscience Authors: Peng Ding Wei Chen Xiaodi Yan Jinxiang Zhang Cheng Li Guangming Zhang Yongqiang Wang Yonghua Li Source Type: research

BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway
CONCLUSION: BMPER is a neuroprotective hormone that alleviates ischemic brain injury via activating the Smad3/Akt/Nrf2 pathway. These findings may provide potential therapeutic strategies for stroke.PMID:34904361 | DOI:10.1111/cns.13782 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 14, 2021 Category: Neuroscience Authors: Peng Ding Wei Chen Xiaodi Yan Jinxiang Zhang Cheng Li Guangming Zhang Yongqiang Wang Yonghua Li Source Type: research

BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway
CONCLUSION: BMPER is a neuroprotective hormone that alleviates ischemic brain injury via activating the Smad3/Akt/Nrf2 pathway. These findings may provide potential therapeutic strategies for stroke.PMID:34904361 | DOI:10.1111/cns.13782 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 14, 2021 Category: Neuroscience Authors: Peng Ding Wei Chen Xiaodi Yan Jinxiang Zhang Cheng Li Guangming Zhang Yongqiang Wang Yonghua Li Source Type: research