Radiofrequency hyperthermia enhances the effect of OK-432 for Hepatocellular carcinoma by activating of TLR4-cGAS-STING pathway
In conclusion, RFH in combination with OK-432 might reduce the residual and recurrent tumor after RFA of large and irregular HCCs, and serve as a new option for other solid malignancies treated by RFA.PMID:38442584 | DOI:10.1016/j.intimp.2024.111769 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 5, 2024 Category: Allergy & Immunology Authors: Bo Sun Qingqing Zhang Tao Sun Jiayun Liu Yanyan Cao Bin Liang Chuansheng Zheng Xuefeng Kan Source Type: research
Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation
CONCLUSION: Enhanced micronuclei formation upon ATM, ATR, or MRE11 deficiency activated the cGAS/STING, RIG-I-MDA-5-IRF7-IL6 pathway, resulting in its downstream interferon stimulated gene expression following exposure to IR. Our study provides comprehensive information regarding the status of inflammation-related gene expression under DSB repair deficiency after IR. The generated dataset may be useful in developing functional biomarkers to accurately identify patients sensitive to radiotherapy.PMID:38438016 | DOI:10.1016/j.radonc.2024.110198 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 4, 2024 Category: Radiology Authors: Shunji Haruna Ken Okuda Akiko Shibata Mayu Isono Kohei Tateno Hiro Sato Takahiro Oike Yuki Uchihara Yu Kato Atsushi Shibata Source Type: research
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
CONCLUSIONS: Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.PMID:38439028 | DOI:10.1186/s11658-024-00553-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 4, 2024 Category: Biochemistry Authors: Zhixia Song Yao Xia Lang Shi Hongchu Zha Jing Huang Xiaohong Xiang Huiming Li Hua Huang Ruchi Yue Hongtao Wang Jiefu Zhu Source Type: research
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
CONCLUSIONS: Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.PMID:38439028 | DOI:10.1186/s11658-024-00553-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 4, 2024 Category: Molecular Biology Authors: Zhixia Song Yao Xia Lang Shi Hongchu Zha Jing Huang Xiaohong Xiang Huiming Li Hua Huang Ruchi Yue Hongtao Wang Jiefu Zhu Source Type: research
Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation
CONCLUSION: Enhanced micronuclei formation upon ATM, ATR, or MRE11 deficiency activated the cGAS/STING, RIG-I-MDA-5-IRF7-IL6 pathway, resulting in its downstream interferon stimulated gene expression following exposure to IR. Our study provides comprehensive information regarding the status of inflammation-related gene expression under DSB repair deficiency after IR. The generated dataset may be useful in developing functional biomarkers to accurately identify patients sensitive to radiotherapy.PMID:38438016 | DOI:10.1016/j.radonc.2024.110198 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 4, 2024 Category: Radiology Authors: Shunji Haruna Ken Okuda Akiko Shibata Mayu Isono Kohei Tateno Hiro Sato Takahiro Oike Yuki Uchihara Yu Kato Atsushi Shibata Source Type: research
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
CONCLUSIONS: Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.PMID:38439028 | PMC:PMC10910703 | DOI:10.1186/s11658-024-00553-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 4, 2024 Category: Biochemistry Authors: Zhixia Song Yao Xia Lang Shi Hongchu Zha Jing Huang Xiaohong Xiang Huiming Li Hua Huang Ruchi Yue Hongtao Wang Jiefu Zhu Source Type: research
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats
CONCLUSION: This study demonstrated for the first time that spinal BRD4 contributes to pyroptosis and switch of microglia polarization via STING-IRF3 signaling pathway during the development of morphine tolerance, which extend the understanding of the neuroinflammation mechanism of morphine tolerance and provide an alternative strategy for the precaution against of this medical condition.PMID:38432572 | DOI:10.1016/j.ejphar.2024.176428 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 3, 2024 Category: Drugs & Pharmacology Authors: Xiaoqian Jia Jie Ju Zheng Li Xiaoling Peng Jihong Wang Feng Gao Source Type: research
Effect of resveratrol on herpesvirus encephalitis: Evidences for its mechanisms of action
CONCLUSION: Resveratrol acted as a non-classical HSP90β inhibitor, binding to the STING-HSP90β interaction site to promote STING degradation and attenuate HSV-1-induced encephalitis and neuroinflammation. These findings suggest the alternative strategy of targeting HSP90β and resveratrol-mediated inhibition of HSP90β as a potential antiviral approach.PMID:38430586 | DOI:10.1016/j.phymed.2024.155476 (Source: Herpes)
Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Ziwei Huang Shan Li Lishan Zhong Yuan Su Menghe Li Xiaohui Wang Zexu Wang Zhiping Wang Cuifang Ye Zhe Ren Xiao Wang Qiongzhen Zeng Kai Zheng Yifei Wang Source Type: research
Interleukin-1 β promotes human metapneumovirus replication via activating the cGAS-STING pathway
CONCLUSION: This study found that IL-1β could promote hMPV replication through the cGAS-STING pathway, which has the potential to serve as a candidate to fight against hMPV infection, targeting IL-1β may be an effective new strategy to restrain virus replication.PMID:38431054 | DOI:10.1016/j.virusres.2024.199344 (Source: Virus Research)
Source: Virus Research - March 2, 2024 Category: Virology Authors: Guojin Wu Yueyan Zhang Linlin Niu Yuan Hu Yuting Yang Yao Zhao Source Type: research
Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA-cGAS-STING signaling
This study proposes an anti-tumor immunotherapy through mitochondrial proteotoxicity.PMID:38430646 | DOI:10.1016/j.biomaterials.2024.122512 (Source: Biomaterials)
Source: Biomaterials - March 2, 2024 Category: Materials Science Authors: Xinying Yu Bei Li Jie Yan Wenxi Li Hao Tian Guohao Wang Songtao Zhou Yunlu Dai Source Type: research
Effect of resveratrol on herpesvirus encephalitis: Evidences for its mechanisms of action
CONCLUSION: Resveratrol acted as a non-classical HSP90β inhibitor, binding to the STING-HSP90β interaction site to promote STING degradation and attenuate HSV-1-induced encephalitis and neuroinflammation. These findings suggest the alternative strategy of targeting HSP90β and resveratrol-mediated inhibition of HSP90β as a potential antiviral approach.PMID:38430586 | DOI:10.1016/j.phymed.2024.155476 (Source: Herpes)
Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Ziwei Huang Shan Li Lishan Zhong Yuan Su Menghe Li Xiaohui Wang Zexu Wang Zhiping Wang Cuifang Ye Zhe Ren Xiao Wang Qiongzhen Zeng Kai Zheng Yifei Wang Source Type: research
Interleukin-1 β promotes human metapneumovirus replication via activating the cGAS-STING pathway
CONCLUSION: This study found that IL-1β could promote hMPV replication through the cGAS-STING pathway, which has the potential to serve as a candidate to fight against hMPV infection, targeting IL-1β may be an effective new strategy to restrain virus replication.PMID:38431054 | DOI:10.1016/j.virusres.2024.199344 (Source: Virus Research)
Source: Virus Research - March 2, 2024 Category: Virology Authors: Guojin Wu Yueyan Zhang Linlin Niu Yuan Hu Yuting Yang Yao Zhao Source Type: research
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease
In conclusion, STING deficiency protected against diabetic renal injury via alleviating ferroptosis through stabilizing FPN1 and reducing oxidative stress, providing a possible potential approach for the treatment of DKD.PMID:38428828 | DOI:10.1016/j.bcp.2024.116102 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Qin-Xiao Zhao Sen-Bo Yan Fen Wang Xiao-Xing Li Guo-Kai Shang Zi-Jie Zheng Jie Xiao Zong-Wei Lin Chuan-Bao Li Xiao-Ping Ji Source Type: research
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease
In conclusion, STING deficiency protected against diabetic renal injury via alleviating ferroptosis through stabilizing FPN1 and reducing oxidative stress, providing a possible potential approach for the treatment of DKD.PMID:38428828 | DOI:10.1016/j.bcp.2024.116102 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Qin-Xiao Zhao Sen-Bo Yan Fen Wang Xiao-Xing Li Guo-Kai Shang Zi-Jie Zheng Jie Xiao Zong-Wei Lin Chuan-Bao Li Xiao-Ping Ji Source Type: research
GSE199635 Overcoming dysfunctional innate sensing in myeloid cells circumvents cancer vaccine resistance
This study comprehensively profiled the highly dimensional, temporal dynamics of acquired vaccine resistance and associated immune dysfunction and identified cell populations which could serve as therapeutic targets to improve T cell immunotherapy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
