Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury

CONCLUSIONS: Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.PMID:38439028 | PMC:PMC10910703 | DOI:10.1186/s11658-024-00553-1

Source: Cellular and Molecular Biology Letters - March 4, 2024 Category: Biochemistry Authors: Zhixia Song Yao Xia Lang Shi Hongchu Zha Jing Huang Xiaohong Xiang Huiming Li Hua Huang Ruchi Yue Hongtao Wang Jiefu Zhu Source Type: research