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Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
CONCLUSION: Our results support that Rab4b, by controlling the sorting of the cation-independent mannose-6-phosphate receptor towards VPS52 microdomains, confers a directional specificity for cargo carriers en route to the trans-Golgi network. Given the importance of the endocytic recycling in cell homeostasis, disruption of the Rab4b/Golgi-associated retrograde protein complex-dependent step could have serious consequences in pathologies.PMID:38627612 | DOI:10.1186/s11658-024-00574-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 16, 2024 Category: Biochemistry Authors: J érôme Gilleron Abderrahman Chafik Sandra Lacas-Gervais Jean-Fran çois Tanti Mireille Cormont Source Type: research

Role of reactive oxygen species in myelodysplastic syndromes
Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0.ABSTRACTReactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndro...
Source: Cellular and Molecular Biology Letters - April 14, 2024 Category: Biochemistry Authors: Qiangan Jing Chaoting Zhou Junyu Zhang Ping Zhang Yunyi Wu Junyu Zhou Xiangmin Tong Yanchun Li Jing Du Ying Wang Source Type: research

CRISPR-Cas9 applications in T cells and adoptive T cell therapies
Cell Mol Biol Lett. 2024 Apr 12;29(1):52. doi: 10.1186/s11658-024-00561-1.ABSTRACTT cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on antigen stimulation levels, metabolic conditions, and the degree of inflammation. T cell-based therapeutic strategies are gaining widespread adoption in oncology and treating inflammatory conditions. Emerging researches reveal that clustered regularly interspaced palindromic repeats-associated protein 9 (C...
Source: Cellular and Molecular Biology Letters - April 12, 2024 Category: Biochemistry Authors: Xiaoying Chen Shuhan Zhong Yonghao Zhan Xuepei Zhang Source Type: research

Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA-miRNA/protein axis
CONCLUSIONS: Our study revealed the requirement for site-specific methylation of lncRNAs in the tumorigenesis of GCSCs, contributing novel insights into cancer development.PMID:38600465 | PMC:PMC11005211 | DOI:10.1186/s11658-024-00568-8 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 10, 2024 Category: Biochemistry Authors: Yuan Ci Yuan Zhang Xiaobo Zhang Source Type: research

Correction: A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Cell Mol Biol Lett. 2024 Apr 9;29(1):49. doi: 10.1186/s11658-024-00567-9.NO ABSTRACTPMID:38594613 | PMC:PMC11005147 | DOI:10.1186/s11658-024-00567-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research

Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma
CONCLUSION: These findings establish a preclinical foundation for the combined use of an anti-HER2 drug conjugate and a BRAF inhibitor in the treatment of BRAF-mutant cutaneous melanoma.PMID:38594618 | PMC:PMC11005275 | DOI:10.1186/s11658-024-00555-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Weisong Li Chao Zheng Xi Xu Yujie Xia Kai Zhang Ao Huang Xinyu Zhang Yong Zheng Guofang Chen Shuyong Zhang Source Type: research

Correction: A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Cell Mol Biol Lett. 2024 Apr 9;29(1):49. doi: 10.1186/s11658-024-00567-9.NO ABSTRACTPMID:38594613 | DOI:10.1186/s11658-024-00567-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research

Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma
CONCLUSION: These findings establish a preclinical foundation for the combined use of an anti-HER2 drug conjugate and a BRAF inhibitor in the treatment of BRAF-mutant cutaneous melanoma.PMID:38594618 | DOI:10.1186/s11658-024-00555-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Weisong Li Chao Zheng Xi Xu Yujie Xia Kai Zhang Ao Huang Xinyu Zhang Yong Zheng Guofang Chen Shuyong Zhang Source Type: research

Escaping from CRISPR-Cas-mediated knockout: the facts, mechanisms, and applications
Cell Mol Biol Lett. 2024 Apr 8;29(1):48. doi: 10.1186/s11658-024-00565-x.ABSTRACTClustered regularly interspaced short palindromic repeats and associated Cas protein (CRISPR-Cas), a powerful genome editing tool, has revolutionized gene function investigation and exhibits huge potential for clinical applications. CRISPR-Cas-mediated gene knockout has already become a routine method in research laboratories. However, in the last few years, accumulating evidences have demonstrated that genes knocked out by CRISPR-Cas may not be truly silenced. Functional residual proteins could be generated in such knockout organisms to compe...
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ying Wang Yujing Zhai Mingzhe Zhang Chunlin Song Yuqing Zhang Gang Zhang Source Type: research

G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1-Bax-mediated mitochondrial apoptosis pathway
CONCLUSION: Our study showed that the G6PD-VDAC1-Bax axis is a vital switch in VSMC apoptosis and is essential for VSMC phenotypic switching and neointimal hyperplasia, providing mechanistic insight into early VRDs.PMID:38589823 | PMC:PMC11003121 | DOI:10.1186/s11658-024-00566-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ting Zhang Rui-Jie Cao Jiang-Ling Niu Zhi-Huan Chen Shi-Qing Mu Tong Cao Jie-Xin Pang Li-Hua Dong Source Type: research

G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1-Bax-mediated mitochondrial apoptosis pathway
CONCLUSION: Our study showed that the G6PD-VDAC1-Bax axis is a vital switch in VSMC apoptosis and is essential for VSMC phenotypic switching and neointimal hyperplasia, providing mechanistic insight into early VRDs.PMID:38589823 | DOI:10.1186/s11658-024-00566-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ting Zhang Rui-Jie Cao Jiang-Ling Niu Zhi-Huan Chen Shi-Qing Mu Tong Cao Jie-Xin Pang Li-Hua Dong Source Type: research