Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.
Conclusion: Our results indicate that miR-15 inhibition alleviates CVB3-induced myocardial inflammation and cell injury. This may be partially due to NLRX1-mediated NLRP3 inflammasome inactivation. PMID: 32099552 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 28, 2020 Category: Biochemistry Authors: Tong R, Jia T, Shi R, Yan F Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF- κB pathway.
Conclusion: We provide important insight into miR-429 as a tumor suppressor through interaction with IKKβ, which is a catalytic subunit of the IKK complex that activates NF-κB nuclear transport. Our results demonstrate that miR-429 may be a new target for the treatment of neuroblastoma. PMID: 32082390 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 24, 2020 Category: Biochemistry Authors: Zhou X, Lu H, Li F, Hao X, Han L, Dong Q, Chen X Tags: Cell Mol Biol Lett Source Type: research

Deficiency of αII-spectrin affects endothelial cell-matrix contact and migration leading to impairment of angiogenesis in vitro.
Conclusion: Our data confirm the role of αII-spectrin in the control of cell adhesion and spreading. Moreover, our findings further support the participation of αII-spectrin in capillary tube formation in vitro through control of adhesion molecules, such as integrins. This indicates a new function of αII-spectrin in angiogenesis. PMID: 32042281 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 12, 2020 Category: Biochemistry Authors: Machnicka B, Ponceau A, Picot J, Colin Y, Lecomte MC Tags: Cell Mol Biol Lett Source Type: research

LINC00511 promotes proliferation and invasion by sponging miR-515-5p in gastric cancer.
Conclusion: We established that LINC00511 may contribute to the proliferation and invasion of gastric cancer cells by modulating miR-515-5p, indicating that LINC00511 may be a potential molecular target for the development of anti-cancer drugs. PMID: 32042282 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 12, 2020 Category: Biochemistry Authors: Wang D, Liu K, Chen E Tags: Cell Mol Biol Lett Source Type: research

The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer.
Abstract The ubiquitin system, known as a common feature in eukaryotes, participates in multiple cellular processes, such as signal transduction, cell-cycle progression, receptor trafficking and endocytosis, and even the immune response. In lung cancer, evidence has revealed that aberrant events in ubiquitin-mediated processes can cause a variety of pathological outcomes including tumorigenesis and metastasis. Likewise, ubiquitination on the core components contributing to the activity of cell signaling controls bio-signal turnover and cell final destination. Given this, inhibitors targeting the ubiquitin system h...
Source: Cellular and Molecular Biology Letters - January 30, 2020 Category: Biochemistry Authors: Fan Q, Wang Q, Cai R, Yuan H, Xu M Tags: Cell Mol Biol Lett Source Type: research

DNA-dependent protein kinase in telomere maintenance and protection.
Abstract This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku ...
Source: Cellular and Molecular Biology Letters - January 30, 2020 Category: Biochemistry Authors: Sui J, Zhang S, Chen BPC Tags: Cell Mol Biol Lett Source Type: research

Editorial focus: understanding off-target effects as the key to successful RNAi therapy.
Abstract With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we witness the RNAi therapy field reaching a critical turning point, when further improvements in drug candidate design and delivery pipelines should enable fast delivery of novel life changing treatments to patients. Nevertheless, ignoring parallel development of RNAi dedicated in vitro pharmacological profiling aiming to identify undesirable off-target activity may slow down or halt progress in the RNAi field. Since academic research is currently fueling the RNAi development pipeline with new therapeutic options, the objec...
Source: Cellular and Molecular Biology Letters - December 24, 2019 Category: Biochemistry Authors: Bartoszewski R, Sikorski AF Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-582-3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2.
Conclusion: These findings indicate new functions and mechanisms for miR-582-3p in AML development. Further study could clarify if miR-582-3p and CCNB2 are potential therapeutic targets for the treatment of AML. PMID: 31844417 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 19, 2019 Category: Biochemistry Authors: Li H, Tian X, Wang P, Huang M, Xu R, Nie T Tags: Cell Mol Biol Lett Source Type: research

Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.
Conclusion: Our data suggest that miR-376c-3p downregulated ING5 to exert protective effects against OGD-induced cell injury in PC-12 and SH-SY5Y cells. This might represent a novel therapeutic approach for neonatal HIE treatment. PMID: 31844418 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 19, 2019 Category: Biochemistry Authors: Zhang H, Zhou J, Zhang M, Yi Y, He B Tags: Cell Mol Biol Lett Source Type: research

MiR-214 prevents the progression of diffuse large B-cell lymphoma by targeting PD-L1.
Conclusion: By targeting PD-L1, miR-214 regulates the progression of DLBCL in vitro and in vivo. PMID: 31844419 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 19, 2019 Category: Biochemistry Authors: Sun JR, Zhang X, Zhang Y Tags: Cell Mol Biol Lett Source Type: research

Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats.
Conclusions: The results may have revealed some aberrantly expressed lncRNAs and mRNAs that contribute to the underlying pathophysiological mechanisms of myocardial infarction. PMID: 31827539 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Meng Q, Sun Z, Gu H, Luo J, Wang J, Wang C, Han S Tags: Cell Mol Biol Lett Source Type: research

Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling.
Conclusions: The in vitro study revealed that the duration of hypoxia is crucial for osteogenic differentiation of precursor cells. The results from both the in vitro and in vivo studies show the role of STAT3 signaling in hypoxia-induced osteogenic differentiation of precursor cells and bone defect healing. PMID: 31827540 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Yu X, Wan Q, Ye X, Cheng Y, Pathak JL, Li Z Tags: Cell Mol Biol Lett Source Type: research

Estrogen stimulates SREBP2 expression in hepatic cell lines via an estrogen response element in the SREBP2 promoter.
Conclusions: An ERE was identified in the SREBP2 gene promoter. It mediates the regulation of SREBP2 expression by estrogen in hepatocytes. This study provides a mechanism to link cardiovascular disease with estrogen. PMID: 31827541 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Meng Y, Zong L Tags: Cell Mol Biol Lett Source Type: research

MiR-7-5p suppresses tumor metastasis of non-small cell lung cancer by targeting NOVA2.
Conclusion: MiR-7-5p suppresses NSCLC metastasis. Targeting miR-7-5p may contribute to the success of NSCLC therapy. PMID: 31832068 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Xiao H Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1.
Conclusions: MicroRNA-146a exerts a protective effect against MIRI, which might be partially mediated by the target gene Med1 and related to the apoptosis signalling pathway. PMID: 31798643 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 6, 2019 Category: Biochemistry Authors: Zhang T, Ma Y, Gao L, Mao C, Zeng H, Wang X, Sun Y, Gu J, Wang Y, Chen K, Han Z, Fan Y, Gu J, Zhang J, Wang C Tags: Cell Mol Biol Lett Source Type: research

Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven.
Conclusions: Inhibition of miR-30b-5p could protect cardiomyocytes against hypoxia-induced injury by targeting Aven. PMID: 31768184 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 27, 2019 Category: Biochemistry Authors: Zhang L, Jia X Tags: Cell Mol Biol Lett Source Type: research

Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells.
Conclusions: Our data suggests that MAO-A activity is required for tumorsphere formation and that its expression in breast tumor cells is associated with BTIC-related properties. The discovery that a selective MAO-A inhibitor targets tumorsphere-forming cells with potencies in the nanomolar range provides the first evidence of this agent's anticancer property. These data warrant further investigation of the link between MAO-A and BTIC. PMID: 31754354 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 24, 2019 Category: Biochemistry Authors: Gwynne WD, Shakeel MS, Wu J, Hallett RM, Girgis-Gabardo A, Dvorkin-Gheva A, Hassell JA Tags: Cell Mol Biol Lett Source Type: research

PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer.
Conclusion: These results suggest that miR-9-5p targeting of PAK4 could have therapeutic potential for CRC treatment. PMID: 31728150 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 19, 2019 Category: Biochemistry Authors: Wang M, Gao Q, Chen Y, Li Z, Yue L, Cao Y Tags: Cell Mol Biol Lett Source Type: research

GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway.
Conclusions: These data reveal that GRP78 is an important regulator of milk biosynthesis and the proliferation of BMECs through the mTOR signaling pathway. PMID: 31660059 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 31, 2019 Category: Biochemistry Authors: Liu Y, Wang X, Zhen Z, Yu Y, Qiu Y, Xiang W Tags: Cell Mol Biol Lett Source Type: research

SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1 α signaling.
Conclusions: Our results highlight the essential role of SOX2 in breast cancer cell motility. The upregulation of SOX2 under hypoxic conditions may facilitate NEDD9 transcription and expression, and subsequent activation of Rac1 and HIF-1α expression. This could accelerate breast cancer cell migration. PMID: 31462898 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 31, 2019 Category: Biochemistry Authors: Wang Y, Bibi M, Min P, Deng W, Zhang Y, Du J Tags: Cell Mol Biol Lett Source Type: research

Correction to: Mesenchymal stem cells decrease blood-brain barrier permeability in rats with severe acute pancreatitis.
Abstract [This corrects the article DOI: 10.1186/s11658-019-0167-8.]. PMID: 31462899 [PubMed] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 31, 2019 Category: Biochemistry Authors: Lin R, Li M, Luo M, Teng T, Pan Y, Huang H Tags: Cell Mol Biol Lett Source Type: research

A novel frameshift mutation in the EDA gene in an Iranian patient affected by X-linked hypohidrotic ectodermal dysplasia.
Conclusion: We identified a novel frameshift mutation in the EDA gene in an Iranian patient affected by X-linked HED. The difference between our patient's symptoms and those recorded for some previous subjects may be due to the differences in the mutations involved. PMID: 31452656 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 29, 2019 Category: Biochemistry Authors: Rahbaran M, Hassani Doabsari M, Salavitabar S, Mokhberian N, Morovvati Z, Morovvati S Tags: Cell Mol Biol Lett Source Type: research

microRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN.
Conclusions: Our study indicated that miR211 has an important role in the development and progress of osteosarcoma, and it might become a novel target in the diagnosis and treatment of human osteosarcoma. PMID: 31333725 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 25, 2019 Category: Biochemistry Authors: Pei Y, Yao Q, Li Y, Zhang X, Xie B Tags: Cell Mol Biol Lett Source Type: research

Silencing of Synuclein- γ inhibits human cervical cancer through the AKT signaling pathway.
Silencing of Synuclein-γ inhibits human cervical cancer through the AKT signaling pathway. Cell Mol Biol Lett. 2019;24:49 Authors: Zhang C, Gu L, Li X, Wang J Abstract Background: Synuclein-γ has been demonstrated to be highly expressed in various human cancers including cervical cancer, and has been shown to play a critical role in tumor aggressiveness. We aimed to investigate the role of Synuclein-γ in human cervical cancer in vitro and in vivo. Method: Reverse transcription-quantitative polymerase chain reaction assay and Western blot assay were used to detect the mRNA and pr...
Source: Cellular and Molecular Biology Letters - July 25, 2019 Category: Biochemistry Authors: Zhang C, Gu L, Li X, Wang J Tags: Cell Mol Biol Lett Source Type: research

Dp71 depleted HBE cells displayed increased DNA damage and apoptosis induced by H2O2.
Abstract Human bronchial epithelium (HBE)-Dp71 anti-sense(AS)cells with stably transfected Dp71 siRNA plasmids were prepared for further exploration of Dp71 biological traits in cells other than PC12. HBE-Dp71AS cells displayed increased DNA damage induced by H2O2. Apoptosis of HBE-Dp71AS cells induced by H2O2 was increased via enhancing caspase 3, caspase 8 and caspase 9. HBE-Dp71AS cells also displayed decreased proliferation and clonogenic formation. RAD51 was proved to be a new binding partner of Dp71 by co-immunoprecipitation (Ip) and immunofluorescence. Reduced RAD51 mRNA and protein levels were observed in ...
Source: Cellular and Molecular Biology Letters - June 28, 2019 Category: Biochemistry Authors: Tan S, Zhao S, Xiao X, Xiao L, Xie J, Tan S Tags: Cell Mol Biol Lett Source Type: research

Mesenchymal stem cells decrease blood-brain barrier permeability in rats with severe acute pancreatitis.
Conclusions: MSCs attenuated the impairment of the BBB and decreased its permeability, producing protective effects in SAP rats. PMID: 31236121 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 28, 2019 Category: Biochemistry Authors: Lin R, Li M, Luo M, Teng T, Pan Y, Huang H Tags: Cell Mol Biol Lett Source Type: research

Progress in research on paclitaxel and tumor immunotherapy.
This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway of paclitaxel. With the advancement of biotechnology, improvements in endophytic fungal strains, and the use of recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has increased significantly. Recently, paclitaxel has been found to play a large role in tumor immunity, and it has a great potential for use in many cancer treatments. PMID: 31223315 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 23, 2019 Category: Biochemistry Authors: Zhu L, Chen L Tags: Cell Mol Biol Lett Source Type: research

LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosis.
Conclusion: In conclusion, GASL1 was downregulated in CHF. GASL1 overexpression may improve CHF by inhibiting cardiomyocyte apoptosis through the inactivation of TGF-β1. PMID: 31223316 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 23, 2019 Category: Biochemistry Authors: Deng H, Ouyang W, Zhang L, Xiao X, Huang Z, Zhu W Tags: Cell Mol Biol Lett Source Type: research

Non-contact co-culture with human vascular endothelial cells promotes epithelial-to-mesenchymal transition of cervical cancer SiHa cells by activating the NOTCH1/LOX/SNAIL pathway.
Conclusion: Co-culture with human umbilical vein endothelial cells promoted the epithelial-to-mesenchymal transition of SiHa cells by activating the NOTCH1/LOX/SNAIL1 pathway in SiHa cells, which enhanced their invasive and metastatic capacities. The results of this study may provide a new perspective on cervical cancer metastasis and a theoretical basis for clinical treatment. PMID: 31205475 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 19, 2019 Category: Biochemistry Authors: Ou J, Guan D, Yang Y Tags: Cell Mol Biol Lett Source Type: research

Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis.
Abstract Background: Accumulating evidence has shown that altered microRNA (miR) modulation is implicated in the pathologies of ischemic stroke. However, it is unclear whether and how hsa-miR-19a-3p mediates cerebral ischemic injury. Herein, we investigated the functional role of miR-19a-3p in cerebral ischemic injury and explored its underlying regulatory mechanism. Methods: In vivo ischemic/reperfusion (I/R) neuronal injury and in vitro oxygen-glucose deprivation (OGD) were established. Expression of miR-19a-3p was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Glucose uptake, lac...
Source: Cellular and Molecular Biology Letters - June 8, 2019 Category: Biochemistry Authors: Ge XL, Wang JL, Liu X, Zhang J, Liu C, Guo L Tags: Cell Mol Biol Lett Source Type: research

Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells.
Conclusions: Collectively, these observations suggest that nutrient stress induces the protein expression of both MITF and TFEB in ARPE-19 cells. TFEB-regulated transcriptional program plays an important role in adaptive response of cells during both nutrient and lysosomal stress. PMID: 31160892 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 6, 2019 Category: Biochemistry Authors: Pan HY, Alamri AH, Valapala M Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-340-5p suppresses non-small cell lung cancer cell growth and metastasis by targeting ZNF503.
Conclusion: Our findings indicate that miR-340-5p inhibits NCI-H1650 cell proliferation and invasion by directly targeting ZNF503 and that miR-340-5p can serve as a potential therapeutic target for treating NSCLC. PMID: 31160893 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 6, 2019 Category: Biochemistry Authors: Lu G, Zhang Y Tags: Cell Mol Biol Lett Source Type: research

Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPAR γ/SGK1 signaling pathway.
Conclusions: Rosiglitazone ameliorated the lung injury and promoted ENaC-mediated AFC via a PPARγ/SGK1-dependent signaling pathway, alleviating pulmonary edema in a mouse model of ALI. PMID: 31160894 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 6, 2019 Category: Biochemistry Authors: He J, Qi D, Tang XM, Deng W, Deng XY, Zhao Y, Wang DX Tags: Cell Mol Biol Lett Source Type: research

The role of different SIRT1-mediated signaling pathways in toxic injury.
Abstract Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation, induction of apoptosis, and inhibition of energy metabolism. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase, is a member of the evolutionarily highly conserved Sir2 (silent information regulator 2) superprotein family, which is located in the nucleus and cytoplasm. It can deacetylate protein substrates in various signal transduction pathways to regulate gene expression, cell apoptosis and senescence,...
Source: Cellular and Molecular Biology Letters - June 6, 2019 Category: Biochemistry Authors: Ren Z, He H, Zuo Z, Xu Z, Wei Z, Deng J Tags: Cell Mol Biol Lett Source Type: research

Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1).
This study aimed to investigate the effect of curcumin on the regulation of EMT and related pathway in PMCs treated with glucose-based PD. Methods: EMT of human peritoneal mesothelial cells (HMrSV5) was induced with glucose-based peritoneal dialysis solutions (PDS). Cells were divided into a control group, PDS group, and PDS group receiving varied concentrations of curcumin. Cell Counting Kit-8 (CCK-8) assay was used to measure cell viability, and a transwell migration assay was used to verify the capacity of curcumin to inhibit EMT in HMrSV5 cells. Real-time quantitative PCR and western blot were used to detect the e...
Source: Cellular and Molecular Biology Letters - June 1, 2019 Category: Biochemistry Authors: Zhao JL, Guo MZ, Zhu JJ, Zhang T, Min DY Tags: Cell Mol Biol Lett Source Type: research

C-Cbl negatively regulates TRAF6-mediated NF- κB activation by promoting K48-linked polyubiquitination of TRAF6.
Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-γ. PMID: 31123462 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 29, 2019 Category: Biochemistry Authors: Jang HD, Hwang HZ, Kim HS, Lee SY Tags: Cell Mol Biol Lett Source Type: research

Concentration changes in gemcitabine and its metabolites after hyperthermia in pancreatic cancer cells assessed using RP-HPLC.
Conclusion: The two heat treatments could alter the mechanism of dFdC metabolism in PANC-1 cells. The effect of 43 °C hyperthermia is more significant. Our observations may be instrumental to explaining the higher anti-tumor efficacy of this combination therapy. PMID: 31131010 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 29, 2019 Category: Biochemistry Authors: Jin HB, Lu L, Xie L, Yang JF, Zhang XF, Ma SL Tags: Cell Mol Biol Lett Source Type: research

MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1.
Conclusion: MiR-107 suppresses the metastasis of colorectal cancer and could be a potential therapy target in colorectal cancer patients. PMID: 31131011 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 29, 2019 Category: Biochemistry Authors: Fu Y, Lin L, Xia L Tags: Cell Mol Biol Lett Source Type: research

MiR-200c downregulates HIF-1 α and inhibits migration of lung cancer cells.
Conclusion: miR-200c negatively affects hypoxia-induced responses by downregulating HIF-1α, a key regulator of hypoxia. Therefore, overexpression of miR-200c might have therapeutic potential as an anticancer agent that inhibits tumor hypoxia. PMID: 31061665 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 9, 2019 Category: Biochemistry Authors: Byun Y, Choi YC, Jeong Y, Lee G, Yoon S, Jeong Y, Yoon J, Baek K Tags: Cell Mol Biol Lett Source Type: research

MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1.
Conclusions: MiR-613 can inhibit proliferation and invasion and induce apoptosis of RASFs by directly targeting DKK1 expression. PMID: 31019537 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 27, 2019 Category: Biochemistry Authors: Liu L, Zuo Y, Xu Y, Zhang Z, Li Y, Pang J Tags: Cell Mol Biol Lett Source Type: research

Upregulation of miR-29b-3p protects cardiomyocytes from hypoxia-induced apoptosis by targeting TRAF5.
Conclusion: These findings suggest that upregulation of miR-29b-3p could protect cardiomyocytes against hypoxia-induced injury through downregulation of TRAF5. Targeting TRAF5 with miR-29b-3p might be a potential therapeutic method for AMI. PMID: 31011336 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 25, 2019 Category: Biochemistry Authors: Cai Y, Li Y Tags: Cell Mol Biol Lett Source Type: research

Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells.
This study aims to employ a culture system using allogenic limbal niche cells (LNCs) instead of mouse-derived 3T3 cells as a feeder layer that could relieve postoperative neovascularization. Methods: Rat oral mucosal epithelial cells (OMECs) were co-cultured with rat LNCs or 3T3 cells. Cultivated oral mucosal epithelial cells (COMECs) of different culture systems were identified by hematoxylin and eosin staining and immunocytochemistry. The expression levels of the angiogenesis-related factors were analyzed by RT-qPCR and western blotting/ELISA. Angiogenic potential was reconfirmed by cell viability and tube formation...
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Duan CY, Xie HT, Zhao XY, Xu WH, Zhang MC Tags: Cell Mol Biol Lett Source Type: research

Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p.
Conclusion: circDENND2A is required for the hypoxia-induced malignancy of glioma cells and functions by sponging miR-625-5p. PMID: 30988674 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Su H, Zou D, Sun Y, Dai Y Tags: Cell Mol Biol Lett Source Type: research

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro.
Conclusion: Our results show that miR-431-5p is critical for pulmonary surfactant expression and that its regulation is closely related to the TGF-β/Smad4 pathway. These results will help us to study the pathophysiological mechanism of lung developmental diseases. PMID: 30988675 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Li S, Sun Z, Chen T, Pan J, Shen Y, Chen X, Zhou X, Cheng R, Yang Y Tags: Cell Mol Biol Lett Source Type: research

The lncRNA MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation by upregulating miRNA-487a.
Conclusion: MIR4435-2HG is upregulated in HCC and promotes cancer cell proliferation possibly by upregulating miRNA-487a. PMID: 30988676 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Kong Q, Liang C, Jin Y, Pan Y, Tong D, Kong Q, Zhou J Tags: Cell Mol Biol Lett Source Type: research

MiR-125a-5p promotes osteoclastogenesis by targeting TNFRSF1B.
Conclusions: In conclusion, overexpression of miR-125a-5p suppresses the expression of TNFRSF1B and promotes osteoclast differentiation. These results reveal the crucial role of miR-125a-5p in the differentiation of osteoclasts. PMID: 30976285 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 13, 2019 Category: Biochemistry Authors: Sun L, Lian JX, Meng S Tags: Cell Mol Biol Lett Source Type: research

Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells.
Conclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed. PMID: 30949212 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 7, 2019 Category: Biochemistry Authors: Meyenberg Cunha-de Padua M, Noleto GR, de Oliveira Petkowicz CL, Cadena SMSC, Bost F, Pouysségur J, Mazure NM Tags: Cell Mol Biol Lett Source Type: research

miR-573 regulates cell proliferation and apoptosis by targeting Bax in nucleus pulposus cells.
Conclusion: These results suggest that overexpression of miR-573 inhibited NP cell apoptosis by down-regulating Bax, which proved to be a novel effective strategy for IDD therapies. PMID: 30936926 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 3, 2019 Category: Biochemistry Authors: Wang R, Wen B, Sun D Tags: Cell Mol Biol Lett Source Type: research

The  Pro12Ala polymorphism in the PPAR-γ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus.
Conclusion: This study suggests that Pro12Ala polymorphism of the PPAR-γ2 gene cannot be considered as a risk factor for NAFLD in the Iranian population. PMID: 30923554 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 31, 2019 Category: Biochemistry Authors: Saremi L, Lotfipanah S, Mohammadi M, Hosseinzadeh H, Fathi-Kazerooni M, Johari B, Saltanatpour Z Tags: Cell Mol Biol Lett Source Type: research

miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes.
Conclusions: In osteocytes (but not osteoblasts), miR-29b-3p was responsive to the mechanical tensile strain and regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically strained osteocytes. PMID: 30915127 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 28, 2019 Category: Biochemistry Authors: Zeng Q, Wang Y, Gao J, Yan Z, Li Z, Zou X, Li Y, Wang J, Guo Y Tags: Cell Mol Biol Lett Source Type: research