An integrated approach of bioinformatic prediction and in vitro analysis identified that miR-34a targets MET and AXL in triple-negative breast cancer.
Conclusions: These findings may indicate that miR-34a is an oncogenic miRNA, downregulated in the distinct breast cancer subtypes. It also targets MET and AXL 3'-UTRs in triple-negative breast cancer. Therefore, it can be considered as a therapeutic target in this type of breast cancer. PMID: 30386383 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 3, 2018 Category: Biochemistry Authors: Hajalirezay Yazdi S, Paryan M, Mohammadi-Yeganeh S Tags: Cell Mol Biol Lett Source Type: research

Microcystin-LR regulates circadian clock and antioxidant gene expression in cultured rat cardiomyocytes.
Conclusions: Our results indicate an influence of MC-LR on the circadian clock system and clock-controlled antioxidant genes, which will shed some light on the explanation of heart toxicity induced by MC-LR from the viewpoint of chronobiology. PMID: 30337942 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 20, 2018 Category: Biochemistry Authors: Xu Y, Wang X, Jiang S, Men C, Xu D, Guo Y, Wu J Tags: Cell Mol Biol Lett Source Type: research

Angiogenesis after administration of basic fibroblast growth factor induces proliferation and differentiation of mesenchymal stem cells in elastic perichondrium in an in vivo model: mini review of three sequential republication-abridged reports.
Abstract To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown. We have attempted to apply cell and tissue engineering methodology for ear reconstruction using cultured chondrocytes. We hypothesized that by inducing angiogenesis with basic fibroblast growth factor (bFGF), MSCs or cartilage precursor cells would proliferate and differentiate into cartilage in vivo and that the regenerated cartilage would maintain its morphology over an extended period. As a resu...
Source: Cellular and Molecular Biology Letters - October 17, 2018 Category: Biochemistry Authors: Miyanaga T, Ueda Y, Miyanaga A, Yagishita M, Hama N Tags: Cell Mol Biol Lett Source Type: research

Experimental research into the potential therapeutic effect of GYY4137 on Ovariectomy-induced osteoporosis.
Abstract Background: Evidence has shown that endogenous H2S plays an important role in the physiological and pathophysiological processes of many organs. The study aimed to explore whether exogenous H2S has a potential therapeutic effect on a rat ovariectomy-induced model of osteoporosis. Methods: The OVX osteoporosis model was established in female Sprague-Dawley rats by full bilateral ovariectomy. The rats were randomly divided into four groups, with the two experimental groups receiving an intraperitoneal injection of GYY4137 or sodium alendronate. The level of H2S in the plasma was determined and common l...
Source: Cellular and Molecular Biology Letters - October 13, 2018 Category: Biochemistry Authors: Xu ZS, Dai F, Chen J, Lv M, Cheng JW, Zhang XM, Lin BW Tags: Cell Mol Biol Lett Source Type: research

Hypoxic stabilization of mRNA is HIF-independent but requires mtROS.
Conclusion: Overall these data suggest that hypoxic mRNA stabilization is independent of HIF transcriptional activity but requires mtROS. PMID: 30305827 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 13, 2018 Category: Biochemistry Authors: Fortenbery GW, Sarathy B, Carraway KR, Mansfield KD Tags: Cell Mol Biol Lett Source Type: research

Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1 α-IL-8-Akt axis.
Conclusion: Hypoxia promotes HCC cell migration and invasion through the HIF-1α-IL-8-Akt axis. PMID: 30258464 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 29, 2018 Category: Biochemistry Authors: Fei M, Guan J, Xue T, Qin L, Tang C, Cui G, Wang Y, Gong H, Feng W Tags: Cell Mol Biol Lett Source Type: research

Editorial focus: entering into the non-coding RNA era.
Abstract Recent developments in high-throughput genotyping technologies have revealed the existence of several new classes of RNA that do not encode proteins but serve other cellular roles. To date, these non-coding RNAs (ncRNAs) have been shown to modulate both gene expression and genome remodeling, thus contributing to the control of both normal and disease-related cellular processes. The attraction of this research topic can be seen in the increasing number of submissions on ncRNAs to molecular biology journals, including Cellular Molecular Biology Letters (CMBL). As researchers attempt to deepen the understand...
Source: Cellular and Molecular Biology Letters - September 27, 2018 Category: Biochemistry Authors: Bartoszewski R, Sikorski AF Tags: Cell Mol Biol Lett Source Type: research

Systematic identification of the key candidate genes in breast cancer stroma.
Conclusions: We found that several conserved tumor stromal genes might regulate breast cancer invasion through ECM remodeling. The clinical outcome analyses of COL1A1 and FN1 suggest these two genes are promising targets for future studies. PMID: 30237810 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 23, 2018 Category: Biochemistry Authors: Wang Y, Xu H, Zhu B, Qiu Z, Lin Z Tags: Cell Mol Biol Lett Source Type: research

WNT and NOTCH signaling pathways as activators for epidermal growth factor receptor in esophageal squamous cell carcinoma.
Conclusion: This study confirms a direct correlation between MSI1 and EGFR and may support the important role of MSI1 in activation of EGFR through NOTCH/WNT pathways in ESCC. PMID: 30202417 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 13, 2018 Category: Biochemistry Authors: Abbaszadegan MR, Riahi A, Forghanifard MM, Moghbeli M Tags: Cell Mol Biol Lett Source Type: research

Lnc-DC regulates cellular turnover and the HBV-induced immune response by TLR9/STAT3 signaling in dendritic cells.
Conclusion: Lnc-DC is important in regulating the growth, apoptosis, and immune response of dendritic cells mediated by TLR9/STAT3 signaling, and was also activated by HBV. This study provides a previously unidentified mechanism underlying the immune response in dendritic cells. PMID: 30202418 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 13, 2018 Category: Biochemistry Authors: Zhuang L, Tian J, Zhang X, Wang H, Huang C Tags: Cell Mol Biol Lett Source Type: research

MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Conclusions: miR-320 plays an important role in regulating cardiomyocyte apoptosis induced by I/R injury by targeting AKIP1 and inducing the mitochondrial apoptotic pathway. PMID: 30181740 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 7, 2018 Category: Biochemistry Authors: Tian ZQ, Jiang H, Lu ZB Tags: Cell Mol Biol Lett Source Type: research

Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats.
Conclusions: Our data suggest that Cxs may be involved in the regulation of T-lymphocyte homeostasis and the production of cytokines. A clear association was found between alterations in Cxs expression or in Cx43-based GJIC and hypertension-mediated inflammation. PMID: 30151015 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 30, 2018 Category: Biochemistry Authors: Ni X, Li XZ, Fan ZR, Wang A, Zhang HC, Zhang L, Li L, Si JQ, Ma KT Tags: Cell Mol Biol Lett Source Type: research

Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice.
Conclusion: Our study demonstrates for the first time that diacerein improves renal function efficiently in endotoxemic AKI mice by suppressing inflammation and altering tubular water and sodium handing. These results suggest that diacerein may be a novel therapeutic agent for the treatment of endotoxemic AKI. PMID: 30140293 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 25, 2018 Category: Biochemistry Authors: Yu G, Liu Q, Dong X, Tang K, Li B, Liu C, Zhang W, Wang Y, Jin Y Tags: Cell Mol Biol Lett Source Type: research

Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element.
Conclusion: Our results indicate that Oct4 is involved in DNA methylation through the regulation of Dnmt1 transcription, especially during the early stages of mouse pre-implantation embryo development. PMID: 30140294 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 25, 2018 Category: Biochemistry Authors: Wu F, Wu Q, Li D, Zhang Y, Wang R, Liu Y, Li W Tags: Cell Mol Biol Lett Source Type: research

Loureirin B inhibits the proliferation of hepatic stellate cells and the Wnt/ β-catenin signaling pathway by regulating miR-148-3p.
Conclusion: Our results suggest that loureirin B inhibited the proliferation and promoted the apoptosis of HSCs, and suppressed the Wnt/β-catenin signaling pathway via regulation of miR-148-3p. PMID: 30123297 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 21, 2018 Category: Biochemistry Authors: Hu JP, Zhang R, Tang M, Li YL, Xun LT, Shi ZZ, An Y, Li T, Song ZJ Tags: Cell Mol Biol Lett Source Type: research

The notch pathway promotes NF- κB activation through Asb2 in T cell acute lymphoblastic leukemia cells.
Conclusion: Notch1 modulates the NF-κB pathway through Asb2α, indicating that Asb2α inhibition is a promising option for targeted therapy against T-ALL. PMID: 30116272 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 18, 2018 Category: Biochemistry Authors: Wu W, Nie L, Zhang L, Li Y Tags: Cell Mol Biol Lett Source Type: research

Overview of the structure-based non-genomic effects of the nuclear receptor RXR α.
Overview of the structure-based non-genomic effects of the nuclear receptor RXRα. Cell Mol Biol Lett. 2018;23:36 Authors: Chen L, Wu L, Zhu L, Zhao Y Abstract The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the expression of multiple genes. Its non-genomic function is largely related to its structure, polymeric forms and modification. Previous research revealed that some non-genomic activity of RXRα occurs via formation of heterodimers with Nur77. RXRα-Nur77 heterodimers translocate from the nucleus to the mitochondria in respons...
Source: Cellular and Molecular Biology Letters - August 11, 2018 Category: Biochemistry Authors: Chen L, Wu L, Zhu L, Zhao Y Tags: Cell Mol Biol Lett Source Type: research

Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress.
In this study, we examined the effects of droxinostat on the growth of HT-29 colon cancer cells. Our results show that droxinostat effectively inhibited cell growth and colony-forming ability by inducing cellular apoptosis and ROS production in HT-29 cells. Notably, the apoptotic inhibitor Z-VAD-FMK significantly decreased the levels of cellular apoptosis and the antioxidant γ-tocotrienol (GT3) significantly decreased ROS production induced by droxinostat treatment. Z-VAD-FMK and GT3 also partially reversed the negative growth effects of droxinstat on HT-29 cells. GT3 treatment decreased cellular apoptosis and increa...
Source: Cellular and Molecular Biology Letters - August 3, 2018 Category: Biochemistry Authors: Huang Y, Yang W, Zeng H, Hu C, Zhang Y, Ding N, Fan G, Shao L, Kuang B Tags: Cell Mol Biol Lett Source Type: research

LAMP3 plays an oncogenic role in osteosarcoma cells partially by inhibiting TP53.
Conclusions: Our findings suggest that LAMP3 promotes OS cell viability and survival by regulating TP53 expression. PMID: 30008754 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 18, 2018 Category: Biochemistry Authors: Liu S, Yue J, Du W, Han J, Zhang W Tags: Cell Mol Biol Lett Source Type: research

DSPP-MMP20 gene silencing downregulates cancer stem cell markers in human oral cancer cells.
Conclusions: We conclude that the downregulation of OCSC markers may signal a reduction in OCSC population following MMP20/DSPP silencing in OSCC cells, while also increasing their sensitivity to cisplatin. Thus, our findings suggest a potential role for DSPP and MMP20 in sustaining OCSC population in OSCCs, possibly, through mechanism(s) that alter OCSC sensitivity to treatment with chemotherapeutic agents such as cisplatin. PMID: 30002682 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 15, 2018 Category: Biochemistry Authors: Nikitakis NG, Gkouveris I, Aseervatham J, Barahona K, Ogbureke KUE Tags: Cell Mol Biol Lett Source Type: research

Laminopathies: what can humans learn from fruit flies.
Abstract Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins provide a skeletal network for chromatin, the nuclear envelope, nuclear pore complexes and the entire nucleus. They are also responsible for proper connections between the karyoskeleton and structural elements in the cytoplasm: actin and the microtubule and cytoplasmic IF networks. Lamins affect transcription and splicing either directly or indirectly. Translocation of active genes into the close pro...
Source: Cellular and Molecular Biology Letters - July 15, 2018 Category: Biochemistry Authors: Pałka M, Tomczak A, Grabowska K, Machowska M, Piekarowicz K, Rzepecka D, Rzepecki R Tags: Cell Mol Biol Lett Source Type: research

ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/ β-catenin signaling pathway.
Conclusion: This study demonstrates that blocking ClC-2-mediated Cl- efflux inhibits AngII-induced cerebrovascular smooth muscle cell proliferation and migration by inhibiting the Wnt/β-catenin pathway. Our data indicate that downregulation of ClC-2 may be a viable strategy in the prevention of hyperplasia and remodeling of cerebrovascular smooth muscle cells. PMID: 29988306 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 12, 2018 Category: Biochemistry Authors: Lu J, Xu F, Zhang Y, Lu H, Zhang J Tags: Cell Mol Biol Lett Source Type: research

Genetic variation and relationships in the mitochondrial DNA D-loop region of Qinghai indigenous and commercial pig breeds.
This study revealed Bamei pigs' genetic diversity at the molecular level and the degree of introgression of commercial breeds into Bamei pigs. Methods: The mitochondrial DNA D-loop region was amplified and sequenced using the ABI 3130 DNA sequencer. Sequences were collected, edited and aligned using the MEGA 5.0, DNASTAR and ClustalX 1.81 software. Haplotypes of all sequences and genetic diversity were analyzed by DnaSP 5.0 software. Results and conclusions: We identified a total of 73 polymorphic sites in our 489 novel sequences, including 1 single variable site and 72 parsimony informative sites.Genetic diversi...
Source: Cellular and Molecular Biology Letters - July 12, 2018 Category: Biochemistry Authors: Zhang J, Yang B, Wen X, Sun G Tags: Cell Mol Biol Lett Source Type: research

Measuring the lactate-to-creatine ratio via 1H NMR spectroscopy can be used to noninvasively evaluate apoptosis in glioma cells after X-ray irradiation.
In this study, we evaluated the relationships between the Lac/Cr ratio, apoptotic rate, and protein kinase C iota (PKC-ι) expression in glioma cells. Methods: Cells of the glioma cell lines C6 and U251 were randomly divided into 4 groups, with every group exposed to X-ray irradiation at 0, 1, 5, 10 and 15 Gy. Single cell gel electrophoresis (SCGE) was conducted to evaluate the DNA damage. Flow cytometry was performed to measure the cell cycle blockage and apoptotic rates. Western blot analysis was used to detect the phosphorylated PKC-ι (p-PKC-ι) level. 1H NMR spectroscopy was employed to determine...
Source: Cellular and Molecular Biology Letters - June 29, 2018 Category: Biochemistry Authors: Li H, Cui Y, Li F, Shi W, Gao W, Wang X, Zeng Q Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3.
Conclusion: miR-488 inhibited cell invasion and EMT of TSCC cells by directly downregulating ATF3 expression. PMID: 29946339 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 29, 2018 Category: Biochemistry Authors: Shi B, Yan W, Liu G, Guo Y Tags: Cell Mol Biol Lett Source Type: research

HIF-1 α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8-NF-κB axis.
Conclusions: HIF-1α promotes HCC cell migration and invasion by modulating IL-8 via the NF-κB pathway. PMID: 29881400 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 9, 2018 Category: Biochemistry Authors: Feng W, Xue T, Huang S, Shi Q, Tang C, Cui G, Yang G, Gong H, Guo H Tags: Cell Mol Biol Lett Source Type: research

Essential genes of the macrophage response to Staphylococcus aureus exposure.
Conclusions: Our systematic analysis identified unique gene expression profiles and specifically changed biological processes of the macrophage response to different S. aureus exposure times. PMID: 29849669 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 2, 2018 Category: Biochemistry Authors: Sun A, Zhang H, Pang F, Niu G, Chen J, Chen F, Zhang J Tags: Cell Mol Biol Lett Source Type: research

Platelets activated by the anti- β2GPI/β2GPI complex release microRNAs to inhibit migration and tube formation of human umbilical vein endothelial cells.
Conclusion: Our study suggests that miR-96 and -26a in p-MPs can inhibit HUVEC behavior by targeting SELP and PDGFRA. PMID: 29785186 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 23, 2018 Category: Biochemistry Authors: Zhang Y, Zhang W, Zha C, Liu Y Tags: Cell Mol Biol Lett Source Type: research

Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis.
Abstract Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione. Several stimuli including cells deprived of nutrients or fail...
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Gwangwa MV, Joubert AM, Visagie MH Tags: Cell Mol Biol Lett Source Type: research

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.
Conclusions: Our results identify Mst1 as a malefactor in the development of post-infarction cardiac injury and that it acts through the JNK-Drp1-mitochondrial fission pathway. PMID: 29760744 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Wang X, Song Q Tags: Cell Mol Biol Lett Source Type: research

Diagnostic value of decoy receptor 3 combined with procalcitonin and soluble urokinase-type plasminogen activator receptor for sepsis.
Abstract The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves. In our analysis, ser...
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Zhao JJ, Lou XL, Chen HW, Zhu FT, Hou YQ Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1.
Conclusion: Upregulation of miR-495 ameliorates the high glucose-induced inflammatory, cell differentiation and extracellular matrix accumulation of human CFs by modulating both the NF-κB and TGF-β1/Smad signaling pathways through downregulation of NOD1 expression. These results provide further evidence for the protective effect of miR-495 overexpression in cases of high glucose-induced cardiac fibrosis. PMID: 29760746 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Wang X, Jin H, Jiang S, Xu Y Tags: Cell Mol Biol Lett Source Type: research

Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2.
Conclusion: LBP protects HSF cells against UV damage via the regulation of Nrf2. PMID: 29743894 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 12, 2018 Category: Biochemistry Authors: Liang B, Peng L, Li R, Li H, Mo Z, Dai X, Jiang N, Liu Q, Zhang E, Deng H, Li Z, Zhu H Tags: Cell Mol Biol Lett Source Type: research

Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress.
Conclusion: These results collectively demonstrated that osthole improves collagen-induced arthritis in a rat model and IL-1β-treated SW982 cells through inhibiting inflammation and cellular stress in vivo and in vitro, and osthole might be a promising therapeutic agent for RA. PMID: 29743895 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 12, 2018 Category: Biochemistry Authors: Xu R, Liu Z, Hou J, Huang T, Yang M Tags: Cell Mol Biol Lett Source Type: research

Knockdown of the lncRNA SNHG8 inhibits cell growth in Epstein-Barr virus-associated gastric carcinoma.
Conclusions: These data indicate the pro-oncogenic potential of SNHG8 in EBV-associated GC, meaning it is a latent therapeutic target for the treatment of this type of cancer. PMID: 29736176 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 9, 2018 Category: Biochemistry Authors: Liu J, Yang C, Gu Y, Li C, Zhang H, Zhang W, Wang X, Wu N, Zheng C Tags: Cell Mol Biol Lett Source Type: research

MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1.
Conclusions: miR-17 is a novel regulator of CYP7A1 signaling in hepatic lipid metabolism, suggesting a potential therapeutic approach for fatty liver. PMID: 29721023 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 5, 2018 Category: Biochemistry Authors: Gong R, Lv X, Liu F Tags: Cell Mol Biol Lett Source Type: research

The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro.
Conclusion: Norpurpureine displays a promising in vitro pharmacological profile as an inhibitor of human platelet activation. Its molecular target could be a common effector between Ca2+ and cAMP signaling, such as the PLC-PKC-Ca2+ pathway and PDEs. This needs further evaluation at the protein isoform level. PMID: 29713353 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 3, 2018 Category: Biochemistry Authors: Sánchez G, Estrada O, Acha G, Cardozo A, Peña F, Ruiz MC, Michelangeli F, Alvarado-Castillo C Tags: Cell Mol Biol Lett Source Type: research

Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNF α-induced apoptosis via increased Bnip3-related mitophagy.
Conclusions: After TNFα-induced inflammatory injury, MA-5 affects microglial mitochondrial homeostasis in a manner mediated via the amplification of protective, Bnip3-related mitophagy, which is mediated via the MAPK-ERK-Yap signaling pathway. PMID: 29636771 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 12, 2018 Category: Biochemistry Authors: Lei Q, Tan J, Yi S, Wu N, Wang Y, Wu H Tags: Cell Mol Biol Lett Source Type: research

Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells.
Conclusions: As2O3 can significantly inhibit the growth of glioma cells and it can induce cell apoptosis in a time- and concentration-dependent manner. ROS were found to be responsible for apoptosis in glioma cells induced by As2O3. These results suggest As2O3 is a promising agent for the treatment of glioma. PMID: 29610575 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 5, 2018 Category: Biochemistry Authors: Sun Y, Wang C, Wang L, Dai Z, Yang K Tags: Cell Mol Biol Lett Source Type: research

STAT3, stem cells, cancer stem cells and p63.
Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its ro...
Source: Cellular and Molecular Biology Letters - March 30, 2018 Category: Biochemistry Authors: Galoczova M, Coates P, Vojtesek B Tags: Cell Mol Biol Lett Source Type: research

GSK-3 β-mediated regulation of cadmium-induced cell death and survival.
Conclusions: Our data suggest that Akt/GSK-3β signaling activated by Cd is involved in neuronal cell survival. PMID: 29563926 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 27, 2018 Category: Biochemistry Authors: Kim S, Cheon H, Kim SM, Kim YY Tags: Cell Mol Biol Lett Source Type: research

The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma.
Conclusion: ESE-16 exerts its antiproliferative effects through microtubule disruption, which induces a mitotic block culminating in apoptosis. This research provided information on ESE-16 as a potential antitumor agent and on cellular targets that could aid in the design of prospective microtubule-disrupting compounds. Further in vitro and in vivo investigations of this novel compound are needed. PMID: 29568313 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 27, 2018 Category: Biochemistry Authors: Boyd LS, Gozuacik D, Joubert AM Tags: Cell Mol Biol Lett Source Type: research

Platelet lysate induces chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells.
Conclusions: Our data suggest that MSCs could be differentiated to chondrocytes in the presence of PL and absence of exogenous TGF-β. Further research needs to be conducted to understand the exact role and potential of PL in chondrogenic differentiation and chondrocyte regeneration. PMID: 29568314 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 27, 2018 Category: Biochemistry Authors: Hassan G, Bahjat M, Kasem I, Soukkarieh C, Aljamali M Tags: Cell Mol Biol Lett Source Type: research

C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance.
Conclusion: C-fos increased the expression of P-gp and mdr1 in the HEp-2/VCR cells, and enhanced the efflux function of the cells, thereby contributing to the development of MDR. PMID: 29483928 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 28, 2018 Category: Biochemistry Authors: Li G, Hu X, Sun L, Li X, Li J, Li T, Zhang X Tags: Cell Mol Biol Lett Source Type: research

Downregulation of microRNA-448 inhibits IL-1 β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3.
Conclusion: The findings showed that miR-448 contributed to the progression of osteoarthritis by directly targeting matrilin-3. This indicates that it has potential as a therapeutic target for the treatment of osteoarthritis. PMID: 29483929 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 28, 2018 Category: Biochemistry Authors: Yang H, Wu D, Li H, Chen N, Shang Y Tags: Cell Mol Biol Lett Source Type: research

The altered expression of perineuronal net elements during neural differentiation.
Conclusions: Our results provide preliminary data on the expression of PNN elements during neural differentiation. Further investigations will be performed on the role of these elements in neurological disease models. PMID: 29456557 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 21, 2018 Category: Biochemistry Authors: Eskici NF, Erdem-Ozdamar S, Dayangac-Erden D Tags: Cell Mol Biol Lett Source Type: research

The Wnt7b/ β-catenin signaling pathway is involved in the protective action of calcitonin gene-related peptide on hyperoxia-induced lung injury in premature rats.
Conclusions: CGRP protected against hyperoxia-induced lung injury in premature rats. This process involves the Wnt7b/β-catenin signaling pathway. PMID: 29416550 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 10, 2018 Category: Biochemistry Authors: Wang S, Dang H, Xu F, Deng J, Zheng X Tags: Cell Mol Biol Lett Source Type: research

Effects of calcium Ionophore A23187 on the apoptosis of hepatic stellate cells stimulated by transforming growth factor- β1.
Effects of calcium Ionophore A23187 on the apoptosis of hepatic stellate cells stimulated by transforming growth factor-β1. Cell Mol Biol Lett. 2018;23:1 Authors: Li Y, Yan Y, Liu F, Wang M, Feng F, Xiao Y Abstract Background: Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apoptosis-related genes. No such evidence has been reported in the literature. Here, we investigate the effect of calcium ionophore A23187 on the apoptosis of rat hepatic ...
Source: Cellular and Molecular Biology Letters - January 9, 2018 Category: Biochemistry Authors: Li Y, Yan Y, Liu F, Wang M, Feng F, Xiao Y Tags: Cell Mol Biol Lett Source Type: research

VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer.
Conclusions: VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer. Targeting VEGF and the SEMA4D signaling pathway could be important for the therapy for EOC. PMID: 29308068 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 9, 2018 Category: Biochemistry Authors: Chen Y, Zhang L, Liu WX, Wang K Tags: Cell Mol Biol Lett Source Type: research

Orally administered endoxifen inhibits tumor growth in melanoma-bearing mice.
Abstract Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to be associated with disease progression. However, the therapeutic benefit of endoxifen in melanoma has not yet been evaluated. Here, we present the first demonstration of the anti-melanogenic activity of endoxifen in vitro and in vivo. The in vitro cytotoxic effect of endoxifen was tested using a cell viability assay. The in vivo anti-melanogenic activity was evaluated in B16F10 cell-bearing C57BL/6 ...
Source: Cellular and Molecular Biology Letters - January 9, 2018 Category: Biochemistry Authors: Chen P, Sheikh S, Ahmad A, Ali SM, Ahmad MU, Ahmad I Tags: Cell Mol Biol Lett Source Type: research