MiR-200c downregulates HIF-1 α and inhibits migration of lung cancer cells.
Conclusion: miR-200c negatively affects hypoxia-induced responses by downregulating HIF-1α, a key regulator of hypoxia. Therefore, overexpression of miR-200c might have therapeutic potential as an anticancer agent that inhibits tumor hypoxia. PMID: 31061665 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 9, 2019 Category: Biochemistry Authors: Byun Y, Choi YC, Jeong Y, Lee G, Yoon S, Jeong Y, Yoon J, Baek K Tags: Cell Mol Biol Lett Source Type: research

MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1.
Conclusions: MiR-613 can inhibit proliferation and invasion and induce apoptosis of RASFs by directly targeting DKK1 expression. PMID: 31019537 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 27, 2019 Category: Biochemistry Authors: Liu L, Zuo Y, Xu Y, Zhang Z, Li Y, Pang J Tags: Cell Mol Biol Lett Source Type: research

Upregulation of miR-29b-3p protects cardiomyocytes from hypoxia-induced apoptosis by targeting TRAF5.
Conclusion: These findings suggest that upregulation of miR-29b-3p could protect cardiomyocytes against hypoxia-induced injury through downregulation of TRAF5. Targeting TRAF5 with miR-29b-3p might be a potential therapeutic method for AMI. PMID: 31011336 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 25, 2019 Category: Biochemistry Authors: Cai Y, Li Y Tags: Cell Mol Biol Lett Source Type: research

Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells.
This study aims to employ a culture system using allogenic limbal niche cells (LNCs) instead of mouse-derived 3T3 cells as a feeder layer that could relieve postoperative neovascularization. Methods: Rat oral mucosal epithelial cells (OMECs) were co-cultured with rat LNCs or 3T3 cells. Cultivated oral mucosal epithelial cells (COMECs) of different culture systems were identified by hematoxylin and eosin staining and immunocytochemistry. The expression levels of the angiogenesis-related factors were analyzed by RT-qPCR and western blotting/ELISA. Angiogenic potential was reconfirmed by cell viability and tube formation...
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Duan CY, Xie HT, Zhao XY, Xu WH, Zhang MC Tags: Cell Mol Biol Lett Source Type: research

Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p.
Conclusion: circDENND2A is required for the hypoxia-induced malignancy of glioma cells and functions by sponging miR-625-5p. PMID: 30988674 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Su H, Zou D, Sun Y, Dai Y Tags: Cell Mol Biol Lett Source Type: research

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro.
Conclusion: Our results show that miR-431-5p is critical for pulmonary surfactant expression and that its regulation is closely related to the TGF-β/Smad4 pathway. These results will help us to study the pathophysiological mechanism of lung developmental diseases. PMID: 30988675 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Li S, Sun Z, Chen T, Pan J, Shen Y, Chen X, Zhou X, Cheng R, Yang Y Tags: Cell Mol Biol Lett Source Type: research

The lncRNA MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation by upregulating miRNA-487a.
Conclusion: MIR4435-2HG is upregulated in HCC and promotes cancer cell proliferation possibly by upregulating miRNA-487a. PMID: 30988676 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 17, 2019 Category: Biochemistry Authors: Kong Q, Liang C, Jin Y, Pan Y, Tong D, Kong Q, Zhou J Tags: Cell Mol Biol Lett Source Type: research

MiR-125a-5p promotes osteoclastogenesis by targeting TNFRSF1B.
Conclusions: In conclusion, overexpression of miR-125a-5p suppresses the expression of TNFRSF1B and promotes osteoclast differentiation. These results reveal the crucial role of miR-125a-5p in the differentiation of osteoclasts. PMID: 30976285 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 13, 2019 Category: Biochemistry Authors: Sun L, Lian JX, Meng S Tags: Cell Mol Biol Lett Source Type: research

Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells.
Conclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed. PMID: 30949212 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 7, 2019 Category: Biochemistry Authors: Meyenberg Cunha-de Padua M, Noleto GR, de Oliveira Petkowicz CL, Cadena SMSC, Bost F, Pouysségur J, Mazure NM Tags: Cell Mol Biol Lett Source Type: research

miR-573 regulates cell proliferation and apoptosis by targeting Bax in nucleus pulposus cells.
Conclusion: These results suggest that overexpression of miR-573 inhibited NP cell apoptosis by down-regulating Bax, which proved to be a novel effective strategy for IDD therapies. PMID: 30936926 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 3, 2019 Category: Biochemistry Authors: Wang R, Wen B, Sun D Tags: Cell Mol Biol Lett Source Type: research

The  Pro12Ala polymorphism in the PPAR-γ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus.
Conclusion: This study suggests that Pro12Ala polymorphism of the PPAR-γ2 gene cannot be considered as a risk factor for NAFLD in the Iranian population. PMID: 30923554 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 31, 2019 Category: Biochemistry Authors: Saremi L, Lotfipanah S, Mohammadi M, Hosseinzadeh H, Fathi-Kazerooni M, Johari B, Saltanatpour Z Tags: Cell Mol Biol Lett Source Type: research

miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes.
Conclusions: In osteocytes (but not osteoblasts), miR-29b-3p was responsive to the mechanical tensile strain and regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically strained osteocytes. PMID: 30915127 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 28, 2019 Category: Biochemistry Authors: Zeng Q, Wang Y, Gao J, Yan Z, Li Z, Zou X, Li Y, Wang J, Guo Y Tags: Cell Mol Biol Lett Source Type: research

Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
In this study, immunolocalization assay showed that MT1 and MT2 are highly expressed in Leydig cell membrane. To understand the biological function of melatonin receptors in hCG-induced testosterone synthesis, we generated melatonin receptor knockdown cells using specific siRNA and performed testosterone detection after hCG treatment. We found that knockdown of melatonin receptors, especially MTNR1A, led to an obvious decrease (> 60%) of testosterone level. Our further study revealed that knockdown of melatonin receptors repressed expression, at both the mRNA level and the protein level, of key steroidogenic gene...
Source: Cellular and Molecular Biology Letters - March 28, 2019 Category: Biochemistry Authors: Gao Y, Wu X, Zhao S, Zhang Y, Ma H, Yang Z, Yang W, Zhao C, Wang L, Zhang Q Tags: Cell Mol Biol Lett Source Type: research

MiR-214 sensitizes human colon cancer cells to 5-FU by targeting Hsp27.
In conclusion, miR-214 sensitizes colon cancer cells to 5-FU by targeting Hsp27, indicating a significant role for this miRNA in colon cancer chemotherapy. PMID: 30915129 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 28, 2019 Category: Biochemistry Authors: Yang Y, Bao Y, Yang GK, Wan J, Du LJ, Ma ZH Tags: Cell Mol Biol Lett Source Type: research

Suppressing microRNA-29c promotes biliary atresia-related fibrosis by targeting DNMT3A and DNMT3B.
This study was designed to investigate the potential role of microRNA-29c (miR-29c) in biliary atresia-related fibrosis. The expression of miR-29c was determined in 15 pairs of peripheral blood samples from infants with biliary atresia (BA) and infants with non-BA neonatal cholestasis using quantitative real-time PCR. EMT was established by induction with TGF-β1 in HIBEpiC cells. MiR-29c was inhibited by lipofectamine transfection. The expressions of proteins related to epithelial-mesenchymal transition (EMT), i.e., E-cadherin, N-cadherin and vimentin, were determined using quantitative real-time PCR and western blott...
Source: Cellular and Molecular Biology Letters - March 26, 2019 Category: Biochemistry Authors: Wang JY, Cheng H, Zhang HY, Ye YQ, Feng Q, Chen ZM, Zheng YL, Wu ZG, Wang B, Yao J Tags: Cell Mol Biol Lett Source Type: research

Inhibition of miR-9-5p suppresses prostate cancer progress by targeting StarD13.
Conclusion: Our results show that miR-9-5p plays a powerful role in the growth, invasion, migration and epithelial-mesenchymal transition (EMT) of prostate cancer cells by regulating StarD13. A therapeutic agent inhibiting miR-9-5p could act as a tumor suppressor for prostate cancer. PMID: 30899277 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 24, 2019 Category: Biochemistry Authors: Chen L, Hu W, Li G, Guo Y, Wan Z, Yu J Tags: Cell Mol Biol Lett Source Type: research

miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN.
This study investigated the expression of miRNA-221 in CSCC and its potential tumor biological functions. Methods: MTT assay, colony assay, PCR, and Western blot were adopted. Results: In this study, miRNA-221 expression was significantly higher in CSCC tissues and cell lines than in normal tissues and cells (P 
Source: Cellular and Molecular Biology Letters - March 21, 2019 Category: Biochemistry Authors: Gong ZH, Zhou F, Shi C, Xiang T, Zhou CK, Wang QQ, Jiang YS, Gao SF Tags: Cell Mol Biol Lett Source Type: research

Downregulation of CDKL1 suppresses neuroblastoma cell proliferation, migration and invasion.
Conclusions: Our findings suggest that CDKL1 plays an important role in NB cell proliferation, migration and invasion. It might serve as a potential target for NB therapy. PMID: 30891073 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 21, 2019 Category: Biochemistry Authors: Li W, Cao J, Liu J, Chu W, Zhang C, Chen S, Kang Z Tags: Cell Mol Biol Lett Source Type: research

MiR-106a directly targets LIMK1 to inhibit proliferation and EMT of oral carcinoma cells.
Conclusion: MiR-106a inhibited the cell proliferation and EMT of OSCC cells by directly decreasing LIMK1 expression. PMID: 30873211 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 17, 2019 Category: Biochemistry Authors: Shi B, Ma C, Liu G, Guo Y Tags: Cell Mol Biol Lett Source Type: research

Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system.
Conclusions: In summary, microgravity significantly promoted chondrogenic differentiation of BMSCs induced by IHH and SHH and attenuated chondrogenic hypertrophy and aging during chondrogenesis. Furthermore, exogenous IHH and SHH had the same effect on chondrogenic differentiation of BMSCs in the RCCS environment. This study provides further evidence of chondrogenic induction of BMSCs in vitro via IHH and SHH gene delivery. PMID: 30858866 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 14, 2019 Category: Biochemistry Authors: Chen L, Liu G, Li W, Wu X Tags: Cell Mol Biol Lett Source Type: research

Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3 β signaling pathway.
Conclusions: Tetramethylpyrazine protected against injury due to AMI by regulating the PI3K/Akt /GSK-3β signaling pathway. PMID: 30858867 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 14, 2019 Category: Biochemistry Authors: Yang Q, Huang DD, Li DG, Chen B, Zhang LM, Yuan CL, Huang HH Tags: Cell Mol Biol Lett Source Type: research

Reliable reference genes for expression analysis of proliferating and adipogenically differentiating human adipose stromal cells.
Conclusions: Applying these findings for future gene expression analyses will help elucidate ASC biology. PMID: 30815013 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 4, 2019 Category: Biochemistry Authors: Krautgasser C, Mandl M, Hatzmann FM, Waldegger P, Mattesich M, Zwerschke W Tags: Cell Mol Biol Lett Source Type: research

Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling.
Conclusion: TSG targeted to miR-129-3p/Smad3 signaling inhibited PA-induced inflammation and apoptosis in cardiomyocytes. PMID: 30820195 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 4, 2019 Category: Biochemistry Authors: Zou Y, Kong M Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma by down-regulation of aquaporin 5.
Conclusions: Our findings clearly demonstrated that introduction of miR-325-3p inhibited proliferation and induced apoptosis of Huh7-1.3 and HepG2.2.15 cells by directly decreasing AQP5 expression, and that silencing AQP5 expression was essential for the pro-apoptotic effect of miR-325-3p overexpression on Huh7-1.3 and HepG2.2.15 cells. It is beneficial to gain insight into the mechanism of HBV infection and pathophysiology of HBV-related HCC. PMID: 30805015 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 27, 2019 Category: Biochemistry Authors: Zhang Z, Han Y, Sun G, Liu X, Jia X, Yu X Tags: Cell Mol Biol Lett Source Type: research

MiR-219-5p suppresses cell proliferation and cell cycle progression in esophageal squamous cell carcinoma by targeting CCNA2.
Conclusions: Our results demonstrate that miR-219-5p might function as a tumor suppressor by directly targeting CCNA2 expression. It could serve as a new therapeutic target for ESCC. PMID: 30766610 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 17, 2019 Category: Biochemistry Authors: Ma Q Tags: Cell Mol Biol Lett Source Type: research

siRNA against TSG101 reduces proliferation and induces G0/G1 arrest in renal cell carcinoma - involvement of c-myc, cyclin E1, and CDK2.
Conclusions: TSG101 promotes proliferation of RCC cells. This positive effect on tumor growth involves activation of c-myc and cyclin E1/CDK2 and their effect on cell cycle distribution. PMID: 30675171 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 26, 2019 Category: Biochemistry Authors: Xu C, Zheng J Tags: Cell Mol Biol Lett Source Type: research

Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study.
Abstract Objective: To investigate the anti-tumor effects and the mechanism of the compound 13-chlorine-3, 15-dioxy-gibberellic acid methyl ester (GA-13315) in lung adenocarcinoma in vitro and in vivo. Methods: The antiproliferative effect of GA-13313 on the A549 cell line was determined by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide) assay. A xenograft model of A549 was established to evaluate the anti-tumor effect and histopathological examination was performed to assess the toxicity of GA-13315. Apoptosis was detected by TUNEL staining in tissues and flow cytometry in cells; activa...
Source: Cellular and Molecular Biology Letters - January 19, 2019 Category: Biochemistry Authors: Xie L, Chen Y, Chen J, Zhang H, Liao Y, Zhou Y, Zhou L, Qing C Tags: Cell Mol Biol Lett Source Type: research

3D visualization of extracellular vesicle uptake by endothelial cells.
Conclusion: The perinuclear localization of the internalized EVs shows their biological stability after their uptake to the endothelial cells. The 3D visualization allows the determination of a more accurate location of EVs relative to the donor cell nucleus. PMID: 30574165 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 25, 2018 Category: Biochemistry Authors: Durak-Kozica M, Baster Z, Kubat K, Stępień E Tags: Cell Mol Biol Lett Source Type: research

The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice.
Conclusion: Co-inhibiting the expressions of PD-1 and CTLA-4 can effectively suppress the growth of H22 hepatoma and promote the apoptosis of tumor cells in mice. Blocking PD-1 and CTLA-4 can improve the vitality of T cells, and improve the immune environment and response. PMID: 30564277 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 20, 2018 Category: Biochemistry Authors: Liang L, Ge K, Zhang F, Ge Y Tags: Cell Mol Biol Lett Source Type: research

Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells.
This study aimed to identify genes associated with MDR development that predict tumor response to chemotherapy in NSCLC. In the present study, a multidrug-resistant NSCLC cell sub-line, A549/MDR, was established from the A549/DDP cell line and characterized. The resistance index (RI) of this subline was calculated according to the IC50 of A549/MDR relative to the parental A549/DDP cells. The gene expression profiles of A549/DDP and A549/MDR were obtained using an oligonucleotide microarray (Agilent SureHyb microarray chip). The microarray results were validated by qRT-PCR and selected genes were analyzed by in vitro loss-o...
Source: Cellular and Molecular Biology Letters - December 7, 2018 Category: Biochemistry Authors: Huang H, Li T, Chen M, Liu F, Wu H, Wang J, Chen J, Li X Tags: Cell Mol Biol Lett Source Type: research

The diagnostic value and pathogenetic role of lncRNA-ATB in patients with osteoarthritis.
Conclusion: We conclude that downregulation of lncRNA-ATB in serum is a reliable diagnostic marker for osteoarthritis and that this lncRNA participates in the pathogenesis of osteoarthritis by regulating the proliferation and viability of chondrocytes through the activation of Akt signaling. PMID: 30505322 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 7, 2018 Category: Biochemistry Authors: Dang X, Lian L, Wu D Tags: Cell Mol Biol Lett Source Type: research

Latent viruses can cause disease by disrupting the competition for the limiting factor p300/CBP.
Abstract CBP and p300 are histone acetyltransferase coactivators that control the transcription of numerous genes in humans, viruses, and other organisms. Although two separate genes encode CBP and p300, they share a 61% sequence identity, and they are often mentioned together as p300/CBP. Zhou et al. showed that under hypoxic conditions, HIF1α and the tumor suppressor p53 compete for binding to the limiting p300/CBP coactivator. Jethanandani & Kramer showed that δEF1 and MYOD genes compete for the limited amount of p300/CBP in the cell. Bhattacharyya et al. showed that the limiting availability of...
Source: Cellular and Molecular Biology Letters - December 7, 2018 Category: Biochemistry Authors: Polansky H, Schwab H Tags: Cell Mol Biol Lett Source Type: research

Systematic analysis of genes involved in oral cancer metastasis to lymph nodes.
This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEG...
Source: Cellular and Molecular Biology Letters - November 23, 2018 Category: Biochemistry Authors: Zhang X, Zhang L, Tan X, Lin Y, Han X, Wang H, Ming H, Li Q, Liu K, Feng G Tags: Cell Mol Biol Lett Source Type: research

Elevated IL-33 promotes expression of MMP2 and MMP9 via activating STAT3 in alveolar macrophages during LPS-induced acute lung injury.
Conclusion: The IL-33/STAT3/MMP2/9 regulatory pathway is activated in alveolar macrophages during acute lung injury, which may exacerbate the pulmonary inflammation. PMID: 30410547 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 10, 2018 Category: Biochemistry Authors: Liang Y, Yang N, Pan G, Jin B, Wang S, Ji W Tags: Cell Mol Biol Lett Source Type: research

An integrated approach of bioinformatic prediction and in vitro analysis identified that miR-34a targets MET and AXL in triple-negative breast cancer.
Conclusions: These findings may indicate that miR-34a is an oncogenic miRNA, downregulated in the distinct breast cancer subtypes. It also targets MET and AXL 3'-UTRs in triple-negative breast cancer. Therefore, it can be considered as a therapeutic target in this type of breast cancer. PMID: 30386383 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 3, 2018 Category: Biochemistry Authors: Hajalirezay Yazdi S, Paryan M, Mohammadi-Yeganeh S Tags: Cell Mol Biol Lett Source Type: research

Microcystin-LR regulates circadian clock and antioxidant gene expression in cultured rat cardiomyocytes.
Conclusions: Our results indicate an influence of MC-LR on the circadian clock system and clock-controlled antioxidant genes, which will shed some light on the explanation of heart toxicity induced by MC-LR from the viewpoint of chronobiology. PMID: 30337942 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 20, 2018 Category: Biochemistry Authors: Xu Y, Wang X, Jiang S, Men C, Xu D, Guo Y, Wu J Tags: Cell Mol Biol Lett Source Type: research

Angiogenesis after administration of basic fibroblast growth factor induces proliferation and differentiation of mesenchymal stem cells in elastic perichondrium in an in vivo model: mini review of three sequential republication-abridged reports.
Abstract To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown. We have attempted to apply cell and tissue engineering methodology for ear reconstruction using cultured chondrocytes. We hypothesized that by inducing angiogenesis with basic fibroblast growth factor (bFGF), MSCs or cartilage precursor cells would proliferate and differentiate into cartilage in vivo and that the regenerated cartilage would maintain its morphology over an extended period. As a resu...
Source: Cellular and Molecular Biology Letters - October 17, 2018 Category: Biochemistry Authors: Miyanaga T, Ueda Y, Miyanaga A, Yagishita M, Hama N Tags: Cell Mol Biol Lett Source Type: research

Experimental research into the potential therapeutic effect of GYY4137 on Ovariectomy-induced osteoporosis.
Abstract Background: Evidence has shown that endogenous H2S plays an important role in the physiological and pathophysiological processes of many organs. The study aimed to explore whether exogenous H2S has a potential therapeutic effect on a rat ovariectomy-induced model of osteoporosis. Methods: The OVX osteoporosis model was established in female Sprague-Dawley rats by full bilateral ovariectomy. The rats were randomly divided into four groups, with the two experimental groups receiving an intraperitoneal injection of GYY4137 or sodium alendronate. The level of H2S in the plasma was determined and common l...
Source: Cellular and Molecular Biology Letters - October 13, 2018 Category: Biochemistry Authors: Xu ZS, Dai F, Chen J, Lv M, Cheng JW, Zhang XM, Lin BW Tags: Cell Mol Biol Lett Source Type: research

Hypoxic stabilization of mRNA is HIF-independent but requires mtROS.
Conclusion: Overall these data suggest that hypoxic mRNA stabilization is independent of HIF transcriptional activity but requires mtROS. PMID: 30305827 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 13, 2018 Category: Biochemistry Authors: Fortenbery GW, Sarathy B, Carraway KR, Mansfield KD Tags: Cell Mol Biol Lett Source Type: research

Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1 α-IL-8-Akt axis.
Conclusion: Hypoxia promotes HCC cell migration and invasion through the HIF-1α-IL-8-Akt axis. PMID: 30258464 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 29, 2018 Category: Biochemistry Authors: Fei M, Guan J, Xue T, Qin L, Tang C, Cui G, Wang Y, Gong H, Feng W Tags: Cell Mol Biol Lett Source Type: research

Editorial focus: entering into the non-coding RNA era.
Abstract Recent developments in high-throughput genotyping technologies have revealed the existence of several new classes of RNA that do not encode proteins but serve other cellular roles. To date, these non-coding RNAs (ncRNAs) have been shown to modulate both gene expression and genome remodeling, thus contributing to the control of both normal and disease-related cellular processes. The attraction of this research topic can be seen in the increasing number of submissions on ncRNAs to molecular biology journals, including Cellular Molecular Biology Letters (CMBL). As researchers attempt to deepen the understand...
Source: Cellular and Molecular Biology Letters - September 27, 2018 Category: Biochemistry Authors: Bartoszewski R, Sikorski AF Tags: Cell Mol Biol Lett Source Type: research

Systematic identification of the key candidate genes in breast cancer stroma.
Conclusions: We found that several conserved tumor stromal genes might regulate breast cancer invasion through ECM remodeling. The clinical outcome analyses of COL1A1 and FN1 suggest these two genes are promising targets for future studies. PMID: 30237810 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 23, 2018 Category: Biochemistry Authors: Wang Y, Xu H, Zhu B, Qiu Z, Lin Z Tags: Cell Mol Biol Lett Source Type: research

WNT and NOTCH signaling pathways as activators for epidermal growth factor receptor in esophageal squamous cell carcinoma.
Conclusion: This study confirms a direct correlation between MSI1 and EGFR and may support the important role of MSI1 in activation of EGFR through NOTCH/WNT pathways in ESCC. PMID: 30202417 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 13, 2018 Category: Biochemistry Authors: Abbaszadegan MR, Riahi A, Forghanifard MM, Moghbeli M Tags: Cell Mol Biol Lett Source Type: research

Lnc-DC regulates cellular turnover and the HBV-induced immune response by TLR9/STAT3 signaling in dendritic cells.
Conclusion: Lnc-DC is important in regulating the growth, apoptosis, and immune response of dendritic cells mediated by TLR9/STAT3 signaling, and was also activated by HBV. This study provides a previously unidentified mechanism underlying the immune response in dendritic cells. PMID: 30202418 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 13, 2018 Category: Biochemistry Authors: Zhuang L, Tian J, Zhang X, Wang H, Huang C Tags: Cell Mol Biol Lett Source Type: research

MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Conclusions: miR-320 plays an important role in regulating cardiomyocyte apoptosis induced by I/R injury by targeting AKIP1 and inducing the mitochondrial apoptotic pathway. PMID: 30181740 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 7, 2018 Category: Biochemistry Authors: Tian ZQ, Jiang H, Lu ZB Tags: Cell Mol Biol Lett Source Type: research

Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats.
Conclusions: Our data suggest that Cxs may be involved in the regulation of T-lymphocyte homeostasis and the production of cytokines. A clear association was found between alterations in Cxs expression or in Cx43-based GJIC and hypertension-mediated inflammation. PMID: 30151015 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 30, 2018 Category: Biochemistry Authors: Ni X, Li XZ, Fan ZR, Wang A, Zhang HC, Zhang L, Li L, Si JQ, Ma KT Tags: Cell Mol Biol Lett Source Type: research

Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice.
Conclusion: Our study demonstrates for the first time that diacerein improves renal function efficiently in endotoxemic AKI mice by suppressing inflammation and altering tubular water and sodium handing. These results suggest that diacerein may be a novel therapeutic agent for the treatment of endotoxemic AKI. PMID: 30140293 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 25, 2018 Category: Biochemistry Authors: Yu G, Liu Q, Dong X, Tang K, Li B, Liu C, Zhang W, Wang Y, Jin Y Tags: Cell Mol Biol Lett Source Type: research

Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element.
Conclusion: Our results indicate that Oct4 is involved in DNA methylation through the regulation of Dnmt1 transcription, especially during the early stages of mouse pre-implantation embryo development. PMID: 30140294 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 25, 2018 Category: Biochemistry Authors: Wu F, Wu Q, Li D, Zhang Y, Wang R, Liu Y, Li W Tags: Cell Mol Biol Lett Source Type: research

Loureirin B inhibits the proliferation of hepatic stellate cells and the Wnt/ β-catenin signaling pathway by regulating miR-148-3p.
Conclusion: Our results suggest that loureirin B inhibited the proliferation and promoted the apoptosis of HSCs, and suppressed the Wnt/β-catenin signaling pathway via regulation of miR-148-3p. PMID: 30123297 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 21, 2018 Category: Biochemistry Authors: Hu JP, Zhang R, Tang M, Li YL, Xun LT, Shi ZZ, An Y, Li T, Song ZJ Tags: Cell Mol Biol Lett Source Type: research

The notch pathway promotes NF- κB activation through Asb2 in T cell acute lymphoblastic leukemia cells.
Conclusion: Notch1 modulates the NF-κB pathway through Asb2α, indicating that Asb2α inhibition is a promising option for targeted therapy against T-ALL. PMID: 30116272 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 18, 2018 Category: Biochemistry Authors: Wu W, Nie L, Zhang L, Li Y Tags: Cell Mol Biol Lett Source Type: research