LAMP3 plays an oncogenic role in osteosarcoma cells partially by inhibiting TP53.
Conclusions: Our findings suggest that LAMP3 promotes OS cell viability and survival by regulating TP53 expression. PMID: 30008754 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 18, 2018 Category: Biochemistry Authors: Liu S, Yue J, Du W, Han J, Zhang W Tags: Cell Mol Biol Lett Source Type: research

DSPP-MMP20 gene silencing downregulates cancer stem cell markers in human oral cancer cells.
Conclusions: We conclude that the downregulation of OCSC markers may signal a reduction in OCSC population following MMP20/DSPP silencing in OSCC cells, while also increasing their sensitivity to cisplatin. Thus, our findings suggest a potential role for DSPP and MMP20 in sustaining OCSC population in OSCCs, possibly, through mechanism(s) that alter OCSC sensitivity to treatment with chemotherapeutic agents such as cisplatin. PMID: 30002682 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 15, 2018 Category: Biochemistry Authors: Nikitakis NG, Gkouveris I, Aseervatham J, Barahona K, Ogbureke KUE Tags: Cell Mol Biol Lett Source Type: research

Laminopathies: what can humans learn from fruit flies.
Abstract Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins provide a skeletal network for chromatin, the nuclear envelope, nuclear pore complexes and the entire nucleus. They are also responsible for proper connections between the karyoskeleton and structural elements in the cytoplasm: actin and the microtubule and cytoplasmic IF networks. Lamins affect transcription and splicing either directly or indirectly. Translocation of active genes into the close pro...
Source: Cellular and Molecular Biology Letters - July 15, 2018 Category: Biochemistry Authors: Pałka M, Tomczak A, Grabowska K, Machowska M, Piekarowicz K, Rzepecka D, Rzepecki R Tags: Cell Mol Biol Lett Source Type: research

ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/ β-catenin signaling pathway.
Conclusion: This study demonstrates that blocking ClC-2-mediated Cl- efflux inhibits AngII-induced cerebrovascular smooth muscle cell proliferation and migration by inhibiting the Wnt/β-catenin pathway. Our data indicate that downregulation of ClC-2 may be a viable strategy in the prevention of hyperplasia and remodeling of cerebrovascular smooth muscle cells. PMID: 29988306 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 12, 2018 Category: Biochemistry Authors: Lu J, Xu F, Zhang Y, Lu H, Zhang J Tags: Cell Mol Biol Lett Source Type: research

Genetic variation and relationships in the mitochondrial DNA D-loop region of Qinghai indigenous and commercial pig breeds.
This study revealed Bamei pigs' genetic diversity at the molecular level and the degree of introgression of commercial breeds into Bamei pigs. Methods: The mitochondrial DNA D-loop region was amplified and sequenced using the ABI 3130 DNA sequencer. Sequences were collected, edited and aligned using the MEGA 5.0, DNASTAR and ClustalX 1.81 software. Haplotypes of all sequences and genetic diversity were analyzed by DnaSP 5.0 software. Results and conclusions: We identified a total of 73 polymorphic sites in our 489 novel sequences, including 1 single variable site and 72 parsimony informative sites.Genetic diversi...
Source: Cellular and Molecular Biology Letters - July 12, 2018 Category: Biochemistry Authors: Zhang J, Yang B, Wen X, Sun G Tags: Cell Mol Biol Lett Source Type: research

Measuring the lactate-to-creatine ratio via 1H NMR spectroscopy can be used to noninvasively evaluate apoptosis in glioma cells after X-ray irradiation.
In this study, we evaluated the relationships between the Lac/Cr ratio, apoptotic rate, and protein kinase C iota (PKC-ι) expression in glioma cells. Methods: Cells of the glioma cell lines C6 and U251 were randomly divided into 4 groups, with every group exposed to X-ray irradiation at 0, 1, 5, 10 and 15 Gy. Single cell gel electrophoresis (SCGE) was conducted to evaluate the DNA damage. Flow cytometry was performed to measure the cell cycle blockage and apoptotic rates. Western blot analysis was used to detect the phosphorylated PKC-ι (p-PKC-ι) level. 1H NMR spectroscopy was employed to determine...
Source: Cellular and Molecular Biology Letters - June 29, 2018 Category: Biochemistry Authors: Li H, Cui Y, Li F, Shi W, Gao W, Wang X, Zeng Q Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3.
Conclusion: miR-488 inhibited cell invasion and EMT of TSCC cells by directly downregulating ATF3 expression. PMID: 29946339 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 29, 2018 Category: Biochemistry Authors: Shi B, Yan W, Liu G, Guo Y Tags: Cell Mol Biol Lett Source Type: research

HIF-1 α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8-NF-κB axis.
Conclusions: HIF-1α promotes HCC cell migration and invasion by modulating IL-8 via the NF-κB pathway. PMID: 29881400 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 9, 2018 Category: Biochemistry Authors: Feng W, Xue T, Huang S, Shi Q, Tang C, Cui G, Yang G, Gong H, Guo H Tags: Cell Mol Biol Lett Source Type: research

Essential genes of the macrophage response to Staphylococcus aureus exposure.
Conclusions: Our systematic analysis identified unique gene expression profiles and specifically changed biological processes of the macrophage response to different S. aureus exposure times. PMID: 29849669 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 2, 2018 Category: Biochemistry Authors: Sun A, Zhang H, Pang F, Niu G, Chen J, Chen F, Zhang J Tags: Cell Mol Biol Lett Source Type: research

Platelets activated by the anti- β2GPI/β2GPI complex release microRNAs to inhibit migration and tube formation of human umbilical vein endothelial cells.
Conclusion: Our study suggests that miR-96 and -26a in p-MPs can inhibit HUVEC behavior by targeting SELP and PDGFRA. PMID: 29785186 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 23, 2018 Category: Biochemistry Authors: Zhang Y, Zhang W, Zha C, Liu Y Tags: Cell Mol Biol Lett Source Type: research

Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis.
Abstract Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione. Several stimuli including cells deprived of nutrients or fail...
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Gwangwa MV, Joubert AM, Visagie MH Tags: Cell Mol Biol Lett Source Type: research

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.
Conclusions: Our results identify Mst1 as a malefactor in the development of post-infarction cardiac injury and that it acts through the JNK-Drp1-mitochondrial fission pathway. PMID: 29760744 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Wang X, Song Q Tags: Cell Mol Biol Lett Source Type: research

Diagnostic value of decoy receptor 3 combined with procalcitonin and soluble urokinase-type plasminogen activator receptor for sepsis.
Abstract The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves. In our analysis, ser...
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Zhao JJ, Lou XL, Chen HW, Zhu FT, Hou YQ Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1.
Conclusion: Upregulation of miR-495 ameliorates the high glucose-induced inflammatory, cell differentiation and extracellular matrix accumulation of human CFs by modulating both the NF-κB and TGF-β1/Smad signaling pathways through downregulation of NOD1 expression. These results provide further evidence for the protective effect of miR-495 overexpression in cases of high glucose-induced cardiac fibrosis. PMID: 29760746 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 16, 2018 Category: Biochemistry Authors: Wang X, Jin H, Jiang S, Xu Y Tags: Cell Mol Biol Lett Source Type: research

Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2.
Conclusion: LBP protects HSF cells against UV damage via the regulation of Nrf2. PMID: 29743894 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 12, 2018 Category: Biochemistry Authors: Liang B, Peng L, Li R, Li H, Mo Z, Dai X, Jiang N, Liu Q, Zhang E, Deng H, Li Z, Zhu H Tags: Cell Mol Biol Lett Source Type: research

Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress.
Conclusion: These results collectively demonstrated that osthole improves collagen-induced arthritis in a rat model and IL-1β-treated SW982 cells through inhibiting inflammation and cellular stress in vivo and in vitro, and osthole might be a promising therapeutic agent for RA. PMID: 29743895 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 12, 2018 Category: Biochemistry Authors: Xu R, Liu Z, Hou J, Huang T, Yang M Tags: Cell Mol Biol Lett Source Type: research

Knockdown of the lncRNA SNHG8 inhibits cell growth in Epstein-Barr virus-associated gastric carcinoma.
Conclusions: These data indicate the pro-oncogenic potential of SNHG8 in EBV-associated GC, meaning it is a latent therapeutic target for the treatment of this type of cancer. PMID: 29736176 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 9, 2018 Category: Biochemistry Authors: Liu J, Yang C, Gu Y, Li C, Zhang H, Zhang W, Wang X, Wu N, Zheng C Tags: Cell Mol Biol Lett Source Type: research

MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1.
Conclusions: miR-17 is a novel regulator of CYP7A1 signaling in hepatic lipid metabolism, suggesting a potential therapeutic approach for fatty liver. PMID: 29721023 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 5, 2018 Category: Biochemistry Authors: Gong R, Lv X, Liu F Tags: Cell Mol Biol Lett Source Type: research

The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro.
Conclusion: Norpurpureine displays a promising in vitro pharmacological profile as an inhibitor of human platelet activation. Its molecular target could be a common effector between Ca2+ and cAMP signaling, such as the PLC-PKC-Ca2+ pathway and PDEs. This needs further evaluation at the protein isoform level. PMID: 29713353 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 3, 2018 Category: Biochemistry Authors: Sánchez G, Estrada O, Acha G, Cardozo A, Peña F, Ruiz MC, Michelangeli F, Alvarado-Castillo C Tags: Cell Mol Biol Lett Source Type: research

Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNF α-induced apoptosis via increased Bnip3-related mitophagy.
Conclusions: After TNFα-induced inflammatory injury, MA-5 affects microglial mitochondrial homeostasis in a manner mediated via the amplification of protective, Bnip3-related mitophagy, which is mediated via the MAPK-ERK-Yap signaling pathway. PMID: 29636771 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 12, 2018 Category: Biochemistry Authors: Lei Q, Tan J, Yi S, Wu N, Wang Y, Wu H Tags: Cell Mol Biol Lett Source Type: research

Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells.
Conclusions: As2O3 can significantly inhibit the growth of glioma cells and it can induce cell apoptosis in a time- and concentration-dependent manner. ROS were found to be responsible for apoptosis in glioma cells induced by As2O3. These results suggest As2O3 is a promising agent for the treatment of glioma. PMID: 29610575 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 5, 2018 Category: Biochemistry Authors: Sun Y, Wang C, Wang L, Dai Z, Yang K Tags: Cell Mol Biol Lett Source Type: research

STAT3, stem cells, cancer stem cells and p63.
Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its ro...
Source: Cellular and Molecular Biology Letters - March 30, 2018 Category: Biochemistry Authors: Galoczova M, Coates P, Vojtesek B Tags: Cell Mol Biol Lett Source Type: research

GSK-3 β-mediated regulation of cadmium-induced cell death and survival.
Conclusions: Our data suggest that Akt/GSK-3β signaling activated by Cd is involved in neuronal cell survival. PMID: 29563926 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 27, 2018 Category: Biochemistry Authors: Kim S, Cheon H, Kim SM, Kim YY Tags: Cell Mol Biol Lett Source Type: research

The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma.
Conclusion: ESE-16 exerts its antiproliferative effects through microtubule disruption, which induces a mitotic block culminating in apoptosis. This research provided information on ESE-16 as a potential antitumor agent and on cellular targets that could aid in the design of prospective microtubule-disrupting compounds. Further in vitro and in vivo investigations of this novel compound are needed. PMID: 29568313 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 27, 2018 Category: Biochemistry Authors: Boyd LS, Gozuacik D, Joubert AM Tags: Cell Mol Biol Lett Source Type: research

Platelet lysate induces chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells.
Conclusions: Our data suggest that MSCs could be differentiated to chondrocytes in the presence of PL and absence of exogenous TGF-β. Further research needs to be conducted to understand the exact role and potential of PL in chondrogenic differentiation and chondrocyte regeneration. PMID: 29568314 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 27, 2018 Category: Biochemistry Authors: Hassan G, Bahjat M, Kasem I, Soukkarieh C, Aljamali M Tags: Cell Mol Biol Lett Source Type: research

C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance.
Conclusion: C-fos increased the expression of P-gp and mdr1 in the HEp-2/VCR cells, and enhanced the efflux function of the cells, thereby contributing to the development of MDR. PMID: 29483928 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 28, 2018 Category: Biochemistry Authors: Li G, Hu X, Sun L, Li X, Li J, Li T, Zhang X Tags: Cell Mol Biol Lett Source Type: research

Downregulation of microRNA-448 inhibits IL-1 β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3.
Conclusion: The findings showed that miR-448 contributed to the progression of osteoarthritis by directly targeting matrilin-3. This indicates that it has potential as a therapeutic target for the treatment of osteoarthritis. PMID: 29483929 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 28, 2018 Category: Biochemistry Authors: Yang H, Wu D, Li H, Chen N, Shang Y Tags: Cell Mol Biol Lett Source Type: research

The altered expression of perineuronal net elements during neural differentiation.
Conclusions: Our results provide preliminary data on the expression of PNN elements during neural differentiation. Further investigations will be performed on the role of these elements in neurological disease models. PMID: 29456557 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 21, 2018 Category: Biochemistry Authors: Eskici NF, Erdem-Ozdamar S, Dayangac-Erden D Tags: Cell Mol Biol Lett Source Type: research

The Wnt7b/ β-catenin signaling pathway is involved in the protective action of calcitonin gene-related peptide on hyperoxia-induced lung injury in premature rats.
Conclusions: CGRP protected against hyperoxia-induced lung injury in premature rats. This process involves the Wnt7b/β-catenin signaling pathway. PMID: 29416550 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 10, 2018 Category: Biochemistry Authors: Wang S, Dang H, Xu F, Deng J, Zheng X Tags: Cell Mol Biol Lett Source Type: research

Effects of calcium Ionophore A23187 on the apoptosis of hepatic stellate cells stimulated by transforming growth factor- β1.
Effects of calcium Ionophore A23187 on the apoptosis of hepatic stellate cells stimulated by transforming growth factor-β1. Cell Mol Biol Lett. 2018;23:1 Authors: Li Y, Yan Y, Liu F, Wang M, Feng F, Xiao Y Abstract Background: Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apoptosis-related genes. No such evidence has been reported in the literature. Here, we investigate the effect of calcium ionophore A23187 on the apoptosis of rat hepatic ...
Source: Cellular and Molecular Biology Letters - January 9, 2018 Category: Biochemistry Authors: Li Y, Yan Y, Liu F, Wang M, Feng F, Xiao Y Tags: Cell Mol Biol Lett Source Type: research

VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer.
Conclusions: VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer. Targeting VEGF and the SEMA4D signaling pathway could be important for the therapy for EOC. PMID: 29308068 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 9, 2018 Category: Biochemistry Authors: Chen Y, Zhang L, Liu WX, Wang K Tags: Cell Mol Biol Lett Source Type: research

Orally administered endoxifen inhibits tumor growth in melanoma-bearing mice.
Abstract Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to be associated with disease progression. However, the therapeutic benefit of endoxifen in melanoma has not yet been evaluated. Here, we present the first demonstration of the anti-melanogenic activity of endoxifen in vitro and in vivo. The in vitro cytotoxic effect of endoxifen was tested using a cell viability assay. The in vivo anti-melanogenic activity was evaluated in B16F10 cell-bearing C57BL/6 ...
Source: Cellular and Molecular Biology Letters - January 9, 2018 Category: Biochemistry Authors: Chen P, Sheikh S, Ahmad A, Ali SM, Ahmad MU, Ahmad I Tags: Cell Mol Biol Lett Source Type: research

The role of bone marrow mononuclear cell-conditioned medium in the proliferation and migration of human dermal fibroblasts.
Conclusion: When considered together with the observed increase in growth factor levels in conditioned medium, it appears that these cells act through a paracrine mechanism. PMID: 29270201 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 24, 2017 Category: Biochemistry Authors: Menéndez-Menéndez Y, Otero-Hernández J, Vega JA, Pérez-Basterrechea M, Pérez-López S, Álvarez-Viejo M, Ferrero-Gutiérrez A Tags: Cell Mol Biol Lett Source Type: research

Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
Conclusions: We inferred that Rab21 silencing can induce apoptosis and inhibit proliferation in human glioma cells, indicating that Rab21 might act as an oncogene and serve as a novel target for glioma therapy. PMID: 29270202 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 24, 2017 Category: Biochemistry Authors: Ge J, Chen Q, Liu B, Wang L, Zhang S, Ji B Tags: Cell Mol Biol Lett Source Type: research

Bio- and chemocatalysis cascades as a bridge between biology and chemistry for green polymer synthesis.
Abstract The development and integration of bio- and chemocatalytic processes to convert renewable or biomass feedstocks into polymers is a vibrant field of research with enormous potential for environmental protection and the mitigation of global warming. Here, we review the biotechnological and chemical synthetic strategies for producing platform monomers from bio-based sources and transforming them into eco-polymers. We also discuss their advanced bio-application using the example of polylactide (PLA), the most valuable green polymer on the market. PMID: 29225630 [PubMed - in process] (Source: Cellular and...
Source: Cellular and Molecular Biology Letters - December 13, 2017 Category: Biochemistry Authors: Marszałek-Harych A, Jędrzkiewicz D, Ejfler J Tags: Cell Mol Biol Lett Source Type: research

Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population.
Abstract Background: The rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the risk of aSAH in a South Indian population. Methods: The study was performed on 200 subjects with aSAH and 253 healthy control subjects. Blood samples (5 ml) were used to isolate DNA and genotyping was performed for rs7412 and rs429358 using a Taqman allelic discrimination assay. Statistical software R.3.0.11 was used to statistically analyze the data and a p value
Source: Cellular and Molecular Biology Letters - December 9, 2017 Category: Biochemistry Authors: Suvatha A, Kandi SM, Bhat DI, Rao N, Vazhayil V, Kasturirangan CG Tags: Cell Mol Biol Lett Source Type: research

IFN- λ1 in CHO cells: its expression and biological activity.
Conclusion: The Flp-In-CHO system is suitable for stably expressing rhIFN-λ1 that possesses the predicted anti-viral, anti-proliferation and natural killer cell cytotoxicity-promoting activities. PMID: 29213292 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 9, 2017 Category: Biochemistry Authors: Yuan WM, Zhang WJ, Ma FL, Li JS, Zhang Q, Zheng LS Tags: Cell Mol Biol Lett Source Type: research

Collagen-derived dipeptide prolyl-hydroxyproline promotes osteogenic differentiation through Foxg1.
Abstract Prolyl-hydroxyproline (Pro-Hyp) is one of the major constituents of collagen-derived dipeptides. We previously reported that Pro-Hyp promotes the differentiation of osteoblasts by increasing Runx2, osterix and Col1α1 mRNA expression levels. Here, to elucidate the mechanism of Pro-Hyp promotion of osteoblast differentiation, we focus on the involvement of Foxo1 in osteoblast differentiation via Runx2 regulation and the role of Foxg1 in Foxo1 regulation. The addition of Pro-Hyp had no effect on MC3T3-E1 cell proliferation in Foxo1- or Foxg1-knockdown cells. In Foxo1-knockdown cells, the addition of Pr...
Source: Cellular and Molecular Biology Letters - December 9, 2017 Category: Biochemistry Authors: Kimira Y, Odaira H, Nomura K, Taniuchi Y, Inoue N, Nakatani S, Shimizu J, Wada M, Mano H Tags: Cell Mol Biol Lett Source Type: research

Heat shock protein 27 plays a protective role in thoracic aortic dissection by promoting cell proliferation and inhibiting apoptosis.
Conclusions: These results suggest that HSP27 expression promotes VSMC viability, suppresses cell apoptosis, and confers protection against oxidative stress in TAD. PMID: 29209372 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 7, 2017 Category: Biochemistry Authors: Zou S, Liao M, Yang J, Huang T, Green M, Wu J, Qu L Tags: Cell Mol Biol Lett Source Type: research

miR-200b downregulates CFTR during hypoxia in human lung epithelial cells.
Conclusion: The data suggest that miR-200b may be a suitable target for modulating CFTR levels in vivo. PMID: 29167681 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 24, 2017 Category: Biochemistry Authors: Bartoszewska S, Kamysz W, Jakiela B, Sanak M, Króliczewski J, Bebok Z, Bartoszewski R, Collawn JF Tags: Cell Mol Biol Lett Source Type: research

TGF- β1-induced epithelial-mesenchymal transition in lung cancer cells involves upregulation of miR-9 and downregulation of its target, E-cadherin.
Conclusions: TGF-β1 induced EMT in NSCLC cells by upregulating miR-9 and downregulating miR-9's target, E-cadherin. PMID: 29118814 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 10, 2017 Category: Biochemistry Authors: Wang H, Wu Q, Zhang Y, Zhang HN, Wang YB, Wang W Tags: Cell Mol Biol Lett Source Type: research

The novel protein C3orf43 accelerates hepatocyte proliferation.
CONCLUSION: These findings reveal that C3orf43 may contribute to hepatocyte proliferation and may have the potential to promote liver repair and regeneration. PMID: 28932249 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 23, 2017 Category: Biochemistry Authors: Zhang C, Chang C, Li D, Zhang F, Xu C Tags: Cell Mol Biol Lett Source Type: research

Luteolin, quercetin, genistein and quercetagetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in H9c2 cardiomyoblasts.
CONCLUSION: We conclude that the tested flavonoids inhibit inflammatory responses induced by LPS in H9c2 cells. PMID: 28878808 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 8, 2017 Category: Biochemistry Authors: Gutiérrez-Venegas G, Torras-Ceballos A, Gómez-Mora JA, Fernández-Rojas B Tags: Cell Mol Biol Lett Source Type: research

Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?
CONCLUSIONS: Early breast cancer is currently considered a systemic disease and a complex ecosystem with behaviour determined by the complex genetic and molecular signatures of the tumour cells, mammary stem cells, microenvironment and host immune system. We anticipate that molecular profiling will continue to evolve, expanding beyond the primary tumour to include the tumour microenvironment, cancer stem cells and host immune system. This should further refine therapeutic decisions and optimise clinical outcome. This article was specially invited by the editors and represents work by leading researchers. PMID: 2887880...
Source: Cellular and Molecular Biology Letters - September 8, 2017 Category: Biochemistry Authors: Wazir U, Mokbel K, Carmichael A, Mokbel K Tags: Cell Mol Biol Lett Source Type: research

PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2.
We examined the role of the PIWI-like protein HIWI2 in RB and its effect on the stem cell markers in cells of the RB line, Y79. The expression of HIWI2 is significantly increased in Y79 compared with its level in HeLa and ARPE19 cells. The stem cell markers Oct-3/4, Nanog and Sox-2 were not altered upon HIWI2 knockdown in Y79 cells. Interestingly, OTX2 was significantly downregulated in the absence of HIWI2. Otx2 transcripts also decreased in HIWI2-silenced Y79 and ARPE19 cells. Moreover, silencing HIWI2 in Y79 accumulated the cells at G2-M phase and reduced the levels of proliferating cell nuclear antigen (PCNA) and the t...
Source: Cellular and Molecular Biology Letters - September 3, 2017 Category: Biochemistry Authors: Sivagurunathan S, Arunachalam JP, Chidambaram S Tags: Cell Mol Biol Lett Source Type: research

Gene functioning and storage within a folded genome.
This article was specially invited by the editors and represents work by leading researchers. PMID: 28861108 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 3, 2017 Category: Biochemistry Authors: Razin SV, Ulianov SV Tags: Cell Mol Biol Lett Source Type: research

ADAM23 promotes neuronal differentiation of human neural progenitor cells.
CONCLUSIONS: Our results suggest that ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during hNPC differentiation. PMID: 28828010 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 24, 2017 Category: Biochemistry Authors: Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J Tags: Cell Mol Biol Lett Source Type: research

Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation.
Abstract Nur-77, a member of the NR4A sub-family of nuclear orphan receptors, is downregulated in the placentae of pre-eclamptic women. Here, we investigate the relevance of Nor-1, Nurr-1 and Nur-77 in trophoblastic cell differentiation. Their transcript levels were found to be significantly upregulated in BeWo cells treated with forskolin. The maximum increase was observed after 2 h, with a second peak in the expression levels after 48 h. The expression of NR4A sub-family members was also found to be upregulated in BeWo cells after treatment with hCG and GnRH. A similar significant increase was observed...
Source: Cellular and Molecular Biology Letters - August 18, 2017 Category: Biochemistry Authors: Malhotra SS, Gupta SK Tags: Cell Mol Biol Lett Source Type: research

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway.
CONCLUSIONS: The results suggest that SFRP2 could bind to locally present Wnt ligands and alter the balance of intracellular Wnt signaling to antagonize the canonical Wnt pathway in SCAPs. This elucidates the molecular mechanism underlying the SFRP2-mediated directed differentiation of SCAPs and indicates potential target genes for improving dental tissue regeneration. PMID: 28794794 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 12, 2017 Category: Biochemistry Authors: Jin L, Cao Y, Yu G, Wang J, Lin X, Ge L, Du J, Wang L, Diao S, Lian X, Wang S, Dong R, Shan Z Tags: Cell Mol Biol Lett Source Type: research

Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades.
CONCLUSIONS: Our study provides a detailed delineation of the LA-mediated activation of ERK1/2 in HEK293 cells that are stably transfected with human FFA1. We also present evidence of Gi/Gq-induced synergism in the regulation of ERK1/2 phosphorylation. These observations may provide new insights into the pharmacological effects of FFA1 and the physiological functions modulated by FFA1-mediated activation of ERK1/2. PMID: 28747926 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - July 29, 2017 Category: Biochemistry Authors: Qian J, Gu Y, Wu C, Yu F, Chen Y, Zhu J, Yao X, Bei C, Zhu Q Tags: Cell Mol Biol Lett Source Type: research