Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT.
Conclusions: The miR-361-3p level is lower in the plasma of PAH patients. Upregulation of miR-361-3p suppresses serotonin-induced proliferation of hPASMCs by targeting SERT. Our results suggest that miR-361-3p is a potential therapeutic target in PAH. PMID: 33061998 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 20, 2020 Category: Biochemistry Authors: Zhang Y, Chen Y, Chen G, Zhou Y, Yao H, Tan H Tags: Cell Mol Biol Lett Source Type: research

Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1.
Conclusion: LINC00665 knockdown inhibited BC cell proliferation and invasion by binding miR-3619-5p and inhibiting β-catenin expression. PMID: 32983239 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 30, 2020 Category: Biochemistry Authors: Lv M, Mao Q, Li J, Qiao J, Chen X, Luo S Tags: Cell Mol Biol Lett Source Type: research

Arsenic trioxide as a novel anti-glioma drug: a review.
Abstract Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regulation of apoptosis and autophagy; promotion of the intracellular production of reactive oxygen species, causing oxidative damage; and inhibition of tumor stem cells. However, glioma cells and tissues from other sources show different responses to arsenic trioxide. Researchers are working to enhance its efficacy in anti-glioma treatments and reducing any adverse reactions. Here, we review recent rese...
Source: Cellular and Molecular Biology Letters - September 30, 2020 Category: Biochemistry Authors: Fang Y, Zhang Z Tags: Cell Mol Biol Lett Source Type: research

Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth.
Conclusion: These results suggest that the antler main beam has stronger growth capacity involved in chondrogenesis and cartilage development compared to the brow tine during rapid antler growth, which is mainly achieved through regulation of Sox9 and its target genes, whereas the antler brow tine has stronger capacities of endochondral bone formation and resorption compared to the main beam during rapid antler growth, which is mainly achieved through the genes involved in regulating osteoblast and osteoclast activities. Thus, the current research has deeply expanded our understanding of the intrinsic molecular regulation ...
Source: Cellular and Molecular Biology Letters - September 20, 2020 Category: Biochemistry Authors: Yao B, Wang C, Zhou Z, Zhang M, Zhao D, Bai X, Leng X Tags: Cell Mol Biol Lett Source Type: research

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276.
Conclusion: Genetic inactivation of TP53, or the use of the MDM2 ligand Nutlin-3, alters the expression of the immune blockade receptors PD-L1 and CD276. The biological function of elevated CD276 is to promote altered cell cycle progression in response to Nutlin-3, whilst the major effect of elevated PD-L1 is T-cell suppression. These data indicate that TP53 gene status, ATM and MDM2 influence PD-L1 and CD276 paralogs on the cell surface. These data have implications for the use of drugs that target the p53 pathway as modifiers of immune checkpoint receptor expression. PMID: 32874188 [PubMed - in process] (Source: Cel...
Source: Cellular and Molecular Biology Letters - September 4, 2020 Category: Biochemistry Authors: Li R, Zatloukalova P, Muller P, Gil-Mir M, Kote S, Wilkinson S, Kemp AJ, Hernychova L, Wang Y, Ball KL, Tao K, Hupp T, Vojtesek B Tags: Cell Mol Biol Lett Source Type: research

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift.
Conclusions: Overexpression of miR-143 and miR-145 leads to a unique dilated cardiomyopathy phenotype with a reductive redox shift despite marked downregulation of HK2 expression. Reductive stress may be involved in a wider range of cardiomyopathies than previously thought. PMID: 32855642 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 30, 2020 Category: Biochemistry Authors: Ogawa K, Noda A, Ueda J, Ogata T, Matsuyama R, Nishizawa Y, Qiao S, Iwata S, Ito M, Fujihara Y, Ichihara M, Adachi K, Takaoka Y, Iwamoto T Tags: Cell Mol Biol Lett Source Type: research

Specific functions of Exostosin-like 3 (EXTL3) gene products.
Abstract Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix. A lack of EXTL3 reduces HS levels and causes embryonic lethality, indicating its indispensable role in the biosynthesis of HS. EXTL3 has also been identified as a receptor molecule for regenerating islet-derived (REG) protein ligands, which have been shown to stimulate islet β-cell growth. REG proteins also play roles in keratinocyte proliferat...
Source: Cellular and Molecular Biology Letters - August 28, 2020 Category: Biochemistry Authors: Yamada S Tags: Cell Mol Biol Lett Source Type: research

Effects of HPV16 E6 protein on Daxx-induced apoptosis in C33A cells.
Conclusions: HPV16 E6 is involved in inhibiting apoptosis through deregulation of Daxx-induced caspase-8 activities. PMID: 32782452 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 14, 2020 Category: Biochemistry Authors: Tang S, Ding S, Yu L, Shen H, Wan Y, Wu Y Tags: Cell Mol Biol Lett Source Type: research

Do ABC transporters regulate plasma membrane organization?
Abstract The plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical properties of the membrane bilayer and thus play a crucial role in all membrane-dependent cellular processes. It is known that lipid content and distribution in the PM are not random, and their transversal and lateral organization is highly controlled. Mainly sphingolipid- and cholesterol-rich lipid nanodomains, historically referred to as rafts, are extremely dynamic "hot spots" of the PM contr...
Source: Cellular and Molecular Biology Letters - July 11, 2020 Category: Biochemistry Authors: Wu A, Wojtowicz K, Savary S, Hamon Y, Trombik T Tags: Cell Mol Biol Lett Source Type: research

The usefulness of lactate dehydrogenase measurements in current oncological practice.
Abstract One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), which regulates the processing of glucose to lactic acid. As serum LDH levels were found to be commonly increased in cancer patients and correlated with poor clinical outcome and resistance to therapy, the determination of LDH has become a standard supportive tool in diagnosing cancers or monitoring the effects ...
Source: Cellular and Molecular Biology Letters - June 14, 2020 Category: Biochemistry Authors: Forkasiewicz A, Dorociak M, Stach K, Szelachowski P, Tabola R, Augoff K Tags: Cell Mol Biol Lett Source Type: research

Silibinin suppresses epithelial-mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1.
Conclusions: These findings shown an anti-tumor impact of silibinin on NSCLC cells via repression of RHBDD1. PMID: 32528541 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 14, 2020 Category: Biochemistry Authors: Xu S, Zhang H, Wang A, Ma Y, Gan Y, Li G Tags: Cell Mol Biol Lett Source Type: research

On the physiological and cellular homeostasis of ascorbate.
Abstract Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well-being and recovery from a variety of medical conditions. The effect of ascorbate on the local body environment highly depends on its local concentration; at low concentrations it can cause the reduction of reactive oxygen and facilitate activities of enzymes, while at high concentrations it generates free radicals by reducing ferric ions. Ascorbate serving as an electron donor assists the iron-conta...
Source: Cellular and Molecular Biology Letters - June 11, 2020 Category: Biochemistry Authors: Przybyło M, Langner M Tags: Cell Mol Biol Lett Source Type: research

Asiaticoside inhibits TGF- β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5.
Conclusions: Asiaticoside inhibited the TGF-β1-induced MMT and ROS via Nrf2 activation, thus protecting the peritoneal membrane and preventing PF. PMID: 32514269 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 11, 2020 Category: Biochemistry Authors: Zhao J, Shi J, Shan Y, Yu M, Zhu X, Zhu Y, Liu L, Sheng M Tags: Cell Mol Biol Lett Source Type: research

LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis.
Conclusion: LncRNA NNT-AS1 contributes to cell carcinogenesis in LUSC by regulating the miR-22/FOXM1 axis, providing a novel insight into the pathogenesis of LUSC and a new potential therapeutic target for LUSC treatment. PMID: 32514270 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - June 11, 2020 Category: Biochemistry Authors: Ma J, Qi G, Li L Tags: Cell Mol Biol Lett Source Type: research

Role of angiotensin-converting enzyme in myeloid cell immune responses.
Abstract Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a potent vasoconstrictor. Because of its wide substrate specificity and tissue distribution, ACE affects many diverse biological processes. In inflammatory diseases, including granuloma, atherosclerosis, chronic kidney disease and bacterial infection, ACE expression gets upregulated in immune cells, especially in myeloid cells. With increasing evidences connecting ACE functions to the pathogenesis of these acquired diseases, it is suggest...
Source: Cellular and Molecular Biology Letters - June 10, 2020 Category: Biochemistry Authors: Cao DY, Saito S, Veiras LC, Okwan-Duodu D, Bernstein EA, Giani JF, Bernstein KE, Khan Z Tags: Cell Mol Biol Lett Source Type: research

Downregulation of miR-637 promotes vascular smooth muscle cell proliferation and migration via regulation of insulin-like growth factor-2.
Conclusion: MiR-637 targeting IGF-2 contributes to atherosclerosis inhibition and could be a potential target for this disease. PMID: 32399056 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 15, 2020 Category: Biochemistry Authors: Yang N, Dong B, Song Y, Li Y, Kou L, Yang J, Qin Q Tags: Cell Mol Biol Lett Source Type: research

LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
Conclusion: DRAIC suppresses GC proliferation and metastasis via interfering with the combination of UCHL5 and NFRKB and mediating ubiquitination degradation. PMID: 32351584 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 2, 2020 Category: Biochemistry Authors: Zhang Z, Hu X, Kuang J, Liao J, Yuan Q Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration.
Conclusion: Overexpression of miR-186-5p has a certain diagnostic significance for atherosclerosis. Upregulation of miR-186-5p stimulates VSMC proliferation and migration. Therefore, it is a possible target for atherosclerosis interventions. PMID: 32336973 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 29, 2020 Category: Biochemistry Authors: Sun B, Cao Q, Meng M, Wang X Tags: Cell Mol Biol Lett Source Type: research

Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response.
Conclusions: Our results demonstrate that targeting the 4-1BB molecule using agonistic scFvs could be an effective strategy for T-cell stimulation as part of an ACT approach to cancer treatment. PMID: 32336974 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 29, 2020 Category: Biochemistry Authors: Bagheri S, Safaie Qamsari E, Yousefi M, Riazi-Rad F, Sharifzadeh Z Tags: Cell Mol Biol Lett Source Type: research

The role of miR-711 in cardiac cells in response to oxidative stress and its biogenesis: a study on H9C2 cells.
Conclusion: Oxidative stress increases the expression of miR-711. Over-expression of miR-711 induces cell apoptosis/death. HIF-1α and NFКB regulate miR-711 in H9c2 cells during oxidative stress. miR-711 is a new target for preventing oxidative stress. PMID: 32308692 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 22, 2020 Category: Biochemistry Authors: Zhao D, Zheng H, Greasley A, Ling F, Zhou Q, Wang B, Ni T, Topiwala I, Zhu C, Mele T, Liu K, Zheng X Tags: Cell Mol Biol Lett Source Type: research

TCF 4 tumor suppressor: a molecular target in the prognosis of sporadic colorectal cancer in humans.
Conclusions: A remarkable decrease in TCF-4 mRNA and protein expression was detected in tumorous and adjoining tissues compared to normal mucosa. Hence the alterations in genomic architecture along with downregulation of TCF-4 mRNA and decreased expression of TCF-4 protein in tumors, which is in accordance with clinical features, suggest its involvement in the pathogenesis of CRC. Thus, deregulation and collaboration of TCF-4 with CRC could be a concrete and distinctive feature in the prognosis of the disease at an early stage of development. PMID: 32265994 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2020 Category: Biochemistry Authors: Anwar M, Malhotra P, Kochhar R, Bhatia A, Mahmood A, Singh R, Mahmood S Tags: Cell Mol Biol Lett Source Type: research

Quantitative proteomics analysis of differentially expressed proteins induced by astragaloside IV in cervical cancer cell invasion.
Conclusions: We conclude that AS-IV could inhibit cervical cancer invasion by inducing autophagy in cervical cancer cells. Since iTRAQ combination by PRM has been observed to be useful in identifying macromolecular target compounds, it may be considered as a novel strategy in the screening of anticancer compounds used in the treatment of cervical cancer. PMID: 32265995 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2020 Category: Biochemistry Authors: Xia C, He Z, Cai Y Tags: Cell Mol Biol Lett Source Type: research

The role of phosphatidylserine recognition receptors in multiple biological functions.
Abstract Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis. Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase-dependent apoptosis, which in turn promotes the expression of "eat me" signals on the surface of dying cells and the release of soluble "find me" signals for the recruitment of phagocytes. To date, many "eat me" signals have been recognized, including phosphatidylserine (PS), intercellular adhesion molecule-3, carbohydrates (e.g., amino sugars, mannose) and calreticulin. Among them, PS is the most st...
Source: Cellular and Molecular Biology Letters - April 2, 2020 Category: Biochemistry Authors: Naeini MB, Bianconi V, Pirro M, Sahebkar A Tags: Cell Mol Biol Lett Source Type: research

miR-144-3p inhibits cell proliferation of colorectal cancer cells by targeting BCL6 via inhibition of Wnt/ β-catenin signaling.
Conclusions: Overall, the effect of the miR-144-3p/BCL6 axis on regulating CRC carcinogenesis was demonstrated, and miR-144-3p was identified as a potential prognostic and therapeutic target in colorectal cancer. PMID: 32206063 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 26, 2020 Category: Biochemistry Authors: Sun N, Zhang L, Zhang C, Yuan Y Tags: Cell Mol Biol Lett Source Type: research

Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3.
Conclusions: MiR-483-5p, which targets MAPK3, might be a potential therapeutic target for the diagnosis and prevention of hypoxia-induced myocardial injury. PMID: 32206064 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 26, 2020 Category: Biochemistry Authors: Hao Y, Yuan H, Yu H Tags: Cell Mol Biol Lett Source Type: research

LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
Conclusion: CASC2 attenuated hypoxia-induced PASMC proliferation and migration by regulating the miR-222/ING5 axis to prevent vascular remodeling and the development of PAH, providing a novel insight and therapeutic strategy for hypoxia-induced PAH. PMID: 32206065 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 26, 2020 Category: Biochemistry Authors: Han Y, Liu Y, Yang C, Gao C, Guo X, Cheng J Tags: Cell Mol Biol Lett Source Type: research

MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C.
Conclusion: Our study reveals that miR-206 functions as a tumor metastasis suppressor and sheds new light on the clinical significance of miR-206 in NSCLC therapy. PMID: 32206066 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 26, 2020 Category: Biochemistry Authors: Liao M, Peng L Tags: Cell Mol Biol Lett Source Type: research

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia.
Abstract During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their induced signaling pathways have many distinct targets, there are some important connections as well. Despite the extensive studies on both of these signaling pathways, the exact mechanisms involved that determine survival versus apoptosis remain largely unexplained and therefore beyond therapeutic control. Here we discuss the complex relationship between the HIF and UPR signaling pathways and the impor...
Source: Cellular and Molecular Biology Letters - March 20, 2020 Category: Biochemistry Authors: Bartoszewska S, Collawn JF Tags: Cell Mol Biol Lett Source Type: research

Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells.
Conclusion: We characterized a new function of O-GlcNAcylation in the suppression of autophagy via regulation of AMPK. Graphical abstract: Blockage of O-linked GlcNAcylation induces AMPK dependent autophagy in bladder cancer cells. PMID: 32174982 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 17, 2020 Category: Biochemistry Authors: Jin L, Yuan F, Dai G, Yao Q, Xiang H, Wang L, Xue B, Shan Y, Liu X Tags: Cell Mol Biol Lett Source Type: research

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis.
Conclusions: Our study indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroptosis may become a novel target in the treatment of ALI patients. PMID: 32161620 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 13, 2020 Category: Biochemistry Authors: Liu P, Feng Y, Li H, Chen X, Wang G, Xu S, Li Y, Zhao L Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-125b exerts antitumor functions in cutaneous squamous cell carcinoma by targeting the STAT3 pathway.
Conclusions: Our findings indicate that miR-125b acts as a tumor suppressor in CSCC by targeting the STAT3 pathway. This observation increases our understanding of the molecular mechanisms of CSCC. Therapies aimed at activating miR-125b or inhibiting STAT3 signaling should be explored as potential treatments for CSCC. PMID: 32161621 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 13, 2020 Category: Biochemistry Authors: Tian K, Liu W, Zhang J, Fan X, Liu J, Zhao N, Yao C, Miao G Tags: Cell Mol Biol Lett Source Type: research

Metabolic host response and therapeutic approaches to influenza infection.
Abstract Based on available metabolomic studies, influenza infection affects a variety of cellular metabolic pathways to ensure an optimal environment for its replication and production of viral particles. Following infection, glucose uptake and aerobic glycolysis increase in infected cells continually, which results in higher glucose consumption. The pentose phosphate shunt, as another glucose-consuming pathway, is enhanced by influenza infection to help produce more nucleotides, especially ATP. Regarding lipid species, following infection, levels of triglycerides, phospholipids, and several lipid derivatives und...
Source: Cellular and Molecular Biology Letters - March 13, 2020 Category: Biochemistry Authors: Keshavarz M, Solaymani-Mohammadi F, Namdari H, Arjeini Y, Mousavi MJ, Rezaei F Tags: Cell Mol Biol Lett Source Type: research

Adipose-derived stromal cells in regulation of hematopoiesis.
Abstract Over the past decade, mesenchymal stromal cells (MSCs) found in the bone marrow microenvironment have been considered to be important candidates in cellular therapy. However, the application of MSCs in clinical settings is limited by the difficulty and low efficiency associated with the separation of MSCs from the bone marrow. Therefore, distinct sources of MSCs have been extensively explored. Adipose-derived stromal cells (ASCs), a cell line similar to MSCs, have been identified as a promising source. ASCs have become increasingly popular in many fields, as they can be conveniently extracted from fat tis...
Source: Cellular and Molecular Biology Letters - March 13, 2020 Category: Biochemistry Authors: Zhang J, Liu Y, Yin W, Hu X Tags: Cell Mol Biol Lett Source Type: research

Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.
Conclusion: Our results indicate that miR-15 inhibition alleviates CVB3-induced myocardial inflammation and cell injury. This may be partially due to NLRX1-mediated NLRP3 inflammasome inactivation. PMID: 32099552 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 28, 2020 Category: Biochemistry Authors: Tong R, Jia T, Shi R, Yan F Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF- κB pathway.
Conclusion: We provide important insight into miR-429 as a tumor suppressor through interaction with IKKβ, which is a catalytic subunit of the IKK complex that activates NF-κB nuclear transport. Our results demonstrate that miR-429 may be a new target for the treatment of neuroblastoma. PMID: 32082390 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 24, 2020 Category: Biochemistry Authors: Zhou X, Lu H, Li F, Hao X, Han L, Dong Q, Chen X Tags: Cell Mol Biol Lett Source Type: research

Deficiency of αII-spectrin affects endothelial cell-matrix contact and migration leading to impairment of angiogenesis in vitro.
Conclusion: Our data confirm the role of αII-spectrin in the control of cell adhesion and spreading. Moreover, our findings further support the participation of αII-spectrin in capillary tube formation in vitro through control of adhesion molecules, such as integrins. This indicates a new function of αII-spectrin in angiogenesis. PMID: 32042281 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 12, 2020 Category: Biochemistry Authors: Machnicka B, Ponceau A, Picot J, Colin Y, Lecomte MC Tags: Cell Mol Biol Lett Source Type: research

LINC00511 promotes proliferation and invasion by sponging miR-515-5p in gastric cancer.
Conclusion: We established that LINC00511 may contribute to the proliferation and invasion of gastric cancer cells by modulating miR-515-5p, indicating that LINC00511 may be a potential molecular target for the development of anti-cancer drugs. PMID: 32042282 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 12, 2020 Category: Biochemistry Authors: Wang D, Liu K, Chen E Tags: Cell Mol Biol Lett Source Type: research

The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer.
Abstract The ubiquitin system, known as a common feature in eukaryotes, participates in multiple cellular processes, such as signal transduction, cell-cycle progression, receptor trafficking and endocytosis, and even the immune response. In lung cancer, evidence has revealed that aberrant events in ubiquitin-mediated processes can cause a variety of pathological outcomes including tumorigenesis and metastasis. Likewise, ubiquitination on the core components contributing to the activity of cell signaling controls bio-signal turnover and cell final destination. Given this, inhibitors targeting the ubiquitin system h...
Source: Cellular and Molecular Biology Letters - January 30, 2020 Category: Biochemistry Authors: Fan Q, Wang Q, Cai R, Yuan H, Xu M Tags: Cell Mol Biol Lett Source Type: research

DNA-dependent protein kinase in telomere maintenance and protection.
Abstract This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku ...
Source: Cellular and Molecular Biology Letters - January 30, 2020 Category: Biochemistry Authors: Sui J, Zhang S, Chen BPC Tags: Cell Mol Biol Lett Source Type: research

Editorial focus: understanding off-target effects as the key to successful RNAi therapy.
Abstract With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we witness the RNAi therapy field reaching a critical turning point, when further improvements in drug candidate design and delivery pipelines should enable fast delivery of novel life changing treatments to patients. Nevertheless, ignoring parallel development of RNAi dedicated in vitro pharmacological profiling aiming to identify undesirable off-target activity may slow down or halt progress in the RNAi field. Since academic research is currently fueling the RNAi development pipeline with new therapeutic options, the objec...
Source: Cellular and Molecular Biology Letters - December 24, 2019 Category: Biochemistry Authors: Bartoszewski R, Sikorski AF Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-582-3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2.
Conclusion: These findings indicate new functions and mechanisms for miR-582-3p in AML development. Further study could clarify if miR-582-3p and CCNB2 are potential therapeutic targets for the treatment of AML. PMID: 31844417 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 19, 2019 Category: Biochemistry Authors: Li H, Tian X, Wang P, Huang M, Xu R, Nie T Tags: Cell Mol Biol Lett Source Type: research

Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.
Conclusion: Our data suggest that miR-376c-3p downregulated ING5 to exert protective effects against OGD-induced cell injury in PC-12 and SH-SY5Y cells. This might represent a novel therapeutic approach for neonatal HIE treatment. PMID: 31844418 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 19, 2019 Category: Biochemistry Authors: Zhang H, Zhou J, Zhang M, Yi Y, He B Tags: Cell Mol Biol Lett Source Type: research

MiR-214 prevents the progression of diffuse large B-cell lymphoma by targeting PD-L1.
Conclusion: By targeting PD-L1, miR-214 regulates the progression of DLBCL in vitro and in vivo. PMID: 31844419 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 19, 2019 Category: Biochemistry Authors: Sun JR, Zhang X, Zhang Y Tags: Cell Mol Biol Lett Source Type: research

Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats.
Conclusions: The results may have revealed some aberrantly expressed lncRNAs and mRNAs that contribute to the underlying pathophysiological mechanisms of myocardial infarction. PMID: 31827539 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Meng Q, Sun Z, Gu H, Luo J, Wang J, Wang C, Han S Tags: Cell Mol Biol Lett Source Type: research

Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling.
Conclusions: The in vitro study revealed that the duration of hypoxia is crucial for osteogenic differentiation of precursor cells. The results from both the in vitro and in vivo studies show the role of STAT3 signaling in hypoxia-induced osteogenic differentiation of precursor cells and bone defect healing. PMID: 31827540 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Yu X, Wan Q, Ye X, Cheng Y, Pathak JL, Li Z Tags: Cell Mol Biol Lett Source Type: research

Estrogen stimulates SREBP2 expression in hepatic cell lines via an estrogen response element in the SREBP2 promoter.
Conclusions: An ERE was identified in the SREBP2 gene promoter. It mediates the regulation of SREBP2 expression by estrogen in hepatocytes. This study provides a mechanism to link cardiovascular disease with estrogen. PMID: 31827541 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Meng Y, Zong L Tags: Cell Mol Biol Lett Source Type: research

MiR-7-5p suppresses tumor metastasis of non-small cell lung cancer by targeting NOVA2.
Conclusion: MiR-7-5p suppresses NSCLC metastasis. Targeting miR-7-5p may contribute to the success of NSCLC therapy. PMID: 31832068 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 14, 2019 Category: Biochemistry Authors: Xiao H Tags: Cell Mol Biol Lett Source Type: research

MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1.
Conclusions: MicroRNA-146a exerts a protective effect against MIRI, which might be partially mediated by the target gene Med1 and related to the apoptosis signalling pathway. PMID: 31798643 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 6, 2019 Category: Biochemistry Authors: Zhang T, Ma Y, Gao L, Mao C, Zeng H, Wang X, Sun Y, Gu J, Wang Y, Chen K, Han Z, Fan Y, Gu J, Zhang J, Wang C Tags: Cell Mol Biol Lett Source Type: research

Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven.
Conclusions: Inhibition of miR-30b-5p could protect cardiomyocytes against hypoxia-induced injury by targeting Aven. PMID: 31768184 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 27, 2019 Category: Biochemistry Authors: Zhang L, Jia X Tags: Cell Mol Biol Lett Source Type: research

Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells.
Conclusions: Our data suggests that MAO-A activity is required for tumorsphere formation and that its expression in breast tumor cells is associated with BTIC-related properties. The discovery that a selective MAO-A inhibitor targets tumorsphere-forming cells with potencies in the nanomolar range provides the first evidence of this agent's anticancer property. These data warrant further investigation of the link between MAO-A and BTIC. PMID: 31754354 [PubMed - in process] (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 24, 2019 Category: Biochemistry Authors: Gwynne WD, Shakeel MS, Wu J, Hallett RM, Girgis-Gabardo A, Dvorkin-Gheva A, Hassell JA Tags: Cell Mol Biol Lett Source Type: research