Effect of resveratrol on herpesvirus encephalitis: Evidences for its mechanisms of action

CONCLUSION: Resveratrol acted as a non-classical HSP90β inhibitor, binding to the STING-HSP90β interaction site to promote STING degradation and attenuate HSV-1-induced encephalitis and neuroinflammation. These findings suggest the alternative strategy of targeting HSP90β and resveratrol-mediated inhibition of HSP90β as a potential antiviral approach.PMID:38430586 | DOI:10.1016/j.phymed.2024.155476

Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Ziwei Huang Shan Li Lishan Zhong Yuan Su Menghe Li Xiaohui Wang Zexu Wang Zhiping Wang Cuifang Ye Zhe Ren Xiao Wang Qiongzhen Zeng Kai Zheng Yifei Wang Source Type: research