Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway
This study is the first to demonstrate how NK cells promote AKI by releasing perforin, interferon-gamma (IFN-γ) and other inflammatory factors in vivo and in vitro. Differential gene expression between AKI and normal tissues was assessed using bioinformatic analyses. Quantitative real-time PCR, western blotting, and immunohistochemical staining were used to detect target protein mRNA and protein expression. Levels of inflammatory factors were measured using enzyme-linked immunosorbent assay. We found the high doses of the 2'-deoxyadenosine treatment significantly alleviated FA-induced renal damage in vivo, and alleviated ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Shuang Li Wei Pang Yuzhu Wang Yiting Zhang Source Type: research
Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING
In this study, we utilized a lipopolysaccharide (LPS)-induced NPC senescence model and a rat acupuncture-induced IVDD model to investigate the role of MAGL in IVDD both in vitro and in vivo. Initially, our results showed that MAGL expression was increased 2.41-fold and 1.52-fold within NP tissues from IVDD patients and rats induced with acupuncture, respectively. This increase in MAGL expression was accompanied by elevated expression of p16INK4α. Following this, it was noted that the suppression of MAGL resulted in a notable decrease in the quantity of SA-β-gal-positive cells and hindered the manifestation of p16INK4α a...
Source: International Immunopharmacology - March 22, 2024 Category: Allergy & Immunology Authors: Chunyang Fan Jiacheng Du Zilin Yu Jiale Wang Lingye Yao Zhongwei Ji Wei He Yongkang Deng Dechun Geng Xiexing Wu Haiqing Mao Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway
This study is the first to demonstrate how NK cells promote AKI by releasing perforin, interferon-gamma (IFN-γ) and other inflammatory factors in vivo and in vitro. Differential gene expression between AKI and normal tissues was assessed using bioinformatic analyses. Quantitative real-time PCR, western blotting, and immunohistochemical staining were used to detect target protein mRNA and protein expression. Levels of inflammatory factors were measured using enzyme-linked immunosorbent assay. We found the high doses of the 2'-deoxyadenosine treatment significantly alleviated FA-induced renal damage in vivo, and alleviated ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Shuang Li Wei Pang Yuzhu Wang Yiting Zhang Source Type: research
Activation of STING signaling aggravates chronic alcohol exposure-induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis
CONCLUSION: Activation of STING signaling played an essential role in alcohol-induced inflammation and mitochondrial apoptosis in the mPFC. This study identifies STING as a promising therapeutic target for AUD.PMID:38516831 | PMC:PMC10958405 | DOI:10.1111/cns.14689 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 22, 2024 Category: Neuroscience Authors: Xinrou Lin Xiangpen Li Chenguang Li Hongxuan Wang Lubin Zou Jingrui Pan Xiaoni Zhang Lei He Xiaoming Rong Ying Peng Source Type: research
Viruses, Vol. 16, Pages 485: The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication
Carsten Münk
The innate immune response to viruses is formed in part by interferon (IFN)-induced restriction factors, including ISG15, p21, and SAMHD1. IFN production can be blocked by the ISG15-specific protease USP18. HIV-1 has evolved to circumvent host immune surveillance. This mechanism might involve USP18. In our recent studies, we demonstrate that HIV-1 infection induces USP18, which dramatically enhances HIV-1 replication by abrogating the antiviral function of p21. USP18 downregulates p21 by accumulating misfolded dominant negative p53, which inactivates wild-type p53 transactivation, leading to the upregul...
Source: Viruses - March 22, 2024 Category: Virology Authors: Chaohui Lin Edmund Osei Kuffour Taolan Li Christoph G. W. Gertzen Jesko Kaiser Tom Luedde Renate K önig Holger Gohlke Carsten M ünk Tags: Review Source Type: research
cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.ABSTRACTType I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA in the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signal...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Guohao Li Xiangqian Zhao Zuda Zheng Hucheng Zhang Yundi Wu Yangkun Shen Qi Chen Source Type: research
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Cell Mol Life Sci. 2024 Mar 20;81(1):148. doi: 10.1007/s00018-024-05190-7.ABSTRACTPropagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swine cells during FMDV infection an...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Miguel Ángel Sanz Miryam Polo Miguel Rodr íguez-Pulido Ranjitha Huildore Bommanna Margarita S áiz Source Type: research
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Cell Mol Life Sci. 2024 Mar 20;81(1):148. doi: 10.1007/s00018-024-05190-7.ABSTRACTPropagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swine cells during FMDV infection an...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Miguel Ángel Sanz Miryam Polo Miguel Rodr íguez-Pulido Ranjitha Huildore Bommanna Margarita S áiz Source Type: research
cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.ABSTRACTType I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA in the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signal...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Guohao Li Xiangqian Zhao Zuda Zheng Hucheng Zhang Yundi Wu Yangkun Shen Qi Chen Source Type: research
cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.ABSTRACTType I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA in the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signal...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Guohao Li Xiangqian Zhao Zuda Zheng Hucheng Zhang Yundi Wu Yangkun Shen Qi Chen Source Type: research
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Cell Mol Life Sci. 2024 Mar 20;81(1):148. doi: 10.1007/s00018-024-05190-7.ABSTRACTPropagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swine cells during FMDV infection an...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Miguel Ángel Sanz Miryam Polo Miguel Rodr íguez-Pulido Ranjitha Huildore Bommanna Margarita S áiz Source Type: research
cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.ABSTRACTType I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA in the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signal...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Guohao Li Xiangqian Zhao Zuda Zheng Hucheng Zhang Yundi Wu Yangkun Shen Qi Chen Source Type: research
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Cell Mol Life Sci. 2024 Mar 20;81(1):148. doi: 10.1007/s00018-024-05190-7.ABSTRACTPropagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swine cells during FMDV infection an...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Miguel Ángel Sanz Miryam Polo Miguel Rodr íguez-Pulido Ranjitha Huildore Bommanna Margarita S áiz Source Type: research
Cancers, Vol. 16, Pages 1234: Correction: Reschke, R.; Olson, D.J. Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce a & ldquo;Hot & rdquo; Tumor Microenvironment That Is Responsive to Immunotherapy. Cancers 2022, 14, 2458
Cancers, Vol. 16, Pages 1234: Correction: Reschke, R.; Olson, D.J. Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce a “Hot” Tumor Microenvironment That Is Responsive to Immunotherapy. Cancers 2022, 14, 2458
Cancers doi: 10.3390/cancers16061234
Authors:
Robin Reschke
Daniel J. Olson
The authors would like to make the following corrections to their published paper [...] (Source: Cancers)
Source: Cancers - March 21, 2024 Category: Cancer & Oncology Authors: Robin Reschke Daniel J. Olson Tags: Correction Source Type: research
