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Paediatric onset lymphomatoid papulosis: results of a multicentre retrospective cohort study, on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG)
CONCLUSIONS: We report epidemiological data from a large international cohort of children and adolescents with LyP. Overall the prognosis of the disease is good, with excellent survival rates for all patients. Due to increased risk of associated HM, a long-term follow-up should be recommended for LyP patients.PMID:38595050 | DOI:10.1093/bjd/ljae150 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Ma ël Blanchard Marie-Anne Morren Anne-Marie Busschots Esther Hauben Silvia Alberti-Violetti Emilio Berti Gianluca Avallone Gianluca Tavoletti Michele Panzone Pietro Quaglino Cristiana Colonna Rutger C Melchers Maarten H Vermeer Robert Gniadecki Christin Source Type: research

New frontiers in the cGAS-STING intracellular DNA-sensing pathway
We describe two recent and surprising insights into cGAS-STING biology: that cGAS is tightly tethered to the nucleosome and that the cGAMP product of cGAS is an immunotransmitter acting at a distance to control innate immunity. We consider how these advances influence our understanding of the emerging roles of cGAS in the DNA damage response (DDR), senescence, aging, and cancer biology. Finally, we describe emerging approaches to harness cGAS-STING biology for therapeutic benefit.PMID:38599167 | DOI:10.1016/j.immuni.2024.02.019 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Steve Dvorkin Stephanie Cambier Hannah E Volkman Daniel B Stetson Source Type: research

The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
J Mol Med (Berl). 2024 Apr 11. doi: 10.1007/s00109-024-02444-6. Online ahead of print.ABSTRACTThe accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly present in many age-related diseases and in the cancer microenvironment. The escape of abnormal cells from immune surveillance indicates that there is some defect in the function of cytotoxic immune cells, e.g., CD8+ T cells and natural killer (NK) cells. Recent studies have revealed that the expression of programmed death-ligand 1 (PD-L1) protein is abundantly increased in senescent cells. An increase in the am...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Antero Salminen Source Type: research

STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Mol Cell Biochem. 2024 Apr 9. doi: 10.1007/s11010-024-04970-w. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the gen...
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Wei Wang Fengqing Zhang Yan Hu Guangming Liu Source Type: research

Viruses, Vol. 16, Pages 574: STINGing Defenses: Unmasking the Mechanisms of DNA Oncovirus-Mediated Immune Escape
idis DNA oncoviruses represent an intriguing subject due to their involvement in oncogenesis. These viruses have evolved mechanisms to manipulate the host immune response, facilitating their persistence and actively contributing to carcinogenic processes. This paper describes the complex interactions between DNA oncoviruses and the innate immune system, with a particular emphasis on the cGAS-STING pathway. Exploring these interactions highlights that DNA oncoviruses strategically target and subvert this pathway, exploiting its vulnerabilities for their own survival and proliferation within the host. Understanding these...
Source: Viruses - April 9, 2024 Category: Virology Authors: Mayra F Mart ínez-López Claire Muslin Nikolaos C. Kyriakidis Tags: Review Source Type: research

Combination of IFN-gamma with STING agonist and PD-1 immune checkpoint blockade: a potential immunotherapy for gastric cancer
AbstractSuppression of the cGAS-STING pathway is an immune escape mechanism in cancer cells. The critical role of this pathway in gastric cancer (GC) is not fully understood. Herein, we evaluated the effect of the interferon-gamma (IFN-gamma), STING agonist, PD-1 immune checkpoint blockade, and their combination on the cGAS-STING pathway in GC. Expression of cGAS and STING in tumor tissue samples and adjacent normal tissue (ANT) biopsies of fifty new GC patients was evaluated by quantitative real-time PCR (qRT-PCR). Moreover, cGAS and STING expression levels were examined in Peripheral Blood Mononuclear Cells (PBMC) sample...
Source: Medical Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research

STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 8, 2024 Category: Neurology Authors: Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi and Hong Liao Tags: Research Source Type: research

Fucoidan MF4 from Fucus vesiculosus inhibits Lewis lung cancer via STING-TBK1-IRF3 pathway
In this study, a novel fucoidan MF4 was extracted from Fucus vesiculosus and isolated using Q-Sepharose fast-flow ion-exchange chromatography. The physicochemical properties of MF4 were characterized. MF4 is primarily composed of fucose, xylose, galactose, glucose, and mannose in a molar ratio of 12.3: 4.9: 1.1: 1.0: 1.1, with an average molecular weight of 67.7 kDa. Notably, MF4 demonstrated suppression of LLC tumor growth in vivo. RNA-sequencing analysis revealed that MF4 enhanced the expression of type I interferon-associated downstream genes in macrophages. Furthermore, MF4 increased the levels of phosphorylated TBK1 a...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Chuanqin Shi Shihua Zhao Liyan Mi Deying Niu Fanwen Hu Wenwei Han Bing Li Source Type: research

The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10.101...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research