Aberrant regulation of retinoic acid signaling genes in cerebral arterio venous malformation nidus and neighboring astrocytes
Cerebral arterio venous malformations (AVM) are a major causal factor for intracranial hemorrhage, which result in permanent disability or death. The molecular mechanisms of AVM are complex, and their pathogen... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 1, 2021 Category: Neurology Authors: Jaya Mary Thomas, Dhakshmi Sasankan, Sumi Surendran, Mathew Abraham, Arumugam Rajavelu and Chandrasekharan C. Kartha Tags: Short report Source Type: research

Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life
The term sepsis is used to designate a systemic condition of infection and inflammation associated with hemodynamic changes that result in organic dysfunction. Gestational sepsis can impair the development of ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 25, 2021 Category: Neurology Authors: Marcelo Gomes Granja, Let ícia Pires Alves, Marina Leardini-Tristão, Michelle Edelman Saul, Letícia Coelho Bortoni, Flávia Maciel de Moraes, Erica Camila Ferreira, Bianca Portugal Tavares de Moraes, Victória Zerboni da Silva, Adrielle Ferreira Ribeir Tags: Research Source Type: research

Correction to: Differential neurovirulence of Usutu viruslineages in mice and neuronal cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 23, 2021 Category: Neurology Authors: Marion Cl é, Orianne Constant, Jonathan Barthelemy, Caroline Desmetz, Marie France Martin, Lina Lapeyre, Daniel Cadar, Giovanni Savini, Liana Teodori, Federica Monaco, Jonas Schmidt-Chanasit, Juan-Carlos Saiz, Gaëlle Gonzales, Sylvie Lecollinet, Cécile Tags: Correction Source Type: research

Systemic administration of β-glucan induces immune training in microglia
An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively. Exposing monocyte... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 22, 2021 Category: Neurology Authors: Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman and Bart J. L. Eggen Tags: Research Source Type: research

Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and female mice?
Ischemic stroke is an acquired brain injury with gender-dependent outcomes. A persistent obstacle in understanding the sex-specific neuroinflammatory contributions to ischemic brain injury is distinguishing be... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 22, 2021 Category: Neurology Authors: Kimberly F. Young, Rebeca Gardner, Victoria Sariana, Susan A. Whitman, Mitchell J. Bartlett, Torsten Falk and Helena W. Morrison Tags: Research Source Type: research

Anti-NMDAR encephalitis induced in mice by active immunization with a peptide from the amino-terminal domain of the GluN1 subunit
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesia, and seizures. However, the underlying mechanisms of this disease rema... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2021 Category: Neurology Authors: Yuewen Ding, Zheye Zhou, Jinyu Chen, Yu Peng, Haitao Wang, Wei Qiu, Wei Xie, Jun Zhang and Honghao Wang Tags: Research Source Type: research

Interleukin-1 β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers
The lack of effective treatments for Alzheimer ’s disease (AD) reflects an incomplete understanding of disease mechanisms. Alterations in proteins involved in mitochondrial dynamics, an essential process for mi... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2021 Category: Neurology Authors: Andre F. Batista, Tayn á Rody, Leticia Forny-Germano, Suzana Cerdeiro, Maria Bellio, Sergio T. Ferreira, Douglas P. Munoz and Fernanda G. De Felice Tags: Research Source Type: research

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status
Hypoxic-ischemic encephalopathy (HIE) is an important cause of permanent damage to central nervous system (CNS) that may result in neonatal death or manifest later as mental retardation, epilepsy, cerebral pal... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2021 Category: Neurology Authors: John Sieh Dumbuya, Lu Chen, Jang-Yen Wu and Bin Wang Tags: Review Source Type: research

Interactions of neuroimmune signaling and glutamate plasticity in addiction
Chronic use of drugs of abuse affects neuroimmune signaling; however, there are still many open questions regarding the interactions between neuroimmune mechanisms and substance use disorders (SUDs). Further, ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2021 Category: Neurology Authors: Cassandra D. Gipson, Scott Rawls, Michael D. Scofield, Benjamin M. Siemsen, Emma O. Bondy and Erin E. Maher Tags: Review Source Type: research

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke
To investigate the association of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post-thrombolysis early neurological outcomes including e... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 20, 2021 Category: Neurology Authors: Pengyu Gong, Yukai Liu, Yachi Gong, Gang Chen, Xiaohao Zhang, Siyu Wang, Feng Zhou, Rui Duan, Wenxiu Chen, Ting Huang, Meng Wang, Qiwen Deng, Hongchao Shi, Junshan Zhou, Teng Jiang and Yingdong Zhang Tags: Research Source Type: research

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice
In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated th... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 18, 2021 Category: Neurology Authors: Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham and Guido Stoll Tags: Research Source Type: research

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation
Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are commonly used new-generation drugs for depression. Depressive symptoms are thought to be closely rel... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 18, 2021 Category: Neurology Authors: Jia-Hui He, Rong-Pei Liu, Yi-Man Peng, Qing Guo, Lan-Bing Zhu, Yi-Zhi Lian, Bei-Lei Hu, Hui-Hui Fan, Xiong Zhang and Jian-Hong Zhu Tags: Research Source Type: research

Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain
Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors. However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse effect during paclitaxel treatment, which results in ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 18, 2021 Category: Neurology Authors: Yuanyuan Li, Chengyu Yin, Boyu Liu, Huimin Nie, Jie Wang, Danyi Zeng, Ruixiang Chen, Xiaofen He, Junfan Fang, Junying Du, Yi Liang, Yongliang Jiang, Jianqiao Fang and Boyi Liu Tags: Research Source Type: research

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis
This study investigated the efficacy of a novel topical α4β1 integrin inhibitor (GW559090, GW) in a mouse model for non-infectious po... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 18, 2021 Category: Neurology Authors: Yi Hsing Chen, Malihe Eskandarpour, Xiaozhe Zhang, Grazyna Galatowicz, John Greenwood, Sue Lightman and Virginia Calder Tags: Research Source Type: research

Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury
The pathological process of traumatic spinal cord injury (SCI) involves excessive activation of microglia leading to the overproduction of proinflammatory cytokines and causing neuronal injury. Sphingosine kin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 18, 2021 Category: Neurology Authors: Chenjian Wang, Tianzhen Xu, Brittany Bolduc Lachance, Xiqiang Zhong, Guangjie Shen, Tao Xu, Chengxuan Tang and Xiaofeng Jia Tags: Research Source Type: research

On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
Many patients with major depressive disorder (MDD) are reported to have higher levels of multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre-clinical and clinical have advoc... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 16, 2021 Category: Neurology Authors: Elnaz Roohi, Nematollah Jaafari and Farshad Hashemian Tags: Review Source Type: research

Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive oxygen species (ROS) that may subsequently cause severe white matter injury. The process of oligodendrocyte progenitor cell (OPC) di... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 15, 2021 Category: Neurology Authors: Jingwei Zheng, Jia ’nan Lu, Shuhao Mei, Haijian Wu, Zeyu Sun, Yuanjian Fang, Shenbin Xu, Xiaoyu Wang, Ligen Shi, Weilin Xu, Sheng Chen, Jun Yu, Feng Liang and Jianmin Zhang Tags: Research Source Type: research

ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex
Intracellular Ca2+ modulates several microglial activities, such as proliferation, migration, phagocytosis, and inflammatory mediator secretion. Extracellular ATP, the levels of which significantly change during ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 15, 2021 Category: Neurology Authors: Nicole Piera Palomba, Katiuscia Martinello, Germana Cocozza, Sara Casciato, Addolorata Mascia, Giancarlo Di Gennaro, Roberta Morace, Vincenzo Esposito, Heike Wulff, Cristina Limatola and Sergio Fucile Tags: Research Source Type: research

Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture
Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with deposition of redox active cell-free hemoglobin (Hb), derived from hemorrhagic cerebrospinal fluid (CSF), in the cerebrum and cerebellum.... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 11, 2021 Category: Neurology Authors: Alex Adusei Agyemang, Suvi Vallius Kvist, Nathan Brinkman, Thomas Gentinetta, Miriam Illa, Niklas Ortenl öf, Bo Holmqvist, David Ley and Magnus Gram Tags: Research Source Type: research

Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
Postoperative cognitive dysfunction (POCD) is a very common complication that might increase the morbidity and mortality of elderly patients after surgery. However, the mechanism of POCD remains largely unknow... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 4, 2021 Category: Neurology Authors: Qiang Liu, Yi-Man Sun, Hui Huang, Chen Chen, Jie Wan, Lin-Hui Ma, Yin-Ying Sun, Hui-Hui Miao and Yu-Qing Wu Tags: Research Source Type: research

Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host
Bacterial meningitis is a fatal disease with a mortality up to 30% and neurological sequelae in one fourth of survivors. Available vaccines do not fully protect against this lethal disease. Here, we report the... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 2, 2021 Category: Neurology Authors: S. Ribes, L. Zacke, S. Nessler, N. Saiepour, E. Avenda ño-Guzmán, M. Ballüer, U. K. Hanisch and R. Nau Tags: Research Source Type: research

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats
Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 2, 2021 Category: Neurology Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo and John H. Zhang Tags: Research Source Type: research

Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression
Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied and prescribed antidepressants, while their exact molecular and cellular mechanism are yet to be defined. We investigated the ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 1, 2021 Category: Neurology Authors: Weifen Li, Tahir Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, Fawad Ali Shah, Qingguo Ren, Shafiq Ur Rahman, Ningning Li, Zhi-Jian Yu and Shupeng Li Tags: Research Source Type: research

Changes of blood-brain-barrier function and transfer of amyloid beta in rats with collagen-induced arthritis
Rheumatoid arthritis (RA) is characterized by synovial inflammation, cartilage damage, and systemic inflammation. RA is also associated with the occurrence of neuroinflammation and neurodegenerative diseases. ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 30, 2021 Category: Neurology Authors: Po-Hsuan Lai, Ting-Hsuan Wang, Nai-You Zhang, Kuo-Chen Wu, Chung-Chen Jane Yao and Chun-Jung Lin Tags: Research Source Type: research

Microglia as target for anti-inflammatory approaches to prevent secondary brain injury after subarachnoid hemorrhage (SAH)
Microglia-driven cerebral spreading inflammation is a key contributor to secondary brain injury after SAH. Genetic depletion or deactivation of microglia has been shown to ameliorate neuronal cell death. There... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 30, 2021 Category: Neurology Authors: Rebecca Heinz, Susan Brandenburg, Melina Nieminen-Kelh ä, Irina Kremenetskaia, Philipp Boehm-Sturm, Peter Vajkoczy and Ulf C. Schneider Tags: Research Source Type: research

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia
The role of the immune system in stroke is well-recognised. Fingolimod, an immunomodulatory agent licensed for the management of relapsing-remitting multiple sclerosis, has been shown to provide benefit in rod... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 30, 2021 Category: Neurology Authors: Kyle Malone, Andrea C. Diaz Diaz, Jennifer A. Shearer, Anne C. Moore and Christian Waeber Tags: Research Source Type: research

Acute systemic LPS-exposure impairs perivascular CSF distribution in mice
The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 29, 2021 Category: Neurology Authors: Oscar Manouchehrian, Marta Ramos, Sara Bachiller, Iben Lundgaard and Tomas Deierborg Tags: Research Source Type: research

Correction to: The role of microglia membrane potentialin chemotaxis
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 28, 2021 Category: Neurology Authors: Laura Laprell, Christian Schulze, Marie-Luise Brehme and Thomas G. Oertner Tags: Correction Source Type: research

Chronic exposure to IL-6 induces a desensitized phenotype of the microglia
When the homeostasis of the central nervous system (CNS) is altered, microglial cells become activated displaying a wide range of phenotypes that depend on the specific site, the nature of the activator, and p... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 22, 2021 Category: Neurology Authors: Mireia Recasens, Beatriz Almolda, Je ús Pérez-Clausell, Iain L. Campbell, Berta González and Bernardo Castellano Tags: Research Source Type: research

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
Age-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 22, 2021 Category: Neurology Authors: Keng Siang Lee, Shuxiao Lin, David A. Copland, Andrew D. Dick and Jian Liu Tags: Review Source Type: research

Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Protein aggregates can be found in peripheral organs, such as the heart, kidney, and pancreas, but little is known about the impact of peripherally misfolded proteins on neuroinflammation and brain functional ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 20, 2021 Category: Neurology Authors: Yanying Liu, Kalpana Subedi, Aravind Baride, Svetlana Romanova, Eduardo Callegari, Christa C. Huber, Xuejun Wang and Hongmin Wang Tags: Research Source Type: research

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis
Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor- β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a n... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 20, 2021 Category: Neurology Authors: Petri Elo, Xiang-Guo Li, Heidi Liljenb äck, Maria Gardberg, Olli Moisio, Maxwell Miner, Jenni Virta, Antti Saraste, Madduri Srinivasarao, Michael Pugh, Philip S. Low, Juhani Knuuti, Sirpa Jalkanen, Laura Airas, Yingjuan June Lu and Anne Roivainen Tags: Research Source Type: research

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats
Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammato... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 19, 2021 Category: Neurology Authors: Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yijun Yang, Cameron Lenahan, Gaigai Li, Dujuan Li, Lifei Lian, Jiping Tang, Jun Lu and John H. Zhang Tags: Research Source Type: research

Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis
Follicular regulatory T (TFR) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (TFH) cell-GC-antibody (Ab) response secondary to... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 19, 2021 Category: Neurology Authors: Lin Luo, Xianzhen Hu, Michael L. Dixon, Brandon J. Pope, Jonathan D. Leavenworth, Chander Raman, William R. Meador and Jianmei W. Leavenworth Tags: Research Source Type: research

Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity
Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural net... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 19, 2021 Category: Neurology Authors: Arash Tadjalli, Yasin B. Seven, Raphael R. Perim and Gordon S. Mitchell Tags: Research Source Type: research

Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease
Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2021 Category: Neurology Authors: Ya-Nan Zhang, Jing-Kai Fan, Li Gu, Hui-Min Yang, Shu-Qin Zhan and Hong Zhang Tags: Research Source Type: research

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits
Disruptions of brain-gut axis have been implicated in the progression of a variety of gastrointestinal (GI) disorders and central nervous system (CNS) diseases and injuries, including traumatic brain injury (T... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2021 Category: Neurology Authors: Marie Hanscom, David J. Loane, Taryn Aubretch, Jenna Leser, Kara Molesworth, Nivedita Hedgekar, Rodney M. Ritzel, Gelareh Abulwerdi, Terez Shea-Donohue and Alan I. Faden Tags: Research Source Type: research

The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke
Through considerable effort in research and clinical studies, the immune system has been identified as a participant in the onset and progression of brain injury after ischaemic stroke. Due to the involvement ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2021 Category: Neurology Authors: Tian-Yu Lei, Ying-Ze Ye, Xi-Qun Zhu, Daniel Smerin, Li-Juan Gu, Xiao-Xing Xiong, Hong-Fei Zhang and Zhi-Hong Jian Tags: Review Source Type: research

The role of microglia membrane potential in chemotaxis
Microglia react to danger signals by rapid and targeted extension of cellular processes towards the source of the signal. This positive chemotactic response is accompanied by a hyperpolarization of the microgl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2021 Category: Neurology Authors: Laura Laprell, Christian Schulze, Marie-Luise Brehme and Thomas G. Oertner Tags: Short report Source Type: research

Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury
Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role again... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2021 Category: Neurology Authors: Brigitta Dukay, Fruzsina R. Walter, Judit P. Vigh, Be áta Barabási, Petra Hajdu, Tamás Balassa, Ede Migh, András Kincses, Zsófia Hoyk, Titanilla Szögi, Emőke Borbély, Bálint Csoboz, Péter Horváth, Lívia Fülöp, Botond Penke, László Vígh & Tags: Research Source Type: research

Propofol suppresses microglial phagocytosis through the downregulation of MFG-E8
Microglia are highly motile phagocytic cells in the healthy brain with surveillance and clearance functions. Although microglia have been shown to engulf cellular debris following brain insult, less is known a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 9, 2021 Category: Neurology Authors: Xiaoying Cai, Ying Li, Xiaoyang Zheng, Rong Hu, Yingyuan Li, Liangcan Xiao and Zhongxing Wang Tags: Research Source Type: research

Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer ’s disease models
Genetic variants and mutations in triggering receptor expressed in myeloid cells (TREM2) are associated with premature and late onset Alzheimer ’s disease (AD). (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 9, 2021 Category: Neurology Authors: Michael Fassler, Maya Saban Rappaport, Clara Benaim Cu ño and Jacob George Tags: Research Source Type: research

The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson ’s disease
Recent work has established that Parkinson ’s disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances i... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 9, 2021 Category: Neurology Authors: Zach Dwyer, Melany Chaiquin, Jeffrey Landrigan, Kiara Ayoub, Pragya Shail, Julianna Rocha, Christie L. Childers, Kenneth B. Storey, Dana J. Philpott, Hongyu Sun and Shawn Hayley Tags: Research Source Type: research

Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model
Both genetic factors and environmental hazards, including environmental noise stress, have been associated with gut microbiome that exacerbates Alzheimer ’s disease (AD) pathology. However, the role and mechani... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2021 Category: Neurology Authors: Huimin Chi, Wa Cao, Ming Zhang, Donghong Su, Honglian Yang, Zhe Li, Chao Li, Xiaojun She, Kun Wang, Xiujie Gao, Kefeng Ma, Pengfang Zheng, Xiaofang Li and Bo Cui Tags: Research Source Type: research

Differential neurovirulence of Usutu virus lineages in mice and neuronal cells
Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2021 Category: Neurology Authors: Marion Cl é, Orianne Constant, Jonathan Barthelemy, Caroline Desmetz, Marie France Martin, Lina Lapeyre, Daniel Cadar, Giovanni Savini, Liana Teodori, Federica Monaco, Jonas Schmidt-Chanasit, Juan-Carlos Saiz, Gaëlle Gonzales, Sylvie Lecollinet, Cécile Tags: Research Source Type: research

mGlu3 receptor regulates microglial cell reactivity in neonatal rats
Perinatal inflammation is a key factor of brain vulnerability in neonates born preterm or with intra-uterine growth restriction (IUGR), two leading conditions associated with brain injury and responsible for n... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2021 Category: Neurology Authors: Manuela Zinni, J érôme Mairesse, Julien Pansiot, Francesco Fazio, Luisa Iacovelli, Nico Antenucci, Rosamaria Orlando, Ferdinando Nicoletti, Daniel Vaiman and Olivier Baud Tags: Research Source Type: research

Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticus
P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel playing important roles in a variety of physiological functions, including inflammation, and apoptotic or necrotic cell death. An extracellul... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2021 Category: Neurology Authors: Duk-Shin Lee and Ji-Eun Kim Tags: Research Source Type: research

A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
Microglia are resident immunocompetent and phagocytic cells in the CNS. Pro-inflammatory microglia, stimulated by microbial signals such as bacterial lipopolysaccharide (LPS), viral RNAs, or inflammatory cytok... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2021 Category: Neurology Authors: Nicholas W. Mathy, Olivia Burleigh, Andrew Kochvar, Erin R. Whiteford, Matthew Behrens, Patrick Marta, Cong Tian, Ai-Yu Gong, Kristen M. Drescher, Peter S. Steyger, Xian-Ming Chen and Annemarie Shibata Tags: Research Source Type: research

Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events following TBI, but the regulatory and functiona... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 5, 2021 Category: Neurology Authors: Haijian Wu, Jingwei Zheng, Shenbin Xu, Yuanjian Fang, Yingxi Wu, Jianxiong Zeng, Anwen Shao, Ligen Shi, Jianan Lu, Shuhao Mei, Xiaoyu Wang, Xinying Guo, Yirong Wang, Zhen Zhao and Jianmin Zhang Tags: Research Source Type: research

Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke
Inflammatory response plays an important role in many processes related to acute ischemic stroke (AIS). Calprotectin (S100A8/S100A9), released by monocytes and neutrophils, is a key protein in the regulation o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 5, 2021 Category: Neurology Authors: Juan Marta-Enguita, Manuel Navarro-Oviedo, Idoia Rubio-Baines, Nuria Aymerich, Maria Herrera, Beatriz Zandio, Sergio Mayor, Jose-Antonio Rodriguez, Jose-Antonio P áramo, Estefania Toledo, Maite Mendioroz, Roberto Muñoz and Josune Orbe Tags: Research Source Type: research