CSF1R antagonism results in increased supraspinal infiltration in EAE
Colony stimulating factor 1 receptor (CSF1R) signaling is crucial for the maintenance and function of various myeloid subsets. CSF1R antagonism was previously shown to mitigate clinical severity in experimenta... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 20, 2024 Category: Neurology Authors: Marilyn Wang, Sofia E. Caryotakis, Glendalyn G. Smith, Alan V. Nguyen, David E. Pleasure and Athena M. Soulika Tags: Research Source Type: research

Microbiota-derived acetate attenuates neuroinflammation in rostral ventrolateral medulla of spontaneously hypertensive rats
Increased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both human and animal studies suggests a link between hypertension and gut mic... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 18, 2024 Category: Neurology Authors: Xiaopeng Yin, Changhao Duan, Lin Zhang, Yufang Zhu, Yueyao Qiu, Kaiyi Shi, Sen Wang, Xiaoguang Zhang, Huaxing Zhang, Yinchao Hao, Fang Yuan and Yanming Tian Tags: Research Source Type: research

Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 18, 2024 Category: Neurology Authors: Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng and Yujie Chen Tags: Review Source Type: research

Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain
The pathogenesis of memory impairment, a common complication of chronic neuropathic pain (CNP), has not been fully elucidated. Schwann cell (SC)-derived extracellular vesicles (EVs) contribute to remote organ ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 17, 2024 Category: Neurology Authors: Yidan Tang, Jiahui Wu, Changliang Liu, Lu Gan, Hai Chen, Ya-Lan Sun, Jin Liu, Yuan-Xiang Tao, Tao Zhu and Chan Chen Tags: Research Source Type: research

IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 17, 2024 Category: Neurology Authors: Kevin Budding, Jeroen W. Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Eva M. Zekveld, Ewout J.N. Groen, Bart C. Jacobs, Ruth Huizinga, H. Stephan Goedee, Elisabeth A. Cats, Jeanette H.W. Leusen, Leonard H. van den Berg, C. Erik Hack and Tags: Research Source Type: research

Complement propagates visual system pathology following traumatic brain injury
Traumatic brain injury (TBI) is associated with the development of visual system disorders. Visual deficits can present with delay and worsen over time, and may be associated with an ongoing neuroinflammatory ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 17, 2024 Category: Neurology Authors: Davis M. Borucki, Baerbel Rohrer and Stephen Tomlinson Tags: Research Source Type: research

LXR agonism for CNS diseases: promises and challenges
The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 16, 2024 Category: Neurology Authors: Ruiyi Zhang, Emily Wuerch, V. Wee Yong and Mengzhou Xue Tags: Review Source Type: research

GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain largely unclear. Dynam... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 16, 2024 Category: Neurology Authors: Qun Fu, Yi-Bao Zhang, Chang-Xi Shi, Ming Jiang, Kai Lu, Zi-Hui Fu, Jia-Ping Ruan, Jing Wu and Xiao-Ping Gu Tags: Research Source Type: research

Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inf... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2024 Category: Neurology Authors: Terry Dean, Andrew S. Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga, Katerina Akassoglou and Jae Kyu Ryu Tags: Research Source Type: research

Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson ’s disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2024 Category: Neurology Authors: Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman and Eliezer Masliah Tags: Research Source Type: research

A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies
Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2024 Category: Neurology Authors: Ogochukwu J. Uweru, Akhabue K. Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S. Thomas, Georgia Davidson, Kendall Cox and Ukpong B. Eyo Tags: Research Source Type: research

Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 12, 2024 Category: Neurology Authors: Maria T. Cencioni, Roberta Magliozzi, Ilaria Palmisano, Keittisak Suwan, Antonella Mensi, Laura Fuentes-Font, Luisa M. Villar, Jos é I. Fernández-Velasco, Noelia Villarrubia Migallón, Lucienne Costa-Frossard, Enric Monreal, Rehiana Ali, Marina Romozzi, Tags: Research Source Type: research

Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Si... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 12, 2024 Category: Neurology Authors: Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz, Esther Luquin, Pedro Clavero, Elisa Mengual, Sandra Herv ás-Stubbs and Maria S. Aymerich Tags: Research Source Type: research

Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE ’s pathogenesis has not been fully elucidated, clinical imaging studies ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting and Chaim Putterman Tags: Research Source Type: research

Correction: Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer ’s disease
(Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Carla Cun í‑López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White and Hazel Quek Tags: Correction Source Type: research