Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice
Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by cognitive impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear. Bra... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 16, 2020 Category: Neurology Authors: Li-Li Qiu, Wei Pan, Dan Luo, Guang-Fen Zhang, Zhi-Qiang Zhou, Xiao-Yun Sun, Jian-Jun Yang and Mu-Huo Ji Tags: Research Source Type: research

Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 14, 2020 Category: Neurology Authors: Naiara Celarain and Jordi Tomas-Roig Tags: Review Source Type: research

Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
The increasing risk of obesity and diabetes among other metabolic disorders are the consequence of shifts in dietary patterns with high caloric-content food intake. We previously reported that megalin regulate... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 14, 2020 Category: Neurology Authors: Fernando Bartolome, Desiree Antequera, Macarena de la Cueva, Marcos Rubio-Fernandez, Nerea Castro, Consuelo Pascual, Antoni Camins and Eva Carro Tags: Research Source Type: research

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation of the sp... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 13, 2020 Category: Neurology Authors: Honglu Ding, Jialiang Chen, Minzhi Su, Zhijun Lin, Hailun Zhan, Fei Yang, Wenbiao Li, Juncong Xie, Yong Huang, Xianguo Liu, Bolong Liu and Xiangfu Zhou Tags: Research Source Type: research

Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members
There is a paucity of human data on exposure to blast traumatic brain injury (bTBI) and the corresponding systemic cytokine immune response at later time points (i.e., months, years) post-injury. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 13, 2020 Category: Neurology Authors: Jennifer Rusiecki, Lynn I. Levin, Li Wang, Celia Byrne, Jayasree Krishnamurthy, Ligong Chen, Zygmunt Galdzicki and Louis M. French Tags: Research Source Type: research

Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage
The potential roles and mechanisms of pericytes in maintaining blood –brain barrier (BBB) integrity, which would be helpful for the development of therapeutic strategies for subarachnoid hemorrhage (SAH), remai... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2020 Category: Neurology Authors: Pengyu Pan, Hengli Zhao, Xuan Zhang, Qiang Li, Jie Qu, Shilun Zuo, Fan Yang, Guobiao Liang, John H. Zhang, Xin Liu, Haiyang He, Hua Feng and Yujie Chen Tags: Research Source Type: research

Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported to be involved in neuroinflammation in Alzheimer ’s disease and traumatic brain injury. The present study was designed to investig... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2020 Category: Neurology Authors: Xin-Chun Ye, Qi Hao, Wei-Jing Ma, Qiu-Chen Zhao, Wei-Wei Wang, Han-Han Yin, Tao Zhang, Miao Wang, Kun Zan, Xin-Xin Yang, Zuo-Hui Zhang, Hong-Juan Shi, Jie Zu, Hafiz Khuram Raza, Xue-Ling Zhang, De-Qin Geng & hellip; Tags: Research Source Type: research

Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation
Microglial activation is a prominent feature of neuroinflammation, which is present in almost all neurodegenerative diseases. While an initial inflammatory response mediated by microglia is considered to be pr... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2020 Category: Neurology Authors: Xiaoxia Ye, Mingming Zhu, Xiaohang Che, Huiyang Wang, Xing-Jie Liang, Chunfu Wu, Xue Xue and Jingyu Yang Tags: Research Source Type: research

Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression
Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-infla... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2020 Category: Neurology Authors: Shuai Shao, Huan Xia, Min Hu, Chengjuan Chen, Junmin Fu, Gaona Shi, Qinglan Guo, Yu Zhou, Wenjie Wang, Jiangong Shi and Tiantai Zhang Tags: Research Source Type: research

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression
Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients. Uncontrolled neuroinflammation and ischemic... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2020 Category: Neurology Authors: Chao Ren, Ren-qi Yao, Hui Zhang, Yong-wen Feng and Yong-ming Yao Tags: Review Source Type: research

HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia
Microglial mediated neuroinflammation in the rostral ventrolateral medulla (RVLM) plays roles in the etiology of stress-induced hypertension (SIH). It was reported that autophagy influenced inflammation via im... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2020 Category: Neurology Authors: Shutian Zhang, Li Hu, Jialun Jiang, Hongji Li, Qin Wu, Kokwin Ooi, Jijiang Wang, Yi Feng, Danian Zhu and Chunmei Xia Tags: Research Source Type: research

Serum dickkopf-3 is associated with death and vascular events after ischemic stroke: an observational study from CATIS
This study aimed to investigate the association between serum Dkk-3 and the prognosis of ischemic stroke. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 9, 2020 Category: Neurology Authors: Zhengbao Zhu, Daoxia Guo, Chongke Zhong, Aili Wang, Tan Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang and Jiang He Tags: Research Source Type: research

Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis
The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunom... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 8, 2020 Category: Neurology Authors: Lisa Thiele n ée Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese and Andrew Chan Tags: Short report Source Type: research

Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
Alzheimer ’s disease is associated with the accumulation of intracellular Tau tangles within neurons and extracellular amyloid-β plaques in the brain parenchyma, which altogether results in synaptic loss and ne... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 8, 2020 Category: Neurology Authors: Rashmi Das, Abhishek Ankur Balmik and Subashchandrabose Chinnathambi Tags: Research Source Type: research

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease
Emerging evidence indicates that inflammasome-induced inflammation plays a crucial role in the pathogenesis of Parkinson ’s disease (PD). Several proteins including α-synuclein trigger the activation of NLRP3 i... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 8, 2020 Category: Neurology Authors: Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma and Xiao-Min Wang Tags: Research Source Type: research

Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs
The circumventricular organs (CVOs) are blood-brain-barrier missing structures whose activation through lipopolysaccharide (LPS) is a starting point for TLR-driven (Toll-like receptors) neuroinflammation. The ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2020 Category: Neurology Authors: Alejandra Vargas-Caraveo, Aline Sayd, Javier Robledo-Monta ña, Javier R. Caso, José L. M. Madrigal, Borja García-Bueno and Juan C. Leza Tags: Research Source Type: research

The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction
Inflammation is associated with poor outcome after stroke. A relationship between ex vivo cytokine synthesis and stroke outcome remains unclear. We explored an association between ex vivo cytokine release, cir... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2020 Category: Neurology Authors: Elzbieta Klimiec-Moskal, Marcin Piechota, Joanna Pera, Kazimierz Weglarczyk, Agnieszka Slowik, Maciej Siedlar and Tomasz Dziedzic Tags: Research Source Type: research

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
Cognitive impairment in schizophrenia, aging, and Alzheimer ’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critic... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 6, 2020 Category: Neurology Authors: Dibyadeep Datta, Shannon N. Leslie, Yury M. Morozov, Alvaro Duque, Pasko Rakic, Christopher H. van Dyck, Angus C. Nairn and Amy F. T. Arnsten Tags: Research Source Type: research

Neuroinflammation trajectories precede cognitive impairment after experimental meningitis —evidence from an in vivo PET study
Bacterial meningitis is a devastating central nervous system (CNS) infection with acute and long-term neurological consequences, including cognitive impairment. The aim of this study was to understand the asso... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 4, 2020 Category: Neurology Authors: Vijayasree V. Giridharan, Allan Collodel, Jaqueline S. Generoso, Giselli Scaini, Rico Wassather, Sudhakar Selvaraj, Rodrigo Hasbun, Felipe Dal-Pizzol, Fabricia Petronilho and Tatiana Barichello Tags: Research Source Type: research

IL-1 β induces rod degeneration through the disruption of retinal glutamate homeostasis
Age-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mononuclear Phagocytes-derived I... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 3, 2020 Category: Neurology Authors: Hugo Charles-Messance, Guillaume Blot, Aude Couturier, Lucile Vignaud, Sara Touhami, Fanny Beguier, Lourdes Siqueiros, Val érie Forster, Nour Barmo, Sébastien Augustin, Serge Picaud, José-Alain Sahel, Alvaro Rendon, Antje Grosche, Ramin Tadayoni, Flori Tags: Research Source Type: research

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus
Diabetes mellitus (DM) and chronic cerebral hypoperfusion(CCH)are both risk factors for cognitive impairment. However, whether DM and CCH can synergistically promote cognitive impairment and the related pathol... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 3, 2020 Category: Neurology Authors: Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo, Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang and Jianliang Fu Tags: Research Source Type: research

MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries
Nerve injury-induced chronic pain has been an urgent problem for both public health and clinical practice. While transition to chronic pain is not an inevitable consequence of nerve injuries, the susceptibilit... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 3, 2020 Category: Neurology Authors: You-Quan Ding, Han Luo and Jian-Guo Qi Tags: Review Source Type: research

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer ’s disease mice
Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 3, 2020 Category: Neurology Authors: Yan Liu, John Man Tak Chu, Tim Yan, Yan Zhang, Ying Chen, Raymond Chuen Chung Chang and Gordon Tin Chun Wong Tags: Research Source Type: research

Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury
The prognosis of spinal cord injury (SCI) is closely related to secondary injury, which is dominated by neuroinflammation. There is evidence that α-synuclein aggregates after SCI and that inhibition of α-synuc... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 30, 2019 Category: Neurology Authors: Hong Zeng, Nan Liu, Yan-yan Yang, Hua-yi Xing, Xiao-xie Liu, Fang Li, Gao-yan La, Meng-jie Huang and Mou-wang Zhou Tags: Research Source Type: research

Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events
Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer ’s disease (AD); however, VCID is commonly found as a co-morbidity with sporadic... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 30, 2019 Category: Neurology Authors: Erica M. Weekman, Tiffany L. Sudduth, Brittani R. Price, Abigail E. Woolums, Danielle Hawthorne, Charles E. Seaks and Donna M. Wilcock Tags: Research Source Type: research

CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells
Recent studies have demonstrated that natural killer (NK) cells can modulate other immune components and are involved in the development or progression of several autoimmune diseases. However, the roles and me... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 29, 2019 Category: Neurology Authors: Chun-Lin Yang, Peng Zhang, Ru-Tao Liu, Na Zhang, Min Zhang, Heng Li, Tong Du, Xiao-Li Li, Ying-Chun Dou and Rui-Sheng Duan Tags: Research Source Type: research

Unique molecular signature in mucolipidosis type IV microglia
Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depend... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 28, 2019 Category: Neurology Authors: Antony Cougnoux, Rebecca A. Drummond, Mason Fellmeth, Fatemeh Navid, Amanda L. Collar, James Iben, Ashok B. Kulkarni, James Pickel, Raphael Schiffmann, Christopher A. Wassif, Niamh X. Cawley, Michail S. Lionakis and Forbes D. Porter Tags: Research Source Type: research

Deletion of SIRP α (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury
Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physica... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 28, 2019 Category: Neurology Authors: Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal and Shlomo Rotshenker Tags: Research Source Type: research

KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
Uveitis is a potentially sight-threatening form of ocular inflammation that affects the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited profound adverse side effects. How... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 28, 2019 Category: Neurology Authors: Tian Niu, Lu Cheng, Hanying Wang, Shaopin Zhu, Xiaolu Yang, Kun Liu, Huiyi Jin and Xun Xu Tags: Research Source Type: research

Complement factor H contributes to mortality in humans and mice with bacterial meningitis
The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal menin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 28, 2019 Category: Neurology Authors: E. Soemirien Kasanmoentalib, Mercedes Valls Ser ón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer and Diederik van de Beek Tags: Research Source Type: research

The history of neuromyelitis optica. Part 2: ‘Spinal amaurosis’, or how it all began
Neuromyelitis optica (NMO) was long considered a clinical variant of multiple sclerosis (MS). However, the discovery of a novel and pathogenic anti-astrocytic serum autoantibody targeting aquaporin-4 (termed N... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 28, 2019 Category: Neurology Authors: S. Jarius and B. Wildemann Tags: Review Source Type: research

Interleukin-1 β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated wi... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 27, 2019 Category: Neurology Authors: Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger and W. Sue T. Griffin Tags: Research Source Type: research

The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson ’s disease
Recent studies described a critical role for microglia in Parkinson ’s disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 26, 2019 Category: Neurology Authors: Jia Lu, Fangfang Dou and Zhihua Yu Tags: Research Source Type: research

Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity
Palmitoylethanolamide (PEA) is a pleiotropic endogenous lipid mediator currently used as a “dietary food for special medical purposes” against neuropathic pain and neuro-inflammatory conditions. Several mechan... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 26, 2019 Category: Neurology Authors: Stefania Petrosino, Aniello Schiano Moriello, Roberta Verde, Marco Allar à, Roberta Imperatore, Alessia Ligresti, Ali Mokhtar Mahmoud, Alessio Filippo Peritore, Fabio Arturo Iannotti and Vincenzo Di Marzo Tags: Research Source Type: research

Molecular biomarkers in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 23, 2019 Category: Neurology Authors: Tjalf Ziemssen, Katja Akg ün and Wolfgang Brück Tags: Review Source Type: research

Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer ’s disease
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal lipid phosphatase activities. It is expressed in various cell types in the brain and is involved in the pa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 17, 2019 Category: Neurology Authors: Hsueh-Te Lee, Kuan-I Lee, Chia-Hui Chen and Tzong-Shyuan Lee Tags: Research Source Type: research

Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem
Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation, pain, and nerve abnormalities. We studied the peripheral and central neuroinflammatory responses that occur during... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 17, 2019 Category: Neurology Authors: Darine Fakih, Zhanlin Zhao, Pierre Nicolle, Elodie Reboussin, Fanny Joubert, Jade Luzu, Antoine Labb é, William Rostène, Christophe Baudouin, Stéphane Mélik Parsadaniantz and Annabelle Réaux-Le Goazigo Tags: Research Source Type: research

Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C
Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 17, 2019 Category: Neurology Authors: Samuel D. Shin, Alexandra Shin, Karina Mayagoitia, Lorraine Siebold, Marsilio Rubini, Christopher G. Wilson, Denise L. Bellinger and Salvador Soriano Tags: Research Source Type: research

Association of LAG3 genetic variation with an increased risk of PD in Chinese female population
Emerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson’s disease (PD) and the toxic fibrillary α-syn binds lymphocyte-activation... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 17, 2019 Category: Neurology Authors: Wenyuan Guo, Miaomiao Zhou, Jiewen Qiu, Yuwan Lin, Xiang Chen, Shuxuan Huang, Mingshu Mo, Hanqun Liu, Guoyou Peng, Xiaoqin Zhu and Pingyi Xu Tags: Research Source Type: research

Intrathecal injection of bone marrow stromal cells attenuates neuropathic pain via inhibition of P2X4R in spinal cord microglia
Neuropathic pain is one of the most debilitating of all chronic pain syndromes. Intrathecal (i.t.) bone marrow stromal cell (BMSC) injections have a favorable safety profile; however, results have been inconsi... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 17, 2019 Category: Neurology Authors: Yongbo Teng, Yang Zhang, Shouwei Yue, Huanwen Chen, Yujuan Qu, Hui Wei and Xiaofeng Jia Tags: Research Source Type: research

Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition with no known etiology or cure. Several possible contributing factors, both genetic and environmental, are being actively investigated... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 14, 2019 Category: Neurology Authors: Kazi Farhana Afroz and Karina Alvi ña Tags: Review Source Type: research

Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer ’s disease animal model
Alzheimer ’s disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities and memory leading to dementia. Electroacupuncture (EA) is a complementary alternative medicine... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 13, 2019 Category: Neurology Authors: Mudan Cai, Jun-Hwan Lee and Eun Jin Yang Tags: Research Source Type: research

CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
The mechanisms underlying the pathogenesis and progression of Parkinson ’s disease (PD) remain elusive, but recent opinions and perspectives have focused on whether the inflammation process induced by microglia... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 12, 2019 Category: Neurology Authors: Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu and Jun Liu Tags: Research Source Type: research

TGF βRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment
HIV-1 –associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 11, 2019 Category: Neurology Authors: Gladys Chompre, Neysha Martinez-Orengo, Myrella Cruz, James T. Porter and Richard J. Noel Jr Tags: Research Source Type: research

IL-1 β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer ’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have p... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 10, 2019 Category: Neurology Authors: F átima Rivera-Escalera, Jonathan J. Pinney, Laura Owlett, Hoda Ahmed, Juilee Thakar, John A. Olschowka, Michael R. Elliott and M. Kerry O’Banion Tags: Research Source Type: research

URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion
Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 9, 2019 Category: Neurology Authors: Shao-Hua Su, Yi-Fang Wu, Qi Lin, Da-Peng Wang and Jian Hai Tags: Research Source Type: research

Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis
Recent studies of cortical pathology in secondary progressive multiple sclerosis have shown that a more severe clinical course and the presence of extended subpial grey matter lesions with significant neuronal... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 7, 2019 Category: Neurology Authors: Roberta Magliozzi, Owain William Howell, Pascal Durrenberger, Eleonora Aric ò, Rachel James, Carolina Cruciani, Cheryl Reeves, Federico Roncaroli, Richard Nicholas and Richard Reynolds Tags: Research Source Type: research

Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke
Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/ β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroi... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 6, 2019 Category: Neurology Authors: Degang Song, Xiangjian Zhang, Junmin Chen, Xiaoxia Liu, Jing Xue, Lan Zhang and Xifa Lan Tags: Research Source Type: research

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines
Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune syst... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 6, 2019 Category: Neurology Authors: Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias and Elisabetta Mantuano Tags: Research Source Type: research

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer ’s disease, Parkinson’s disease (PD) and sepsis. Despite microglial cells being the cent... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 6, 2019 Category: Neurology Authors: Andro Montoya, Daniela Elgueta, Javier Campos, Ornella Chovar, Paulina Falc ón, Soledad Matus, Iván Alfaro, María Rosa Bono and Rodrigo Pacheco Tags: Research Source Type: research