Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKC ε in rat dorsal root ganglion neurons
Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen peroxide, plays a pivotal role in neuropathic pain.... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 6, 2021 Category: Neurology Authors: Jing Xu, Shinan Wu, Junfei Wang, Jianmei Wang, Yi Yan, Mengye Zhu, Daying Zhang, Changyu Jiang and Tao Liu Tags: Research Source Type: research

Conditional knockout of Tsc1 in ROR γt-expressing cells induces brain damage and early death in mice
Tuberous sclerosis complex 1 (Tsc1) is known to regulate the development and function of various cell types, and ROR γt is a critical transcription factor in the immune system. However, whether Tsc1 participates i... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 6, 2021 Category: Neurology Authors: Yafei Deng, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Shuju Zhang, Baige Yao, Shuhui Li, Yuan Gao, Xiaohui Li, Liping Li and Youcai Deng Tags: Research Source Type: research

Serum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder
Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with a relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are a yet unmet cli... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 1, 2021 Category: Neurology Authors: Patrick Schindler, Ulrike Grittner, Johanna Oechtering, David Leppert, Nadja Siebert, Ankelien S. Duchow, Frederike C. Oertel, Susanna Asseyer, Joseph Kuchling, Hanna G. Zimmermann, Alexander U. Brandt, Pascal Benkert, Markus Reindl, Sven Jarius, Friedema Tags: Research Source Type: research

Identification of aberrant innate and adaptive immunity based on changes in global gene expression in the blood of adults with autism spectrum disorder
Autism spectrum disorder (ASD) is characterized as a neurodevelopmental disorder, and one of the main hypotheses regarding its cause is genetic factors. A previous meta-analysis of seven microarray studies and... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 30, 2021 Category: Neurology Authors: Fumie Horiuchi, Yuta Yoshino, Hiroshi Kumon, Rie Hosokawa, Kiwamu Nakachi, Kentaro Kawabe, Jun-ichi Iga and Shu-ichi Ueno Tags: Research Source Type: research

Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study
Our understanding of the relationship between plasma and cerebrospinal fluid (CSF) remains limited, which poses an obstacle to the identification of blood-based markers of neuroinflammatory disorders. To bette... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 30, 2021 Category: Neurology Authors: Sarinnapha M. Vasunilashorn, Long H. Ngo, Simon T. Dillon, Tamara G. Fong, Becky C. Carlyle, Pia Kivis äkk, Bianca A. Trombetta, Kamen V. Vlassakov, Lisa J. Kunze, Steven E. Arnold, Zhongcong Xie, Sharon K. Inouye, Towia A. Libermann and Edward R. Marcan Tags: Research Source Type: research

Traumatic brain injury does not disrupt costimulatory blockade-induced immunological tolerance to glial-restricted progenitor allografts
Cell transplantation-based treatments for neurological disease are promising, yet graft rejection remains a major barrier to successful regenerative therapies. Our group and others have shown that long-lasting... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 30, 2021 Category: Neurology Authors: Rui Wang, Chengyan Chu, Zhiliang Wei, Lin Chen, Jiadi Xu, Yajie Liang, Miroslaw Janowski, Robert D. Stevens and Piotr Walczak Tags: Research Source Type: research

Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model
Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 27, 2021 Category: Neurology Authors: Louisa Nitsch, Simon Petzinna, Julian Zimmermann, Linda Schneider, Marius Krauthausen, Michael T. Heneka, Daniel R. Getts, Albert Becker and Marcus M üller Tags: Research Source Type: research

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
The α7 nicotinic acetylcholine receptor (α7 nAChR) negatively regulates the synthesis and release of pro-inflammatory cytokines by immune cells. Our previous studies showed that in encephalitogenic T cells, α7... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 26, 2021 Category: Neurology Authors: Tehila Mizrachi, Oshrit Marsha, Karen Brusin, Yael Ben-David, Ganesh A. Thakur, Adi Vaknin-Dembinsky, Millet Treinin and Talma Brenner Tags: Research Source Type: research

Minocycline attenuation of rat corpus callosum abnormality mediated by low-dose lipopolysaccharide-induced microglia activation
Microglia are resident innate immune cells in the brain, and activation of these myeloid cells results in secretion of a variety of pro-inflammatory molecules, leading to the development of neurodegenerative d... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 26, 2021 Category: Neurology Authors: Jingdong Zhang, Michael Boska, Ya Zheng, Jianuo Liu, Howard S. Fox and Huangui Xiong Tags: Research Source Type: research

Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats
Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ische... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 20, 2021 Category: Neurology Authors: Lixuan Zhan, Xiaomei Lu, Wensheng Xu, Weiwen Sun and En Xu Tags: Research Source Type: research

STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis
Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the patho... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 20, 2021 Category: Neurology Authors: Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li and Zizhen Kang Tags: Research Source Type: research

Human Huntington ’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species
Neuroinflammation may contribute to the pathogenesis of Huntington ’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 19, 2021 Category: Neurology Authors: Grace C. O ’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood-Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi and Ralph Andre Tags: Research Source Type: research

4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice
Chronic brain inflammation has been implicated in the pathogenesis of various neurodegenerative diseases and disorders. For example, overexpression of pro-inflammatory cytokines has been associated with impair... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 19, 2021 Category: Neurology Authors: Luis A. Rojas-Col ón, Pramod K. Dash, Fabiola A. Morales-Vías, Madeline Lebrón-Dávila, Pedro A. Ferchmin, John B. Redell, Geronimo Maldonado-Martínez and Wanda I. Vélez-Torres Tags: Research Source Type: research

Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia
Postherpetic neuralgia (PHN) is a devastating complication after varicella-zoster virus infection. Brain-derived neurotrophic factor (BDNF) has been shown to participate in the pathogenesis of PHN. A truncated... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 19, 2021 Category: Neurology Authors: Xiang Wei, Lina Wang, Jie Hua, Xiao-hong Jin, Fuhai Ji, Ke Peng, Bin Zhou, Jianping Yang and Xiao-wen Meng Tags: Research Source Type: research

Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling
Postoperative pain is a common phenomenon after surgery and is closely associated with the development of postoperative cognitive dysfunction (POCD). Persistent pain and systemic inflammation caused by surgery... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2021 Category: Neurology Authors: Inja Cho, Jeong Min Kim, Eun Jung Kim, So Yeon Kim, Eun Hee Kam, Eunji Cheong, Minah Suh and Bon-Nyeo Koo Tags: Research Source Type: research

TNF- α acutely enhances acid-sensing ion channel currents in rat dorsal root ganglion neurons via a p38 MAPK pathway
Tumor necrosis factor- α (TNF-α) is a pro-inflammatory cytokine involved in pain processing and hypersensitivity. It regulates not only the expression of a variety of inflammatory mediators but also the functio... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 14, 2021 Category: Neurology Authors: Shuang Wei, Chun-Yu Qiu, Ying Jin, Ting-Ting Liu and Wang-Ping Hu Tags: Research Source Type: research

Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain
We previously reported a correlation between small doses of oxaliplatin penetrating onto the spinal cord and acute pain after chemotherapy. Here, we propose that MT2 within the spinal dorsal horns participates... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 13, 2021 Category: Neurology Authors: Xuelin Huang, Jie Deng, Ting Xu, Wenjun Xin, Yuehong Zhang and Xiangcai Ruan Tags: Research Source Type: research

High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke
In this study, whe... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 12, 2021 Category: Neurology Authors: Mengyan Hu, Yinyao Lin, Xuejiao Men, Shisi Wang, Xiaobo Sun, Qiang Zhu, Danli Lu, Sanxin Liu, Bingjun Zhang, Wei Cai and Zhengqi Lu Tags: Research Source Type: research

Corneal confocal microscopy differentiates inflammatory from diabetic neuropathy
Immune-mediated neuropathies, such as chronic inflammatory demyelinating polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic neuropathy, it remains a challenge to identify those i... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 8, 2021 Category: Neurology Authors: Michael Fleischer, Inn Lee, Friedrich Erdlenbruch, Lena Hinrichs, Ioannis N. Petropoulos, Rayaz A. Malik, Hans-Peter Hartung, Bernd C. Kieseier, Christoph Kleinschnitz and Mark Stettner Tags: Research Source Type: research

The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson ’s disease
It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson ’s disease (PD). Consequently, the modulation of microglial activati... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 6, 2021 Category: Neurology Authors: Neus Rabaneda-Lombarte, Joan Serratosa, Jordi Bov é, Miquel Vila, Josep Saura and Carme Solà Tags: Research Source Type: research

Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion
In this study, we... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 3, 2021 Category: Neurology Authors: Kaoru Suzuki, Mitsuru Shinohara, Yoshihiro Uno, Yoshitaka Tashiro, Ghupurjan Gheni, Miho Yamamoto, Akio Fukumori, Akihiko Shindo, Tomoji Mashimo, Hidekazu Tomimoto and Naoyuki Sato Tags: Research Source Type: research

Correction to: CCL3 contributes to secondary damage after spinal cord injury
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 3, 2021 Category: Neurology Authors: Nicolas Pelisch, Jose Rosas Almanza, Kyle E. Stehlik, Brandy V. Aperi and Antje Kroner Tags: Correction Source Type: research

Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats
Prenatal synthetic glucocorticoid (sGC) exposure increases the susceptibility to cognitive and affective disorders in postnatal life. We previously demonstrated that prenatal sGC exposure results in an increas... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 2, 2021 Category: Neurology Authors: You Zheng, Yan-Min Zhang, Zheng-Shan Tang, Jian-Kui Du, De-Wei Guo, Yong-Jun Xu, Hui Sheng, Jian-Qiang Lu and Xin Ni Tags: Research Source Type: research

The NLRP3 inflammasome: an emerging therapeutic target for chronic pain
Chronic pain affects the life quality of the suffering patients and posts heavy problems to the health care system. Conventional medications are usually insufficient for chronic pain management and oftentimes ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 30, 2021 Category: Neurology Authors: Ruixiang Chen, Chengyu Yin, Jianqiao Fang and Boyi Liu Tags: Review Source Type: research

Viscoelastic properties of white and gray matter-derived microglia differentiate upon treatment with lipopolysaccharide but not upon treatment with myelin
The biomechanical properties of the brain have increasingly been shown to relate to brain pathology in neurological diseases, including multiple sclerosis (MS). Inflammation and demyelination in MS induce sign... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 29, 2021 Category: Neurology Authors: Thecla A. van Wageningen, Nelda Antonovaite, Erik Paardekam, John J. P. Brev é, Davide Iannuzzi and Anne-Marie van Dam Tags: Research Source Type: research

Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury
Inflammation constitutes both positive and negative aspects to recovery following peripheral nerve injury. Following damage to the peripheral nervous system (PNS), immune cells such as macrophages play a benef... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 24, 2021 Category: Neurology Authors: Erin-Mai F. Lim, Vahid Hoghooghi, Kathleen M. Hagen, Kunal Kapoor, Ariana Frederick, Trisha M. Finlay and Shalina S. Ousman Tags: Research Source Type: research

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity
Pain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions. Acting as a key player in nociceptive processing, neuroinflammation, and neuron-glia communication,... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 23, 2021 Category: Neurology Authors: Marc-Andr é Dansereau, Élora Midavaine, Valérie Bégin-Lavallée, Mounir Belkouch, Nicolas Beaudet, Jean-Michel Longpré, Stéphane Mélik-Parsadaniantz and Philippe Sarret Tags: Research Source Type: research

Activated STAT3 signaling pathway by ligature-induced periodontitis could contribute to neuroinflammation and cognitive impairment in rats
Increasing evidence suggests a causal link between periodontitis and cognitive disorders. Systemic inflammation initiated by periodontitis may mediate the development of cognitive impairment. Our study aims to... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 23, 2021 Category: Neurology Authors: Yi Hu, Xu Zhang, Jing Zhang, Xinyi Xia, Huxiao Li, Che Qiu, Yue Liao, Huiwen Chen, Zhiyan He, Zhongchen Song and Wei Zhou Tags: Research Source Type: research

Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage
Ischemia can induce rapid activation of microglia in the brain. As key immunocompetent cells, reactive microglia play an important role in pathological development of ischemic stroke. However, the role of acti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 23, 2021 Category: Neurology Authors: Ting Li, Jin Zhao, Wenguang Xie, Wanru Yuan, Jing Guo, Shengru Pang, Wen-Biao Gan, Diego G ómez-Nicola and Shengxiang Zhang Tags: Research Source Type: research

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy
While the etiology remains elusive, macrophages and T cells in peripheral nerves are considered as effector cells mediating autoimmune peripheral neuropathy (APN), such as Guillain-Barre syndrome. By recognizi... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 22, 2021 Category: Neurology Authors: Oladayo Oladiran, Xiang Qun Shi, Mu Yang, Sylvie Fournier and Ji Zhang Tags: Research Source Type: research

The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of various autoimmune subtypes in which the peripheral nervous system (PNS) is attacked. CIDP can follow a relapsing-remitting or progr... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 22, 2021 Category: Neurology Authors: Kathleen M. Hagen and Shalina S. Ousman Tags: Review Source Type: research

Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy
The translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising immunotherapeutic target for the treatment of Alzheimer ’s disease (AD... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 19, 2021 Category: Neurology Authors: Lauren H. Fairley, Naruhiko Sahara, Ichio Aoki, Bin Ji, Tetsuya Suhara, Makoto Higuchi and Anna M. Barron Tags: Research Source Type: research

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation
Aging and age-related diseases are strong risk factors for the development of neurodegenerative diseases. Neuroinflammation (NIF), as the brain ’s immune response, plays an important role in aged associated deg... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 18, 2021 Category: Neurology Authors: Andr és Fernández, Elena Quintana, Patricia Velasco, Belén Moreno-Jimenez, Belén de Andrés, Maria Luisa Gaspar, Isabel Liste, Marçal Vilar, Helena Mira and Eva Cano Tags: Research Source Type: research

A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury
Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor outcomes in this population are not well understood. TBI patients are highly susceptible to n... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 17, 2021 Category: Neurology Authors: Rishabh Sharma, Akram Zamani, Larissa K. Dill, Mujun Sun, Erskine Chu, Marcus J. Robinson, Terence J. O ’Brien, Sandy R. Shultz and Bridgette D. Semple Tags: Research Source Type: research

Pharmacological ablation of astrocytes reduces A β degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease
Astrocytes provide a vital support to neurons in normal and pathological conditions. In Alzheimer ’s disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic s... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 17, 2021 Category: Neurology Authors: Nicola Davis, Bibiana C. Mota, Larissa Stead, Emily O. C. Palmer, Laura Lombardero, Rafael Rodr íguez-Puertas, Vincenzo de Paola, Samuel J. Barnes and Magdalena Sastre Tags: Research Source Type: research

Uncovering sex differences of rodent microglia
There are inherent structural and functional differences in the central nervous systems (CNS) of females and males. It has been gradually established that these sex-specific differences are due to a spectrum o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 17, 2021 Category: Neurology Authors: Jinming Han, Yueshan Fan, Kai Zhou, Klas Blomgren and Robert A. Harris Tags: Review Source Type: research

The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve
Following peripheral nerve injury, multiple cell types, including axons, Schwann cells, and macrophages, coordinate to promote nerve regeneration. However, this capacity for repair is limited, particularly in ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 15, 2021 Category: Neurology Authors: John A. Fissel and Mohamed H. Farah Tags: Review Source Type: research

X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals
Stroke is a sexually dimorphic disease. Previous studies have found that young females are protected against ischemia compared to males, partially due to the protective effect of ovarian hormones, particularly... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 12, 2021 Category: Neurology Authors: Shaohua Qi, Abdullah Al Mamun, Conelius Ngwa, Sharmeen Romana, Rodney Ritzel, Arthur P. Arnold, Louise D. McCullough and Fudong Liu Tags: Research Source Type: research

Fetal inflammation induces acute immune tolerance in the neonatal rat hippocampus
Infants born preterm due to chorioamnionitis are frequently affected by a fetal inflammatory response syndrome (FIRS) and then by subsequent postnatal infections. FIRS and postnatal systemic inflammatory event... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 11, 2021 Category: Neurology Authors: Garima Singh, Bradley J. Segura, Michael K. Georgieff and Tate Gisslen Tags: Research Source Type: research

Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF- κB pathway
Neuroinflammation plays a critical role in central nervous system diseases. Exosomal miRNAs released from various cells are implicated in cell-to-cell communication. Prior studies have placed substantial empha... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 9, 2021 Category: Neurology Authors: Liuqing Hu, Linjie Si, Xiaonan Dai, Hongquan Dong, Zijian Ma, Zhaochu Sun, Nana Li, Huanhuan Sha, Yinan Chen, Yanning Qian and Zhiyuan Zhang Tags: Research Source Type: research

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes
Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily express... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2021 Category: Neurology Authors: Michelle M. Boyd, Suzanne J. Litscher, Laura L. Seitz, Albee Messing, Tracy L. Hagemann and Lara S. Collier Tags: Research Source Type: research

Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice
Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease in premature neonates with high mortality and morbidity, while the underlining mechanism of intestinal injury and profound neurologic... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 6, 2021 Category: Neurology Authors: Fangxinxing Zhu, Lingyu Wang, Zizhen Gong, Yanyan Wang, Yanhong Gao, Wei Cai and Jin Wu Tags: Research Source Type: research

Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis
As a classic innate immunity pathway, Toll-like receptor 4 (TLR4) signaling has been intensively investigated for its function of pathogen recognition. The receptor is located not only on immune cells but also... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 5, 2021 Category: Neurology Authors: Wenliang Su, Huan Cui, Danning Wu, Jiawen Yu, Lulu Ma, Xiuhua Zhang, Yuguang Huang and Chao Ma Tags: Research Source Type: research

Recruitment of γδ T cells to the lesion via the CCL2/CCR2 signaling after spinal cord injury
Immune cell infiltration and neuroinflammation are heavily associated with spinal cord injury (SCI). C-C motif chemokine ligand 2/C-C chemokine receptor type 2 (CCL2/CCR2) axis has been identified as a critica... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 2, 2021 Category: Neurology Authors: Ping Xu, Feng Zhang, Min-min Chang, Cheng Zhong, Cheng-Hong Sun, Hao-Ran Zhu, Jing-Chun Yao, Zhi-Zhong Li, Si-Tao Li, Wen-Cai Zhang and Guo-Dong Sun Tags: Research Source Type: research

Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice
Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH-induced neurological injuries. C-C Chem... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 1, 2021 Category: Neurology Authors: Shuixiang Deng, Peng Jin, Prativa Sherchan, Shengpeng Liu, Yuhui Cui, Lei Huang, John H. Zhang, Ye Gong and Jiping Tang Tags: Research Source Type: research

The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties
Synthetic cathinones are a category of psychostimulants belonging to the growing number of designer drugs also known as “Novel Psychoactive Substances” (NPS). In recent years, NPS have gained popularity in the... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 1, 2021 Category: Neurology Authors: Tetyana P. Buzhdygan, Cassidy R. Rodrigues, Hannah M. McGary, Jana A. Khan, Allison M. Andrews, Scott M. Rawls and Servio H. Ramirez Tags: Research Source Type: research

Aberrant regulation of retinoic acid signaling genes in cerebral arterio venous malformation nidus and neighboring astrocytes
Cerebral arterio venous malformations (AVM) are a major causal factor for intracranial hemorrhage, which result in permanent disability or death. The molecular mechanisms of AVM are complex, and their pathogen... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 1, 2021 Category: Neurology Authors: Jaya Mary Thomas, Dhakshmi Sasankan, Sumi Surendran, Mathew Abraham, Arumugam Rajavelu and Chandrasekharan C. Kartha Tags: Short report Source Type: research

Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life
The term sepsis is used to designate a systemic condition of infection and inflammation associated with hemodynamic changes that result in organic dysfunction. Gestational sepsis can impair the development of ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 25, 2021 Category: Neurology Authors: Marcelo Gomes Granja, Let ícia Pires Alves, Marina Leardini-Tristão, Michelle Edelman Saul, Letícia Coelho Bortoni, Flávia Maciel de Moraes, Erica Camila Ferreira, Bianca Portugal Tavares de Moraes, Victória Zerboni da Silva, Adrielle Ferreira Ribeir Tags: Research Source Type: research

Correction to: Differential neurovirulence of Usutu viruslineages in mice and neuronal cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 23, 2021 Category: Neurology Authors: Marion Cl é, Orianne Constant, Jonathan Barthelemy, Caroline Desmetz, Marie France Martin, Lina Lapeyre, Daniel Cadar, Giovanni Savini, Liana Teodori, Federica Monaco, Jonas Schmidt-Chanasit, Juan-Carlos Saiz, Gaëlle Gonzales, Sylvie Lecollinet, Cécile Tags: Correction Source Type: research

Systemic administration of β-glucan induces immune training in microglia
An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively. Exposing monocyte... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 22, 2021 Category: Neurology Authors: Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman and Bart J. L. Eggen Tags: Research Source Type: research