An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration
Inflammation and particularly interleukin-1 β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegene... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 27, 2020 Category: Neurology Authors: Rabah Dabouz, Colin W. H. Cheng, P énélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera and Sylvain Chemtob Tags: Research Source Type: research

Immunological classification of gliomas based on immunogenomic profiling
Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 27, 2020 Category: Neurology Authors: Qiushi Feng, Lin Li, Mengyuan Li and Xiaosheng Wang Tags: Research Source Type: research

Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia
Activation of NF-kappaB RelA deacetylated at the lysine residues, except the lysine 310, drives pro-apoptotic transcription in noxious brain ischemia. We showed that the sinergistic combination of the histone ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 27, 2020 Category: Neurology Authors: Mariana Mota, Vanessa Porrini, Edoardo Parrella, Marina Benarese, Arianna Bellucci, Sina Rhein, Markus Schwaninger and Marina Pizzi Tags: Research Source Type: research

CCL3 contributes to secondary damage after spinal cord injury
Secondary damage after spinal cord injury (SCI) is characterized by a cascade of events including hemorrhage, apoptosis, oxidative stress, and inflammation which increase the lesion size which can influence th... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 27, 2020 Category: Neurology Authors: Nicolas Pelisch, Jose Rosas Almanza, Kyle E. Stehlik, Brandy V. Aperi and Antje Kroner Tags: Research Source Type: research

Oleanolic acid ameliorates intestinal alterations associated with EAE
Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease affecting the CNS. Recent studies have indicated that intestinal alterations play key pathogenic roles in the development of autoimmune dis... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 27, 2020 Category: Neurology Authors: Beatriz Gutierrez, Isabel Gallardo, Lorena Ruiz, Yolanda Alvarez, Victoria Cachofeiro, Abelardo Margolles, Marita Hernandez and Maria Luisa Nieto Tags: Research Source Type: research

Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy
T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-T... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 26, 2020 Category: Neurology Authors: Julia Loos, Samantha Schmaul, Theresa Marie Noll, Magdalena Paterka, Miriam Schillner, Julian T. L öffel, Frauke Zipp and Stefan Bittner Tags: Research Source Type: research

Insulin inhibits inflammation-induced cone death in retinal detachment
Rhegmatogenous retinal detachment (RD) involving the macula is a major cause of visual impairment despite high surgical success rate, mainly because of cone death. RD causes the infiltration of activated immun... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 26, 2020 Category: Neurology Authors: Jean-Baptiste Conart, Guillaume Blot, S ébastien Augustin, Géraldine Millet-Puel, Christophe Roubeix, Fanny Beguier, Hugo Charles-Messance, Sara Touhami, José-Alain Sahel, Jean-Paul Berrod, Thierry Léveillard, Xavier Guillonneau, Cécile Delarasse and Tags: Research Source Type: research

The good, the bad, and the opportunities of the complement system in neurodegenerative disease
The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 25, 2020 Category: Neurology Authors: Nicole D. Schartz and Andrea J. Tenner Tags: Review Source Type: research

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration
Macular fibrosis causes irreparable vision loss in neovascular age-related macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) therapy. Inflammation is known to play an importa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 25, 2020 Category: Neurology Authors: Karis Little, Maria Llori án-Salvador, Miao Tang, Xuan Du, Stephen Marry, Mei Chen and Heping Xu Tags: Research Source Type: research

Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review
The existence of the neural control of mast cell functions has long been proposed. Mast cells (MCs) are localized in association with the peripheral nervous system (PNS) and the brain, where they are closely a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 25, 2020 Category: Neurology Authors: Huaping Xu, Xiaoyun Shi, Xin Li, Jiexin Zou, Chunyan Zhou, Wenfeng Liu, Huming Shao, Hongbing Chen and Linbo Shi Tags: Review Source Type: research

Correction to: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 24, 2020 Category: Neurology Authors: Yi-wei Wang, Qin Zhou, Xiang Zhang, Qing-qing Qian, Jia-wen Xu, Peng-fei Ni and Yan-ning Qian Tags: Correction Source Type: research

Retraction Note: Bone mesenchymal stem cell-derivedexosomal microRNA-29b-3p preventshypoxic-ischemic injury in rat brain byactivating the PTEN-mediated Aktsignaling pathway
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 23, 2020 Category: Neurology Authors: Kun Hou, Guichen Li, Jinchuan Zhao, Baofeng Xu, Yang Zhang, Jinlu Yu and Kan Xu Tags: Retraction Note Source Type: research

CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease that damages myelin in the central nervous system (CNS). We investigated the profile of CCN3, a known regulator of immune function and a potential mediator... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 22, 2020 Category: Neurology Authors: Michelle Naughton, Jill Moffat, George Eleftheriadis, Nira de la Vega Gallardo, Andrew Young, John Falconer, Kristen Hawkins, Ben Pearson, Bernard Perbal, Andrew Hogan, Paul Moynagh, Sam Loveless, Neil P. Robertson, Bruno Gran, Rachael Kee, Stella Hughes Tags: Research Source Type: research

K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway
Alzheimer ’s disease (AD) is one of the most prevalent neurodegenerative disorders characterized by gradual memory loss and neuropsychiatric symptoms. We have previously demonstrated that the 2-({3-[2-(1-cycloh... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 22, 2020 Category: Neurology Authors: Hyeon Joo Ham, Yong Sun Lee, Jaesuk Yun, Dong Ju Son, Hee Pom Lee, Sang-Bae Han and Jin Tae Hong Tags: Research Source Type: research

Diesel exhaust impairs TREM2 to dysregulate neuroinflammation
Air pollution has been linked to neurodegenerative diseases, including Alzheimer ’s disease (AD), and the underlying neuroimmune mechanisms remain poorly understood. TREM2 is a myeloid cell membrane receptor th... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 22, 2020 Category: Neurology Authors: Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Prasada R. S. Kodavanti, Joyce L. Royland, Urmila P. Kodavanti and Michelle L. Block Tags: Research Source Type: research

Correction to: Three-dimensional morphometric analysisreveals time-dependent structural changesin microglia and astrocytes in the centralamygdala and hypothalamicparaventricular nucleus of heart failure rats
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 22, 2020 Category: Neurology Authors: Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Anne Murphy, Daniel N. Cox and Javier E. Stern Tags: Correction Source Type: research

Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice
The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in late-onset Parkinson ’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with the pathogenesis of P... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 19, 2020 Category: Neurology Authors: Yu-Kun Feng, Qiong-Li Wu, Yan-Wen Peng, Feng-Yin Liang, Hua-Jing You, Yi-Wei Feng, Ge Li, Xue-Jiao Li, Shu-Hua Liu, Yong-Chao Li, Yu Zhang and Zhong Pei Tags: Research Source Type: research

Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids
Human immunodeficiency virus type-1 (HIV-1) and opiates cause long-term inflammatory insult to the central nervous system (CNS) and worsen disease progression and HIV-1-related neuropathology. The combination ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 18, 2020 Category: Neurology Authors: Douglas J. Hermes, Ian R. Jacobs, Megan C. Key, Alexis F. League, Barkha J. Yadav-Samudrala, Changqing Xu, Virginia D. McLane, Sara R. Nass, Wei Jiang, Rick B. Meeker, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Zibo Li, Zhanhong Wu, Hong Yuan, Pamel Tags: Research Source Type: research

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model
Glioblastoma is the most common and deadly form of primary brain cancer, accounting for more than 13,000 new diagnoses annually in the USA alone. Microglia are the innate immune cells within the central nervou... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 18, 2020 Category: Neurology Authors: Jee-Wei Emily Chen, Jan Lumibao, Sarah Leary, Jann N. Sarkaria, Andrew J. Steelman, H. Rex Gaskins and Brendan A. C. Harley Tags: Research Source Type: research

Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF- κB pathway activation and oxidative stress
The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent pyroptosis has been shown to play a vital role in the pathology of manganese (Mn)-induced neurotoxicity. Sodium para-aminosalicylic ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 17, 2020 Category: Neurology Authors: Dongjie Peng, Junyan Li, Yue Deng, Xiaojuan Zhu, Lin Zhao, Yuwen Zhang, Zhaocong Li, Shiyan Ou, Shaojun Li and Yueming Jiang Tags: Research Source Type: research

Correction to: Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 17, 2020 Category: Neurology Authors: Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona and Amanda M. Brown Tags: Correction Source Type: research

Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson ’s disease and roles of microglia, proinflammatory factors, and MAPK
Smad3 signaling is indicated to regulate microglia activity. Parkinson ’s disease (PD) neurodegeneration is shown to be associated with aging and neuroinflammation. However, it remains unclear about the relatio... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 16, 2020 Category: Neurology Authors: Ying Liu, Lijia Yu, Yaling Xu, Xiaohui Tang and Xijin Wang Tags: Research Source Type: research

Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Neovascular age-related macular degeneration (nAMD) commonly causes vision loss from aberrant angiogenesis, termed choroidal neovascularization (CNV). Macrophages are heterogeneous cells that are necessary for... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 13, 2020 Category: Neurology Authors: Steven Droho, Benjamin R. Thomson, Hadijat M. Makinde, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine Tags: Research Source Type: research

Lectin complement pathway initiators after subarachnoid hemorrhage — an observational study
This exploratory study investigated the time-course of lectin complement pathway (LCP) initiators in cerebrospinal fluid (CSF) and plasma in patients with subarachnoid hemorrhage (SAH), as well as their relati... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 12, 2020 Category: Neurology Authors: Jeppe Sillesen Matzen, Charlotte Loumann Krogh, Julie Lyng Forman, Peter Garred, Kirsten M øller and Søren Bache Tags: Research Source Type: research

Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury
Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against se... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 12, 2020 Category: Neurology Authors: Susan A. Farr, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo, Michael L. Niehoff, Timothy M. Doyle and Daniela Salvemini Tags: Research Source Type: research

Microglial responses to peripheral type 1 interferon
Interferon α (IFNα) is a cytokine whose production is increased endogenously in response to viral infection and in autoimmune diseases such as systemic lupus erythematosus (SLE). An elevated IFNα signature has... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 12, 2020 Category: Neurology Authors: Ernest Aw, Yingying Zhang and Michael Carroll Tags: Research Source Type: research

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice
The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 11, 2020 Category: Neurology Authors: Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John and Gareth R. Howell Tags: Research Source Type: research

Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea
Intermittent hypoxia (IH) caused by obstructive sleep apnea (OSA) leads to neuroinflammation. Pinocembrin has been shown to have neuroprotective effects, while the therapeutic functions under IH condition are ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 11, 2020 Category: Neurology Authors: Lin-Jing Gong, Xin-Yuan Wang, Wen-Yu Gu and Xu Wu Tags: Research Source Type: research

Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice
Perioperative neurocognitive disorders (PNDs) occur frequently after surgery and worsen patient outcome. How C-X-C motif chemokine (CXCL) 13 and its sole receptor CXCR5 contribute to PNDs remains poorly unders... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 8, 2020 Category: Neurology Authors: Yanan Shen, Yuan Zhang, Lihai Chen, Jiayue Du, Hongguang Bao, Yan Xing, Mengmeng Cai and Yanna Si Tags: Research Source Type: research

Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model
Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 6, 2020 Category: Neurology Authors: Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu and Dai-Shi Tian Tags: Research Source Type: research

Air pollution as a contributor to the inflammatory activity of multiple sclerosis
Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying the clinical association between air pollution, n... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 6, 2020 Category: Neurology Authors: Andrea Cortese, Luca Lova, Patrizia Comoli, Elisabetta Volpe, Silvia Villa, Giulia Mallucci, Sabrina La Salvia, Alfredo Romani, Diego Franciotta, Valentina Bollati, Sabrina Basso, Ilaria Guido, Giuseppe Quartuccio, Luca Battistini, Cristina Cereda and Rob Tags: Research Source Type: research

Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia
Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia are activated and polarized to either the pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype, which act as a critical me... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 5, 2020 Category: Neurology Authors: Tingting He, Wanlu Li, Yaying Song, Zongwei Li, Yaohui Tang, Zhijun Zhang and Guo-Yuan Yang Tags: Research Source Type: research

Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury
Inflammatory response has been recognized as a pivotal pathophysiological process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation of inflammatory cascade, can simultaneously lea... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 5, 2020 Category: Neurology Authors: Rui Sun, Mengna Peng, Pengfei Xu, Feihong Huang, Yi Xie, Juanji Li, Ye Hong, Hongquan Guo, Qian Liu and Wusheng Zhu Tags: Research Source Type: research

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer ’s disease features in cortical neurons
After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer ’s disease (sAD) still has no known etiology. Adding to the myriad of different pathways involved, bacterial neu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 5, 2020 Category: Neurology Authors: Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, Jo ão D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas and Sandra M. Cardoso Tags: Research Source Type: research

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration
Retinal degenerative diseases significantly contribute to visual impairment and blindness. Microglia reactivity is a hallmark of neurodegenerative diseases including retinal cell death and immunomodulation eme... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 3, 2020 Category: Neurology Authors: Amir Saeed Khan and Thomas Langmann Tags: Research Source Type: research

Cellular infiltration in traumatic brain injury
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident cells to release cytokines and chemokines. These ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 3, 2020 Category: Neurology Authors: Aftab Alam, Eric P. Thelin, Tamara Tajsic, Danyal Z. Khan, Abdelhakim Khellaf, Rickie Patani and Adel Helmy Tags: Review Source Type: research

Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis
Multiple sclerosis is an immune-mediated disease of the central nervous system (CNS) characterized by inflammation, oligodendrocytes loss, demyelination, and damaged axons. Tyro3, Axl, and MerTK belong to a fa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 29, 2020 Category: Neurology Authors: Juwen C. DuBois, Alex K. Ray, Peter Davies and Bridget Shafit-Zagardo Tags: Research Source Type: research

The formyl peptide receptor agonist Ac2-26 alleviates neuroinflammation in a mouse model of pneumococcal meningitis
Bacterial meningitis is still a cause of severe neurological disability. The brain is protected from penetrating pathogens by the blood-brain barrier and the innate immune system. The invading pathogens are re... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 29, 2020 Category: Neurology Authors: Marvin R üger, Eugenia Kipp, Nadine Schubert, Nicole Schröder, Thomas Pufe, Matthias B. Stope, Markus Kipp, Christian Blume, Simone C. Tauber and Lars-Ove Brandenburg Tags: Research Source Type: research

Microglia dynamics in adolescent traumatic brain injury
Repetitive, mild traumatic brain injuries (RmTBIs) are increasingly common in adolescents and encompass one of the largest neurological health concerns in the world. Adolescence is a critical period for brain ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 29, 2020 Category: Neurology Authors: Eric Eyolfson, Asher Khan, Richelle Mychasiuk and Alexander W. Lohman Tags: Review Source Type: research

Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling
In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression, abnormal excessive opening of Cx43 hemich... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 28, 2020 Category: Neurology Authors: Hailong Yu, Xiang Cao, Wei Li, Pinyi Liu, Yuanyuan Zhao, Lilong Song, Jian Chen, Beilei Chen, Wenkui Yu and Yun Xu Tags: Research Source Type: research

Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immun... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 28, 2020 Category: Neurology Authors: Kristina Berve, Brian L. West, Rudolf Martini and Janos Groh Tags: Research Source Type: research

Regulatory coupling between long noncoding RNAs and senescence in irradiated microglia
Microglia have been implicated in the pathogenesis of radiation-induced brain injury (RIBI), which severely influences the quality of life during long-term survival. Recently, irradiated microglia were specula... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 28, 2020 Category: Neurology Authors: Anan Xu, Rong Li, Anbang Ren, Haifeng Jian, Zhong Huang, Qingxing Zeng, Baiyao Wang, Jieling Zheng, Xiaoyu Chen, Naiying Zheng, Ronghui Zheng, Yunhong Tian, Mengzhong Liu, Zixu Mao, Aimin Ji and Yawei Yuan Tags: Research Source Type: research

Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling
We previously found that high-dose methylprednisolone increased the incidence of critical illness-related corticosteroid insufficiency (CIRCI) and mortality in rats with traumatic brain injury (TBI), whereas l... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 25, 2020 Category: Neurology Authors: Bin Zhang, Miao Bai, Xiaojian Xu, Mengshi Yang, Fei Niu, Fei Gao and Baiyun Liu Tags: Research Source Type: research

Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model
Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 25, 2020 Category: Neurology Authors: Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan and Sujatha Kannan Tags: Research Source Type: research

Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy
Aberrant hippocampal neurogenesis is an important pathological feature of sepsis-associated encephalopathy. In the current study, we examined the potential role of the long noncoding RNA (lncRNA) sex-determini... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 25, 2020 Category: Neurology Authors: Jialin Yin, Yanan Shen, Yanna Si, Yuan Zhang, Jiayue Du, Xiajuan Hu, Mengmeng Cai, Hongguang Bao and Yan Xing Tags: Research Source Type: research

Efficient control of Japanese encephalitis virus in the central nervous system of infected pigs occurs in the absence of a pronounced inflammatory immune response
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. JEV infection of mice and humans can lead to an uncontrolled inflammatory response in the central nervous system (CNS), res... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 23, 2020 Category: Neurology Authors: Valerie Redant, Herman W. Favoreel, Kai Dallmeier, Willem Van Campe and Nick De Regge Tags: Research Source Type: research

Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways
Neuroinflammation is a critical feature of sensitisation of spinal nociceptive processing in chronic pain states. We hypothesised that the resolvin pathways, a unique endogenous control system, may ameliorate ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 23, 2020 Category: Neurology Authors: Pongsatorn Meesawatsom, Gareth Hathway, Andrew Bennett, Dumitru Constantin-Teodosiu and Victoria Chapman Tags: Research Source Type: research

The peri-menopause in a woman ’s life: a systemic inflammatory phase that enables later neurodegenerative disease
The peri-menopause or menopausal transition —the time period that surrounds the final years of a woman’s reproductive life—is associated with profound reproductive and hormonal changes in a woman’s body and exp... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 23, 2020 Category: Neurology Authors: Micheline McCarthy and Ami P. Raval Tags: Review Source Type: research

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents
Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that s... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 22, 2020 Category: Neurology Authors: Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel and Daniela Salvemini Tags: Short report Source Type: research

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model
Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggeri... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 21, 2020 Category: Neurology Authors: Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan and Wen Wu Tags: Research Source Type: research