The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome
Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 1, 2020 Category: Neurology Authors: Xiangming Liu, Yiming Ma, Ruoyun Ouyang, Zihang Zeng, Zijie Zhan, Huanhuan Lu, Yanan Cui, Zhongshang Dai, Lijuan Luo, Chenjie He, Herui Li, Dandan Zong and Yan Chen Tags: Review Source Type: research

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans. However, whether and how the nature of the CNS insult —ac... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 31, 2020 Category: Neurology Authors: Sudeshna Das, Zhaozhi Li, Ayush Noori, Bradley T. Hyman and Alberto Serrano-Pozo Tags: Research Source Type: research

Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of multiple sclerosis (MS), a neuroinflammatory and demyelinating disease characterized by multifocal perivascular infiltrates of... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 31, 2020 Category: Neurology Authors: Giovanni Ferrara, Andrea Benzi, Laura Sturla, Daniela Marubbi, Davide Frumento, Sonia Spinelli, Elena Abbotto, Federico Ivaldi, Maria von Holtey, Maximilien Murone, Alessio Nencioni, Antonio Uccelli and Santina Bruzzone Tags: Research Source Type: research

A pivotal role for Interferon- α receptor-1 in neuronal injury induced by HIV-1
HIV-1 infection remains a major public health concern despite effective combination antiretroviral therapy (cART). The virus enters the central nervous system (CNS) early in infection and continues to cause HI... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 29, 2020 Category: Neurology Authors: Hina Singh, Daniel Ojeda-Ju árez, Ricky Maung, Rohan Shah, Amanda J. Roberts and Marcus Kaul Tags: Research Source Type: research

NF- κB p65-dependent transcriptional regulation of histone deacetylase 2 contributes to the chronic constriction injury-induced neuropathic pain via the microRNA-183/TXNIP/NLRP3 axis
Neuropathic pain is related to the sustained activation of neuroglial cells and the production of proinflammatory cytokines in the spinal dorsal horn. However, the clinical efficacy of currently available trea... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 28, 2020 Category: Neurology Authors: Jiamin Miao, Xuelong Zhou, Tianjiao Ji and Gang Chen Tags: Research Source Type: research

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation
The presence of foamy macrophages and microglia containing intracellular myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple sclerosis (MS). Despite the importance of mye... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 27, 2020 Category: Neurology Authors: Elien Grajchen, Elien Wouters, Britt van de Haterd, Mansour Haidar, K évin Hardonnière, Tess Dierckx, Jana Van Broeckhoven, Celine Erens, Sven Hendrix, Saadia Kerdine-Römer, Jerome J. A. Hendriks and Jeroen F. J. Bogie Tags: Research Source Type: research

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. The mechanisms underlying the contribution of CAA to neurodegeneration are not currently understood. Although CAA is ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 25, 2020 Category: Neurology Authors: Xavier Taylor, Pablo Cisternas, Yanwen You, Yingjian You, Shunian Xiang, Yamil Marambio, Jie Zhang, Ruben Vidal and Cristian A. Lasagna-Reeves Tags: Research Source Type: research

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is hindered by the heterogenous nature of TBI presentation and pathophysiology. In... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 25, 2020 Category: Neurology Authors: Tamara L. Baker, Mujun Sun, Bridgette D. Semple, Shiraz Tyebji, Christopher J. Tonkin, Richelle Mychasiuk and Sandy R. Shultz Tags: Review Source Type: research

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
Chondroitin sulfate proteoglycans (CSPGs) are potent inhibitors of axonal regrowth and remyelination. More recently, they have also been highlighted as a modulator of macrophage infiltration into the central n... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 23, 2020 Category: Neurology Authors: Annie Pu, Manoj K. Mishra, Yifei Dong, Samira Ghorbanigazar, Erin L. Stephenson, Khalil S. Rawji, Claudia Silva, Hiroshi Kitagawa, Stephen Sawcer and V. Wee Yong Tags: Research Source Type: research

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats
Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 23, 2020 Category: Neurology Authors: Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Daniel N. Cox and Javier E. Stern Tags: Research Source Type: research

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury
Brain injury is the leading cause of death and disability in survivors of cardiac arrest, where neuroinflammation is believed to play a pivotal role, but the underlying mechanism remains unclear. Pyroptosis is... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 23, 2020 Category: Neurology Authors: Yuan Chang, Juan Zhu, Di Wang, Hua Li, Yihua He, Kewei Liu, Xiaoqiang Wang, Yuqin Peng, Suyue Pan and Kaibin Huang Tags: Research Source Type: research

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats
Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent med... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 22, 2020 Category: Neurology Authors: Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian and Hong-Quan Dong Tags: Research Source Type: research

Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer ’s disease
Muramyl dipeptide (MDP) is a component derived from minimal peptidoglycan motif from bacteria, and it is a ligand for the NOD2 receptor. Peripheral administration of MDP converts Ly6Chigh into Ly6Clow monocytes. ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 22, 2020 Category: Neurology Authors: Adham Fani Maleki, Giulia Cisbani, Marie-Mich èle Plante, Paul Préfontaine, Nataly Laflamme, Jean Gosselin and Serge Rivest Tags: Research Source Type: research

Comparison of different optomotor response readouts for visual testing in experimental autoimmune encephalomyelitis-optic neuritis
Optomotor response is increasingly used in preclinical research for evaluating the visual function in rodents. However, the most suitable measuring protocol for specific scientific questions is not always esta... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 18, 2020 Category: Neurology Authors: Christina Hecker, Michael Dietrich, Andrea Issberner, Hans-Peter Hartung and Philipp Albrecht Tags: Short report Source Type: research

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice
An association between neuroinflammation and age-related neurologic disorders has been established but the molecular mechanisms and cell types involved have not been thoroughly characterized. Activity of the p... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 17, 2020 Category: Neurology Authors: Katharine M. von Herrmann, Faith L. Anderson, Eileen M. Martinez, Alison L. Young and Matthew C. Havrda Tags: Research Source Type: research

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
α-Synuclein (α-syn) is a pre-synaptic protein which progressively accumulates in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB),... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 17, 2020 Category: Neurology Authors: Michiyo Iba, Changyoun Kim, Michelle Sallin, Somin Kwon, Anjali Verma, Cassia Overk, Robert A. Rissman, Ranjan Sen, Jyoti Misra Sen and Eliezer Masliah Tags: Research Source Type: research

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
High inflammation status despite an absence of known infection characterizes a subpopulation of people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse ne... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 17, 2020 Category: Neurology Authors: Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker and Cynthia Shannon Weickert Tags: Research Source Type: research

Oxidized cell-free DNA as a stress-signaling factor activating the chronic inflammatory process in patients with autism spectrum disorders
This study ’s aim was to investigate the role of cell-free DNA in chronic inflammato... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 16, 2020 Category: Neurology Authors: Galina V. Shmarina, Elizaveta S. Ershova, Natalia V. Simashkova, Svetlana G. Nikitina, Julia M. Chudakova, Natalia N. Veiko, Lev N. Porokhovnik, Anna Y. Basova, Antonina F. Shaposhnikova, Daria A. Pukhalskaya, Vladimir M. Pisarev, Natalia J. Korovina, Nat Tags: Research Source Type: research

CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage
Microglial activation-mediated neuroinflammation is a major contributor to early brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the most abundant miRNAs in the central nervou... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 14, 2020 Category: Neurology Authors: Xiao Chen, Ming Jiang, Haiying Li, Yang Wang, Haitao Shen, Xiang Li, Yunhai Zhang, Jiang Wu, Zhengquan Yu and Gang Chen Tags: Research Source Type: research

BDNF reverses aging-related microglial activation
Excessive microglial activation is implicated in the pathogenesis of various age-related neurodegenerative diseases. In addition to neurons, brain-derived neurotrophic factor (BDNF) and its receptor TrkB are a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 14, 2020 Category: Neurology Authors: Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yi-Ting Chiang, Bu-Miin Huang, Fan-E Mo and Yu-Min Kuo Tags: Research Source Type: research

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain
Activated astrocytes play important roles in chronic post-surgical pain (CPSP). Recent studies have shown reactive astrocytes are classified into A1 and A2 phenotypes, but their precise roles in CPSP remain un... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 14, 2020 Category: Neurology Authors: Ting Li, Tongtong Liu, Xuhui Chen, Li Li, Miaomiao Feng, Yue Zhang, Li Wan, Chuanhan Zhang and Wenlong Yao Tags: Research Source Type: research

Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning
P301S tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. However, there is hither... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 13, 2020 Category: Neurology Authors: Florian Eckenweber, Jose Medina-Luque, Tanja Blume, Christian Sacher, Gloria Biechele, Karin Wind, Maximilian Deussing, Nils Briel, Simon Lindner, Guido Boening, Barbara von Ungern-Sternberg, Marcus Unterrainer, Nathalie L. Albert, Andreas Zwergal, Johann Tags: Research Source Type: research

CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons
Clinical and animal studies show that alcohol consumption during pregnancy produces lasting behavioral disturbances in offspring, including increased alcohol drinking, which are linked to inflammation in the b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 10, 2020 Category: Neurology Authors: Guo-Qing Chang, Olga Karatayev, Devi Sai Sri Kavya Boorgu and Sarah F. Leibowitz Tags: Research Source Type: research

Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod
Progressive multifocal leukoencephalopathy (PML) caused by JC virus (JCV) is a rare but serious complication of some disease-modifying drugs used to treat multiple sclerosis (MS). Japanese MS patients treated ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 9, 2020 Category: Neurology Authors: Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Masami Tanaka, Ayako Sakoda, Fumie Hayashi, Yuji Kawano, Ryo Yamasaki, Takuya Matsushita and Jun-ichi Kira Tags: Research Source Type: research

Correction to: Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 7, 2020 Category: Neurology Authors: Kun Hou, Guichen Li, Jinchuan Zhao, Baofeng Xu, Yang Zhang, Jinlu Yu and Kan Xu Tags: Correction Source Type: research

TREM2 ectodomain and its soluble form in Alzheimer ’s disease
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed on the surface of microglia. It mediates multiple pathophysiological processes in various diseases. Recently, TREM2 has b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 7, 2020 Category: Neurology Authors: Jiaolong Yang, Zhihui Fu, Xingyu Zhang, Min Xiong, Lanxia Meng and Zhentao Zhang Tags: Review Source Type: research

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- and stress-related disorders such as posttraumatic stress disorder (PTSD) and anxiety disorder. Despite the... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 7, 2020 Category: Neurology Authors: Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou, Zengqiang Yuan and Jinbo Cheng Tags: Research Source Type: research

Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model
Spinal cord injury (SCI) triggers the primary mechanical injury and secondary inflammation-mediated injury. Neuroinflammation-mediated insult causes secondary and extensive neurological damage after SCI. Micro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 6, 2020 Category: Neurology Authors: Wen-Kai Chen, Lin-Juan Feng, Qiao-Dan Liu, Qing-Feng Ke, Pei-Ya Cai, Pei-Ru Zhang, Li-Quan Cai, Nian-Lai Huang and Wen-Ping Lin Tags: Research Source Type: research

Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis
Recent clinical and basic research implicated a strong correlation between NAFLD/NASH phenotypes with ectopic manifestations including neuroinflammation and neurodegeneration, but the mediators and critical pa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 4, 2020 Category: Neurology Authors: Ayan Mondal, Dipro Bose, Punnag Saha, Sutapa Sarkar, Ratanesh Seth, Diana Kimono, Muayad Albadrani, Mitzi Nagarkatti, Prakash Nagarkatti and Saurabh Chatterjee Tags: Research Source Type: research

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment
Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear. Here, we stu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 1, 2020 Category: Neurology Authors: He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu and Xiao-Xia Jiang Tags: Research Source Type: research

27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction
Research on the brain-gut-microbiota axis has led to accumulating interest in gut microbiota dysbiosis and intestinal barrier dysfunction in Alzheimer ’s disease (AD). Our previous studies have demonstrated neu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 27, 2020 Category: Neurology Authors: Ying Wang, Yu An, Weiwei Ma, Huiyan Yu, Yanhui Lu, Xiaona Zhang, Yushan Wang, Wen Liu, Tao Wang and Rong Xiao Tags: Research Source Type: research

Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis
Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions primarily located on t... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 25, 2020 Category: Neurology Authors: Ye Gong, Ya-ling Zhang, Zhen Wang, Huan-huan Song, Yuan-chu Liu, Ao-wei Lv, Li-li Tian, Wen-li Zhu, Ying Fu, Xiao-li Ding, Lang-jun Cui and Ya-ping Yan Tags: Research Source Type: research

Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants
Neurological manifestations and the co-occurrence of multiple sclerosis (MS) have been reported in patients with autoinflammatory diseases (AID) and variants of the NLRP3-, MEFV-, or TNFRSF1A gene. However, type ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 20, 2020 Category: Neurology Authors: Elisabeth Mulazzani, Danny Wagner, Joachim Havla, Miriam Schl üter, Ingrid Meinl, Lisa-Ann Gerdes and Tania Kümpfel Tags: Research Source Type: research

Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells
Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of inflammation, including macrophages... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 20, 2020 Category: Neurology Authors: Syed Faaiz Enam, Sajidur Rahman Kader, Nicholas Bodkin, Johnathan G. Lyon, Mark Calhoun, Cesar Azrak, Pooja Munnilal Tiwari, Daryll Vanover, Haichen Wang, Philip J. Santangelo and Ravi Venkat Bellamkonda Tags: Research Source Type: research

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 19, 2020 Category: Neurology Authors: Natalia Kolosowska, Maria Gotkiewicz, Hiramani Dhungana, Luca Giudice, Rosalba Giugno, Daphne Box, Mikko T. Huuskonen, Paula Korhonen, Flavia Scoyni, Katja M. Kanninen, Seppo Yl ä-Herttuala, Tiia A. Turunen, Mikko P. Turunen, Jari Koistinaho and Tarja Ma Tags: Research Source Type: research

Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation
A growing body of evidence shows that hypothalamic inflammation is an important factor in the initiation of obesity. In particular, reactive gliosis accompanied by inflammatory responses in the hypothalamus ar... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 19, 2020 Category: Neurology Authors: Sungho Jin, Kwang Kon Kim, Byong Seo Park, Dong Hee Kim, Bora Jeong, Dasol Kang, Tae Hwan Lee, Jeong Woo Park, Jae Geun Kim and Byung Ju Lee Tags: Research Source Type: research

25-Hydroxycholesterol amplifies microglial IL-1 β production in an apoE isoform-dependent manner
Genome-wide association studies of Alzheimer ’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 17, 2020 Category: Neurology Authors: Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul and Wenjie Luo Tags: Research Source Type: research

Neuroinflammatory mechanisms of post-traumatic epilepsy
Traumatic brain injury (TBI) occurs in as many as 64 –74 million people worldwide each year and often results in one or more post-traumatic syndromes, including depression, cognitive, emotional, and behavioral ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 17, 2020 Category: Neurology Authors: Sanjib Mukherjee, Gabriel M. Arisi, Kaley Mims, Gabriela Hollingsworth, Katherine O ’Neil and Lee A. Shapiro Tags: Review Source Type: research

Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease. Some children with OMS also have neuroblastoma (NB). We and others have previously documented that serum IgG from children with OMS and NB in... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 16, 2020 Category: Neurology Authors: Xu Ding, Wei Yang, Qinghua Ren, Jiajian Hu, Shen Yang, Wei Han, Jing Wang, Xu Wang and Huanmin Wang Tags: Research Source Type: research

Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway
The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 16, 2020 Category: Neurology Authors: Sichen Li, Yuan Shi, Peixi Liu, Yaying Song, Yingjun Liu, Lingwen Ying, Kai Quan, Guo Yu, Zhiyuan Fan and Wei Zhu Tags: Research Source Type: research

Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis
To characterize long-term repopulation of peripheral immune cells following alemtuzumab-induced lymphopenia in relapsing-remitting MS (RRMS), with a focus on regulatory cell types, and to explore associations ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 15, 2020 Category: Neurology Authors: Wendy Gilmore, Brett T. Lund, Peili Li, Alex M. Levy, Eve E. Kelland, Omid Akbari, Susan Groshen, Steven Yong Cen, Daniel Pelletier, Leslie P. Weiner, Adil Javed, Jeffrey E. Dunn and Anthony L. Traboulsee Tags: Research Source Type: research

Orexin A alleviates neuroinflammation via OXR2/CaMKK β/AMPK signaling pathway after ICH in mice
Orexins are two neuropeptides (orexin A, OXA; orexin B, OXB) secreted mainly from the lateral hypothalamus, which exert a wide range of physiological effects by activating two types of receptors (orexin recept... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 15, 2020 Category: Neurology Authors: Tao Li, Weilin Xu, Jinsong Ouyang, Xiaoyang Lu, Prativa Sherchan, Cameron Lenahan, Giselle Irio, John H. Zhang, Jianhua Zhao, Yongfa Zhang and Jiping Tang Tags: Research Source Type: research

Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury
Aucubin (Au), an iridoid glycoside from natural plants, has antioxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain injury (TBI) model remain unknown. We explored the poten... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 15, 2020 Category: Neurology Authors: Han Wang, Xiao-Ming Zhou, Ling-Yun Wu, Guang-Jie Liu, Wei-Dong Xu, Xiang-Sheng Zhang, Yong-Yue Gao, Tao Tao, Yan Zhou, Yue Lu, Juan Wang, Chu-Lei Deng, Zong Zhuang, Chun-Hua Hang and Wei Li Tags: Research Source Type: research

Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain
Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. T... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 12, 2020 Category: Neurology Authors: Mohammed Shaqura, Li Li, Doaa M. Mohamed, Xiongjuan Li, Sascha Treskatsch, Constanze Buhrmann, Mehdi Shakibaei, Antje Beyer, Shaaban A. Mousa and Michael Sch äfer Tags: Research Source Type: research

The impact of regional astrocyte interferon- γ signaling during chronic autoimmunity: a novel role for the immunoproteasome
In early autoimmune neuroinflammation, interferon (IFN) γ and its upregulation of the immunoproteasome (iP) is pathologic. However, during chronic multiple sclerosis (MS), IFNγ has protective properties. Althou... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 12, 2020 Category: Neurology Authors: Brandon C. Smith, Maksim Sinyuk, Julius E. Jenkins III, Morgan W. Psenicka and Jessica L. Williams Tags: Research Source Type: research

CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats
Inflammation is a common pathophysiological trait found in both hypertension and cardiac vascular disease. Recent evidence indicates that fractalkine (FKN) and its receptor CX3CR1 have been linked to inflammat... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 12, 2020 Category: Neurology Authors: Chiu-Yi Ho, Yu-Te Lin, Hsin-Hung Chen, Wen-Yu Ho, Gwo-Ching Sun, Michael Hsiao, Pei-Jung Lu, Pei-Wen Cheng and Ching-Jiunn Tseng Tags: Research Source Type: research

Myelination- and immune-mediated MR-based brain network correlates
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by inflammatory and neurodegenerative processes. Despite demyelination being a hallmark of the disease, how i... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 12, 2020 Category: Neurology Authors: Manuela Cerina, Muthuraman Muthuraman, Marco Gallus, Nabin Koirala, Andre Dik, Lydia Wachsmuth, Petra Hundehege, Patrick Schiffler, Jan-Gerd Tenberge, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Venu Narayanan, Julia Kr ämer, Cornelius Faber, Thomas B Tags: Research Source Type: research

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)
Tolerogenic vaccines represent antigen-specific interventions designed to re-establish self-tolerance and thereby alleviate autoimmune diseases, which collectively comprise over 100 chronic inflammatory diseas... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 10, 2020 Category: Neurology Authors: Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca and Mark D. Mannie Tags: Research Source Type: research

Extrasynaptic CaMKII α is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model
A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 10, 2020 Category: Neurology Authors: Xiao-Hui Tang, Guang-Fen Zhang, Ning Xu, Gui-Fang Duan, Min Jia, Ru Liu, Zhi-Qiang Zhou and Jian-Jun Yang Tags: Research Source Type: research

Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKC ε pathway in a rat model of neonatal HIE
Hypoxic-ischemic encephalopathy (HIE) is a life-threatening cerebrovascular disease. Neuroinflammation plays an important role in the pathogenesis of HIE, in which microglia are key cellular mediators in the r... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 10, 2020 Category: Neurology Authors: Xiao Hu, Shirong Li, Desislava Met Doycheva, Lei Huang, Cameron Lenahan, Rui Liu, Juan Huang, Shucai Xie, Jiping Tang, Gang Zuo and John H. Zhang Tags: Research Source Type: research