Border-associated macrophages in the central nervous system
Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchy... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 13, 2024 Category: Neurology Authors: Rui Sun and Haowu Jiang Tags: Review Source Type: research

TYROBP/DAP12 knockout in Huntington ’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
Huntington ’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. D... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2024 Category: Neurology Authors: Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby and Michelle E. Ehrlich Tags: Research Source Type: research

Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 7, 2024 Category: Neurology Authors: Rami A. Shahror, Carol A. Morris, Aya A. Mohammed, Melissa Wild, Bushra Zaman, Christian D. Mitchell, Paul H. Phillips, Nancy J. Rusch, Esraa Shosha and Abdelrahman Y. Fouda Tags: Review Source Type: research

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 5, 2024 Category: Neurology Authors: Alice Brandli, Kirstan A. Vessey and Erica L. Fletcher Tags: Review Source Type: research

Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cor... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 1, 2024 Category: Neurology Authors: Ellen R. Gillespie, Laura F. Grice, Isabel G. Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A. Brown, James Walsham, Kristen J. Radford, Quan H. Nguyen and Marc J. Ruitenberg Tags: Research Source Type: research

Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington ’s disease
We previously identified solute carrier family 7 member 2 (SLC7A2) as one of the top upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high affinity for l-arginine. Arginine is implicated in infl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 28, 2024 Category: Neurology Authors: Ian D. Gaudet, Hongyuan Xu, Emily Gordon, Gianna A. Cannestro, Michael L. Lu and Jianning Wei Tags: Research Source Type: research

IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathological conditions. Multiple cytokines are released into the cerebrospinal fluid (CSF), ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 28, 2024 Category: Neurology Authors: Ning Yu, Huan Cui, Sixuan Jin, Penghao Liu, Yehong Fang, Fengrun Sun, Yan Cao, Bo Yuan, Yikuan Xie, Wanru Duan and Chao Ma Tags: Research Source Type: research

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 28, 2024 Category: Neurology Authors: Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong and Shao-Ming Wang Tags: Research Source Type: research

Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely reported. That such peripheral factors may be involved in central nervous system pathophysiology wa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 28, 2024 Category: Neurology Authors: Pretty Garg, Franziska W ürtz, Fabian Hobbie, Klemens Buttgereit, Abhishek Aich, Kristian Leite, Peter Rehling, Sebastian Kügler and Mathias Bähr Tags: Research Source Type: research

Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia
Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1 β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ effl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 26, 2024 Category: Neurology Authors: Ali Rifat, Bernardino Ossola, Roland W. B ürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger and Christian Madry Tags: Research Source Type: research

Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury
Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently, cells not directly affected by an acute event or genetic va... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 22, 2024 Category: Neurology Authors: Josef Biber, Yassin Jabri, Sarah Gl änzer, Aaron Dort, Patricia Hoffelner, Christoph Q. Schmidt, Oliver Bludau, Diana Pauly and Antje Grosche Tags: Research Source Type: research

SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis of NP remains a complicated issue for pain management practitioners. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 22, 2024 Category: Neurology Authors: Chenglong Wang, Yitong Xu, Miao Xu, Cong Sun, Xiaojiao Zhang, Xueshu Tao and Tao Song Tags: Research Source Type: research

Parkinson ’s disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Parkinson ’s disease (PD) is a common age-related neurodegenerative disorder characterized by the aggregation of α-Synuclein (αSYN) building up intraneuronal inclusions termed Lewy pathology. Mounting evidence ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2024 Category: Neurology Authors: Cansu Yildirim-Balatan, Alexis Fenyi, Pierre Besnault, Lina Gomez, Julia E. Sepulveda-Diaz, Patrick P. Michel, Ronald Melki and St éphane Hunot Tags: Research Source Type: research

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer ’s disease
Neuroinflammation substantially contributes to the pathology of Alzheimer ’s disease (AD), the most common form of dementia. Studies have reported that nuclear factor erythroid 2-related factor 2 (Nrf2) attenua... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2024 Category: Neurology Authors: Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C. Saido, Takashi Saito and Koji Yamanaka Tags: Research Source Type: research

Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson ’s disease
Parkinson ’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2024 Category: Neurology Authors: Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae ‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon and Sang Myun Park Tags: Research Source Type: research