Exercise suppresses neuroinflammation for alleviating Alzheimer ’s disease
Alzheimer ’s disease (AD) is a chronic neurodegenerative disease, with the characteristics of neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses have been made in clinical ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 19, 2023 Category: Neurology Authors: Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang and Ning Chen Tags: Review Source Type: research
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 19, 2023 Category: Neurology Authors: Brittney R. Lins, Chidozie C. Anyaegbu, Sarah C. Hellewell, Melissa Papini, Terence McGonigle, Luca De Prato, Matthew Shales and Melinda Fitzgerald Tags: Review Source Type: research
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice
Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 17, 2023 Category: Neurology Authors: Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi and Hao Fang Tags: Research Source Type: research
Decrease in naturally occurring antibodies against epitopes of Alzheimer ’s disease (AD) risk gene products is associated with cognitive decline in AD
Naturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as apoptotic and necrotic cells. However, NAbs pathological relevance in Alzh... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 15, 2023 Category: Neurology Authors: Dongmei Gu, Luchun Wang, Nan Zhang, Huali Wang and Xin Yu Tags: Research Source Type: research
Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer ’s disease (AD). To provide novel insights into the roles of astrocytes in the pathop... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 14, 2023 Category: Neurology Authors: Marie-Kim St-Pierre, Mica ël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent and Marie-Ève Tremblay Tags: Research Source Type: research
IL-1 β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease
Systemic activation of the immune system can exert detrimental effects on the central nervous system. Periodontitis, a chronic disease of the oral cavity, is a common source of systemic inflammation. Neuroinfl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 13, 2023 Category: Neurology Authors: Rachel Pei-Hsuan Wang, Jianpan Huang, Kannie Wai Yan Chan, Wai Keung Leung, Tetsuya Goto, Yuen-Shan Ho and Raymond Chuen-Chung Chang Tags: Research Source Type: research
TGF- β1 signalling in Alzheimer’s pathology and cytoskeletal reorganization: a specialized Tau perspective
Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its detachment from microtubules and formation of insoluble intracellular aggregates within the neurons. Recent findings have ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 13, 2023 Category: Neurology Authors: Mahima Kapoor and Subashchandrabose Chinnathambi Tags: Review Source Type: research
[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data
In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PE... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 11, 2023 Category: Neurology Authors: Anna Ballweg, Carolin Klaus, Letizia Vogler, Sabrina Katzdobler, Karin Wind, Artem Zatcepin, Sibylle I. Ziegler, Birkan Secgin, Florian Eckenweber, Bernd Bohr, Alexander Bernhardt, Urban Fietzek, Boris-Stephan Rauchmann, Sophia Stoecklein, Stefanie Quach, Tags: Research Source Type: research
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy
Microglial activation-mediated neuroinflammation is one of the essential pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence suggests that high mobility group box-1 protein (HMGB... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 11, 2023 Category: Neurology Authors: Xiao-Yu Yin, Xiao-Hui Tang, Shi-Xu Wang, Yong-Chang Zhao, Min Jia, Jian-Jun Yang, Mu-Huo Ji and Jin-Chun Shen Tags: Research Source Type: research
Association of admission neutrophil serine proteinases levels with the outcomes of acute ischemic stroke: a prospective cohort study
Neutrophil serine proteinases (NSPs), released by activated neutrophils, are key proteins involved in the pathophysiologic processes of stroke. NSPs are also implicated in the process and response of thromboly... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 11, 2023 Category: Neurology Authors: Lingzhi Li, Ziping Han, Rongliang Wang, Junfen Fan, Yangmin Zheng, Yuyou Huang, Zhenhong Yang, Feng Yan, Ping Liu, Haiping Zhao, Qingfeng Ma and Yumin Luo Tags: Research Source Type: research
Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research
Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with over 2.8 million affected annually in the U.S., including over 56,000 deaths, with over 5 million total survivors exh... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 9, 2023 Category: Neurology Authors: Michael R. Grovola, Catherine von Reyn, David J. Loane and D. Kacy Cullen Tags: Review Source Type: research
Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor- κappa B activation and cause neuronal damage in vivo in a murine model
Helicobacter pylori (Hp) infects the stomach of 50% of the world ’s population. Importantly, chronic infection by this bacterium correlates with the appearance of several extra-gastric pathologies, including neuro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 9, 2023 Category: Neurology Authors: Esteban Palacios, Lorena Lobos-Gonz ález, Simón Guerrero, Marcelo J. Kogan, Baohai Shao, Jay W. Heinecke, Andrew F. G. Quest, Lisette Leyton and Manuel Valenzuela-Valderrama Tags: Research Source Type: research
Peripheral inflammation in behavioural variant frontotemporal dementia: associations with central degeneration and clinical measures
Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD). However, the association between peripheral inflammatory factors and brain neurodegeneration is poorly understood... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2023 Category: Neurology Authors: Min Chu, Lulu Wen, Deming Jiang, Li Liu, Haitian Nan, Ailing Yue, Yingtao Wang, Yihao Wang, Miao Qu, Ningqun Wang and Liyong Wu Tags: Research Source Type: research
Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model
In this study, we characterized the molecular m... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2023 Category: Neurology Authors: Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai and Junwei Hao Tags: Research Source Type: research
Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology
Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer ’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innat... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2023 Category: Neurology Authors: Gr égoire Stym-Popper, Karen Matta, Thomas Chaigneau, Roshan Rupra, Alexandros Demetriou, Stéphane Fouquet, Cira Dansokho, Cécile Toly-Ndour and Guillaume Dorothée Tags: Research Source Type: research
