Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

CONCLUSIONS: Negative regulation of any molecule in the mtDNA-cGAS-STING-IRF7/IRF3 pathway can affect the activation of NLRP3 inflammasomes, thereby reducing macrophage pyroptosis and improving SAP-ALI in mouse model.PMID:38671352 | DOI:10.1186/s11658-024-00575-9

Source: Cellular and Molecular Biology Letters - April 26, 2024 Category: Biochemistry Authors: Yiqiu Peng Yuxi Yang Yingying Li Tingjuan Shi Ning Xu Ruixia Liu Yingyi Luan Yongming Yao Chenghong Yin Source Type: research