Metformin alleviates crystalline silica-induced pulmonary fibrosis by remodeling endothelial cells to mesenchymal transition via autophagy signaling
In conclusion, Met can alleviate inflammatory response and collagen deposition in the process of pulmonary fibrosis induced by silica via suppressing EndoMT through the AMPK/mTOR signaling pathway.PMID:36155331 | DOI:10.1016/j.ecoenv.2022.114100 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Ning Li Zhang Lin Qiang Zhou Meiyu Chang Yongheng Wang Yi Guan Haibin Li Yingzheng Zhao Nan Liu Yulan Jin Sanqiao Yao Source Type: research

Sulphur dioxide and fluoride co-exposure induce incisor hypomineralization and amelogenin upregulation via YAP/RUNX2 signaling pathway
Ecotoxicol Environ Saf. 2022 Sep 22;245:114106. doi: 10.1016/j.ecoenv.2022.114106. Online ahead of print.ABSTRACTSulphur dioxide (SO2) and fluoride are among the most common environmental pollutants affecting human health, and both co-exist in areas predominantly consuming coal. It is vital to analyse the combined toxicity of SO2 and fluoride, and their effects on health and the underlying mechanisms of their co-exposure have not yet been adequately assessed. In the present study, we used ICR mice and LS8 cells to investigate the toxicity of SO2 and fluoride exposure to the enamel, alone or in combination. Factorial design...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Junlin Yang Tongtong Huang Jie Yao Jianghui Zhang Guohui Bai Zheng Chen Chenglong Tu Source Type: research

The multigenerational effects of clothianidin on Chironomus xanthus: Larvae exposed to this acetylcholine super agonist show no clear resistance
In this study, we evaluated how CLO affects the survival and the complete life cycle of the tropical insect Chironomus xanthus, a non-target species, considering the Parental (P) and Filial (F1) generations. We found a 48 h-lethal concentration (LC50) of CLO of 3.78 µg/L. The lowest observed effect concentrations (LOECs) were: i) for body growth and head capsule width in P generation = 47.3 ng/L CLO; ii) for body growth and head capsule width in F1 generation larvae = 80 and 36.4 ng/L CLO, respectively; iii) for cumulative emergence it was 80 ng/L CLO in the P generation, while there was no significant difference in the F...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Bruno Silva Melo Fabianne Ribeiro Althi éris S Saraiva Rone da Silva Barbosa Joel Santiago de Jesus Ferreira M árcio Silva Melo Laina Pires Rosa Carlos Gravato Amadeu M V M Soares Renato Almeida Sarmento Source Type: research

Plant volatile compound methyl benzoate is highly effective against Spodoptera frugiperda and safe to non-target organisms as an eco-friendly botanical-insecticide
Ecotoxicol Environ Saf. 2022 Sep 22;245:114101. doi: 10.1016/j.ecoenv.2022.114101. Online ahead of print.ABSTRACTRecent studies have indicated that the plant volatile methyl benzoate (MB) exhibits significant insecticidal bioactivity against several common insects. However, the potential environmental hazards of MB and its safety to non-target organisms is poorly understood. In the present study, these characteristics were investigated through laboratory experiments and field investigations. The results revealed that MB was highly toxic to the agricultural pest, fall armyworm Spodoptera frugiperda. Compared with the commer...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Rui Zhao Huan-Huan Wang Jie Gao Yong-Jun Zhang Xianchun Li Jing-Jiang Zhou Pei Liang Xi-Wu Gao Shao-Hua Gu Source Type: research

Seasonal dynamics survey and association analysis of microbiota communities, antibiotic resistance genes distribution, and biotoxicities characterization in landfill-leachate
CONCLUSION: As the mature landfill, the quality of this leachate met the pollution control standards for domestic waste landfills. Thiomycetes, Pseudomonas, Desulfurization, and Thiopterus acidophyllum constitute the dominant microbiota. However, leachate in the second quarter had more serious contamination, the higher biotoxicity, higher concentration of AR genes, together with higher microbiota richness and diversity, which deserved more attention for the potential threat to the surrounding environment.PMID:36155335 | DOI:10.1016/j.ecoenv.2022.114103 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Lijuan Liu Lu Shi Pu Li Xinxin Ma Xinyao Hou Sijin Jiang Jia Lv Hongmei Xu Yue Cheng Bei Han Source Type: research

The Characteristics and Potential Risks of Neonicotinoid Residues in Soils of Different Types of Land Use in Hangzhou
Ecotoxicol Environ Saf. 2022 Sep 22;245:114091. doi: 10.1016/j.ecoenv.2022.114091. Online ahead of print.ABSTRACTDue to the wide existence of neonicotinoid insecticides (neonics) and their potential impact on ecosystems and human health, they have received special attention in recent years. Soil is not only a sink of neonics but also a source of neonics, so it plays a key role in the ubiquity of neonics in the environment. The purpose of this research was to compare neonics residues in soils of different types of land use and estimate their exposure to different populations via ingestion. A total of 130 soil samples from s...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Zeteng Ying Bin Guo Guomei Zhang Lihua Sun Xifan Yang Quan Zhang Source Type: research

Prediction study on the distribution of polycyclic aromatic hydrocarbons and their halogenated derivatives in the atmospheric particulate phase
In this study, we first checked the correlation between experimental f values of 53 PAH derivatives and their octanol-air partitioning coefficients (log KOA), which is frequently used to characterize the distribution of chemicals in organic phase, and yielded R2 = 0.803. Then, quantum chemical descriptors derived from molecular structural optimization by M06-2X/6-311 +G (d,p) method were further employed to develop Quantitative Structure-Property Relationship (QSPR) model. The model contains two descriptors, the average molecular polarizability (α) and the equilibrium parameter of molecular electrostatic potential (τ), a...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Siqi Cao Jue Hu Qiang Wu Xiaoxuan Wei Guangcai Ma Haiying Yu Source Type: research

Gender difference in hepatic AMPK pathway activated lipid metabolism induced by aged polystyrene microplastics exposure
Ecotoxicol Environ Saf. 2022 Sep 22;245:114105. doi: 10.1016/j.ecoenv.2022.114105. Online ahead of print.ABSTRACTMicroplastics (MPs) pollution becomes an increasing concern and researchers keep exploring the health effects caused by MPs exposure. The ageing process in the environment significantly alters the physicochemical characteristics of MPs and subsequently affects their toxicities. The health effects of aged MPs exposure and the mechanism underlying are worthy of exploration. Polystyrene microplastics (PS-MPs) (with size less than 50 µm) were obtained by grinding and screening polystyrene materials. PS-MPs continue...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Xiaona Yang Jin Jiang Qing Wang Jiawei Duan Na Chen Di Wu Yankai Xia Source Type: research

Toxicological and transcriptomic-based analysis of monensin and sulfamethazine co-exposure on male SD rats
In this study, male Sprague Dawley rats were exposed to monensin (M) (1, 2, 10 mg/(kg·body weight (BW)) combined with sulfamethazine (S) (60, 120, 600 mg/(kg·BW)) or single drugs for 28 consecutive days. The body weight, hematological and blood biochemical parameters, organ coefficients, and histopathology were analyzed to discover their combined toxicity effect. Transcriptomic analysis was used to reveal the possible mechanisms of their joint toxicity. Compared with the control group, the weight gain rate was significantly reduced in the H-M+S and H-S, and alkaline phosphatase in H-M+S was significantly increased. Furth...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Junjie Zhao Yehui Luan Yanan Chen Linli Cheng Qianxi Qin Source Type: research

Exogenous 5-aminolevulinic acid alleviates low-temperature injury by regulating glutathione metabolism and β-alanine metabolism in tomato seedling roots
In this study, we hope to fill the above gaps by exploring the effects of exogenous ALA on morphology, mitochondrial ultrastructure, reactive oxygen species (ROS) enrichment, physiological indicators, related gene expression, and metabolic pathway in tomato seedlings root under LTS. Results showed that ALA pretreatment could increase the activity of antioxidant enzymes and the content of antioxidant substances in tomato seedlings roots under LTS to scavenge the massively accumulated ROS, thereby protecting the mitochondrial structure of roots and promoting root development under LTS. Combined transcriptomic and metabolomic...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Zhengda Zhang Yuhui Zhang Luqiao Yuan Fan Zhou Yi Gao Zhen Kang Tianlai Li Xiaohui Hu Source Type: research

Effects of polycyclic aromatic hydrocarbons on gestational hormone production in a placental cell line: Application of passive dosing to in vitro tests
Ecotoxicol Environ Saf. 2022 Sep 23;245:114090. doi: 10.1016/j.ecoenv.2022.114090. Online ahead of print.ABSTRACTAir pollution includes polycyclic aromatic hydrocarbons (PAHs), which have been correlated to endocrine disruptor pathways during early pregnancy. PAHs have been found in the placenta and cord blood, which may affect the hormones involved in placental development. We studied the effects of some airborne PAHs on beta human chorionic gonadotropin (β-hCG) and progesterone production by using a syncytial BeWo cell line as a placental model. PAH congeners were spiked in silicon rubber membrane (SRMs) and were then i...
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Jhon Fredy Narv áez Valderrama Vanessa Correa Gil Viviana Alzate B Edison Andr és Tavera Edgar Nore ña Jazm ín Porras Juan Carlos Quintana-Castillo Juan Jos é García L Francisco Jos é Molina P Carlos Ramos-Contreras Julio Bueno Sanchez Source Type: research

Long-term exposure to PM < sub > 2.5 < /sub > constituents in relation to glucose levels and diabetes in middle-aged and older Chinese
CONCLUSIONS: Exposures to PM2.5 and its constituents (i.e., BC, OM, NO3-, and NH4+) were positively associated with increased risks of prevalent diabetes and elevated glucose levels in middle-aged and older adults.PMID:36162351 | DOI:10.1016/j.ecoenv.2022.114096 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - September 26, 2022 Category: Environmental Health Authors: Peixuan Zhou Shaocai Mo Minjin Peng Zhiming Yang Fang Wang Kejia Hu Yunquan Zhang Source Type: research

Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage
Ecotoxicol Environ Saf. 2022 Sep 21;245:114099. doi: 10.1016/j.ecoenv.2022.114099. Online ahead of print.ABSTRACTMethylmercury (MeHg) is a ubiquitous environmental pollutant, which can cross the placenta and blood brain barrier, thus affecting fetal growth and development. Although previous studies have demonstrated that MeHg induces endoplasmic reticulum (ER) stress in rat cerebral cortex and primary neurons, the role of ER stress in MeHg-induced neurodevelopmental toxicity remains unclear. Here, we used ICR pregnant mice and hippocampal neurons cells (HT22 cells) to investigate the molecular mechanism by which MeHg expos...
Source: Ecotoxicology and Environmental Safety - September 24, 2022 Category: Environmental Health Authors: Jingjing Pan Xiaoyang Li Haihui Liu Chen Wang Si Xu Bin Xu Yu Deng Tianyao Yang Wei Liu Source Type: research

Physiological response and oxidative stress of grass carp (Ctenopharyngodon idellus) under single and combined toxicity of polystyrene microplastics and cadmium
Ecotoxicol Environ Saf. 2022 Sep 21;245:114080. doi: 10.1016/j.ecoenv.2022.114080. Online ahead of print.ABSTRACTThe harm of microplastics (MPs) to aquatic ecosystems is caused by their stable and non-degradable properties. Additionally, the pollutants such as heavy metals in the water are easy to be adsorbed on their surface with their small particle size and large specific surface area, resulting in environmental pollution. Therefore, the study on the mixture toxicity of MPs and heavy metals has theoretical significance for the risk assessment of aquatic ecosystems. In the present study, 10 nm polystyrene (PS) and cadmiu...
Source: Ecotoxicology and Environmental Safety - September 24, 2022 Category: Environmental Health Authors: Xuan Chen Jing Wang Yijie Xie Yibing Ma Jiaen Zhang Hui Wei Ahmed Ibrahim Elsayed Abdou Source Type: research

Cross-redox and simultaneous removal of Cr(VI) and As(III): Influences of Fe(II), Fe(III), oxalic acid, and dissolved organic carbon
This study unravelled the interference from ubiquitous species in the co-removal of Cr(VI) and As(III), which provides insightful remediation for heavy metal contaminations.PMID:36152429 | DOI:10.1016/j.ecoenv.2022.114084 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - September 24, 2022 Category: Environmental Health Authors: Kim Hoong Ng Liang-Ching Hsu Yu-Ting Liu Chuan-Yen Hsiao Po-Neng Chiang Heng Yi Teah Jui-Ting Hung Yu-Min Tzou Source Type: research