Ethoprophos induces cardiac toxicity in zebrafish embryos
In this study, zebrafish embryo model was used to evaluated the toxicity of ethoprophos during cardiovascular developmental process of zebrafish. Zebrafish embryos were separately exposed to 10 mg/L, 20 mg/L, 30 mg/L, 40 mg/L and 50 mg/L of ethoprophos exposure at 96 h post-fertilization (hpf), which induced cardiac defects, such as low heart rate, pericardium edema and long SV-BA distance, but had no influence to vascular development. Mechanistically, the expression of cardiac-related genes were abnormal. Moreover, ethoprophos exposure significantly increased oxidative stress in zebrafish embryos by inhibiting the product...
Source: Ecotoxicology and Environmental Safety - November 30, 2021 Category: Environmental Health Authors: Meifeng Li Tingting Yu Jingli Lai Xue Han Jihuan Hu Zeyuan Deng Dongming Li Zuocheng Ye Shanghong Wang Chengyu Hu Xiaowen Xu Source Type: research

Antibiotics as a silent driver of climate change? A case study investigating methane production in freshwater sediments
Ecotoxicol Environ Saf. 2021 Nov 27;228:113025. doi: 10.1016/j.ecoenv.2021.113025. Online ahead of print.ABSTRACTMethane (CH4) is the second most important greenhouse gas after carbon dioxide (CO2) and is inter alia produced in natural freshwater ecosystems. Given the rise in CH4 emissions from natural sources, researchers are investigating environmental factors and climate change feedbacks to explain this increment. Despite being omnipresent in freshwaters, knowledge on the influence of chemical stressors of anthropogenic origin (e.g., antibiotics) on methanogenesis is lacking. To address this knowledge gap, we incubated ...
Source: Ecotoxicology and Environmental Safety - November 30, 2021 Category: Environmental Health Authors: E Bollinger J P Zubrod F Y Lai L Ahrens S Filker A Lorke M Bundschuh Source Type: research

Enhancement of algae ponds for rural domestic sewage treatment by prolonging daylight using artificial lamps
In this study, four algae ponds were set up, daylight was prolonged by 0, 2, 4, and 6 h with an illuminating intensity of 3000 lx. The highest removal efficiencies of total nitrogen, ammonium, and total phosphorus were 37.36%, 41.20%, and 21.56% due to the highest microbial abundance under optimum conditions (2 h PD), respectively. Excessive PD (4 h and 6 h) could inhibit the removal abilities. PD also increased the maximum relative electron transport rate of algae, leading to an increase in the photosynthetic capacity of APs. Meanwhile, the high microbial abundance indicates that chemoheterotrophic bacteria are the main i...
Source: Ecotoxicology and Environmental Safety - November 29, 2021 Category: Environmental Health Authors: Yuxuan Mao Hongfang Tan Kemei Wang Yejian Zhang Zhan Jin Min Zhao Yiqing Li Xiangyong Zheng Source Type: research

Molybdenum and cadmium co-induce hypothalamus toxicity in ducks via disturbing Nrf2-mediated defense response and triggering mitophagy
Ecotoxicol Environ Saf. 2021 Nov 26;228:113022. doi: 10.1016/j.ecoenv.2021.113022. Online ahead of print.ABSTRACTGrowing evidences reveal that Nrf2-mediated antioxidant defense response and mitophagy are involved in the toxic mechanism of heavy metals, but the effects of molybdenum (Mo) and cadmium (Cd) co-exposure on Nrf2-mediated antioxidant defense response and mitophagy in duck hypothalamus have yet to be elucidated. Herein, 40 healthy 7-day-old ducks were randomly assigned to 4 groups and fed diets containing different doses of Mo or/and Cd for 16 weeks, respectively. The data demonstrated that Mo or/and Cd notably el...
Source: Ecotoxicology and Environmental Safety - November 29, 2021 Category: Environmental Health Authors: Ting Cui Wenjuan Jiang Fan Yang Junrong Luo Ruiming Hu Huabin Cao Guoliang Hu Caiying Zhang Source Type: research

The first comprehensive study evaluating the ecotoxicity and biodegradability of water-soluble polymers used in personal care products and cosmetics
In this study four polyacrylic acid- based WSPs (three in the solid state and one in the liquid state), which are widely used in cosmetic industry, were tested in terms of their ecotoxicity and biodegradability. The ecotoxicity tests were performed using aquatic plant Lemna minor, microalga Pseudokirchneriella subcapitata, crustacean Daphnia magna, bacterium Allivibrio fischeri, and a mixed bacterial culture of activated sludge (with heterotrophic and nitrifying microorganisms tested separately). All four WSPs had low or moderate effects on the tested organisms at several endpoints. However, the liquid WSP had a specific t...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Ula Rozman Gabriela Kal číková Source Type: research

Integrated physiological, transcriptome and metabolome analyses of the hepatopancreas of the female swimming crab Portunus trituberculatus under ammonia exposure
In this study, we aimed to investigate ammonia toxicity and metabolism mechanisms in the hepatopancreas, a major organ for Vitellogenin (Vtg) synthesis and defending against ammonia stress, of female swimming crab Portunus trituberculatus which is an important fishery and aquaculture species, by integrating physiological, transcriptome and metabolome analyses. The results revealed that ammonia exposure (10 mg/L, an environmentally relevant concentration) resulted in a remarkable reduction in vtg expression and depression of multiple signaling pathways for reproductive regulators including methyl farnesoate, ecdysone and ne...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Xianliang Meng Nishad Jayasundara Jingyan Zhang Xianyun Ren Baoquan Gao Jian Li Ping Liu Source Type: research

Prokaryotic expression of human-sourced and zebrafish-sourced protein kinase A alpha catalytic subunits combined with in vitro and in silico assay
Ecotoxicol Environ Saf. 2021 Nov 26;228:113023. doi: 10.1016/j.ecoenv.2021.113023. Online ahead of print.ABSTRACTThe extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation. Therefore, PKA has been viewed increasingly as potential target for variety of drugs and environmental endocrine disruptors. Consequentially, the preparation of PKA protein became an important initial step for the subsequent exploration of PKA's character in endocrine disrupting effects of pesticides. To investigate PKA protein, whi...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Kun Qiao Yao Jiang Tiantian Hu Shuying Li Wenjun Gui Source Type: research

Emerging roles of circRNAs in regulating thermal and hypoxic stresses in Apostichopus japonicus (Echinodermata: Holothuroidea)
Ecotoxicol Environ Saf. 2021 Nov 25;228:112994. doi: 10.1016/j.ecoenv.2021.112994. Online ahead of print.ABSTRACTSome sea cucumbers are economically and ecologically important, but they are threatened by thermal and hypoxic stress in changing oceanographic conditions. We construct circRNAs profiles, reveal circRNAs characters, and illustrate the potential regulatory roles of circRNAs in one commercially important species of sea cucumber, Apostichopus japonicus. Reads are distributed in intergenic (44.14%), exonic (48.26%) and intronic (7.60%) regions of the genome. A total of 1684 circRNAs were identified, and the most com...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Da Huo Lina Sun Jingchun Sun Chenggang Lin Shilin Liu Libin Zhang Hongsheng Yang Source Type: research

Effects of chronic exposure to the water-soluble fraction of crude oil and in situ burn residue of oil on egg-bearing Northern shrimp (Pandalus borealis)
Ecotoxicol Environ Saf. 2021 Nov 25;228:113013. doi: 10.1016/j.ecoenv.2021.113013. Online ahead of print.ABSTRACTOil spill clean-up measures using in situ burning can potentially result in seafloor contamination affecting benthic organisms. To mimic realistic exposure and measure effects, ovigerous Northern shrimp were continuously exposed for two weeks to the water-soluble fraction of oil coated on gravel followed by two weeks in clean seawater. North Sea crude oil (NSC) and field generated in situ burn residue (ISBR) of NSC were used (Low: 3 g/kg gravel, Medium: 6 g/kg gravel and High: 12 g/kg gravel). The concentrations...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Frederike Keitel-Gr öner Shaw Bamber Ren ée K Bechmann Emily Lyng Alessio Gomiero Valentina Tronci Naouel Gharbi Frode Engen Ingrid C Taban Thierry Baussant Source Type: research

Effects of nanometer alumina and humic acid on the retention and transport of hexavalent chromium in porous media
Ecotoxicol Environ Saf. 2021 Nov 26;228:113005. doi: 10.1016/j.ecoenv.2021.113005. Online ahead of print.ABSTRACTColumn experiments were conducted to investigate the effects of ion type, ion strength, humic acid (HA), and nanometer alumina (NA) particles on the transport of hexavalent chromium (HC) in saturated porous media. A one-dimensional model is developed to simulate the migration of HC affected by NA particles. The results show that nano-alumina particles would enhance the mobility of HC in saturated porous media. However, the influence of NA on the migration of HC in porous media is complex. When the concentration ...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Ming Wu Huihui Cao Guoping Lu Bill X Hu Zhou Cheng Cehui Mo Jianfeng Wu Jichun Wu Source Type: research

The first comprehensive study evaluating the ecotoxicity and biodegradability of water-soluble polymers used in personal care products and cosmetics
In this study four polyacrylic acid- based WSPs (three in the solid state and one in the liquid state), which are widely used in cosmetic industry, were tested in terms of their ecotoxicity and biodegradability. The ecotoxicity tests were performed using aquatic plant Lemna minor, microalga Pseudokirchneriella subcapitata, crustacean Daphnia magna, bacterium Allivibrio fischeri, and a mixed bacterial culture of activated sludge (with heterotrophic and nitrifying microorganisms tested separately). All four WSPs had low or moderate effects on the tested organisms at several endpoints. However, the liquid WSP had a specific t...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Ula Rozman Gabriela Kal číková Source Type: research

Integrated physiological, transcriptome and metabolome analyses of the hepatopancreas of the female swimming crab Portunus trituberculatus under ammonia exposure
In this study, we aimed to investigate ammonia toxicity and metabolism mechanisms in the hepatopancreas, a major organ for Vitellogenin (Vtg) synthesis and defending against ammonia stress, of female swimming crab Portunus trituberculatus which is an important fishery and aquaculture species, by integrating physiological, transcriptome and metabolome analyses. The results revealed that ammonia exposure (10 mg/L, an environmentally relevant concentration) resulted in a remarkable reduction in vtg expression and depression of multiple signaling pathways for reproductive regulators including methyl farnesoate, ecdysone and ne...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Xianliang Meng Nishad Jayasundara Jingyan Zhang Xianyun Ren Baoquan Gao Jian Li Ping Liu Source Type: research

Prokaryotic expression of human-sourced and zebrafish-sourced protein kinase A alpha catalytic subunits combined with in vitro and in silico assay
Ecotoxicol Environ Saf. 2021 Nov 26;228:113023. doi: 10.1016/j.ecoenv.2021.113023. Online ahead of print.ABSTRACTThe extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation. Therefore, PKA has been viewed increasingly as potential target for variety of drugs and environmental endocrine disruptors. Consequentially, the preparation of PKA protein became an important initial step for the subsequent exploration of PKA's character in endocrine disrupting effects of pesticides. To investigate PKA protein, whi...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Kun Qiao Yao Jiang Tiantian Hu Shuying Li Wenjun Gui Source Type: research

Emerging roles of circRNAs in regulating thermal and hypoxic stresses in Apostichopus japonicus (Echinodermata: Holothuroidea)
Ecotoxicol Environ Saf. 2021 Nov 25;228:112994. doi: 10.1016/j.ecoenv.2021.112994. Online ahead of print.ABSTRACTSome sea cucumbers are economically and ecologically important, but they are threatened by thermal and hypoxic stress in changing oceanographic conditions. We construct circRNAs profiles, reveal circRNAs characters, and illustrate the potential regulatory roles of circRNAs in one commercially important species of sea cucumber, Apostichopus japonicus. Reads are distributed in intergenic (44.14%), exonic (48.26%) and intronic (7.60%) regions of the genome. A total of 1684 circRNAs were identified, and the most com...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Da Huo Lina Sun Jingchun Sun Chenggang Lin Shilin Liu Libin Zhang Hongsheng Yang Source Type: research

Effects of chronic exposure to the water-soluble fraction of crude oil and in situ burn residue of oil on egg-bearing Northern shrimp (Pandalus borealis)
Ecotoxicol Environ Saf. 2021 Nov 25;228:113013. doi: 10.1016/j.ecoenv.2021.113013. Online ahead of print.ABSTRACTOil spill clean-up measures using in situ burning can potentially result in seafloor contamination affecting benthic organisms. To mimic realistic exposure and measure effects, ovigerous Northern shrimp were continuously exposed for two weeks to the water-soluble fraction of oil coated on gravel followed by two weeks in clean seawater. North Sea crude oil (NSC) and field generated in situ burn residue (ISBR) of NSC were used (Low: 3 g/kg gravel, Medium: 6 g/kg gravel and High: 12 g/kg gravel). The concentrations...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Frederike Keitel-Gr öner Shaw Bamber Ren ée K Bechmann Emily Lyng Alessio Gomiero Valentina Tronci Naouel Gharbi Frode Engen Ingrid C Taban Thierry Baussant Source Type: research

Effects of nanometer alumina and humic acid on the retention and transport of hexavalent chromium in porous media
Ecotoxicol Environ Saf. 2021 Nov 26;228:113005. doi: 10.1016/j.ecoenv.2021.113005. Online ahead of print.ABSTRACTColumn experiments were conducted to investigate the effects of ion type, ion strength, humic acid (HA), and nanometer alumina (NA) particles on the transport of hexavalent chromium (HC) in saturated porous media. A one-dimensional model is developed to simulate the migration of HC affected by NA particles. The results show that nano-alumina particles would enhance the mobility of HC in saturated porous media. However, the influence of NA on the migration of HC in porous media is complex. When the concentration ...
Source: Ecotoxicology and Environmental Safety - November 28, 2021 Category: Environmental Health Authors: Ming Wu Huihui Cao Guoping Lu Bill X Hu Zhou Cheng Cehui Mo Jianfeng Wu Jichun Wu Source Type: research

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532-3p/Acyl-CoA oxidase 1(ACOX1) pathway
In this study, we investigated the lipid metabolism disorders of 6:2 Cl-PFESA through miRNA-gene interaction mode in Huh-7 cells. Our results showed that 6:2 Cl-PFESA significantly promoted cellular lipid accumulation and increased the expression of Acyl-CoA oxidase 1 (ACOX1), with the lowest effective concentrations (LOECs) of 3 μM. In silico analysis showed that hsa-miR-532-3p is a potential miRNA molecule targeting ACOX1. Fluorescent-based RNA electrophoretic mobility shift assay (FREMSA) and ACOX1-mediated luciferase reporter gene assays showed that hsa-miR-532-3p could directly bind to ACOX1 and inhibit its transcr...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Chuanhai Li Lidan Jiang Yuan Jin Donghui Zhang Jing Chen Yuan Qi Rongrong Fan Jiao Luo Lin Xu Wanli Ma Kunming Zhao Dianke Yu Source Type: research

Effects of single and combined exposure to BDE-47 and PFOA on distribution, bioaccumulation, and toxicity in blue mussel (Mytilus galloprovincialis)
Ecotoxicol Environ Saf. 2021 Nov 24;228:113014. doi: 10.1016/j.ecoenv.2021.113014. Online ahead of print.ABSTRACTThe contamination of 2,2',4,4'-Tetrabrmodiphenyl ether (BDE-47) and perfluorooctanoic acid (PFOA) has drawn a worldwide attention over the risks in ecological and food safety. In this work, blue mussel (Mytilus galloprpvincialis) was employed to investigate the combined effects of BDE-47 (10 ng mL-1) and PFOA (100 ng mL-1) on tissue distribution, accumulation, elimination, and toxicity. Results suggested that BDE-47 and PFOA accumulated mostly in digestive gland, followed by gills and gonad, and M. galloprovinci...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Qianqian Geng Mengmeng Guo Haiyan Wu Jixing Peng Guanchao Zheng Xiaoyu Liu Yuxiu Zhai Zhijun Tan Source Type: research

Arsenic exposure from drinking water and staple food (rice): A field scale study in rural Bengal for assessment of human health risk
This study deals with arsenic exposure and associated increased lifetime cancer risk for populations in arsenic-endemic regions of rural Bengal, where arsenic-safe drinking water is being supplied at present. We found a median total exposure of inorganic arsenic to be 2. 9 μg/Kg BW/day (5th and 95th percentiles were 1.1 μg/Kg BW/day and 7.9 μg/Kg BW/day); with major contribution from cooked rice intake (2.4 µg/Kg BW/day). A significant number of households drank arsenic safe water but used arsenic-rich water for rice cooking. As a result, 67% participants had inorganic arsenic intake above the JEFCA threshol...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Bratisha Biswas Arijit Chakraborty Debashis Chatterjee Sreemanta Pramanik Bhaswati Ganguli Kunal Kanti Majumdar Jerome Nriagu Ketki Y Kulkarni Amit Bansiwal Pawan Labhasetwar Subhamoy Bhowmick Source Type: research

Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
Ecotoxicol Environ Saf. 2021 Nov 24;228:113024. doi: 10.1016/j.ecoenv.2021.113024. Online ahead of print.ABSTRACTEpidemiological evidence of short-term fine particulate matter (PM2.5) exposure on blood pressure (BP), heart rate (HR) and related inflammation biomarkers has been inconsistent. We aimed to explore the acute effect of PM2.5 on BP, HR and the mediation effect of related inflammation biomarkers. A total of 32 healthy college students were recruited to perform 4 h of exposure at two sites with different PM2.5 concentrations in Wuhan between May 2019 and June 2019. The individual levels of PM2.5 concentration, BP a...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Zhaoyuan Li Yisi Liu Tianjun Lu Shouxin Peng Feifei Liu Jinhui Sun Hao Xiang Source Type: research

Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF- κB/NLRP3 inflammasome-mediated inflammation
In conclusion, our results suggested that Se inhibited energy metabolism disorder and inflammation by regulating mitochondrial dynamics, thereby alleviating HgCl2-induced liver injury in chickens. These results are expected to provide potential intervention and therapeutic targets for diseases caused by inorganic mercury poisoning.PMID:34837874 | DOI:10.1016/j.ecoenv.2021.113018 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Pei-Chao Gao Jia-Hong Chu Xue-Wei Chen Lan-Xin Li Rui-Feng Fan Source Type: research

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532-3p/Acyl-CoA oxidase 1(ACOX1) pathway
In this study, we investigated the lipid metabolism disorders of 6:2 Cl-PFESA through miRNA-gene interaction mode in Huh-7 cells. Our results showed that 6:2 Cl-PFESA significantly promoted cellular lipid accumulation and increased the expression of Acyl-CoA oxidase 1 (ACOX1), with the lowest effective concentrations (LOECs) of 3 μM. In silico analysis showed that hsa-miR-532-3p is a potential miRNA molecule targeting ACOX1. Fluorescent-based RNA electrophoretic mobility shift assay (FREMSA) and ACOX1-mediated luciferase reporter gene assays showed that hsa-miR-532-3p could directly bind to ACOX1 and inhibit its transcr...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Chuanhai Li Lidan Jiang Yuan Jin Donghui Zhang Jing Chen Yuan Qi Rongrong Fan Jiao Luo Lin Xu Wanli Ma Kunming Zhao Dianke Yu Source Type: research

Effects of single and combined exposure to BDE-47 and PFOA on distribution, bioaccumulation, and toxicity in blue mussel (Mytilus galloprovincialis)
Ecotoxicol Environ Saf. 2021 Nov 24;228:113014. doi: 10.1016/j.ecoenv.2021.113014. Online ahead of print.ABSTRACTThe contamination of 2,2',4,4'-Tetrabrmodiphenyl ether (BDE-47) and perfluorooctanoic acid (PFOA) has drawn a worldwide attention over the risks in ecological and food safety. In this work, blue mussel (Mytilus galloprpvincialis) was employed to investigate the combined effects of BDE-47 (10 ng mL-1) and PFOA (100 ng mL-1) on tissue distribution, accumulation, elimination, and toxicity. Results suggested that BDE-47 and PFOA accumulated mostly in digestive gland, followed by gills and gonad, and M. galloprovinci...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Qianqian Geng Mengmeng Guo Haiyan Wu Jixing Peng Guanchao Zheng Xiaoyu Liu Yuxiu Zhai Zhijun Tan Source Type: research

Arsenic exposure from drinking water and staple food (rice): A field scale study in rural Bengal for assessment of human health risk
This study deals with arsenic exposure and associated increased lifetime cancer risk for populations in arsenic-endemic regions of rural Bengal, where arsenic-safe drinking water is being supplied at present. We found a median total exposure of inorganic arsenic to be 2. 9 μg/Kg BW/day (5th and 95th percentiles were 1.1 μg/Kg BW/day and 7.9 μg/Kg BW/day); with major contribution from cooked rice intake (2.4 µg/Kg BW/day). A significant number of households drank arsenic safe water but used arsenic-rich water for rice cooking. As a result, 67% participants had inorganic arsenic intake above the JEFCA threshol...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Bratisha Biswas Arijit Chakraborty Debashis Chatterjee Sreemanta Pramanik Bhaswati Ganguli Kunal Kanti Majumdar Jerome Nriagu Ketki Y Kulkarni Amit Bansiwal Pawan Labhasetwar Subhamoy Bhowmick Source Type: research

Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
Ecotoxicol Environ Saf. 2021 Nov 24;228:113024. doi: 10.1016/j.ecoenv.2021.113024. Online ahead of print.ABSTRACTEpidemiological evidence of short-term fine particulate matter (PM2.5) exposure on blood pressure (BP), heart rate (HR) and related inflammation biomarkers has been inconsistent. We aimed to explore the acute effect of PM2.5 on BP, HR and the mediation effect of related inflammation biomarkers. A total of 32 healthy college students were recruited to perform 4 h of exposure at two sites with different PM2.5 concentrations in Wuhan between May 2019 and June 2019. The individual levels of PM2.5 concentration, BP a...
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Zhaoyuan Li Yisi Liu Tianjun Lu Shouxin Peng Feifei Liu Jinhui Sun Hao Xiang Source Type: research

Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF- κB/NLRP3 inflammasome-mediated inflammation
In conclusion, our results suggested that Se inhibited energy metabolism disorder and inflammation by regulating mitochondrial dynamics, thereby alleviating HgCl2-induced liver injury in chickens. These results are expected to provide potential intervention and therapeutic targets for diseases caused by inorganic mercury poisoning.PMID:34837874 | DOI:10.1016/j.ecoenv.2021.113018 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - November 27, 2021 Category: Environmental Health Authors: Pei-Chao Gao Jia-Hong Chu Xue-Wei Chen Lan-Xin Li Rui-Feng Fan Source Type: research

Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis
Ecotoxicol Environ Saf. 2021 Nov 23;228:113006. doi: 10.1016/j.ecoenv.2021.113006. Online ahead of print.ABSTRACTFluoride (F) exposure was widely reported to be associated with renal diseases. Since absorbed F enters the organism from drinking water mostly through the gastrointestinal tract, investigating changes of gut microbes may have profound implications for the prevention of chronic F exposure because increasing evidence supported the existence of the gut-kidney axis. In the present study, we aimed to explore the potential positive effects of probiotics on high F exposure-induced renal lesions and dysfunction in mice...
Source: Ecotoxicology and Environmental Safety - November 26, 2021 Category: Environmental Health Authors: Jinge Xin Ning Sun Hesong Wang Hailin Ma Bangyuan Wu Lianxin Li Yanyan Wang Haonan Huang Dong Zeng Xiuquan Bai Ali Chen Shenhai Gong Xueqin Ni Yang Bai Source Type: research

Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
This study provides more accurate data to investigate the environmental impact of penthiopyrad at the enantiomer level.PMID:34826729 | DOI:10.1016/j.ecoenv.2021.113010 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - November 26, 2021 Category: Environmental Health Authors: Bo Ren Tingting Zhao Yanhong Li Hanlin Liang Yuexing Zhao Haiyue Chen Li Li Hongwu Liang Source Type: research

iTRAQ-based quantitative proteomic reveals proteomic changes in Serratia sp. CM01 and mechanism of Cr( Ⅵ) resistance
CONCLUSION: Domesticated CM01 displayed a complex biological network to exhibit the tolerance of Cr(Ⅵ), which may be attributed to the following aspects: (a) CM01 reduced the consumption of glucose by inhibiting the metabolism of carbohydrates, which was an energy-saving survival mode. (b) The inositol phosphate metabolism pathway played an important role. (c) Oxidative stress proteins enhanced the adaptability. (d) CM01 enhanced biosynthesis of hydrophobic amino acids to resistance to Cr(Ⅵ). (e) Several key systems and proteins, such as UvrABC system, Lon protease, porin OmpC, also may play an important role.PMID:3482...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Yuan Liu Yanlun Qiu Qi Yin Xinglong Li Qunhua Bai Yingli Li Hong Xiao Source Type: research

Occurrence of total mercury and methylmercury in rice: Exposure and health implications in Nepal
In this study, total Hg (THg) and MeHg levels in rice samples (n = 172) across Nepal were first investigated. The geometric mean THg was 7.05 ± 7.71 µg/kg with a range of 0.622 µg/kg to 158 µg/kg, and the maximum THg level was up to 791% of the Chinese National Standard Limit for THg in rice (20 µg/kg). The geometric mean MeHg was 0.820 ± 0.660 µg/kg with a range of 0.189 µg/kg to 8.59 µg/kg. Overall, the mean MeHg exposure (0.00445 ± 0.00477 µg/kg bw/day) and inorganic Hg (IHg) exposure (0.0360 ± 0.0739 µg/kg bw/day) were lower than the refe...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Le Wang Jialiang Han Hem Bahadur Katuwal Pinhua Xia Xiaohang Xu Xinbin Feng Guangle Qiu Source Type: research

Physiological and transcriptomic analyses reveal novel insights into the cultivar-specific response to alkaline stress in alfalfa (Medicago sativa L.)
In this study, we performed physiological and transcriptomic analyses using two alfalfa cultivars (Medicago sativa L.) with different sensitivities to alkaline conditions. The chlorophyll content and shoot fresh mass drastically declined in the alkaline-sensitive cultivar Algonquin (AG) following alkaline treatment (0-25 mM Na2CO3 solution), while the alkaline-tolerant cultivar Gongnong NO.1 (GN) maintained relatively stable growth and chlorophyll content. Compared with AG, GN had higher contents of Ca2+ and Mg2+; the ratios of Ca2+ and Mg2+ to Na+, proline and soluble sugar, as well as higher enzyme activities of peroxida...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Tian-Jiao Wei Guang Li Ming-Ming Wang Yang-Yang Jin Guo-Hui Zhang Miao Liu Hao-Yu Yang Chang-Jie Jiang Zheng-Wei Liang Source Type: research

Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue
This article explored the effects of subacute Cd exposure on pig liver fibrosis, as well as the polarization of microRNA (miRNA) and M1/M2 macrophages during this process. Based on the establishment of the pig subacute CdCl2 exposure model, we used immunofluorescence staining, Masson staining, qRT-PCR and western blotting to conduct further research. The results showed that Cd exposure can increase the expression of miRNA-21, decrease the expression of TGF-β and SMAD7, increase the expression of PI3K/AKT signaling pathway, cause the M1/M2 imbalance and the increase of M1 polarization. Meantime, it causes the secretion...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Wei Cui Sitong Zhou YuLin Wang Xu Shi Honggui Liu Source Type: research

iTRAQ-based quantitative proteomic reveals proteomic changes in Serratia sp. CM01 and mechanism of Cr( Ⅵ) resistance
CONCLUSION: Domesticated CM01 displayed a complex biological network to exhibit the tolerance of Cr(Ⅵ), which may be attributed to the following aspects: (a) CM01 reduced the consumption of glucose by inhibiting the metabolism of carbohydrates, which was an energy-saving survival mode. (b) The inositol phosphate metabolism pathway played an important role. (c) Oxidative stress proteins enhanced the adaptability. (d) CM01 enhanced biosynthesis of hydrophobic amino acids to resistance to Cr(Ⅵ). (e) Several key systems and proteins, such as UvrABC system, Lon protease, porin OmpC, also may play an important role.PMID:3482...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Yuan Liu Yanlun Qiu Qi Yin Xinglong Li Qunhua Bai Yingli Li Hong Xiao Source Type: research

Occurrence of total mercury and methylmercury in rice: Exposure and health implications in Nepal
In this study, total Hg (THg) and MeHg levels in rice samples (n = 172) across Nepal were first investigated. The geometric mean THg was 7.05 ± 7.71 µg/kg with a range of 0.622 µg/kg to 158 µg/kg, and the maximum THg level was up to 791% of the Chinese National Standard Limit for THg in rice (20 µg/kg). The geometric mean MeHg was 0.820 ± 0.660 µg/kg with a range of 0.189 µg/kg to 8.59 µg/kg. Overall, the mean MeHg exposure (0.00445 ± 0.00477 µg/kg bw/day) and inorganic Hg (IHg) exposure (0.0360 ± 0.0739 µg/kg bw/day) were lower than the refe...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Le Wang Jialiang Han Hem Bahadur Katuwal Pinhua Xia Xiaohang Xu Xinbin Feng Guangle Qiu Source Type: research

Physiological and transcriptomic analyses reveal novel insights into the cultivar-specific response to alkaline stress in alfalfa (Medicago sativa L.)
In this study, we performed physiological and transcriptomic analyses using two alfalfa cultivars (Medicago sativa L.) with different sensitivities to alkaline conditions. The chlorophyll content and shoot fresh mass drastically declined in the alkaline-sensitive cultivar Algonquin (AG) following alkaline treatment (0-25 mM Na2CO3 solution), while the alkaline-tolerant cultivar Gongnong NO.1 (GN) maintained relatively stable growth and chlorophyll content. Compared with AG, GN had higher contents of Ca2+ and Mg2+; the ratios of Ca2+ and Mg2+ to Na+, proline and soluble sugar, as well as higher enzyme activities of peroxida...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Tian-Jiao Wei Guang Li Ming-Ming Wang Yang-Yang Jin Guo-Hui Zhang Miao Liu Hao-Yu Yang Chang-Jie Jiang Zheng-Wei Liang Source Type: research

Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue
This article explored the effects of subacute Cd exposure on pig liver fibrosis, as well as the polarization of microRNA (miRNA) and M1/M2 macrophages during this process. Based on the establishment of the pig subacute CdCl2 exposure model, we used immunofluorescence staining, Masson staining, qRT-PCR and western blotting to conduct further research. The results showed that Cd exposure can increase the expression of miRNA-21, decrease the expression of TGF-β and SMAD7, increase the expression of PI3K/AKT signaling pathway, cause the M1/M2 imbalance and the increase of M1 polarization. Meantime, it causes the secretion...
Source: Ecotoxicology and Environmental Safety - November 25, 2021 Category: Environmental Health Authors: Wei Cui Sitong Zhou YuLin Wang Xu Shi Honggui Liu Source Type: research

Potential of Vis-NIR to measure heavy metals in different varieties of organic-fertilizers using Boruta and deep belief network
Ecotoxicol Environ Saf. 2021 Nov 20;228:112996. doi: 10.1016/j.ecoenv.2021.112996. Online ahead of print.ABSTRACTThe quick identification of heavy metals is of major importance and is beneficial for controlling the fertilizer production process in the fertilizer industries. This work aimed to use visible and near-infrared spectroscopy (Vis-NIR), Boruta, and deep learning to establish rapid heavy metals screening methods. Boruta algorithm was used to extract appropriate wavelengths, and a deep belief network (DBN) was computed to determine the amounts of various heavy metals such as chromium (Cr), cadmium (Cd), lead (Pb), a...
Source: Ecotoxicology and Environmental Safety - November 23, 2021 Category: Environmental Health Authors: Mahamed Lamine Guindo Muhammad Hilal Kabir Rongqin Chen Fei Liu Source Type: research

Potential of Vis-NIR to measure heavy metals in different varieties of organic-fertilizers using Boruta and deep belief network
Ecotoxicol Environ Saf. 2021 Nov 19;228:112996. doi: 10.1016/j.ecoenv.2021.112996. Online ahead of print.ABSTRACTThe quick identification of heavy metals is of major importance and is beneficial for controlling the fertilizer production process in the fertilizer industries. This work aimed to use visible and near-infrared spectroscopy (Vis-NIR), Boruta, and deep learning to establish rapid heavy metals screening methods. Boruta algorithm was used to extract appropriate wavelengths, and a deep belief network (DBN) was computed to determine the amounts of various heavy metals such as chromium (Cr), cadmium (Cd), lead (Pb), a...
Source: Ecotoxicology and Environmental Safety - November 23, 2021 Category: Environmental Health Authors: Mahamed Lamine Guindo Muhammad Hilal Kabir Rongqin Chen Fei Liu Source Type: research

Potential of Vis-NIR to measure heavy metals in different varieties of organic-fertilizers using Boruta and deep belief network
Ecotoxicol Environ Saf. 2021 Nov 19;228:112996. doi: 10.1016/j.ecoenv.2021.112996. Online ahead of print.ABSTRACTThe quick identification of heavy metals is of major importance and is beneficial for controlling the fertilizer production process in the fertilizer industries. This work aimed to use visible and near-infrared spectroscopy (Vis-NIR), Boruta, and deep learning to establish rapid heavy metals screening methods. Boruta algorithm was used to extract appropriate wavelengths, and a deep belief network (DBN) was computed to determine the amounts of various heavy metals such as chromium (Cr), cadmium (Cd), lead (Pb), a...
Source: Ecotoxicology and Environmental Safety - November 23, 2021 Category: Environmental Health Authors: Mahamed Lamine Guindo Muhammad Hilal Kabir Rongqin Chen Fei Liu Source Type: research

Phenotypic responses and potential genetic mechanism of lepidopteran insects under exposure to graphene oxide
Ecotoxicol Environ Saf. 2021 Nov 19;228:113008. doi: 10.1016/j.ecoenv.2021.113008. Online ahead of print.ABSTRACTClarification of the interactions between engineered nanomaterials and multiple generations of insects is crucial to understanding the impact of nanotechnology on the environment and agriculture, particularly in toxicity management, pest management and genetic engineering. To date, there has been very limited information about nanoparticle-insect interactions at the genetic and proteomic levels. Here, we examined the phenotypic responses and potential mechanism of a lepidopteran insect Asian corn borer (ACB) to ...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Xiuping Wang Tiantao Zhang Haicui Xie Zhenying Wang Dapeng Jing Kanglai He Xiaoduo Gao Source Type: research

Integrated metabolomics and transcriptomics reveal di(2-ethylhexyl) phthalate-induced mitochondrial dysfunction and glucose metabolism disorder through oxidative stress in rat liver
Ecotoxicol Environ Saf. 2021 Nov 19;228:112988. doi: 10.1016/j.ecoenv.2021.112988. Online ahead of print.ABSTRACTDi(2-ethylhexyl) phthalate (DEHP) is a ubiquitous pollutant that results in hepatotoxicity. However, an understanding of the systematic mechanism of hepatic injury caused by DEHP remains limited. Here, we performed a comprehensive metabolomics and transcriptomics analyses to describe hepatic responses of rats to long-term DEHP exposure and, together with pathology and functional injury of liver, systematically analyzed the pathogenesis and mechanisms of liver damage. SD rats were exposed to 0 and 600 mg/kg/day D...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Gang Li Chen-Yang Zhao Qian Wu Si-Yuan Guan Hong-Wei Jin Xiao-Lin Na Yun-Bo Zhang Source Type: research

Arbuscular mycorrhizal fungi reverse selenium stress in Zea mays seedlings by improving plant and soil characteristics
Ecotoxicol Environ Saf. 2021 Nov 19;228:113000. doi: 10.1016/j.ecoenv.2021.113000. Online ahead of print.ABSTRACTSelenium (Se) is a beneficial trace element for certain animals including humans, while remaining controversial for plants. High Se concentration in soil is toxic to plants especially at seedling stage of the plants. Although, arbuscular mycorrhizal fungi (AMF) are important for plant stress resistance; but the mechanisms by which AMF alleviate Se stress in crop seedlings are unclear. Therefore, we investigated the potential strategies of AMF symbiosis to alleviate Se stress in maize (Zea mays) from plants and s...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Chenyu Sun Yisen Yang Muhammad Zeeshan Shengfeng Qin Junqing Ma Lu Liu Juan Yang Xunbo Zhou Jinghua Huang Source Type: research

Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules
Ecotoxicol Environ Saf. 2021 Nov 19;228:112993. doi: 10.1016/j.ecoenv.2021.112993. Online ahead of print.ABSTRACTAcute exposure to cadmium (Cd) causes vacuolar degeneration in buffalo rat liver 3 A (BRL 3 A) cells. The present study aimed to determine the relationship between Cd-induced microtubule damage and intracellular vacuolar degeneration. Western blotting results showed that Cd damaged the microtubule network and downregulated the expression of microtubule-associated proteins-kinesin-1 heavy chain (KIF5B), γ-tubulin, and acetylated α-tubulin in BRL 3 A cells. Immunofluorescence staining revealed that Cd ...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Junzhao Yuan Yumeng Zhao Yuni Bai Jianhong Gu Yan Yuan Xuezhong Liu Zongping Liu Hui Zou Jianchun Bian Source Type: research

Effects of embryonic exposure to bixafen on zebrafish (Danio rerio) retinal development
In this study, the effects of bixafen on retinal development were evaluated in embryo-larval zebrafish. We exposed zebrafish embryos to 0, 0.1, and 0.3 μM bixafen. Exposure of zebrafish embryos to bixafen caused severe retinal defects, including extreme microphthalmia and a significantly increased cell density of the ganglion cell layer (GCL). Compared with the controls, the expression levels of rod and cone photoreceptor marker genes (rho, opn1sw2, opn1mw1, opn1lw1, and opn1sw1) in the outer nuclear layer (ONL) were significantly downregulated after bixafen exposure. Furthermore, bixafen caused significantly increased ...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Peng Xiao Wenhua Li Jinfang Lu Yang Liu Qiulan Luo He Zhang Source Type: research

Exposure of the residents around the Three Gorges Reservoir, China to chromium, lead and arsenic and their health risk via food consumption
Ecotoxicol Environ Saf. 2021 Nov 19;228:112997. doi: 10.1016/j.ecoenv.2021.112997. Online ahead of print.ABSTRACTHydrological management of the Three Gorges Dam has resulted in the interception of heavy metals in the Three Gorges Reservoir (TGR). However, the exposure to heavy metals and health risks among local residents remained poorly understood. Here we collected 208 biomarker samples (hair) and 20 food species from typical regions in the TGR to assess the exposure levels of three toxic metals (Cr, Pb and As) in residents of the TGR, and subsequently investigated their health risk via dietary intake. Results indicated ...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Jingwen Yang Qing Xie Yongmin Wang Juan Wang Yongjiang Zhang Cheng Zhang Dingyong Wang Source Type: research

The distribution of microplastics in water, sediment, and fish of the Dafeng River, a remote river in China
In this study, we determined the distribution and characteristics of microplastics in the surface water, sediment, and fish of the river. During the dry and rainy seasons, the microplastics content of the surface water ranged from 3 × 10-4-2.5 × 10-3 items/L (7 × 10-4-0.12 items/m2) and 4 × 10-5-9 × 10-4 items/L (2 × 10-3-2.8 × 10-2 items/m2), while those in the sediment samples ranged from 9.4 to 50.3 items/kg (dry weight) and 0.0-21.3 items/kg, respectively. The pollution level during the dry season was approximately two to three times higher than that during the rainy season (P ...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Shuo Liu Huan Chen Jingzhen Wang Lei Su Xilong Wang Jingmin Zhu Wenlu Lan Source Type: research

The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure
Ecotoxicol Environ Saf. 2021 Nov 19;228:112959. doi: 10.1016/j.ecoenv.2021.112959. Online ahead of print.ABSTRACTDisruption of cholinergic neurotransmission can affect cognition, but little is known about whether low-to-moderate fluoride exposure affects cholinergic system and its effect on the prevalence of dental fluorosis (DF) and intelligence quotient (IQ). A cross-sectional study was conducted to explore the associations of moderate fluoride exposure and cholinergic system in relation to children's DF and IQ. We recruited 709 resident children in Tianjin, China. Ion selective electrode method was used to detect fluori...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Sumei Wang Qian Zhao Gaochun Li Mengwei Wang Hongliang Liu Xingchen Yu Jingwen Chen Pei Li Lixin Dong Guoyu Zhou Yushan Cui Mengru Wang Li Liu Aiguo Wang Source Type: research

Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
Ecotoxicol Environ Saf. 2021 Nov 19;228:112992. doi: 10.1016/j.ecoenv.2021.112992. Online ahead of print.ABSTRACTMCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis ...
Source: Ecotoxicology and Environmental Safety - November 22, 2021 Category: Environmental Health Authors: Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng Source Type: research

Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
Ecotoxicol Environ Saf. 2021 Nov 18;228:113003. doi: 10.1016/j.ecoenv.2021.113003. Online ahead of print.ABSTRACTThe eco-risk of roxarsone (ROX) was evaluated using multiple responses of earthworm biomarkers under different ROX concentrations for 28 d. With the increasing total arsenic accumulation (TAs-E), biological responses in earthworm generally showed a two-stage changes of homeostasis dysregulation and dose-dependent alterations. At the early periods, ROX stress increased the reactive oxygen species (ROS) and lipid peroxidation (LPO) in a similar manner, and apparently disrupted mitochondrial calcium ([Ca2+]m). But ...
Source: Ecotoxicology and Environmental Safety - November 21, 2021 Category: Environmental Health Authors: Songge Deng Hao Tang Hanqi Duan Yizhao Wu Jiangping Qiu Yinsheng Li Source Type: research

Changes in metabolomics and lipidomics in brain tissue and their correlations with the gut microbiome after chronic food-derived arsenic exposure in mice
In this study, to discuss the disturbances on brain metabolome and lipidome under subchronic arsenic exposure, we treated mice with the arsenic-containing feed (concentration of total arsenic = 30 mg/kg) prepared in accordance with the proportion of rice arsenicals for 16 weeks and performed metabolomics and lipidomics studies respectively using UHPLC-Triple-TOF-MS/MS and UHPLC-Q Exactive Focus MS/MS on mice brain. In addition, the distributions of arsenical metabolites along the feed-gut-blood-brain chain were analyzed by ICP-MS and HPLC-ICP-MS, and fecal microbial variations were investigated by 16 s sequencing. The data...
Source: Ecotoxicology and Environmental Safety - November 21, 2021 Category: Environmental Health Authors: Chenfei Wang Hongyu Deng Dongbin Wang Jiating Wang Hairong Huang Jiayi Qiu Yinfei Li Tangbin Zou Lianxian Guo Source Type: research