Ecotoxicology and Environmental Safety This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Identification of Bromophenols' glucuronidation and its induction on UDP- glucuronosyltransferases isoforms
This study aims to identify UDP- glucuronosyltransferases (UGTs) isoforms involved in the metabolic elimination of BPs. Mono-glucuronides of BPs were detected in human liver microsomes (HLMs) incubated with the co-factor uridine-diphosphate glucuronic acid (UDPGA). The glucuronidation metabolism reactions catalyzed by HLMs followed Michaelis-Menten or substrate inhibition kinetics. Recombinant enzymes and inhibition experiments with chemical reagents were employed to phenotype the principal UGT isoforms participating in BP glucuronidation. UGT1A6 emerged as the major enzyme in the glucuronidation of 4-Bromophenol (4-BP), w...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Haoqian Zhang Li Yang Dandan Shen Yuanhang Zhu Lihua Zhang Source Type: research

Linc01588 deletion inhibits the malignant biological characteristics of hydroquinone-induced leukemic cells via miR-9-5p/SIRT1
This study is the first to reveal the expression of aberrant genes in leukemic cells of HQ-induced malignant transformation, which may correspond to chronic lymphocytic leukemia (CLL). The expression of Linc01588, a long non-coding RNA (lncRNA), was significantly up-regulated in CLL patients and leukemic cell line model which previously described. After gain-of-function assays and loss-of-function assays, feeble cell viability, severe apoptotic phenotype and the increased secretion of TNF-α were easily observed in malignant leukemic TK6 cells with Linc01588 deletion after HQ intervention. The tumors derived from malignant...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Yanquan Liu Minjuan Zeng Zhengzhen Li Caixiong Lin Jie Bao Weihua Ding Shimei Wang Qin Fan Qian Sun Hao Luo Jinqi Huang Shaopeng Chen Huanwen Tang Source Type: research

Cylindrospermopsin enhances the conjugative transfer of plasmid-mediated multi-antibiotic resistance genes through glutathione biosynthesis inhibition
Ecotoxicol Environ Saf. 2024 Apr 5;276:116288. doi: 10.1016/j.ecoenv.2024.116288. Online ahead of print.ABSTRACTCylindrospermopsin (CYN), a cyanobacterial toxin, has been detected in the global water environment. However, information concerning the potential environmental risk of CYN is limited, since the majority of previous studies have mainly focused on the adverse health effects of CYN through contaminated drinking water. The present study reported that CYN at environmentally relevant levels (0.1-100 μg/L) can significantly enhance the conjugative transfer of RP4 plasmid in Escherichia coli genera, wherein application...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Shuran Yang Jinrui Cao Chen Zhao Xi Zhang Chenyu Li Shang Wang Xiaobo Yang Zhigang Qiu Chao Li Jingfeng Wang Bin Xue Zhiqiang Shen Source Type: research

Rifampicin synergizes the toxicity of insecticides against the green peach aphid, Myzus persicae
Ecotoxicol Environ Saf. 2024 Apr 5;276:116291. doi: 10.1016/j.ecoenv.2024.116291. Online ahead of print.ABSTRACTMyzus persicae is an important pest that has developed resistance to nearly all currently used insecticidal products. The employment of insecticide synergists is one of the effective strategies that need to be developed for the management of this resistance. Our study showed that treatment with a combination of the antibiotic, rifampicin, with imidacloprid, cyantraniliprole, or clothianidin significantly increased their toxicities against M. persicae, by 2.72, 3.59, and 2.41 folds, respectively. Rifampicin treatm...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Zengxin Li Wenhong Li Qing Mu Yicheng Zhu Weiwei Qin Xiaobin Shi Yueping He Source Type: research

Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research

Protective effects of sodium butyrate on fluorosis in rats by regulating bone homeostasis and serum metabolism
In this study, a rat model of fluorosis induced by 100 mg/L sodium fluoride was used to investigate the impact of NaB on bone homeostasis and serum metabolomics. It was found that NaB significantly reduced the levels of bone resorption markers CTX-Ⅰ and TRACP-5B in fluorosis rats. Moreover, NaB increased calcium and magnesium levels in bone, while decreasing phosphorus levels. In addition, NaB improved various bone microstructure parameters, including bone mineral density (BMD), trabecular thickness (Tb. Th), trabecular bone separation (Tb. SP), and structural model index (SMI) in the femur. Notably, NaB intervention als...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Ying Li Fengmei Yang Jie Liu Mengqi Jiang Ye Yu Qingyi Zhou Lu Sun Zhuo Zhang Lin Zhou Source Type: research

Integrated assessment of potentially toxic elements in soil of the Kangdian metallogenic province: A two-point machine learning approach
This study explored a comprehensive approach that combinescombines the spatial prediction by the two-point machine learning method and ecological-health risk assessment to quantitatively assess the comprehensive potential ecological risk index (PERI), the total hazard index (THI) and the total carcinogenic risk (TCR). The proportions of copper (Cu), cadmium (Cd), manganese (Mn), lead (Pb), zinc (Zn), and arsenic (As) concentrations exceeding the risk screening values (RSVs) were 15.03%, 5.1%, 3.72%, 1.24%, 1.1%, and 0.13%, respectively, across the 725 collected samples. Spatial prediction revealed elevated levels of As, Cd...
Source: Ecotoxicology and Environmental Safety - April 5, 2024 Category: Environmental Health Authors: Wantao Yang Liankai Zhang Bingbo Gao Xiaojie Liu Xingwu Duan Chenyi Wang Ya Zhang Qiang Li Lingqing Wang Source Type: research

Cell type-dependent response to benzo(a)pyrene exposure of human placental cell lines under normoxic, hypoxic, and pro-inflammatory conditions
In conclusion, our results showed that BaP affected mitochondrial function in trophoblast cell lines by increasing ΔΨm. This increased ΔΨm may have rescued the trophoblast cells from activation of the NLRP3 inflammasome and apoptosis after BaP treatment. We also observed that different human trophoblast cell lines had cell type-dependent responses to BaP exposure under normoxia, hypoxia, or pro-inflammatory conditions.PMID:38579532 | DOI:10.1016/j.ecoenv.2024.116287 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 5, 2024 Category: Environmental Health Authors: Yifeng Dai Xijin Xu Xia Huo Joost H N Schuitemaker Marijke M Faas Source Type: research

Arsenic mobilization across the sediment-water interface of the Three Gorges Reservoir as a function of water depth using DGT and HR-Peepers, a preliminary study
Ecotoxicol Environ Saf. 2024 Apr 3;276:116276. doi: 10.1016/j.ecoenv.2024.116276. Online ahead of print.ABSTRACTThe artificial regulation of the Three Gorges Reservoir (TGR) creates large water level fluctuation zones (WLFZ) that may change the behavior of metals and metalloid in sediment, particularly redox sensitive elements. Mobilization of As, Fe and Mn across the sediment-water interface (SWI) in the TGR as a function of different water depth (periodically and permanently submerged sediments, respectively) was in situ determined by diffusive gradients in thin films (DGT) and high-resolution dialysis technique (HR-Peep...
Source: Ecotoxicology and Environmental Safety - April 5, 2024 Category: Environmental Health Authors: Yingqun Ma Chenchen Yang Zhichao Liu Chaonan Han Yanwen Qin Source Type: research

Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors
Ecotoxicol Environ Saf. 2024 Apr 3;276:116261. doi: 10.1016/j.ecoenv.2024.116261. Online ahead of print.ABSTRACTSuccinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for these agrochemicals, the interactions of 15 SDHIs with expression and activity of human cytochrome P-450 3A4 (CYP3A4), a major hepatic drug metabolizing enzyme, were investigated in vitro. 12/15 SDHIs, i.e., bixafen, boscalid, fluopyram, flutolanil, fluxapyroxad, furametpyr, isofetamid, isopyrazam, penflufen, penthio...
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Marie Kerhoas Jennifer Carteret Lilou Huchet Elodie Jouan Laurence Huc Marc Le V ée Olivier Fardel Source Type: research

Integrated transcriptomics and metabolomics reveal the mechanism of intestinal damage upon acute patulin exposure in mice
Ecotoxicol Environ Saf. 2024 Apr 3;276:116270. doi: 10.1016/j.ecoenv.2024.116270. Online ahead of print.ABSTRACTMycotoxin contamination has become a major food safety issue and greatly threatens human and animal health. Patulin (PAT), a common mycotoxin in the environment, is exposed through the food chain and damages the gastrointestinal tract. However, its mechanism of enterotoxicity at the genetic and metabolic levels remains to be elucidated. Herein, the intestinal histopathological and biochemical indices, transcriptome, and metabolome of C57BL/6 J mice exposed to different doses of PAT were successively assessed, as ...
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Ting Zhang Min Yan Min Chang Xiaohui Hou Furong Wang Wei Song Yuan Wang Kewei Feng Yahong Yuan Tianli Yue Source Type: research

Particulate matter (PM < sub > 10 < /sub > ) exacerbates on MK-801-induced schizophrenia-like behaviors through the inhibition of ERK-CREB-BDNF signaling pathway
Ecotoxicol Environ Saf. 2024 Apr 3;276:116294. doi: 10.1016/j.ecoenv.2024.116294. Online ahead of print.ABSTRACTParticulate matter (PM), released into the air by a variety of natural and human activities, is a key indicator of air pollution. Although PM is known as the extensive health hazard to affect a variety of illness, few studies have specifically investigated the effects of PM10 exposure on schizophrenic development. In the present study, we aimed to investigate the impact of PM10 on MK-801, N-methyl-D-aspartate (NMDA) receptor antagonist, induced schizophrenia-like behaviors in C57BL/6 mouse. Preadolescent mice wer...
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Seung-Hyuk Choi Ho Jung Bae So-Yeon Kim Tamanna Jahan Mony Hyun-Jeong Kim Ye Eun Cho Yu-Yeong Choi Ju-Yeon An So-Young Cho Dong Hyun Kim Se Jin Park Source Type: research

Effects of multiple metals exposure on abnormal liver function: The mediating role of low-density lipoprotein cholesterol
This study may provide critical public health significances in liver injury prevention and scientific evidence for the establishment of environmental standard.PMID:38574647 | DOI:10.1016/j.ecoenv.2024.116283 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Xu Han Ziquan Lv Mei'an He Jinquan Cheng Yanwei Zhang Tian Wang Jiaxin Chen Yuewei Liu Dongsheng Hu Xuli Wu Rihong Zhai Hui Huang Suli Huang Source Type: research

High-fat diet exacerbates 1-Bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway
In this study, adult C57BL/6 mice were fed either a chow or a high-fat diet for 18 weeks prior to 12-week 1-BP treatment. Subsequent neurobehavioral and neuropathological examinations were conducted to assess the effects of 1-BP exposure on parkinsonian pathology. The results demonstrated that 1-BP exposure produced obvious neurobehavioral abnormalities and dopaminergic degeneration in the nigral region of mice. Importantly, a high-fat diet further exacerbated the impact of 1-BP on motor and cognitive abnormalities in mice. Mechanistic investigation revealed that mitochondrial damage and mtDNA release induced by 1-BP and h...
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Mingxue Song Yalong Qiang Shuai Wang Shan Shan Liwen Zhang Caipei Liu Fuyong Song Xiulan Zhao Source Type: research