Polystyrene microplastics impair the functions of cultured mouse Leydig (TM3) and Sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum damage
This study is the first to elucidate the intracellular mechanism underlying the effects of PS-MPs in somatic testicular cells, corroborating that PS-MP might be one of the causes of an increase in male infertility through the impairment of steroidogenesis in Leydig cells and of the nurse function of Sertoli cells. Thus, our findings contributed with new information to the mechanism underlying the effects of PS-MP on the male reproductive system.PMID:38479314 | DOI:10.1016/j.ecoenv.2024.116202 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Giulia Grillo Sara Falvo Debora Latino Gabriella Chieffi Baccari Massimo Venditti Maria Maddalena Di Fiore Sergio Minucci Alessandra Santillo Source Type: research

Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research

Promoting effect of low concentration strontium on photosynthetic performance of Chinese cabbage seedlings: Combined leaf characteristics, photosynthetic carbon assimilation and chlorophyll fluorescence
Ecotoxicol Environ Saf. 2024 Mar 12;274:116200. doi: 10.1016/j.ecoenv.2024.116200. Online ahead of print.ABSTRACTLow concentration strontium (LC-Sr) can promote the growth of plants. In order to explore its promoting mechanism from the aspect of photosynthesis, the leaf characteristics, CO2 assimilation and chlorophyll (Chl) a fluorescence kinetics were investigated with hydroponically LC-Sr-treated Chinese cabbage seedlings. After a 28-d treatment to SrCl2 at different concentrations (0.1, 0.2, 0.5, and 1.0 mmol L-1), we observed an increase in the specific leaf weight (SLW) of Chinese cabbage compared with the control gr...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Erkun Chao Mengmeng Wu Dongxue Yue Yongxue Yuan Nianwei Qiu Feng Zhou Source Type: research

Assessing the toxicity of pesticides exposure on hepatic miRNA-target gene alterations in rat liver tissues via molecular and integrated network bioinformatics analysis
In conclusion, this study enhances our comprehension of the biological roles of miRNAs in hepatic toxicity induced by PPM and BF. The insights gained here not only shed light on molecular mechanisms but also open avenues for considering these miRNAs as potential diagnostic biomarkers in conditions of pesticide-induced hepatotoxicity, thereby guiding future therapeutic strategies.PMID:38479317 | DOI:10.1016/j.ecoenv.2024.116211 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Hakeemah Al-Nakhle Ahmed El-Tokhy Heba Eltahir Mohammed Almuayrifi Mekky Abouzied Khaled Abdelaal Muayad Albadrani Source Type: research

Transcriptome analysis of the Nile tilapia (Oreochromis niloticus) reveals altered expression of immune genes by cadmium
In this study, by using an RNA sequencing approach, the gene expression profiling was performed in livers of tilapia exposed to 0 (control), 50, 100, and 200 μg/L of Cd for 2 months. The results showed that exposure to 50 μg/L Cd altered the expressions of 911 genes, while exposure to 100 and 200 μg/L Cd resulted in 4318 and 3737 differentially expressed genes compared to the control. Weighted correlation network analysis (WGCNA) and gene ontology (GO) analysis identified a 14-gene network linked to the immune system development. Further, in a fuzzy analysis, the GO term immune system development was enriched in cluster...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Huan Zhong Yi Zhou Jun Xiao Zhongbao Guo Zhanyang Tang Yongju Luo Lingtian Xie Source Type: research

Enhancing the bioreduction and interaction of arsenic and iron by thiosulfate in groundwater
Ecotoxicol Environ Saf. 2024 Mar 12;274:116210. doi: 10.1016/j.ecoenv.2024.116210. Online ahead of print.ABSTRACTThiosulfate influences the bioreduction and migration transformation of arsenic (As) and iron (Fe) in groundwater environments. The aim of this study was to investigate the impact of microbially-mediated sulfur cycling on the bioreduction and interaction of As and Fe. Microcosm experiments were conducted, including bioreduction of thiosulfate, As(V), and Fe(III) by Citrobacter sp. JH012-1, as well as the influence of thiosulfate input at different initial arsenate concentrations on the bioreduction of As(V) and ...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yang Yang Jia Wang Xi Xie Zuoming Xie Mengna Chen Feng Zhong Source Type: research

Polystyrene microplastics impair the functions of cultured mouse Leydig (TM3) and Sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum damage
This study is the first to elucidate the intracellular mechanism underlying the effects of PS-MPs in somatic testicular cells, corroborating that PS-MP might be one of the causes of an increase in male infertility through the impairment of steroidogenesis in Leydig cells and of the nurse function of Sertoli cells. Thus, our findings contributed with new information to the mechanism underlying the effects of PS-MP on the male reproductive system.PMID:38479314 | DOI:10.1016/j.ecoenv.2024.116202 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Giulia Grillo Sara Falvo Debora Latino Gabriella Chieffi Baccari Massimo Venditti Maria Maddalena Di Fiore Sergio Minucci Alessandra Santillo Source Type: research

Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research

Long-term air pollutants exposure and respiratory mortality: A large prospective cohort study
Ecotoxicol Environ Saf. 2024 Mar 12;274:116176. doi: 10.1016/j.ecoenv.2024.116176. Online ahead of print.ABSTRACTAmbient air pollution is a major global health concern. Yet, no study has thoroughly assessed its link to respiratory mortality. Our research evaluated the combined and individual effects of air pollutants on respiratory mortality risks based on the UK Biobank. A total of 366,478 participants were studied. A Cox proportional hazards model was used to estimate the respiratory mortality risk from combined long-term exposure to five pollutants, summarized as a weighted air pollution score. During a median of 13.6 y...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Zhi-Hao Li Xiao-Meng Wang Dan-Qing Liao Qian Zhang Zi-Ting Chen Cheng-Shen Qiu Xu-Lian Tang Hong-Min Li Li-Ying Du Pei-Dong Zhang Dong Shen Xi-Ru Zhang Jian Gao Wen-Fang Zhong Pei-Liang Chen Qing-Mei Huang Wei-Qi Song Dan Liu Chuan Li Huan Chen Chen Mao Source Type: research

Synergistic application of Pseudomonas strains and compost mitigates lead (Pb) stress in sunflower (Helianthus annuus L.) via improved nutrient uptake, antioxidant defense and physiology
Ecotoxicol Environ Saf. 2024 Mar 12;274:116194. doi: 10.1016/j.ecoenv.2024.116194. Online ahead of print.ABSTRACTLead (Pb) is one of the most dreadful non-essential elements whose toxicity has been well reported worldwide due to its interference with the major plant functions and its overall yield. Bioremediation techniques comprising the application of beneficial microorganisms have gained attention in recent times owing to their ecofriendly nature. Addition of organic matter to soil has been reported to stimulate microbial activities. Compost application improves soil structure and binds toxic contaminants due to its lar...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Aqsa Ayub Muhammad Shabaan Mehreen Malik Hafiz Naeem Asghar Usman Zulfiqar Mukkaram Ejaz Khaloud Mohammed Alarjani Dunia A Al Farraj Source Type: research

Probabilistic human health risk assessment of PCDD/Fs near municipal solid-waste incinerator using Monte Carlo analysis coupled with triangular fuzzy numbers
Ecotoxicol Environ Saf. 2024 Mar 11;274:116203. doi: 10.1016/j.ecoenv.2024.116203. Online ahead of print.ABSTRACTPCDD/Fs are dioxins produced by waste incineration and pose risks to human health. We aimed to detail the health risks of airborne and soil PCDD/Fs near a municipal solid-waste incinerator (MSWI) for the surrounding population and develop a new model that improves upon existing methods. Thus, we conducted field sampling and then investigated a MSWI in the Pearl River Delta (2016-2018). Our results showed that the carcinogenic and non-carcinogenic risk values of PCDD/Fs exposed to residents in nearby areas were a...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Qing-Fang Fan Li-Jun Liu Fang Liu Zong-Yao Zhang Yi Xie Chao-Xian Wei Bei-Bei Liu Zhi-Qiang Gao Bi-Gui Lin Xi-Chao Chen Source Type: research

Promoting effect of low concentration strontium on photosynthetic performance of Chinese cabbage seedlings: Combined leaf characteristics, photosynthetic carbon assimilation and chlorophyll fluorescence
Ecotoxicol Environ Saf. 2024 Mar 12;274:116200. doi: 10.1016/j.ecoenv.2024.116200. Online ahead of print.ABSTRACTLow concentration strontium (LC-Sr) can promote the growth of plants. In order to explore its promoting mechanism from the aspect of photosynthesis, the leaf characteristics, CO2 assimilation and chlorophyll (Chl) a fluorescence kinetics were investigated with hydroponically LC-Sr-treated Chinese cabbage seedlings. After a 28-d treatment to SrCl2 at different concentrations (0.1, 0.2, 0.5, and 1.0 mmol L-1), we observed an increase in the specific leaf weight (SLW) of Chinese cabbage compared with the control gr...
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Erkun Chao Mengmeng Wu Dongxue Yue Yongxue Yuan Nianwei Qiu Feng Zhou Source Type: research

Assessing the toxicity of pesticides exposure on hepatic miRNA-target gene alterations in rat liver tissues via molecular and integrated network bioinformatics analysis
In conclusion, this study enhances our comprehension of the biological roles of miRNAs in hepatic toxicity induced by PPM and BF. The insights gained here not only shed light on molecular mechanisms but also open avenues for considering these miRNAs as potential diagnostic biomarkers in conditions of pesticide-induced hepatotoxicity, thereby guiding future therapeutic strategies.PMID:38479317 | DOI:10.1016/j.ecoenv.2024.116211 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Hakeemah Al-Nakhle Ahmed El-Tokhy Heba Eltahir Mohammed Almuayrifi Mekky Abouzied Khaled Abdelaal Muayad Albadrani Source Type: research

Production and release of 2-MIB in Pseudanabaena: Effects of growth phases on cell characteristics and 2-MIB yield
This study investigated the effects of the growth phases on the production of 2-MIB by Pseudanabaena. The effects of cell characteristics on the production and release of 2-MIB were also explored. The total 2-MIB concentration increased during the exponential phase and decreased during the declining phase, which was consistent with the changes in cell density. However, the total 2-MIB yield (1.12-1.27 fg cell-1) of Pseudanabaena did not significantly differ throughout the growth cycle (p > 0.05). Meanwhile, the extracellular 2-MIB yield increased significantly from 0.31 fg cell-1 in the exponential phase to 0.76 fg cell...
Source: Ecotoxicology and Environmental Safety - March 12, 2024 Category: Environmental Health Authors: Hailing Wang Lin Li Shaozhe Cheng Liang Chen Haiyang Zhang Xuezhi Zhang Source Type: research

Periodic DFT calculations for the heterogeneous formation of 2-chlorothiophenoxy radical from 2-chlorothiophenol on Cu(111) surface in fly ash
Ecotoxicol Environ Saf. 2024 Mar 11;274:116186. doi: 10.1016/j.ecoenv.2024.116186. Online ahead of print.ABSTRACTCopper plays a crucial role in the heterogenous dissociation of chlorothiophenols (CTPs) to form chlorothiophenoxy radicals (CTPRs), which is the initial and critical step in the formation of polychlorinated thianthrenes/dibenzothiophenes (PCTA/DTs). Here, first-principles calculations were performed to investigate the activity of Cu(111) surface towards the formation of adsorbed 2-CTPR from 2-CTP. The interaction between 2-CTP and Cu(111) surface was explored to find stable adsorption configurations. Besides, t...
Source: Ecotoxicology and Environmental Safety - March 12, 2024 Category: Environmental Health Authors: Xiaotong Wang Yanan Han Mohammad Hassan Hadizadeh Wei Wang Qi Zhang Yongxia Hu Fei Xu Yanhui Sun Wenxing Wang Source Type: research