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Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome
This study aims to investigate the specific danger signals and mechanisms underlying skin damage in THS through in vivo and in vitro experiments. We identified that cell supernatant containing 15 kDa granulysin (GNLY), released from activated CD3-CD56+NK cells or CD3+CD56+NKT cells in PBMC induced by TCE or its metabolite, promoted apoptosis in HaCaT cells. The apoptosis level decreased upon neutralization of GNLY in the supernatant by a GNLY-neutralizing antibody in HaCaT cells. Subcutaneous injection of recombinant 15 kDa GNLY exacerbated skin damage in the THS mouse model and better mimicked patients' disease states. Re...
Source: Ecotoxicology and Environmental Safety - March 12, 2024 Category: Environmental Health Authors: Bo Jiao Hua Zhang Haiqin Jiang Shuai Liu Yican Wang Yuanyuan Chen Huawei Duan Yong Niu Meili Shen Hongsheng Wang Yufei Dai Source Type: research

Triphenyltin induced darker body coloration by disrupting melanocortin system and pteridine metabolic pathway in a reef fish, Amphiprion ocellaris
In this study, a brightly colored representative reef fish, Amphiprion ocellaris was used to explore the effects of TPT at environmental levels (1, 10, and 100 ng/L) on skin pigment synthesis. After the fish were exposed to TPT for 60 days, the skin became darker, owing to an increase in the relative area of black stripes, a decrease in orange color values while an increase in brown color values, and an increase in the number of melanocytes in the orange part of the skin tissues. To explore the mechanisms by which TPT induces darker body coloration, the enzymatic activity and gene expression levels of the members of melano...
Source: Ecotoxicology and Environmental Safety - March 10, 2024 Category: Environmental Health Authors: Song Liu Yu Hou Ya-Jun Shi Nan Zhang Yi-Guang Hu Wen-Ming Chen Ji-Liang Zhang Source Type: research

Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio
This study provides a foundation for analyzing the mechanism of hepatotoxicity induced by BDE-47 on fish.PMID:38461574 | DOI:10.1016/j.ecoenv.2024.116192 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 10, 2024 Category: Environmental Health Authors: Xin Zhang Yujie Huang Lei Yang Shuhuang Chen Youlian Liu Ni Tang Zhiqiong Li Xiaoli Zhang Liangyu Li Defang Chen Source Type: research

Maternal exposure to deltamethrin during pregnancy and lactation impairs neurodevelopment of male offspring
Ecotoxicol Environ Saf. 2024 Mar 9;274:116196. doi: 10.1016/j.ecoenv.2024.116196. Online ahead of print.ABSTRACTDeltamethrin (DM) is a highly effective and widely used pyrethroid pesticide. It is an environmental factor affecting public and occupational health and exerts direct toxic effects on the central nervous system. As the major target organs for neurotoxicity of DM, the hippocampus and the cerebellum are critical to the learning and motor function. Pregnant Wistar rats were randomly divided into four groups and gavaged at doses of 0, 1, 4or 10 mg/kg/d DM from gestational day (GD) 0 to postnatal day (PN) 21. The PC12...
Source: Ecotoxicology and Environmental Safety - March 10, 2024 Category: Environmental Health Authors: Fei Hao Ye Bu Shasha Huang Wanqi Li Huiwen Feng Yuan Wang Source Type: research

Corrigendum to "Comparison of antibiotic-resistant Escherichia coli and extra-intestinal pathogenic E. coli from main river basins under different levels of the sewer system development" [Ecotoxicol.  Environ. Saf., 2023, 263, 115372]
Ecotoxicol Environ Saf. 2024 Mar 9;274:116188. doi: 10.1016/j.ecoenv.2024.116188. Online ahead of print.NO ABSTRACTPMID:38461576 | DOI:10.1016/j.ecoenv.2024.116188 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 10, 2024 Category: Environmental Health Authors: Jung-Sheng Chen Bing-Mu Hsu Wen-Chien Ko Jiun-Ling Wang Source Type: research